Standard name
Human Ortholog
Description GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Cytoplasm 0.91 – 1.0 0.95 0.95 0.91 0.89 – 0.81 0.82 0.71 0.77 0.95 1.0 0.97 0.94 0.96 0.92 0.67 0.78 0.76 0.8 0.95 0.92
Endoplasmic Reticulum 0.06 – 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0.05 0.1 0.08 0 0 0 0
Endosome 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 – 0 0 0 0 0.06 – 0.14 0.12 0.34 0.18 0 0 0 0 0 0 0.1 0 0.07 0 0 0
Nucleus 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 – 0 0 0 0.06 0.06 – 0 0.05 0 0 0 0 0 0.06 0 0.05 0 0 0.06 0.06 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 2 2 1 4 – 0 1 1 4 0 0 0 0 3 0 3 1 0 0 0 1
Bud 1 – 0 2 0 1 6 – 2 3 7 7 0 0 0 0 0 0 0 0 0 0 0 1
Bud Neck 1 – 1 1 2 1 2 – 5 3 1 2 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 – 0 1 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 1 12 6 6 3 – 5 5 2 3 0 0 4 5 2 20 2 0 1 0 0 0
Cytoplasm 132 – 61 313 516 387 580 – 268 386 231 342 55 204 266 133 186 220 117 34 78 8 88 142
Endoplasmic Reticulum 9 – 0 8 13 21 11 – 7 5 7 18 1 3 1 4 7 11 18 3 2 0 0 0
Endosome 0 – 0 0 2 2 7 – 3 8 2 1 2 0 1 0 0 3 1 0 2 0 0 1
Golgi 0 – 0 0 1 0 1 – 0 0 0 0 0 0 1 1 0 0 3 0 0 0 0 0
Mitochondria 5 – 0 1 1 4 39 – 46 57 110 80 0 0 0 5 2 0 18 0 7 0 0 2
Nucleus 1 – 0 3 3 5 8 – 8 4 1 4 0 3 1 0 0 2 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 1 0 2 – 0 6 3 5 0 0 0 1 0 0 0 0 0 0 0 1
Vac/Vac Membrane 0 – 0 0 17 25 36 – 14 24 7 20 0 1 8 9 5 11 6 0 6 0 0 1
Unique Cell Count 145 61 328 543 427 651 332 472 326 445 58 205 275 142 193 239 176 45 103 10 93 155
Labelled Cell Count 149 63 342 564 453 699 358 504 373 487 58 211 282 158 205 267 176 45 103 10 93 155


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 – 6.2 5.7 6.3 5.1 5.3 – 4.6 4.8 4.3 4.6 6.3 7.4 7.2 7.4 7.6 7.2 – 5.4 6.2
Std Deviation (1e-4) 0.7 – 0.8 0.9 1.1 0.7 1.0 – 0.9 0.8 1.0 1.1 1.2 1.6 1.2 1.2 1.3 1.1 – 1.0 1.3
Intensity Change (Log2) – – – -0.12 0.03 -0.27 -0.22 – -0.44 -0.38 -0.52 -0.43 0.01 0.25 0.2 0.24 0.29 0.22 – -0.19 -0.0

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.7 -1.8 -2.5 -2.7 – -3.7 -3.6 -4.9 -4.2 -1.8 -0.5 -1.4 -2.0 -1.5 -2.3
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2873 1.4419 1.4523 1.0317 0.8092 1.3287 0.7179 1.1361 0.6641 0.3864 0.2332 0.6449 -0.5724 0.0046 -0.2242 -0.2579 0.6084 0.0345
Actin 0.0462 0.0033 0.0408 0.0001 0.041 0.0026 0.0234 0.0003 0.0054 0.0001 0.0002 0.0001 0.0168 0.0012 0.008 0.0008 0.0976 0.0065
Bud 0.0014 0.0038 0.0024 0 0.0014 0.0004 0.0019 0.0002 0.0002 0.0001 0 0 0.0004 0.0004 0.0014 0.0015 0.0051 0.0007
Bud Neck 0.0022 0.0012 0.0012 0.0001 0.0005 0.0017 0.0045 0.0001 0.0002 0.0003 0.0001 0.0003 0.0012 0.0001 0.0005 0.0007 0.0051 0.001
Bud Periphery 0.0048 0.0088 0.0023 0 0.0034 0.0004 0.0016 0.0002 0.0002 0.0002 0 0 0.0005 0.0003 0.0007 0.0014 0.0057 0.0005
Bud Site 0.0043 0.0107 0.0203 0.0001 0.0011 0.0001 0.0141 0.0008 0.0011 0.0001 0 0 0.0032 0.0009 0.0024 0.003 0.0167 0.0005
Cell Periphery 0.0022 0.0007 0.0008 0.0002 0.0001 0.0002 0.0004 0.0004 0.0003 0.0001 0.0001 0.0001 0.0004 0.0003 0.0003 0.0002 0.0011 0.0002
Cytoplasm 0.3633 0.5362 0.4606 0.5644 0.5257 0.6505 0.4199 0.5794 0.5225 0.7009 0.4364 0.7072 0.4045 0.6047 0.545 0.6913 0.2643 0.5844
Cytoplasmic Foci 0.0136 0.0101 0.023 0.0082 0.0105 0.0091 0.0329 0.0137 0.0065 0.0085 0.0436 0.0024 0.0922 0.0198 0.0248 0.0095 0.0514 0.0337
Eisosomes 0.0006 0.0002 0.0006 0 0.0003 0.0001 0.0001 0 0.0001 0 0 0 0.0002 0.0001 0.0001 0 0.0006 0.0001
Endoplasmic Reticulum 0.0261 0.009 0.0111 0.0489 0.0081 0.01 0.0096 0.0092 0.0264 0.0117 0.0066 0.0081 0.0219 0.0151 0.0245 0.02 0.0056 0.0127
Endosome 0.0307 0.0037 0.0186 0.0071 0.0355 0.0074 0.0288 0.0102 0.0127 0.007 0.0302 0.0015 0.0629 0.0105 0.014 0.0237 0.0599 0.0365
Golgi 0.0076 0.0009 0.0114 0.0002 0.0265 0.0019 0.0102 0.0003 0.0054 0.0002 0.0017 0.0001 0.0269 0.0013 0.0099 0.0045 0.1028 0.0437
Lipid Particles 0.0033 0.0009 0.0099 0.0004 0.0268 0.001 0.0356 0.0013 0.0006 0.0003 0.0019 0.0001 0.0421 0.0042 0.0099 0.0005 0.027 0.0186
Mitochondria 0.0124 0.0087 0.0062 0.0003 0.0242 0.0066 0.0071 0.0001 0.0234 0.0002 0.0004 0.0001 0.0088 0.0025 0.0249 0.0195 0.0739 0.0161
None 0.4426 0.3956 0.3682 0.3634 0.2529 0.3002 0.3693 0.3796 0.3884 0.2651 0.476 0.2785 0.263 0.3301 0.313 0.2116 0.2308 0.2025
Nuclear Periphery 0.0179 0.0014 0.0029 0.0025 0.0208 0.0015 0.0027 0.001 0.0016 0.001 0.0005 0.0004 0.02 0.0031 0.0026 0.0032 0.0011 0.0025
Nucleolus 0.0005 0.0002 0.0004 0 0.0006 0.0001 0.0013 0.0001 0 0 0 0 0.0004 0.0002 0.0005 0.0001 0.0006 0.0004
Nucleus 0.0049 0.0016 0.0026 0.0015 0.0023 0.0028 0.002 0.0011 0.0008 0.001 0.0004 0.0006 0.0033 0.0012 0.0016 0.0018 0.0008 0.0021
Peroxisomes 0.001 0.0007 0.0079 0.0001 0.0069 0.0004 0.0229 0 0.0004 0 0.0003 0 0.0231 0.0008 0.01 0.0004 0.0388 0.0167
Punctate Nuclear 0.0028 0.0006 0.0042 0.0006 0.0059 0.0013 0.0014 0.0003 0.0002 0.0002 0.0003 0.0001 0.0031 0.0011 0.0032 0.0005 0.0012 0.0168
Vacuole 0.0084 0.0018 0.0037 0.0016 0.003 0.0014 0.0089 0.0015 0.0032 0.0026 0.0011 0.0004 0.0036 0.002 0.0022 0.0045 0.0072 0.003
Vacuole Periphery 0.0032 0.0001 0.0008 0.0002 0.0025 0.0003 0.0014 0.0001 0.0006 0.0002 0.0002 0 0.0016 0.0002 0.0004 0.0014 0.0028 0.001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.2697 11.8697 15.4138 19.8024 12.0509 16.5884 18.7523 23.6931 27.1664 23.2603
Translational Efficiency 0.5004 0.5781 0.4738 0.5523 0.4297 0.5767 0.5549 0.3816 0.4597 0.388

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1174 400 142 619 1485 1148 1378 122 2659 1548 1520 741

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 698.38 841.51 1075.55 837.81 797.31 720.67 884.55 917.25 753.63 751.89 902.39 850.89
Standard Deviation 79.72 127.88 107.26 209.99 95.74 98.03 109.38 132.05 101.68 118.95 122.52 201.43
Intensity Change Log 2 — 0.268968 0.622990 0.262611 — -0.145802 0.149803 0.202174 — 0.062750 0.390116 0.230709

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000117 0.000516 0.001223 0.001389 0.000394 0.000949 0.000317 0.000317 0.000272 0.000837 0.000402 0.001212
Bud Neck 0.012431 0.018421 0.006308 0.007302 0.011680 0.036552 0.007255 0.005418 0.012012 0.031867 0.007166 0.006992
Bud Site 0.005730 0.019957 0.008258 0.043284 0.007090 0.023836 0.016579 0.011787 0.006490 0.022833 0.015801 0.038098
Cell Periphery 0.000306 0.000183 0.000849 0.000374 0.000413 0.000206 0.000203 0.000129 0.000366 0.000200 0.000264 0.000333
Cytoplasm 0.463300 0.349327 0.292036 0.514636 0.420940 0.330888 0.571215 0.374287 0.439643 0.335653 0.545134 0.491529
Cytoplasmic Foci 0.216887 0.266206 0.039072 0.052124 0.223555 0.300879 0.029410 0.085577 0.220611 0.291919 0.030313 0.057632
Eisosomes 0.000289 0.000164 0.000162 0.000084 0.000378 0.000279 0.000052 0.000098 0.000339 0.000249 0.000063 0.000086
Endoplasmic Reticulum 0.008263 0.020109 0.019917 0.002658 0.061447 0.004077 0.003752 0.001827 0.037965 0.008219 0.005262 0.002521
Endosome 0.022637 0.035643 0.019744 0.009713 0.025957 0.047714 0.003708 0.022759 0.024491 0.044595 0.005206 0.011861
Golgi 0.003532 0.005104 0.000279 0.003492 0.007404 0.009627 0.000262 0.003127 0.005695 0.008459 0.000264 0.003432
Lipid Particles 0.026058 0.012012 0.009412 0.001828 0.027854 0.015537 0.001758 0.002146 0.027061 0.014626 0.002473 0.001881
Mitochondria 0.003867 0.003258 0.000365 0.003491 0.003816 0.012293 0.000716 0.001239 0.003839 0.009958 0.000684 0.003121
Mitotic Spindle 0.000141 0.003900 0.010709 0.019133 0.000268 0.005586 0.019600 0.015988 0.000212 0.005150 0.018770 0.018615
None 0.004955 0.003066 0.000831 0.017669 0.001270 0.000930 0.002466 0.013785 0.002897 0.001482 0.002313 0.017030
Nuclear Periphery 0.001148 0.001790 0.003608 0.000680 0.001624 0.000665 0.001457 0.000773 0.001414 0.000955 0.001658 0.000695
Nuclear Periphery Foci 0.001198 0.004666 0.022604 0.005687 0.003993 0.001202 0.003693 0.002028 0.002759 0.002097 0.005460 0.005085
Nucleolus 0.001321 0.000801 0.000498 0.001211 0.000608 0.001128 0.000180 0.000228 0.000923 0.001043 0.000210 0.001050
Nucleus 0.122048 0.061485 0.226273 0.150592 0.080128 0.053285 0.192328 0.090955 0.098636 0.055404 0.195499 0.140773
Peroxisomes 0.003156 0.008826 0.000684 0.001676 0.003312 0.014957 0.000699 0.001242 0.003243 0.013373 0.000698 0.001605
Vacuole 0.100061 0.179851 0.336678 0.158100 0.114994 0.134873 0.143503 0.365735 0.108401 0.146495 0.161550 0.192286
Vacuole Periphery 0.002554 0.004715 0.000489 0.004876 0.002874 0.004539 0.000846 0.000554 0.002732 0.004585 0.000813 0.004164

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.56 -8.29 -3.01 -1.77 0.73 -2.83 -0.27 1.38 3.31 1.11 -3.85 -2.38 -2.55 -0.51 -1.60
Bud Neck -2.22 2.20 5.28 5.13 2.08 -9.59 3.59 5.09 12.55 1.83 -9.85 4.60 6.44 13.23 1.40
Bud Site -5.16 -2.99 -5.33 -1.72 -4.21 -8.32 -2.35 -0.39 5.57 1.24 -9.83 -2.93 -5.27 -0.42 -3.59
Cell Periphery 6.26 -2.43 1.06 -3.34 2.57 5.43 7.06 9.26 4.30 5.94 6.72 4.70 4.14 -1.84 -0.39
Cytoplasm 7.62 11.46 3.17 -4.08 -8.14 8.71 -4.30 4.77 1.21 6.39 12.45 -0.47 3.34 -5.07 3.34
Cytoplasmic Foci -3.85 25.30 30.53 20.99 -0.78 -9.41 40.79 19.52 24.93 -3.62 -10.50 52.55 41.46 40.53 -4.53
Eisosomes 6.02 5.39 11.91 4.88 4.50 2.18 11.31 10.02 4.97 -2.58 2.81 15.53 14.01 5.73 -1.29
Endoplasmic Reticulum -2.33 -5.78 4.54 3.43 9.24 13.65 13.68 13.79 1.25 1.62 10.98 13.19 14.14 3.59 5.80
Endosome -4.06 1.65 10.22 10.47 4.98 -7.84 17.96 3.02 6.75 -1.65 -9.17 20.21 12.58 17.10 -1.86
Golgi -0.94 7.63 2.47 2.21 -1.87 -2.24 14.56 5.73 6.63 -0.94 -3.41 16.25 6.21 7.53 -2.22
Lipid Particles 6.07 9.09 14.02 5.86 7.86 7.15 20.09 18.79 10.40 -1.53 8.86 23.32 23.79 12.67 2.87
Mitochondria 0.68 4.13 2.01 1.41 -1.69 -4.43 4.41 4.04 6.59 0.14 -4.22 5.93 2.89 5.81 -1.48
Mitotic Spindle -2.88 -1.53 -3.98 -2.68 -0.98 -3.57 -5.68 -1.39 -0.34 1.31 -4.26 -5.89 -4.20 -2.32 0.50
None 0.83 4.40 -1.92 -2.09 -4.09 1.42 -3.51 -1.18 -1.25 -0.94 1.99 1.52 -3.10 -3.76 -3.54
Nuclear Periphery -1.06 -10.03 -0.11 1.04 10.17 4.19 -2.78 0.69 -2.85 3.11 2.23 -6.63 1.48 -1.32 9.42
Nuclear Periphery Foci -3.38 -7.79 -6.58 -0.74 5.85 6.69 1.09 0.42 -2.71 -0.13 1.77 -5.38 -4.09 -4.90 -0.23
Nucleolus 3.53 6.18 3.92 0.66 -1.37 -2.52 6.69 4.55 4.27 -1.08 -0.72 10.82 2.74 2.41 -4.01
Nucleus 9.36 -5.95 -5.34 -11.26 2.72 7.13 -22.67 0.26 -2.39 12.82 12.88 -20.91 -7.54 -13.07 6.97
Peroxisomes -4.05 8.17 4.90 5.60 -1.39 -11.28 9.38 9.15 13.90 -0.87 -11.94 10.55 7.16 14.26 -1.75
Vacuole -8.39 -13.41 -15.45 -6.31 4.25 -3.54 -15.84 -13.80 -12.99 -9.37 -8.15 -20.20 -18.87 -14.51 -5.60
Vacuole Periphery -1.65 7.24 0.43 1.61 -1.88 -2.14 6.33 7.95 6.04 0.60 -2.80 7.61 1.14 2.76 -1.80
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
Localization
Cell Percentages cytoplasm (34%), ER (23%), mixed (39%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Roy1

Roy1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Roy1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available