Standard name
Human Ortholog
Description Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Bud – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Bud Neck – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Bud Site – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Cytoplasm – 0 0 0 0.05 0.09 – 0.08 0.15 0.1 0.11 0.11 – – – 0.12 0.1 0.15 – 0 0 0 0 0
Endoplasmic Reticulum – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0.07 0 – 0 0 0 0 0
Endosome – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0.05 0.1
Golgi – 0 0 0 0.14 0 – 0 0 0.05 0 0.07 – – – 0.06 0.07 0.15 – 0 0 0 0 0
Mitochondria – 0.06 0.08 0.27 0.2 0.4 – 0.52 0.44 0.46 0.48 0.4 – – – 0.12 0.08 0.09 – 0 0 0 0 0
Nucleus – 0.25 0 0 0 0 – 0 0 0 0 0 – – – 0 0.06 0 – 0.05 0 0 0 0
Nuclear Periphery – 0.12 0.2 0.14 0.06 0.05 – 0 0 0.07 0 0 – – – 0.12 0.14 0.3 – 0 0.15 0 0.08 0
Nucleolus – 0.06 0.05 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
SpindlePole – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Vac/Vac Membrane – 0.5 0.93 0.88 0.81 0.62 – 0.55 0.56 0.56 0.61 0.59 – – – 0.76 0.72 0.76 – 0.88 0.77 0.99 0.75 0.8
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 – 1 1 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Bud – 0 0 0 0 2 – 1 1 0 2 2 – – – 0 0 0 – 0 2 0 0 0
Bud Neck – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
Bud Site – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 1 0 – – – – – –
Cell Periphery – 0 0 1 0 0 – 11 4 6 5 8 – – – 0 2 3 – 0 0 0 0 0
Cytoplasm – 0 5 1 10 20 – 29 42 39 33 36 – – – 2 7 10 – 0 0 0 0 0
Endoplasmic Reticulum – 0 2 1 1 3 – 11 9 16 4 9 – – – 0 5 1 – 0 0 0 2 0
Endosome – 0 1 3 1 5 – 3 5 1 5 3 – – – 0 1 1 – 1 3 0 3 5
Golgi – 0 8 5 27 7 – 15 7 17 1 21 – – – 1 5 10 – 0 0 0 1 0
Mitochondria – 1 15 46 39 85 – 192 125 175 145 128 – – – 2 6 6 – 0 5 0 0 0
Nucleus – 4 2 1 0 4 – 2 2 2 0 0 – – – 0 4 2 – 2 0 0 0 0
Nuclear Periphery – 2 37 23 11 10 – 16 8 25 8 14 – – – 2 10 20 – 1 27 0 6 2
Nucleolus – 1 9 3 5 3 – 4 1 0 0 3 – – – 0 1 1 – 0 0 0 1 0
Peroxisomes – 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 – 0 0 0 0 0
SpindlePole – 0 0 0 0 0 – 1 0 0 1 0 – – – 0 1 1 – 0 0 0 0 0
Vac/Vac Membrane – 8 171 148 155 131 – 204 158 211 181 188 – – – 13 51 51 – 44 144 10 58 45
Unique Cell Count 16 183 168 191 212 371 284 377 299 317 17 71 67 51 187 11 77 57
Labelled Cell Count 16 250 232 249 270 490 363 492 385 412 20 94 106 51 187 11 77 57


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 20.0 12.9 12.8 11.2 9.5 – 9.4 9.7 9.3 9.7 9.9 – – – 9.0 9.8 12.0 – 14.5 15.2
Std Deviation (1e-4) – 5.9 2.7 2.8 2.1 2.0 – 1.8 2.0 1.9 2.1 2.3 – – – 2.3 3.9 3.9 – 3.5 3.6
Intensity Change (Log2) – – – -0.0 -0.2 -0.44 – -0.45 -0.41 -0.46 -0.41 -0.39 – – – -0.52 -0.4 -0.11 – 0.17 0.24


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Bud 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Cytoplasm 0 1.2 2.7 – 2.3 4.2 3.1 3.3 3.4 – – – 0 0 0
Endoplasmic Reticulum 0 0 0 – 0 0 2.0 0 0 – – – 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Golgi -0.7 3.2 -0.6 – -0.2 -1.1 0.1 0 1.0 – – – 0 0 0
Mitochondria 4.7 3.4 7.3 – 10.0 8.2 9.0 9.1 7.7 – – – 0 0.1 0.2
Nucleus 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Nuclear Periphery -1.6 -4.2 -4.7 – -6.0 -6.2 -4.8 -6.4 -5.6 – – – 0 -1.1 1.6
Nucleolus -1.6 -1.2 -2.0 – 0 0 0 0 0 – – – 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 – – – 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 – – – 0 0 0
Vacuole -1.7 -3.6 -7.4 – -9.1 -8.7 -8.9 -7.9 -8.2 – – – -2.5 -4.7 -3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin – – – – – – 0.0004 0 0.0034 0 0.0019 0 – – – – – –
Bud – – – – – – 0.0008 0.0002 0.0001 0 0 0 – – – – – –
Bud Neck – – – – – – 0.0006 0 0 0 0 0 – – – – – –
Bud Periphery – – – – – – 0.0021 0.0004 0.0002 0.0001 0.0001 0.0001 – – – – – –
Bud Site – – – – – – 0.0009 0.0001 0.0001 0 0.0001 0 – – – – – –
Cell Periphery – – – – – – 0.0016 0.0013 0.0005 0.0002 0.0002 0.0002 – – – – – –
Cytoplasm – – – – – – 0.0008 0.0003 0.0001 0 0 0 – – – – – –
Cytoplasmic Foci – – – – – – 0.0027 0 0.0021 0 0.0017 0.0002 – – – – – –
Eisosomes – – – – – – 0 0 0.0001 0 0 0 – – – – – –
Endoplasmic Reticulum – – – – – – 0.0013 0.001 0.0011 0.0001 0.0002 0.0003 – – – – – –
Endosome – – – – – – 0.0254 0.0027 0.0036 0.0011 0.003 0.0034 – – – – – –
Golgi – – – – – – 0.003 0.0001 0.001 0.0001 0.0011 0.0002 – – – – – –
Lipid Particles – – – – – – 0.0139 0.0003 0.0042 0.0022 0.0117 0.005 – – – – – –
Mitochondria – – – – – – 0.0521 0.0038 0.0145 0.0076 0.0073 0.0078 – – – – – –
None – – – – – – 0.0002 0.0027 0.0001 0 0.0001 0 – – – – – –
Nuclear Periphery – – – – – – 0.0335 0.0304 0.017 0.0141 0.0051 0.0292 – – – – – –
Nucleolus – – – – – – 0.0047 0.0004 0.0039 0.0002 0.0003 0.0003 – – – – – –
Nucleus – – – – – – 0.0058 0.0011 0.0013 0.0003 0.0002 0.0003 – – – – – –
Peroxisomes – – – – – – 0.0016 0 0.0008 0 0.0322 0 – – – – – –
Punctate Nuclear – – – – – – 0.0001 0 0.0004 0 0.0001 0 – – – – – –
Vacuole – – – – – – 0.2573 0.2282 0.124 0.0961 0.0545 0.0566 – – – – – –
Vacuole Periphery – – – – – – 0.5911 0.7269 0.8216 0.8776 0.8802 0.8965 – – – – – –

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 140.3125 172.9313 155.3087 183.9782 137.2483 95.4261 156.6526 155.9992 134.1749 155.8153
Translational Efficiency 0.6848 0.8037 0.927 0.6496 0.737 0.849 0.6536 0.5897 0.5906 0.5588

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
925 206 154 1268 41 69 2881 81 966 275 3035 1349

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1514.10 1750.24 2123.24 1234.98 298.30 1127.72 1299.20 2171.14 1462.50 1594.04 1341.01 1291.19
Standard Deviation 301.18 431.70 606.26 341.82 5.06 344.34 221.09 540.54 383.32 492.13 312.66 420.52
Intensity Change Log 2 — 0.209092 0.487807 -0.293973 — 1.918573 2.122788 2.863617 — 0.667145 0.917124 0.910228

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000244 0.000074 0.000212 0.000419 0.000040 0.000134 0.000013 0.000049 0.000235 0.000089 0.000024 0.000396
Bud Neck 0.001602 0.000636 0.001917 0.002275 0.000015 0.001533 0.000331 0.000314 0.001535 0.000861 0.000412 0.002157
Bud Site 0.002857 0.001843 0.000365 0.011303 0.000036 0.012078 0.000386 0.000599 0.002737 0.004411 0.000385 0.010660
Cell Periphery 0.002078 0.001359 0.000193 0.003959 0.000094 0.011646 0.001189 0.000943 0.001994 0.003940 0.001138 0.003778
Cytoplasm 0.000551 0.002488 0.000054 0.001460 0.000059 0.005858 0.000043 0.000049 0.000530 0.003334 0.000044 0.001375
Cytoplasmic Foci 0.001404 0.002069 0.004942 0.003498 0.000018 0.002749 0.000065 0.000915 0.001345 0.002240 0.000312 0.003343
Eisosomes 0.000031 0.000025 0.000083 0.000064 0.000070 0.000020 0.000026 0.000039 0.000032 0.000023 0.000029 0.000063
Endoplasmic Reticulum 0.000229 0.000269 0.000216 0.000877 0.000001 0.001528 0.000323 0.000278 0.000220 0.000585 0.000318 0.000841
Endosome 0.003834 0.002843 0.000945 0.006978 0.000002 0.018703 0.000330 0.002108 0.003671 0.006823 0.000361 0.006686
Golgi 0.003883 0.006973 0.002078 0.012958 0.000007 0.004056 0.000140 0.013706 0.003719 0.006241 0.000239 0.013003
Lipid Particles 0.000527 0.000726 0.001063 0.001624 0.000031 0.000475 0.000757 0.000731 0.000506 0.000663 0.000772 0.001570
Mitochondria 0.005936 0.016712 0.062156 0.026132 0.000012 0.002753 0.001701 0.005241 0.005685 0.013209 0.004768 0.024877
Mitotic Spindle 0.000335 0.004145 0.000462 0.000388 0.000352 0.000200 0.000007 0.000019 0.000335 0.003155 0.000030 0.000365
None 0.000244 0.000688 0.001923 0.001245 0.999087* 0.000431 0.000158 0.000410 0.042638 0.000624 0.000248 0.001195
Nuclear Periphery 0.000637 0.001287 0.011747 0.000541 0.000000 0.000849 0.000983 0.000752 0.000610 0.001177 0.001529 0.000554
Nuclear Periphery Foci 0.000306 0.001733 0.008759 0.000562 0.000033 0.000715 0.000254 0.000457 0.000295 0.001478 0.000685 0.000556
Nucleolus 0.002883 0.004921 0.023802 0.004019 0.000034 0.002964 0.002032 0.001749 0.002762 0.004430 0.003137 0.003883
Nucleus 0.001032 0.003643 0.004239 0.001788 0.000014 0.004263 0.001365 0.000150 0.000988 0.003799 0.001511 0.001690
Peroxisomes 0.000874 0.000207 0.000791 0.001154 0.000093 0.001499 0.000030 0.000087 0.000841 0.000531 0.000069 0.001090
Vacuole 0.282299* 0.199860 0.194546 0.358512* 0.000002 0.346293* 0.269596* 0.317022* 0.270318* 0.236601* 0.265788* 0.356021*
Vacuole Periphery 0.688215* 0.747500* 0.679506* 0.560244* 0.000000 0.581252* 0.720269* 0.654381* 0.659005* 0.705787* 0.718201* 0.565897*

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.10 0.22 -1.02 -4.00 -2.31 -1.05 2.21 -0.43 0.94 -1.98 0.98 1.46 -0.99 -3.71 -4.75
Bud Neck 3.13 -0.52 -1.64 -5.06 -0.72 -2.53 -6.10 -4.06 2.01 0.21 2.16 4.27 -1.60 -3.97 -6.40
Bud Site 0.81 3.70 -5.39 -5.35 -7.81 -2.66 -3.19 -2.62 2.53 -0.87 -1.04 3.62 -5.36 -3.26 -7.78
Cell Periphery 0.94 3.20 -2.55 -3.92 -8.67 -1.17 -4.20 -3.96 1.09 0.74 -0.75 1.41 -2.54 0.06 -5.54
Cytoplasm -1.28 2.77 -1.82 1.09 -4.23 -1.42 0.57 0.27 1.42 -0.13 -1.62 2.82 -1.77 1.40 -4.26
Cytoplasmic Foci -0.50 -2.80 -2.27 -1.02 1.04 -2.12 -9.05 -1.27 1.24 -1.21 -0.82 1.98 -2.28 -0.94 -4.26
Eisosomes 0.92 -3.10 -4.62 -6.16 1.11 2.35 2.13 1.08 -0.95 -0.67 1.44 0.61 -4.31 -6.70 -6.52
Endoplasmic Reticulum -0.58 0.09 -7.76 -5.95 -5.11 -3.83 -14.81 -2.44 3.01 0.39 -3.04 -2.44 -7.86 -1.86 -7.02
Endosome 0.70 2.84 -2.71 -3.19 -7.51 -1.88 -7.72 -1.85 1.66 -1.56 -1.12 3.73 -2.73 0.04 -9.74
Golgi -1.10 1.57 -5.21 -2.04 -7.08 -1.81 -13.10 -1.35 -0.93 -1.34 -1.12 3.64 -5.29 -2.72 -8.69
Lipid Particles -1.00 -2.31 -3.46 -2.98 -1.72 -2.56 -18.40 -5.00 -1.15 0.17 -0.86 -1.75 -3.55 -3.26 -3.03
Mitochondria -2.29 -5.31 -7.35 -1.88 3.33 -2.96 -3.35 -2.76 -1.18 -1.81 -2.06 0.62 -7.38 -2.90 -8.41
Mitotic Spindle -0.98 -0.51 -0.32 0.97 0.33 1.45 5.54 5.33 2.15 -2.32 -0.97 1.98 -0.20 0.96 -4.08
None -5.07 -6.10 -10.14 -4.19 2.32 4470.67* 7010.42* 5482.74* 0.11 -2.15 6.48 6.54 6.39 -4.68 -10.17
Nuclear Periphery -2.23 -5.21 0.82 2.66 5.26 -1.73 -8.49 -4.15 0.18 1.07 -2.19 -4.92 0.50 2.53 5.69
Nuclear Periphery Foci -1.78 -2.17 -3.26 1.47 2.11 -1.21 -8.36 -4.46 0.45 -2.08 -1.92 -1.91 -3.50 1.50 0.63
Nucleolus -0.97 -3.71 -1.36 0.47 3.52 -2.23 -6.98 -2.47 0.82 0.38 -1.00 -0.47 -1.41 0.38 -1.24
Nucleus -1.65 -1.57 -2.07 1.37 1.20 -1.91 -6.63 -4.09 1.85 5.89 -2.00 -1.63 -2.03 1.66 -0.61
Peroxisomes 0.92 0.12 -0.34 -2.54 -0.85 -1.59 3.16 0.09 1.59 -0.97 0.43 1.11 -0.31 -1.36 -2.94
Vacuole 5.63 5.57 -7.32 -11.28 -10.80 -13.58 -62.18* -10.96 0.76 -1.62 2.46 0.64 -8.40 -8.86 -12.06
Vacuole Periphery -3.00 0.32 10.85 10.15 5.43 -18.94 -160.67* -21.01 -1.68 2.09 -2.50 -5.72 7.59 8.16 17.99*
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication
Localization
Cell Percentages vacuolar membrane (57%)
Cell Cycle Regulation No
Subcompartmental Group vac memb-2

Zrc1

Zrc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Zrc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available