Standard name
Human Ortholog
Description Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiquitinated forms of Pex5p; deubiquitinates Clb5p, counteracting APC activity, and facilitating both Clb5p accumulation and S phase entry; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.08 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.73 0.89 0.84 0.88 0.87 0.81 0.75 0.72 0.67 – 0.56 0.56 0.98 0.98 0.96 0.91 0.81 0.94 0.45 0.67 0.64 0.8 0.82 0.87
Endoplasmic Reticulum 0.1 0.05 0 0 0 0.07 0 0 0.07 – 0.06 0.08 0 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0.12 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.33 0.16 0.11 0.05 0.06 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.09 0.06 0.17 0.2 0.18 0.29 – 0.38 0.4 0 0 0 0 0 0 0 0 0.07 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0
Vac/Vac Membrane 0 0 0.05 0 0.06 0 0 0.08 0 – 0.1 0.09 0 0 0 0.11 0.27 0.07 0 0 0.07 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 18 2 5 1 3 1 3 5 2 – 6 3 0 0 0 0 2 1 10 7 8 0 1 0
Bud 3 1 10 1 1 3 14 4 6 – 7 13 3 1 1 0 0 0 1 2 1 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 2 2 0 0 0
Bud Site 0 0 0 0 0 0 0 1 1 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 3 2 3 3 0 4 2 12 – 8 11 1 1 0 3 2 2 0 0 0 1 0 0
Cytoplasm 157 208 201 215 244 260 372 348 224 – 192 227 151 202 216 267 204 237 117 182 181 70 169 150
Endoplasmic Reticulum 22 12 10 5 8 21 21 14 25 – 20 32 2 2 2 10 2 15 6 2 3 1 3 3
Endosome 26 7 8 5 8 2 12 13 3 – 4 4 1 0 0 2 10 5 85 42 31 3 11 6
Golgi 1 1 1 0 0 2 0 1 2 – 0 0 0 0 0 1 1 0 11 0 4 1 0 0
Mitochondria 0 7 5 23 16 53 100 85 98 – 131 162 0 3 6 4 0 3 4 9 19 1 3 1
Nucleus 0 0 1 0 0 2 6 3 0 – 4 2 0 0 4 11 1 3 0 1 0 0 1 0
Nuclear Periphery 0 0 0 0 0 1 1 2 0 – 3 2 0 0 0 0 0 0 1 1 1 0 0 1
Nucleolus 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 4 0 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 12 3 5 0 3 2
Vac/Vac Membrane 6 6 11 4 16 5 18 41 14 – 33 37 0 2 1 33 69 17 2 9 20 4 6 1
Unique Cell Count 214 234 239 243 280 321 493 484 335 342 407 154 206 225 295 251 253 259 271 285 88 207 173
Labelled Cell Count 239 248 254 257 299 350 551 520 387 408 493 158 211 230 331 291 283 259 271 285 88 207 173


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.8 7.6 6.7 6.5 6.8 7.0 7.1 7.2 6.9 – 7.0 7.1 8.0 8.6 7.8 12.4 15.0 14.0 7.8 8.2 9.1
Std Deviation (1e-4) 1.3 1.3 1.1 1.2 1.3 1.2 1.5 1.5 1.7 – 1.8 2.0 1.8 1.6 1.4 2.7 3.1 3.3 1.5 1.6 2.3
Intensity Change (Log2) – – – -0.03 0.03 0.07 0.09 0.11 0.06 – 0.07 0.09 0.27 0.36 0.23 0.9 1.17 1.07 0.23 0.3 0.45

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud -2.8 -3.0 -2.5 -1.0 0 -1.7 – -1.5 -0.7 -1.2 -2.5 -2.6 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 2.1 – 0 0 0 0 0 0 0 0
Cytoplasm 1.4 1.0 -1.0 -2.7 -3.6 -4.6 – -7.1 -7.4 4.4 5.0 4.2 2.2 -0.8 3.4
Endoplasmic Reticulum -1.3 -0.8 1.2 0 -0.9 1.6 – 0.9 1.8 0 -2.1 -2.2 -0.5 -2.4 0.9
Endosome -0.9 -0.3 0 -0.7 -0.5 0 – 0 0 0 0 0 0 0.4 -0.9
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 3.5 2.1 5.5 6.6 5.9 8.4 – 10.1 10.6 0 0 0.4 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 2.6 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole -1.9 0.6 -2.1 -0.6 1.9 -0.2 – 2.3 2.1 0 -2.3 -2.8 2.8 6.9 1.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.7936 9.9597 8.8052 8.3151 8.3153 9.1267 4.7988 7.2042 6.6263 5.8215 5.1909 6.419 5.5811 6.5463 5.9609 5.7522 4.8681 6.256
Actin 0.0117 0.0019 0.0133 0.0024 0.0021 0.0079 0.0398 0.0071 0.0079 0.0203 0.0027 0.0025 0.0016 0.0024 0.0079 0.0034 0.0106 0.0032
Bud 0.0005 0.0004 0.0007 0.0007 0.0004 0.0003 0.0004 0.0003 0.0042 0.0003 0.0003 0.0049 0.0003 0.0003 0.0003 0.0007 0.0002 0.0002
Bud Neck 0.0025 0.001 0.0017 0.0026 0.0039 0.0051 0.01 0.0004 0.0014 0.0007 0.0009 0.0041 0.0003 0.0005 0.0004 0.0018 0.0011 0.0073
Bud Periphery 0.0004 0.0002 0.0002 0.0002 0.0001 0.0001 0.0003 0.0001 0.0015 0.001 0.0002 0.002 0.0003 0 0.0001 0.0001 0.0001 0
Bud Site 0.0033 0.0035 0.0045 0.0007 0.0016 0.0004 0.017 0.0072 0.0104 0.0007 0.001 0.0013 0.0013 0.0029 0.0008 0.0008 0.0012 0.0001
Cell Periphery 0.0005 0.0004 0.0002 0.0001 0.0002 0.0001 0.0002 0.0001 0.0004 0.0002 0 0.0001 0.0001 0.0001 0 0 0 0
Cytoplasm 0.7768 0.9035 0.8179 0.8268 0.847 0.855 0.5992 0.837 0.778 0.6782 0.6592 0.7841 0.7605 0.8032 0.8313 0.7551 0.5995 0.7728
Cytoplasmic Foci 0.078 0.0393 0.0704 0.0836 0.0612 0.0599 0.1226 0.1023 0.1044 0.1313 0.1644 0.1242 0.0727 0.09 0.0753 0.1187 0.2138 0.0957
Eisosomes 0 0 0 0 0 0 0.0002 0.0001 0.0001 0.0002 0 0 0 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0208 0.0082 0.0079 0.0039 0.009 0.0147 0.0091 0.0028 0.003 0.003 0.0035 0.0029 0.0079 0.0022 0.0058 0.0028 0.0013 0.003
Endosome 0.0505 0.0185 0.0412 0.0399 0.047 0.0198 0.0742 0.0275 0.0397 0.0784 0.0648 0.0349 0.09 0.0781 0.0332 0.0998 0.0569 0.06
Golgi 0.0076 0.0036 0.0076 0.0142 0.0088 0.003 0.0205 0.0033 0.0066 0.0093 0.0169 0.0092 0.0072 0.0086 0.0042 0.0052 0.0075 0.0067
Lipid Particles 0.0035 0.001 0.0009 0.0004 0.001 0.0003 0.0213 0.0002 0.0027 0.0105 0.0587 0.0007 0.0124 0.0043 0.0008 0.0002 0.0291 0.0002
Mitochondria 0.0104 0.0006 0.0014 0.0018 0.0012 0.0016 0.0029 0.0008 0.004 0.0169 0.002 0.0056 0.0127 0.0007 0.0005 0.0009 0.0011 0.001
None 0.0053 0.0021 0.0025 0.0016 0.0009 0.002 0.0119 0.0034 0.008 0.0078 0.0035 0.0051 0.0111 0.0022 0.009 0.0026 0.0024 0.0419
Nuclear Periphery 0.0037 0.0028 0.0043 0.0018 0.0025 0.0056 0.0125 0.0013 0.0023 0.0022 0.0014 0.0011 0.0022 0.0004 0.0023 0.0008 0.0004 0.0007
Nucleolus 0.0002 0.0001 0.0001 0.0001 0 0.0001 0.0008 0 0.0003 0.0009 0.0001 0.0001 0.0007 0 0 0 0.0001 0
Nucleus 0.0046 0.0071 0.0105 0.0041 0.0078 0.0134 0.0239 0.0014 0.0028 0.003 0.0028 0.0033 0.0023 0.0007 0.0024 0.001 0.0006 0.0018
Peroxisomes 0.0095 0.0012 0.0095 0.01 0.0016 0.0059 0.0209 0.0033 0.0171 0.0111 0.0128 0.0078 0.0042 0.0013 0.0226 0.0027 0.0684 0.0032
Punctate Nuclear 0.0019 0.0015 0.0015 0.0013 0.001 0.0018 0.009 0.0007 0.003 0.0008 0.003 0.0046 0.0021 0.0006 0.0015 0.0008 0.0028 0.001
Vacuole 0.0046 0.0029 0.003 0.0031 0.0021 0.0023 0.0026 0.0006 0.0016 0.0114 0.0012 0.0011 0.0069 0.0013 0.0011 0.0019 0.0023 0.0009
Vacuole Periphery 0.0038 0.0003 0.0007 0.0008 0.0006 0.0006 0.0009 0.0002 0.0005 0.0119 0.0005 0.0004 0.0032 0.0003 0.0004 0.0007 0.0004 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.8233 11.485 16.0538 29.3125 11.4279 24.4866 22.8874 26.885 33.5858 26.4482
Translational Efficiency 0.932 0.9767 0.9151 0.6966 1.0269 0.8924 0.8299 0.5966 0.6378 0.6188

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1531 17 227 1557 1167 1707 197 249 2698 1724 424 1806

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 862.85 1185.80 1541.07 1202.64 755.82 938.97 1354.90 1124.35 816.55 941.40 1454.57 1191.85
Standard Deviation 139.03 150.25 188.23 169.23 126.90 129.29 146.87 148.41 144.03 131.79 193.94 168.69
Intensity Change Log 2 — 0.458679 0.836751 0.479023 — 0.313036 0.842072 0.572977 — 0.392498 0.839238 0.523656

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001896 0.002108 0.023495 0.009096 0.001630 0.001825 0.012974 0.001882 0.001781 0.001827 0.018607 0.008101
Bud Neck 0.006379 0.002561 0.008564 0.009089 0.010428 0.008359 0.009485 0.007249 0.008130 0.008302 0.008992 0.008835
Bud Site 0.023745 0.018253 0.071013 0.053007 0.020911 0.019138 0.073162 0.024567 0.022519 0.019129 0.072011 0.049086
Cell Periphery 0.000122 0.000102 0.000368 0.000168 0.000122 0.000075 0.000229 0.000089 0.000122 0.000075 0.000303 0.000157
Cytoplasm 0.149391 0.131500 0.144015 0.292156 0.204416 0.257071 0.109239 0.188082 0.173192 0.255833 0.127857 0.277807
Cytoplasmic Foci 0.515598 0.608512 0.223494 0.155593 0.459956 0.428937 0.197343 0.154957 0.491530 0.430707 0.211344 0.155505
Eisosomes 0.000090 0.000067 0.000046 0.000056 0.000138 0.000078 0.000074 0.000056 0.000110 0.000078 0.000059 0.000056
Endoplasmic Reticulum 0.001763 0.000881 0.003341 0.002107 0.003161 0.001621 0.002821 0.001984 0.002368 0.001614 0.003099 0.002090
Endosome 0.086261 0.067371 0.084257 0.048925 0.102383 0.086446 0.099008 0.077758 0.093235 0.086257 0.091111 0.052900
Golgi 0.105309 0.016155 0.042051 0.009330 0.050892 0.029246 0.013232 0.002224 0.081771 0.029117 0.028661 0.008350
Lipid Particles 0.010180 0.005432 0.027545 0.009692 0.018222 0.008677 0.023067 0.009654 0.013659 0.008645 0.025465 0.009687
Mitochondria 0.009256 0.000194 0.000087 0.003498 0.012206 0.004392 0.000082 0.000195 0.010532 0.004350 0.000085 0.003043
Mitotic Spindle 0.022237 0.035140 0.209939 0.170514 0.012756 0.022413 0.211035 0.132118 0.018136 0.022538 0.210448 0.165220
None 0.001899 0.000214 0.000161 0.000773 0.004144 0.001612 0.000206 0.001559 0.002870 0.001598 0.000182 0.000881
Nuclear Periphery 0.000107 0.000106 0.000618 0.000853 0.000614 0.000262 0.000730 0.001014 0.000326 0.000261 0.000670 0.000876
Nuclear Periphery Foci 0.002315 0.001812 0.020681 0.005288 0.003163 0.001214 0.018785 0.012111 0.002682 0.001220 0.019800 0.006229
Nucleolus 0.002063 0.000164 0.000120 0.000547 0.001703 0.000772 0.000188 0.000613 0.001908 0.000766 0.000152 0.000556
Nucleus 0.005831 0.003535 0.010495 0.019465 0.013908 0.010539 0.011570 0.021819 0.009325 0.010470 0.010995 0.019790
Peroxisomes 0.025090 0.034423 0.010015 0.019170 0.021615 0.025138 0.035867 0.019888 0.023587 0.025229 0.022027 0.019269
Vacuole 0.025874 0.070860 0.117241 0.182840 0.052834 0.088077 0.179883 0.341337 0.037536 0.087907 0.146346 0.204693
Vacuole Periphery 0.004593 0.000610 0.002454 0.007833 0.004798 0.004109 0.001021 0.000844 0.004682 0.004075 0.001788 0.006869

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.19 -3.53 -3.03 -1.64 3.11 -0.33 -3.22 0.55 0.74 3.30 -0.01 -4.51 -3.16 -2.70 3.84
Bud Neck 3.87 -4.35 -4.52 -6.95 1.54 1.61 -0.68 2.55 1.57 3.26 -0.57 -3.36 -1.23 -0.61 2.77
Bud Site 0.57 -7.57 -2.74 -1.66 6.46 0.93 -5.82 0.24 -0.43 5.72 2.16 -9.39 -3.27 -5.17 7.89
Cell Periphery 0.16 -7.40 0.28 -0.11 7.71 6.48 -6.25 3.96 -1.03 7.99 6.09 -9.20 0.93 -5.75 9.69
Cytoplasm -0.37 -1.65 -18.40 -2.58 -7.76 -5.54 4.49 0.82 4.22 -2.76 -10.56 1.26 -15.85 -4.12 -11.13
Cytoplasmic Foci -0.88 25.09 63.48 8.46 7.94 3.84 22.37 33.41 31.64 4.41 8.81 33.73 72.81 48.79 9.35
Eisosomes 0.59 6.12 8.64 0.65 0.95 7.06 6.25 9.64 4.40 2.83 5.98 8.50 13.27 7.54 3.41
Endoplasmic Reticulum 1.36 -2.36 2.18 -0.56 3.19 2.76 -0.58 2.19 -0.87 3.55 2.31 -2.35 3.79 1.09 5.09
Endosome 1.69 2.59 19.08 2.60 7.58 3.46 4.07 8.87 6.99 2.94 2.20 4.62 24.17 19.81 9.58
Golgi 14.93 12.22 27.96 2.27 5.85 7.20 13.51 18.61 16.54 4.08 18.40 16.64 32.35 15.58 6.45
Lipid Particles 1.92 -5.13 1.18 -1.42 5.48 6.68 -1.28 6.40 -0.07 5.27 4.99 -5.20 5.41 -0.53 7.23
Mitochondria 8.16 8.24 6.96 -3.01 -3.29 3.79 6.22 6.19 5.51 -1.68 4.88 9.91 8.70 4.05 -3.30
Mitotic Spindle -1.37 -9.70 -15.46 -3.77 3.77 -3.55 -8.85 -7.00 -6.31 2.73 -2.13 -13.09 -17.67 -15.90 4.95
None 2.65 2.88 0.86 -4.86 -7.86 1.85 3.25 2.37 0.47 -2.10 1.40 4.29 2.42 0.25 -7.80
Nuclear Periphery -0.42 -6.84 -21.20 -18.70 -6.21 1.30 -2.21 -3.97 -8.76 -2.63 0.35 -5.10 -10.58 -16.69 -5.91
Nuclear Periphery Foci 0.20 -7.87 -6.26 -2.95 6.63 3.02 -7.48 -4.79 -5.68 1.13 3.90 -10.81 -7.22 -11.50 8.18
Nucleolus 3.46 3.53 2.42 -8.50 -10.23 2.89 4.57 2.69 -0.32 -4.06 3.32 5.03 3.35 -0.29 -10.44
Nucleus 1.22 -3.30 -17.46 -14.69 -5.28 2.04 -1.32 -3.18 -4.28 -1.36 -1.30 -3.42 -15.71 -15.00 -6.15
Peroxisomes -0.67 7.63 9.07 2.13 -0.45 -1.75 -0.76 3.67 4.71 2.87 -0.89 2.95 10.65 9.14 2.84
Vacuole -1.99 -9.57 -43.83 -10.89 -11.83 -9.51 -11.59 -20.10 -17.95 -7.65 -15.53 -14.79 -46.56 -35.34 -12.07
Vacuole Periphery 9.28 5.01 3.97 -2.45 -0.03 1.41 9.03 9.89 9.05 2.54 1.56 9.37 5.29 3.59 -0.69
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiquitinated forms of Pex5p; deubiquitinates Clb5p, counteracting APC activity, and facilitating both Clb5p accumulation and S phase entry; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences
Localization
Cell Percentages cytoplasm (45%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-3

Ubp15

Ubp15


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ubp15-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available