Standard name
Human Ortholog
Description Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0.09 0.06 0.05 0 0.05 0.07 0 0.05 0 0 0.05 0.06
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0 0 0.07 0.1 0.08 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0.07 0.2 0.21 0.13 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0.14 0.05 0.12 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.11 0.07 0.11 0 – 0 0 0 0 0 0.06 0.14 0.1 0.13 0.07 0.09 0.11 0.12 0.13 0.14 0.1 0.11
Golgi 0.08 0 0 0 0 0 – 0 0 0 0 0 0.25 0.28 0.29 0.08 0.3 0.4 0.1 0.12 0.06 0.06 0.09 0.11
Mitochondria 0.85 0.92 0.76 0.88 0.84 0.94 – 0.93 0.94 0.95 0.98 0.96 0.48 0.43 0.34 0.09 0.1 0.16 0.62 0.55 0.57 0.52 0.45 0.46
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0.05 0.08 – 0.05 0.09 0.07 0.08 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.07 – 0.06 0.05 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.05 0 0.14 0.09 0 0 – 0 0 0 0 0 0.05 0 0.08 0.23 0.1 0.08 0.11 0.11 0.17 0.18 0.24 0.21
SpindlePole 0 0 0.07 0 0 0 – 0 0 0 0 0 0.08 0.05 0.05 0.16 0.1 0.06 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.07 0 0 0.09 0.06 – 0.05 0 0 0 0 0.06 0.12 0.14 0.08 0.05 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 9 1 1 0 0 – 0 0 0 1 0 9 10 10 6 12 8 9 16 5 10 20 22
Bud 3 4 8 7 3 11 – 9 11 20 13 8 0 2 4 11 12 4 0 1 0 2 2 2
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 4
Bud Site 0 0 0 0 1 3 – 4 4 5 5 4 0 0 0 1 2 0 – – – – – –
Cell Periphery 14 11 8 5 3 0 – 2 2 2 4 1 6 6 5 17 24 10 0 0 0 0 0 0
Cytoplasm 3 6 13 6 9 4 – 6 10 7 3 3 3 7 12 51 50 16 0 0 0 0 0 1
Endoplasmic Reticulum 11 10 4 3 1 3 – 1 4 2 2 4 14 9 22 10 4 4 1 1 0 0 2 2
Endosome 13 6 29 16 35 0 – 9 0 1 0 0 6 25 19 33 16 11 45 40 43 43 37 41
Golgi 29 4 8 2 3 0 – 0 0 0 0 0 24 48 52 21 73 49 42 40 18 19 34 42
Mitochondria 326 310 207 197 263 333 – 503 338 503 368 389 47 75 62 23 24 20 259 193 187 168 171 179
Nucleus 2 0 1 1 2 3 – 4 4 3 3 3 2 1 2 7 8 1 0 0 0 0 0 0
Nuclear Periphery 10 7 4 3 15 30 – 27 33 39 31 26 3 6 1 5 2 3 3 1 2 2 4 1
Nucleolus 8 0 0 4 8 25 – 35 18 22 16 22 0 0 0 2 0 1 0 0 0 1 1 0
Peroxisomes 21 11 39 19 12 4 – 5 1 1 0 1 5 4 14 57 23 10 46 37 55 57 91 80
SpindlePole 13 4 18 5 6 6 – 9 5 2 5 4 8 9 9 41 25 7 2 3 2 2 2 1
Vac/Vac Membrane 40 23 10 7 29 23 – 28 12 15 14 16 6 21 25 19 13 9 4 7 4 5 7 8
Unique Cell Count 382 338 273 223 312 355 541 358 527 375 406 97 174 182 252 242 123 421 350 326 324 381 393
Labelled Cell Count 494 405 350 276 390 445 642 442 622 465 481 133 223 237 304 288 153 421 350 326 324 381 393


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 5.8 5.1 5.1 5.2 4.5 – 4.9 4.5 4.4 4.4 4.3 6.9 7.2 7.0 5.5 6.7 7.2 6.9 7.1 7.3
Std Deviation (1e-4) 0.8 0.9 1.2 1.1 1.4 1.2 – 1.2 1.1 1.4 1.3 1.1 0.9 1.2 0.9 1.0 1.4 1.4 1.5 1.5 1.5
Intensity Change (Log2) – – – -0.01 0.04 -0.17 – -0.07 -0.17 -0.22 -0.21 -0.26 0.43 0.5 0.47 0.12 0.4 0.49 0.44 0.48 0.52


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 3.3 0
Bud 0.1 -1.7 0 – 0 0 0 0 0 0 0 0 0.9 1.2 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.5 -1.7 0 – 0 0 0 0 0 0 0.3 -0.1 2.1 3.3 2.3
Cytoplasm -1.2 -1.2 -2.8 – -3.3 -1.3 -2.9 -3.2 -3.4 0 -0.4 0.8 5.4 5.5 2.9
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 2.3 4.8 1.8 0 0
Endosome -1.3 0.2 0 – 0 0 0 0 0 -1.3 1.2 -0.1 0.9 -1.6 -0.5
Golgi 0 -1.7 0 – 0 0 0 0 0 6.6 7.7 7.9 2.7 8.5 9.7
Mitochondria 3.6 2.6 0 – 0 0 0 0 0 -5.0 -7.0 -8.9 -15.4 -15.0 -11.1
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 2.3 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes -2.0 -4.5 0 – 0 0 0 0 0 -2.4 -4.2 -2.1 2.5 -1.7 -1.7
SpindlePole -2.3 -2.8 0 – 0 0 0 0 0 0.5 -0.6 -0.7 3.5 1.5 -0.3
Vacuole -0.3 2.7 1.6 – 1.0 -0.2 -0.6 0 0.2 0 3.4 4.0 1.9 0.9 1.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.8693 4.6929 3.958 3.7502 3.8854 4.0 5.8054 6.5614 6.3096 6.1746 6.1369 6.3888 6.7749 6.9929 6.9145 7.1188 6.3512 6.8511
Actin 0.0752 0.0161 0.0356 0.0507 0.0187 0.0117 0.0161 0.0113 0.0072 0.0072 0.0028 0.0072 0.0078 0.0163 0.0041 0.0038 0.0007 0.0015
Bud 0.0012 0.0014 0.0008 0.008 0.0009 0.0004 0.0002 0.0003 0.0006 0.0002 0.0002 0.0001 0.0002 0.0007 0.0002 0.0002 0.0001 0.0001
Bud Neck 0.0147 0.0005 0.0052 0.0002 0.0007 0.0004 0.0002 0.0002 0.0004 0.0001 0.0001 0.0008 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001
Bud Periphery 0.0016 0.0014 0.0014 0.0254 0.001 0.0014 0.0003 0.0004 0.0009 0.0003 0.0005 0.0003 0.0004 0.0012 0.0005 0.0016 0.0001 0.0001
Bud Site 0.0206 0.0156 0.0084 0.0026 0.0012 0.0004 0.0005 0.0026 0.0018 0.0003 0.0003 0.0006 0.0008 0.0025 0.0011 0.0006 0.0001 0.0001
Cell Periphery 0.0008 0.0004 0.0004 0.0005 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0006 0.0002 0.0002 0.0004 0.0004 0.0001 0.0001
Cytoplasm 0.0141 0.0027 0.0005 0.0012 0.0006 0.0001 0.0003 0.0002 0.0003 0.0001 0.0001 0.0002 0.0003 0.0004 0.0004 0.0002 0.0001 0.0001
Cytoplasmic Foci 0.0441 0.0224 0.0146 0.0323 0.0255 0.0049 0.012 0.014 0.0143 0.0062 0.0073 0.0063 0.0099 0.0138 0.0117 0.0043 0.0071 0.0048
Eisosomes 0.0017 0.0002 0.0008 0.0002 0.0002 0.0003 0.0003 0.0002 0.0004 0.0002 0.0002 0.0009 0.0002 0.0002 0.0006 0.0019 0.0001 0.0001
Endoplasmic Reticulum 0.0055 0.0003 0.0007 0.0003 0.0001 0.0003 0.0002 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0003 0.0001 0.0002 0.0001 0.0001
Endosome 0.06 0.0477 0.0332 0.067 0.0534 0.0276 0.0346 0.0264 0.0195 0.0326 0.0196 0.021 0.0243 0.0436 0.0179 0.0108 0.0452 0.0209
Golgi 0.0643 0.0812 0.0567 0.0593 0.1254 0.0535 0.0491 0.0664 0.0341 0.033 0.0422 0.061 0.0529 0.0899 0.0627 0.0282 0.1239 0.0557
Lipid Particles 0.0587 0.0251 0.0218 0.0064 0.012 0.0149 0.0384 0.017 0.0151 0.0123 0.0184 0.0198 0.025 0.0105 0.0115 0.0025 0.0101 0.0157
Mitochondria 0.5089 0.7231 0.7733 0.6808 0.7196 0.8626 0.7731 0.8055 0.8591 0.8774 0.8403 0.8138 0.8183 0.7632 0.8425 0.9185 0.7871 0.8645
None 0.0128 0.0002 0.0004 0.0005 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0009 0.0002 0.0001 0.0002 0.0025 0 0
Nuclear Periphery 0.0184 0.0004 0.0005 0.0003 0 0.0002 0.0002 0.0001 0.0001 0.0002 0 0.0003 0.0013 0.0001 0 0.0001 0 0.0001
Nucleolus 0.003 0.0009 0.0003 0.0003 0.0001 0.0001 0.0002 0.0004 0.0001 0.0002 0.0001 0.0004 0.0002 0.0001 0.0002 0.0001 0 0.0001
Nucleus 0.0085 0.0011 0.0002 0.0003 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0002 0.0001 0.0001 0.0001 0.0001 0 0.0001
Peroxisomes 0.0632 0.0446 0.0366 0.0543 0.0371 0.0126 0.0673 0.0507 0.0429 0.0133 0.0659 0.0587 0.0537 0.0519 0.0434 0.0219 0.0224 0.0324
Punctate Nuclear 0.0095 0.0012 0.0003 0.003 0.0001 0.0001 0.0001 0 0.0001 0.0002 0 0.0041 0.0001 0.0001 0.0001 0 0 0
Vacuole 0.0071 0.0083 0.003 0.0031 0.0015 0.0021 0.0023 0.0022 0.0012 0.0067 0.0006 0.0008 0.0011 0.0022 0.001 0.0005 0.0008 0.0011
Vacuole Periphery 0.0063 0.0053 0.0051 0.003 0.0018 0.006 0.0042 0.0017 0.0017 0.0089 0.0009 0.0018 0.0026 0.0022 0.0011 0.0015 0.0018 0.0022

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.7753 20.0907 17.7751 25.5108 21.2939 25.0537 26.2711 35.7261 31.8611 31.8703
Translational Efficiency 0.8411 0.5217 0.6555 0.5876 0.514 0.5372 0.5487 0.4586 0.5604 0.4565

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
158 1533 1741 651 2053 2236 2220 1520 2211 3769 3961 2171

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 993.97 829.77 836.35 852.54 770.23 817.85 833.76 889.81 786.22 822.70 834.90 878.63
Standard Deviation 153.13 118.38 106.72 124.41 88.09 109.81 97.26 112.93 110.46 113.53 101.53 117.74
Intensity Change Log 2 — -0.260491 -0.249095 -0.221435 — 0.086547 0.114343 0.208208 — -0.098631 -0.079071 -0.017980

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.050992 0.008163 0.004921 0.064754 0.003556 0.002431 0.005930 0.046089 0.006946 0.004762 0.005486 0.051686
Bud Neck 0.006198 0.002274 0.007385 0.009408 0.000609 0.001245 0.006063 0.006226 0.001008 0.001664 0.006644 0.007180
Bud Site 0.081931 0.006977 0.019260 0.132702* 0.002489 0.002551 0.031401 0.097442 0.008166 0.004352 0.026065 0.108015*
Cell Periphery 0.000941 0.000841 0.000241 0.000990 0.000238 0.000183 0.000430 0.000853 0.000288 0.000450 0.000347 0.000894
Cytoplasm 0.023211 0.002028 0.005097 0.026274 0.001014 0.001173 0.007149 0.028963 0.002600 0.001521 0.006247 0.028157
Cytoplasmic Foci 0.192506* 0.061947 0.096065 0.122047 0.039960 0.037464 0.029973 0.078994 0.050861 0.047422 0.059023 0.091904
Eisosomes 0.000299 0.000153 0.000100 0.000321 0.000106 0.000081 0.000087 0.000318 0.000120 0.000110 0.000093 0.000319
Endoplasmic Reticulum 0.004820 0.000322 0.001549 0.004609 0.000238 0.000129 0.000572 0.000760 0.000565 0.000207 0.001001 0.001914
Endosome 0.175266 0.106729 0.167299 0.085368 0.093231 0.099197 0.092400 0.064054 0.099093 0.102260 0.125321 0.070445
Golgi 0.174201* 0.154363* 0.153291* 0.130703* 0.126326* 0.126277* 0.073762 0.145687* 0.129747* 0.137700* 0.108718 0.141194*
Lipid Particles 0.004829 0.003686 0.005573 0.002133 0.003565 0.002173 0.000275 0.000659 0.003656 0.002788 0.002604 0.001101
Mitochondria 0.081999 0.571537* 0.333697* 0.178033* 0.681152* 0.678290* 0.631956* 0.359604* 0.638336* 0.634869* 0.500861* 0.305158*
Mitotic Spindle 0.021894 0.007292 0.063614 0.062847 0.002412 0.002940 0.040353 0.027855 0.003804 0.004710 0.050577 0.038348
None 0.000051 0.000186 0.000387 0.000199 0.000104 0.000097 0.000394 0.000170 0.000100 0.000133 0.000391 0.000179
Nuclear Periphery 0.000165 0.000054 0.001034 0.000280 0.000040 0.000026 0.000078 0.000029 0.000049 0.000037 0.000498 0.000105
Nuclear Periphery Foci 0.001209 0.000212 0.001616 0.000594 0.000108 0.000058 0.000115 0.000083 0.000186 0.000121 0.000775 0.000236
Nucleolus 0.000141 0.000320 0.002628 0.000336 0.000219 0.000083 0.000203 0.000050 0.000213 0.000179 0.001269 0.000135
Nucleus 0.004135 0.000300 0.004080 0.001346 0.000159 0.000112 0.000437 0.000485 0.000443 0.000189 0.002039 0.000743
Peroxisomes 0.070517 0.057752 0.048335 0.122141* 0.036451 0.034646 0.038273 0.112665* 0.038885 0.044044 0.042695 0.115506*
Vacuole 0.092596 0.007393 0.057069 0.043080 0.002815 0.005191 0.025691 0.021616 0.009231 0.006087 0.039483 0.028052
Vacuole Periphery 0.012100 0.007472 0.026756 0.011836 0.005210 0.005654 0.014458 0.007397 0.005702 0.006393 0.019863 0.008728

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.72 4.01 -1.14 -9.76 -10.44 1.58 -2.44 -12.94 -13.39 -12.06 1.88 1.21 -14.88 -16.25 -15.98
Bud Neck 3.52 -0.80 -1.91 -5.71 -1.26 -1.62 -9.37 -10.91 -8.01 -0.26 -2.15 -10.49 -11.90 -9.73 -0.73
Bud Site 6.63 5.51 -3.53 -16.39 -14.50 -0.12 -15.55 -21.73 -21.76 -14.02 3.67 -11.17 -25.20 -27.00 -20.35
Cell Periphery 0.28 2.56 -0.11 -0.50 -5.43 2.27 -4.70 -6.88 -7.65 -4.50 -1.60 -1.67 -7.71 -3.60 -7.14
Cytoplasm 4.14 3.49 -0.46 -11.29 -9.43 -0.63 -11.56 -18.37 -18.24 -13.75 2.58 -6.31 -19.48 -21.39 -16.85
Cytoplasmic Foci 10.16 7.39 5.05 -10.29 -4.26 1.25 5.21 -13.08 -14.02 -16.80 1.49 -3.61 -13.46 -16.04 -11.36
Eisosomes 2.57 3.62 -0.41 -7.11 -12.28 3.74 2.88 -12.86 -14.97 -14.60 1.02 3.73 -14.49 -15.11 -18.36
Endoplasmic Reticulum 2.58 1.85 0.08 -3.71 -2.61 1.47 -1.60 -5.28 -9.20 -0.99 2.48 -2.31 -3.58 -4.87 -2.44
Endosome 4.19 0.30 5.55 3.73 12.75 -1.34 0.18 6.92 8.39 6.97 -0.87 -6.39 7.23 9.43 15.34
Golgi 0.90 1.01 2.33 3.11 2.95 0.01 11.48 -3.05 -3.06 -12.95 -1.75 4.71 -1.98 -0.48 -6.76
Lipid Particles 0.78 -0.41 1.75 2.11 4.92 2.02 5.95 4.86 3.08 -2.43 1.40 1.74 4.53 4.10 4.51
Mitochondria -26.82* -14.29 -5.04 28.43* 12.04 0.27 4.85 28.75* 28.81* 24.14* 0.35 14.48 32.47 36.70* 21.48*
Mitotic Spindle 2.45 -5.21 -4.44 -9.19 -0.13 -1.44 -15.88 -12.21 -11.89 4.00 -1.17 -21.90 -14.28 -14.17 3.74
None -3.14 -3.34 -4.14 -0.34 1.77 0.63 -1.63 -2.87 -3.90 1.26 -1.38 -2.68 -3.76 -2.03 1.95
Nuclear Periphery 2.01 -2.45 -0.68 -1.41 1.95 2.29 -3.92 1.01 -1.37 5.00 1.43 -2.92 -1.20 -1.44 2.42
Nuclear Periphery Foci 1.59 -0.49 0.97 -2.29 3.35 1.46 0.05 0.70 -2.04 1.71 1.19 -4.49 -0.56 -2.20 4.32
Nucleolus -0.94 -4.57 -1.46 -0.09 4.17 0.97 0.34 1.12 0.94 3.34 0.46 -3.39 0.69 0.47 4.68
Nucleus 1.33 -0.03 0.94 -4.35 3.43 0.71 -1.58 -2.39 -3.73 -0.64 1.23 -3.90 -1.38 -5.42 3.49
Peroxisomes 1.08 1.94 -4.05 -7.58 -9.00 0.55 -0.53 -13.60 -14.08 -13.33 -1.66 -1.33 -15.84 -15.27 -15.81
Vacuole 6.14 2.81 3.51 -8.92 2.42 -4.93 -16.31 -10.45 -9.02 1.49 2.89 -16.13 -8.87 -12.44 4.54
Vacuole Periphery 1.88 -5.69 0.05 -2.84 7.81 -1.02 -10.55 -2.97 -2.36 6.72 -1.60 -17.22 -4.26 -3.31 11.44
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
Localization
Cell Percentages mitochondrion (94%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Yme2

Yme2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yme2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available