Standard name
Human Ortholog
Description Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0.06 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Bud Neck 0 – 0.07 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.06 0 0 0 0 0 0
Cytoplasm 0.45 – 0.89 0.9 0.85 0.74 0.68 0.64 0.57 0.6 0.49 0.58 0.88 0.87 0.9 0.12 0.15 0.14 0.26 0.5 0.28 0.39 0.34 0.38
Endoplasmic Reticulum 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0 0 0 0 0 0 0
Endosome 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.15 0.19 0 0 0.07 0 0.05 0
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.15 0.09 0.11 0 0 0 0 0 0
Mitochondria 0.61 – 0.07 0.05 0.06 0.23 0.33 0.3 0.5 0.41 0.56 0.41 0 0 0 0.14 0.14 0.13 0.46 0.33 0.43 0.35 0.33 0.28
Nucleus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.16 0.16 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 0.07 0.08 0.09 0.05 0.07 0.06 0.08 0 0 0 0.12 0.14 0.12 0.07 0 0.05 0 0.06 0.05
Vac/Vac Membrane 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.26 0.19 0.22 0.05 0.05 0 0.05 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 2 0 0 0 0 1 0 1 3 0 0 8 3 3 2 0 2 6 11 15
Bud 7 – 0 3 3 2 22 15 11 10 17 10 2 1 0 8 5 10 0 0 0 2 6 12
Bud Neck 0 – 2 9 20 9 15 25 9 12 4 9 7 2 0 0 0 0 2 0 1 2 6 12
Bud Site 0 – 0 0 0 0 2 3 4 4 2 2 2 0 0 0 0 2 – – – – – –
Cell Periphery 0 – 0 6 5 1 3 3 2 1 1 2 3 8 4 9 21 13 0 0 0 0 2 5
Cytoplasm 57 – 25 240 447 278 502 338 169 241 171 243 257 366 446 25 34 28 35 22 16 77 101 156
Endoplasmic Reticulum 1 – 0 1 0 0 0 0 0 1 0 0 2 2 1 15 13 8 2 0 0 0 1 6
Endosome 0 – 1 3 9 7 5 4 2 1 0 3 5 18 11 26 34 38 5 0 4 7 14 14
Golgi 0 – 0 0 0 1 0 0 0 0 0 0 1 0 3 30 20 22 0 0 0 0 2 3
Mitochondria 77 – 2 14 32 87 243 160 148 162 194 170 10 9 3 28 31 26 62 14 26 69 99 116
Nucleus 0 – 0 0 1 3 10 9 9 6 4 3 0 5 3 4 3 2 0 1 0 0 3 3
Nuclear Periphery 0 – 0 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 0 0 0 2
Nucleolus 0 – 0 1 1 0 2 2 0 1 4 0 0 0 2 1 2 2 0 0 0 1 1 1
Peroxisomes 0 – 0 1 0 2 3 4 1 1 0 2 3 9 10 19 35 32 1 0 0 4 5 3
SpindlePole 4 – 0 7 21 25 62 48 15 29 20 35 7 7 12 24 31 25 9 0 2 5 17 21
Vac/Vac Membrane 0 – 1 1 19 8 8 16 3 2 4 10 11 16 16 52 41 44 6 2 1 10 9 26
Unique Cell Count 126 28 268 524 374 739 530 296 400 347 418 291 419 494 202 221 202 136 45 61 197 302 417
Labelled Cell Count 146 31 286 560 423 877 627 373 473 422 490 313 443 511 250 274 255 136 45 61 197 302 417


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.1 – 5.3 4.6 4.9 4.1 3.5 4.1 3.5 3.6 3.3 3.6 5.0 5.4 5.7 6.6 6.9 6.8 5.0 6.8 6.0
Std Deviation (1e-4) 0.5 – 2.1 1.6 2.0 2.5 1.4 1.5 1.7 0.9 1.5 1.1 1.2 1.7 4.9 1.4 1.8 1.9 2.2 10.3 3.2
Intensity Change (Log2) – – – -0.21 -0.11 -0.37 -0.6 -0.36 -0.59 -0.58 -0.68 -0.56 -0.08 0.04 0.1 0.32 0.37 0.35 -0.09 0.35 0.18

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 -0.6 -1.8 -2.4 -2.8 -3.3 -3.1 -4.1 -3.3 -0.2 -0.3 0.2 -9.2 -8.7 -8.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 2.6 0 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.7741 -0.0367 -0.5378 -0.2496 -0.3701 0.2535 -0.425 0.2108 0.0145 -0.051 0.2097 0.1759 -0.9722 -0.5766 -0.7197 -0.6414 -0.6056 -0.9698
Actin 0.0395 0.016 0.003 0.0033 0.0026 0.019 0.0192 0.0047 0.0175 0.0103 0.0036 0.0096 0.0157 0.0159 0.0262 0.0045 0.0146 0.0133
Bud 0.0013 0.0047 0.0014 0.0047 0.0008 0.0013 0.0013 0.0027 0.0019 0.0014 0.0036 0.0005 0.0012 0.0036 0.0029 0.0022 0.006 0.0037
Bud Neck 0.0029 0.0017 0.0074 0.0003 0.0015 0.0035 0.0074 0.0014 0.0023 0.0005 0.0006 0.0096 0.0008 0.0014 0.0121 0.0026 0.0033 0.0032
Bud Periphery 0.0038 0.0098 0.0034 0.0108 0.0049 0.0015 0.0083 0.0055 0.0044 0.0035 0.0127 0.0017 0.005 0.0095 0.0075 0.0064 0.0082 0.0119
Bud Site 0.0042 0.0248 0.0164 0.0007 0.0038 0.001 0.0075 0.0235 0.0097 0.0011 0.0013 0.0006 0.0055 0.0199 0.0176 0.0034 0.0158 0.0014
Cell Periphery 0.0023 0.0021 0.0015 0.0004 0.0011 0.0007 0.0009 0.0029 0.0019 0.0006 0.0004 0.0006 0.0009 0.0023 0.0015 0.0032 0.001 0.0008
Cytoplasm 0.0452 0.0747 0.0552 0.0226 0.0198 0.0968 0.0657 0.0882 0.0989 0.0661 0.1348 0.1056 0.047 0.0793 0.0895 0.0676 0.1236 0.0825
Cytoplasmic Foci 0.0777 0.0781 0.1021 0.0375 0.0776 0.0872 0.0695 0.0786 0.0691 0.0675 0.0662 0.101 0.0933 0.0733 0.08 0.1087 0.0601 0.1304
Eisosomes 0.001 0.001 0.0007 0.0004 0.0007 0.0005 0.0011 0.0011 0.001 0.0013 0.0003 0.0003 0.0011 0.0017 0.0007 0.0025 0.0008 0.0004
Endoplasmic Reticulum 0.0327 0.0213 0.0022 0.0028 0.0021 0.0262 0.0044 0.0096 0.005 0.0056 0.003 0.0031 0.0079 0.0059 0.0052 0.0046 0.0072 0.0034
Endosome 0.0495 0.0674 0.0406 0.0512 0.0674 0.1108 0.076 0.0831 0.0573 0.102 0.0745 0.0814 0.107 0.0819 0.0742 0.0566 0.1142 0.0895
Golgi 0.0212 0.0211 0.0141 0.0129 0.0216 0.0371 0.0226 0.0228 0.0211 0.0276 0.0125 0.018 0.0311 0.024 0.0338 0.0175 0.0282 0.0581
Lipid Particles 0.0466 0.0208 0.0178 0.0689 0.0715 0.0374 0.0626 0.0171 0.0076 0.0113 0.0109 0.014 0.0506 0.0214 0.0232 0.0285 0.0129 0.0342
Mitochondria 0.1544 0.1552 0.2667 0.3658 0.1888 0.1684 0.2017 0.1845 0.1895 0.2127 0.2899 0.2791 0.276 0.1679 0.2935 0.2638 0.4884 0.3496
None 0.4183 0.4321 0.4169 0.3814 0.3877 0.3299 0.3889 0.4155 0.4584 0.4411 0.3462 0.3264 0.2858 0.4221 0.2731 0.3612 0.0563 0.1648
Nuclear Periphery 0.0242 0.0033 0.0008 0.0036 0.0011 0.024 0.0025 0.0021 0.0021 0.0017 0.001 0.0011 0.0054 0.0052 0.0038 0.0016 0.0151 0.0011
Nucleolus 0.0021 0.002 0.0015 0.0009 0.0014 0.0009 0.0046 0.0034 0.0007 0.0004 0.0006 0.0003 0.0007 0.0014 0.0011 0.0011 0.0011 0.0006
Nucleus 0.0222 0.0026 0.0013 0.0018 0.0009 0.0045 0.0026 0.0042 0.0015 0.0011 0.0011 0.0009 0.001 0.0028 0.0024 0.0014 0.0033 0.001
Peroxisomes 0.0296 0.0433 0.0317 0.0154 0.1323 0.0331 0.0341 0.0267 0.0395 0.0354 0.0252 0.0332 0.0478 0.0327 0.0328 0.053 0.0122 0.0396
Punctate Nuclear 0.0076 0.0035 0.0018 0.0032 0.0008 0.0048 0.0056 0.0041 0.0013 0.0011 0.0014 0.0012 0.0028 0.0011 0.008 0.0012 0.0025 0.0016
Vacuole 0.0102 0.0117 0.0109 0.0069 0.0077 0.0071 0.0104 0.0143 0.0066 0.0051 0.0076 0.0078 0.0095 0.0225 0.0075 0.0059 0.0179 0.0051
Vacuole Periphery 0.0034 0.003 0.0024 0.0047 0.0036 0.0044 0.0031 0.0038 0.0029 0.0023 0.0025 0.0038 0.0041 0.0042 0.0034 0.0025 0.0072 0.0039

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 28.9747 16.9153 17.2589 25.9781 24.5335 21.2758 34.2062 28.4979 32.7641 29.6771
Translational Efficiency 0.7986 1.5 0.9594 0.8297 0.843 1.312 0.793 0.9762 1.1026 1.0175

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
593 1284 2571 1672 1513 2017 226 152 2106 3301 2797 1824

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 641.59 722.05 761.31 813.63 612.07 718.18 875.67 891.63 620.38 719.69 770.55 820.13
Standard Deviation 85.36 93.04 99.85 118.24 74.80 87.06 103.83 141.39 79.05 89.45 104.91 122.25
Intensity Change Log 2 — 0.170447 0.246832 0.342721 — 0.230649 0.516691 0.542749 — 0.200153 0.384891 0.443846

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000394 0.001028 0.008043 0.006886 0.000817 0.000988 0.007320 0.008702 0.000698 0.001004 0.007985 0.007037
Bud Neck 0.036178 0.072765 0.050133 0.029475 0.048060 0.073076 0.014680 0.014284 0.044714 0.072955 0.047268 0.028209
Bud Site 0.012425 0.048635 0.075676 0.089582 0.011303 0.027863 0.057216 0.061662 0.011619 0.035943 0.074184 0.087255
Cell Periphery 0.000273 0.000328 0.000393 0.000532 0.000255 0.000177 0.000592 0.000264 0.000260 0.000236 0.000409 0.000509
Cytoplasm 0.309533 0.217730 0.146519 0.162335 0.295640 0.300541 0.166192 0.208096 0.299552 0.268330 0.148108 0.166148
Cytoplasmic Foci 0.279107 0.257318 0.088924 0.088962 0.298513 0.204601 0.157434 0.104379 0.293049 0.225106 0.094460 0.090247
Eisosomes 0.000237 0.000181 0.000146 0.000151 0.000278 0.000150 0.000216 0.000151 0.000266 0.000162 0.000152 0.000151
Endoplasmic Reticulum 0.001259 0.000746 0.002966 0.004621 0.003261 0.000830 0.004432 0.003659 0.002697 0.000797 0.003085 0.004541
Endosome 0.032695 0.052188 0.055514 0.048369 0.033179 0.038112 0.061818 0.052967 0.033043 0.043587 0.056023 0.048752
Golgi 0.010070 0.025288 0.034668 0.036092 0.013308 0.015988 0.056252 0.033429 0.012397 0.019605 0.036412 0.035870
Lipid Particles 0.021054 0.007803 0.006893 0.007521 0.029097 0.007467 0.007244 0.003254 0.026832 0.007598 0.006921 0.007165
Mitochondria 0.036642 0.091639 0.200972 0.152336 0.055319 0.057706 0.058680 0.041930 0.050060 0.070905 0.189475 0.143135
Mitotic Spindle 0.001378 0.018126 0.063722 0.084620 0.001489 0.014898 0.030333 0.055876 0.001458 0.016154 0.061024 0.082225
None 0.005428 0.002096 0.001294 0.003931 0.002966 0.002208 0.001846 0.001236 0.003659 0.002164 0.001338 0.003706
Nuclear Periphery 0.000763 0.000275 0.001271 0.001353 0.000805 0.000639 0.000794 0.000919 0.000794 0.000497 0.001233 0.001317
Nuclear Periphery Foci 0.000434 0.000300 0.000582 0.001361 0.000412 0.000295 0.001902 0.000938 0.000419 0.000297 0.000688 0.001326
Nucleolus 0.002636 0.002267 0.002241 0.002406 0.001853 0.003140 0.001415 0.000653 0.002074 0.002801 0.002174 0.002260
Nucleus 0.157472 0.060972 0.076465 0.100168 0.132071 0.121272 0.176372 0.114239 0.139223 0.097817 0.084537 0.101340
Peroxisomes 0.042714 0.059124 0.073791 0.045859 0.023104 0.038414 0.079878 0.097067 0.028625 0.046470 0.074283 0.050126
Vacuole 0.046626 0.075425 0.101239 0.124207 0.044043 0.086781 0.104867 0.180936 0.044771 0.082364 0.101532 0.128934
Vacuole Periphery 0.002681 0.005768 0.008549 0.009235 0.004225 0.004855 0.010518 0.015360 0.003790 0.005210 0.008709 0.009745

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.04 -9.13 -8.59 -7.52 1.79 -0.59 -2.80 -2.60 -2.50 0.86 -1.54 -9.05 -8.31 -7.89 1.94
Bud Neck -6.72 -3.33 1.90 10.77 8.25 -5.65 8.85 7.17 12.59 -0.38 -8.09 -0.92 6.05 15.95 8.12
Bud Site -9.94 -16.32 -15.03 -6.89 -1.31 -9.01 -5.21 -3.43 -1.32 1.28 -13.98 -20.78 -17.58 -10.73 -1.00
Cell Periphery -0.69 -1.96 -2.68 -1.90 -1.41 2.84 -2.81 1.38 -0.42 3.27 0.87 -4.02 -3.47 -4.00 -0.81
Cytoplasm 6.88 12.92 10.30 4.37 -3.69 -0.58 8.07 4.19 4.47 -1.53 4.13 20.33 14.89 12.08 -3.98
Cytoplasmic Foci 1.95 20.76 21.04 25.62 1.48 12.65 11.92 21.01 12.99 5.72 11.04 36.43 37.27 30.18 3.12
Eisosomes 2.97 5.07 4.99 3.36 -0.13 6.82 1.74 6.31 0.83 3.43 7.31 8.25 8.70 1.97 0.97
Endoplasmic Reticulum 1.75 -4.76 -5.26 -6.54 -2.66 4.59 -2.24 -0.81 -3.95 1.03 4.88 -1.21 -3.05 -6.88 -2.51
Endosome -4.77 -5.53 -2.36 3.29 4.28 -1.81 -2.74 1.24 2.08 3.06 -4.71 -8.00 -2.84 1.35 4.96
Golgi -5.78 -9.25 -6.80 -1.55 1.34 -1.55 -3.80 -0.05 0.35 3.12 -5.10 -11.12 -6.89 -3.74 2.26
Lipid Particles 5.58 5.97 5.81 0.73 -0.16 11.06 9.80 13.37 7.21 4.21 12.35 12.41 12.20 0.99 0.33
Mitochondria -7.37 -20.77 -10.88 -4.25 8.18 -0.32 0.67 4.20 4.47 2.33 -4.78 -21.78 -9.95 -7.06 8.40
Mitotic Spindle -6.98 -20.15 -17.29 -11.84 -2.60 -7.54 -4.27 -2.68 -1.23 -0.04 -10.26 -20.59 -17.45 -13.11 -2.53
None 2.48 3.10 1.29 -1.99 -3.30 1.67 1.85 3.12 2.26 0.93 2.97 4.59 0.31 -1.98 -3.23
Nuclear Periphery 4.16 -3.68 -5.73 -11.67 -2.07 1.17 -1.21 -4.63 -5.60 -3.69 3.01 -4.06 -6.77 -9.89 -2.47
Nuclear Periphery Foci 1.10 -1.52 -5.46 -6.92 -5.07 1.52 -5.95 -4.89 -5.37 2.02 1.87 -4.57 -6.80 -7.70 -4.55
Nucleolus 0.52 0.72 0.53 -0.01 -0.22 -2.46 1.04 1.64 3.32 0.75 -2.10 -0.52 -0.55 1.61 -0.10
Nucleus 10.33 8.19 3.69 -9.61 -6.38 1.57 -3.54 -2.07 -2.57 0.84 8.19 9.02 2.15 -4.69 -5.71
Peroxisomes -2.87 -5.26 0.53 4.61 7.95 -5.15 -4.36 -1.63 -0.41 1.71 -6.65 -12.34 -3.58 1.90 8.05
Vacuole -6.70 -13.03 -18.73 -13.89 -8.85 -11.97 -7.79 -12.25 -10.42 -7.68 -13.76 -17.83 -23.62 -16.22 -10.87
Vacuole Periphery -5.77 -8.63 -7.01 -2.70 0.71 -1.08 -1.70 -0.68 -0.50 0.58 -3.39 -7.24 -5.42 -3.56 0.88
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants
Localization
Cell Percentages mitochondrion (19%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Ppa2

Ppa2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ppa2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available