ORF
Human Ortholog
Description Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.08
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 1.0 0.97 0.96 0.94 0.92 0.87 0.75 0.84 0.8 0.86 0.72 0.99 0.98 1.0 0.97 0.99 0.96 0.91 0.9 0.89 0.93 0.84 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0.07 0.06 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.06 0 0.05 0.16 0.05 0.13 0.07 0.2 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 2 3 0 1 1 4 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 0 0 0 0 2 5 2 3 2 0 0 0 0 0 0 0 5 5 0 2 14 21
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 0 2 4 7 2 9 7 4 6 7 14 1 5 2 7 1 6 0 0 0 0 2 0
Cytoplasm 197 140 115 173 261 192 270 269 178 228 195 199 175 193 220 156 175 161 190 131 116 110 198 232
Endoplasmic Reticulum 0 0 0 2 2 5 14 26 12 9 6 8 1 1 1 2 8 4 0 0 2 0 3 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 2 0 0 1
Golgi 0 0 0 0 0 1 1 2 0 0 0 3 0 1 1 0 0 1 1 0 0 0 0 0
Mitochondria 5 0 0 1 1 1 7 6 12 10 12 11 0 1 0 0 0 2 1 1 1 0 1 1
Nucleus 0 0 0 0 0 5 9 6 1 4 4 1 1 0 0 0 0 0 0 0 0 1 6 3
Nuclear Periphery 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 2 1
Vac/Vac Membrane 1 0 3 5 17 2 17 58 10 38 15 55 0 0 0 3 3 5 1 1 2 0 1 1
Unique Cell Count 201 140 119 181 279 208 311 361 211 284 228 275 177 197 221 160 177 168 209 145 131 119 236 270
Labelled Cell Count 207 140 121 185 288 209 331 382 219 299 242 295 178 202 224 168 187 181 209 145 131 119 236 270


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.3 15.4 11.7 10.4 13.1 13.9 15.4 16.1 15.3 16.0 15.7 17.5 16.9 28.3 33.2 38.5 39.9 37.7 13.7 14.2 16.6
Std Deviation (1e-4) 2.9 6.1 3.9 3.6 4.2 4.0 4.7 4.3 4.7 4.6 4.7 5.2 6.4 10.3 9.5 13.2 12.3 14.7 9.0 7.8 7.1
Intensity Change (Log2) – – – -0.17 0.16 0.25 0.4 0.46 0.39 0.45 0.42 0.58 0.53 1.27 1.51 1.72 1.77 1.69 0.23 0.28 0.5

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.5 -1.2 -1.6 -3.0 -5.2 -3.4 -4.2 -3.2 -5.5 1.3 0.7 2.1 0.4 1.3 -0.4
Endoplasmic Reticulum 0 0 0 0 3.0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.5 0 1.3 3.8 0 3.3 1.6 4.5 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 12.7169 13.9753 12.8072 11.9057 14.0232 12.3 16.3527 16.8978 15.989 15.0159 15.4231 16.4713 12.3629 13.9974 12.6475 13.144 13.7179 15.249
Actin 0.0098 0.0014 0.0074 0.0004 0.0009 0.011 0.0012 0.0029 0.0015 0.0179 0.0029 0.0012 0.0132 0.0014 0.0046 0.0126 0.0044 0.0005
Bud 0.0007 0.0065 0.0012 0.0002 0.0025 0.0009 0.0015 0.002 0.0025 0.0066 0.0078 0.0009 0.0006 0.0011 0.0017 0.0014 0.0044 0.0002
Bud Neck 0.0007 0.0002 0.0006 0.0006 0.0005 0.0014 0.0004 0.0004 0.0006 0.0012 0.0008 0.0013 0.0005 0.0001 0.0005 0.0006 0.0011 0.0006
Bud Periphery 0.0004 0.0024 0.0005 0.0001 0.001 0.0006 0.0011 0.0009 0.002 0.0049 0.0052 0.0006 0.0005 0.0002 0.0013 0.0013 0.0027 0.0001
Bud Site 0.0019 0.0017 0.0025 0.0006 0.0002 0.0018 0.0011 0.0053 0.0024 0.0016 0.0005 0.0002 0.0029 0.003 0.008 0.011 0.0043 0
Cell Periphery 0.0002 0.0001 0.0001 0.0001 0 0 0.0001 0.0002 0.0001 0.0002 0.0001 0 0.0001 0.0001 0.0002 0.0002 0.0001 0
Cytoplasm 0.8827 0.9736 0.9241 0.9108 0.9785 0.9314 0.9493 0.9699 0.9487 0.9232 0.9308 0.9619 0.8519 0.9877 0.9073 0.8989 0.8765 0.9611
Cytoplasmic Foci 0.0217 0.0015 0.01 0.0254 0.0019 0.0107 0.0029 0.0025 0.0028 0.0041 0.0054 0.0037 0.0322 0.001 0.0108 0.0217 0.0293 0.0014
Eisosomes 0.0002 0 0.0001 0 0 0 0 0 0 0 0 0 0.0001 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0042 0.0009 0.0021 0.002 0.0008 0.0027 0.0036 0.0011 0.0021 0.0031 0.0037 0.0026 0.0044 0.0006 0.0052 0.0019 0.0022 0.0014
Endosome 0.0146 0.0006 0.01 0.0122 0.0005 0.0061 0.0015 0.0009 0.0014 0.0017 0.0059 0.0017 0.0383 0.0003 0.0101 0.0161 0.053 0.0162
Golgi 0.0064 0.0001 0.0039 0.0022 0.0001 0.002 0.0001 0.0002 0.0002 0.0003 0.0009 0.0001 0.0094 0 0.0039 0.005 0.003 0.0029
Lipid Particles 0.0113 0 0.0059 0.0084 0 0.0018 0.0001 0 0 0.0001 0.0001 0 0.0042 0 0.0014 0.0019 0.0011 0.0002
Mitochondria 0.006 0.0001 0.0047 0.0023 0.0004 0.001 0.0003 0.0002 0.0003 0.0004 0.0034 0.0002 0.0066 0.0001 0.0117 0.0037 0.0021 0.0026
None 0.0068 0.0057 0.0085 0.0012 0.0025 0.002 0.0058 0.0017 0.005 0.0062 0.0024 0.0023 0.0036 0.0007 0.0143 0.0016 0.0012 0.0006
Nuclear Periphery 0.0046 0.001 0.0016 0.0048 0.0015 0.0066 0.0041 0.0015 0.0036 0.0038 0.0048 0.0031 0.0054 0.0008 0.0031 0.0031 0.0023 0.0022
Nucleolus 0.0003 0 0.0001 0.0007 0 0.0001 0.0001 0 0.0001 0.0001 0 0 0.0002 0 0.0002 0.0005 0.0001 0
Nucleus 0.0119 0.0034 0.0059 0.0138 0.0078 0.0114 0.0237 0.0087 0.0228 0.016 0.0209 0.0171 0.0093 0.0022 0.0039 0.0073 0.0067 0.008
Peroxisomes 0.0097 0.0001 0.0082 0.0052 0.0001 0.0051 0.0001 0.0001 0.0002 0.001 0.0001 0.0001 0.0069 0 0.007 0.0065 0.0018 0
Punctate Nuclear 0.004 0.0004 0.0012 0.0025 0.0005 0.0018 0.0009 0.0006 0.0018 0.0023 0.0016 0.0012 0.0041 0.0002 0.0004 0.0023 0.0017 0.0002
Vacuole 0.0013 0.0003 0.0011 0.0048 0.0003 0.0012 0.0017 0.0008 0.0016 0.0047 0.0021 0.0013 0.0041 0.0002 0.0028 0.0016 0.0016 0.0008
Vacuole Periphery 0.0004 0.0001 0.0003 0.0016 0.0001 0.0005 0.0003 0.0001 0.0003 0.0004 0.0004 0.0002 0.0014 0.0001 0.0015 0.0006 0.0005 0.001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 160.2564 94.88 74.5875 94.4106 75.6181 123.933 124.9029 124.6887 132.0134 116.8221
Translational Efficiency 1.5862 1.9243 1.7926 1.8292 1.8204 2.5974 1.6691 1.6397 1.7908 1.8597

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2241 195 241 116 1780 1926 380 1707 4021 2121 621 1823

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 849.35 998.66 1434.28 1932.46 789.67 988.03 1432.76 1729.30 822.93 989.01 1433.35 1742.23
Standard Deviation 168.90 245.90 336.45 892.15 168.34 250.14 372.80 666.84 171.24 249.77 359.13 685.19
Intensity Change Log 2 — 0.233634 0.755896 1.186007 — 0.323305 0.859475 1.130866 — 0.277533 0.806729 1.159704

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000151 0.000310 0.001042 0.000734 0.000123 0.000352 0.000377 0.001234 0.000139 0.000348 0.000635 0.001202
Bud Neck 0.006371 0.009937 0.003222 0.004506 0.003943 0.004621 0.001951 0.003232 0.005296 0.005110 0.002444 0.003313
Bud Site 0.008741 0.018402 0.006866 0.015001 0.005849 0.014349 0.010445 0.024534 0.007461 0.014722 0.009056 0.023927
Cell Periphery 0.000093 0.000139 0.000438 0.002030 0.000121 0.000101 0.000169 0.000171 0.000105 0.000104 0.000274 0.000290
Cytoplasm 0.720230 0.679226 0.526923 0.745352 0.721635 0.790257 0.707335 0.751299 0.720852 0.780049 0.637320 0.750921
Cytoplasmic Foci 0.117200 0.132944 0.022132 0.029216 0.113280 0.077061 0.014220 0.016937 0.115465 0.082198 0.017291 0.017718
Eisosomes 0.000048 0.000049 0.000024 0.000012 0.000044 0.000026 0.000016 0.000009 0.000046 0.000028 0.000019 0.000009
Endoplasmic Reticulum 0.000693 0.000639 0.003892 0.000173 0.001282 0.000725 0.000901 0.000344 0.000954 0.000717 0.002062 0.000334
Endosome 0.006790 0.017118 0.002707 0.000394 0.005970 0.006278 0.001959 0.007352 0.006427 0.007274 0.002249 0.006909
Golgi 0.002112 0.001346 0.000631 0.000459 0.000864 0.003260 0.000191 0.014813 0.001560 0.003084 0.000362 0.013899
Lipid Particles 0.001907 0.001223 0.002309 0.004960 0.002492 0.001146 0.000946 0.001939 0.002166 0.001153 0.001475 0.002131
Mitochondria 0.002237 0.001370 0.000315 0.000064 0.001537 0.001625 0.000199 0.004594 0.001927 0.001602 0.000244 0.004306
Mitotic Spindle 0.002828 0.001771 0.003860 0.004393 0.001493 0.010808 0.004331 0.057312 0.002237 0.009977 0.004148 0.053945
None 0.006160 0.003655 0.004763 0.013066 0.007875 0.006278 0.008492 0.006818 0.006919 0.006037 0.007045 0.007216
Nuclear Periphery 0.000162 0.000267 0.000946 0.000278 0.000288 0.000143 0.000582 0.000335 0.000218 0.000155 0.000723 0.000331
Nuclear Periphery Foci 0.000913 0.003558 0.007401 0.003602 0.001515 0.001379 0.005265 0.001868 0.001179 0.001579 0.006094 0.001979
Nucleolus 0.000473 0.000739 0.000197 0.000087 0.000621 0.000467 0.000154 0.000228 0.000539 0.000492 0.000170 0.000219
Nucleus 0.072011 0.031616 0.317407 0.091019 0.084753 0.040948 0.159027 0.068537 0.077652 0.040090 0.220492 0.069967
Peroxisomes 0.001858 0.003635 0.000171 0.000097 0.000967 0.001783 0.000106 0.001037 0.001464 0.001953 0.000131 0.000977
Vacuole 0.048007 0.090116 0.094505 0.084470 0.044239 0.037552 0.083196 0.033817 0.046339 0.042385 0.087585 0.037040
Vacuole Periphery 0.001015 0.001939 0.000248 0.000087 0.001109 0.000841 0.000136 0.003591 0.001056 0.000942 0.000180 0.003368

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.22 -8.47 -2.59 -1.76 2.36 -2.63 -5.67 -3.68 -1.52 -0.33 -2.68 -9.84 -3.87 -1.72 2.00
Bud Neck -0.89 0.81 1.38 1.24 0.46 -1.00 0.94 1.57 2.67 0.77 0.45 2.08 5.35 3.00 2.30
Bud Site -4.28 -1.27 -2.36 2.24 -0.76 -5.66 -1.95 -5.46 0.34 -1.74 -5.32 -1.95 -4.63 0.63 -1.88
Cell Periphery -2.66 -6.33 -3.44 -3.26 -1.32 2.44 -4.37 -4.46 -5.72 1.34 0.20 -7.59 -6.18 -6.13 3.27
Cytoplasm 2.52 16.14 4.42 1.50 -5.83 -8.66 9.24 0.52 8.93 -8.83 -8.61 16.65 1.47 8.48 -14.54
Cytoplasmic Foci -1.12 18.86 17.41 7.87 -0.94 7.96 25.09 27.57 20.56 1.45 8.89 32.25 39.24 22.05 2.96
Eisosomes -0.44 3.88 10.01 4.95 4.58 6.85 8.62 16.60 11.20 7.18 7.28 8.63 19.61 12.30 9.48
Endoplasmic Reticulum 0.16 -4.82 4.74 3.46 5.49 2.61 0.77 5.97 4.01 6.57 1.68 -4.31 8.15 4.34 7.13
Endosome -3.40 5.81 11.02 5.61 6.69 -0.32 8.90 6.28 5.68 -0.70 -1.12 10.31 8.03 7.22 0.51
Golgi 1.77 3.99 5.15 2.32 2.74 -3.54 5.67 -2.77 -0.63 -3.29 -2.35 5.76 -2.07 -0.64 -3.12
Lipid Particles 1.93 -4.28 -3.87 -4.40 -1.68 4.80 2.11 0.99 -3.73 -1.03 5.60 -1.78 -0.71 -4.63 0.77
Mitochondria 1.10 3.69 4.19 1.51 9.11 -0.10 2.90 0.21 0.32 -2.13 0.77 4.72 1.02 0.43 -2.04
Mitotic Spindle 0.87 -1.53 -1.63 -1.88 -1.16 -5.19 -3.35 -10.21 -6.08 -6.80 -4.65 -3.42 -10.02 -6.33 -7.83
None 2.27 3.78 -0.37 -1.21 -1.15 1.64 1.51 2.84 1.41 1.52 1.45 2.66 2.66 0.79 -0.28
Nuclear Periphery -0.83 -12.22 -4.25 -1.82 5.33 4.27 -10.63 -4.06 -10.28 8.69 2.52 -16.54 -8.22 -9.78 11.68
Nuclear Periphery Foci -4.66 -10.34 -6.89 -1.19 3.70 0.23 -6.15 -2.18 -2.28 5.48 -3.08 -10.87 -5.49 -2.15 8.77
Nucleolus -1.15 6.49 11.66 2.51 4.83 1.47 4.77 5.06 4.24 0.94 0.52 7.43 7.99 4.83 1.35
Nucleus 9.39 -16.24 -1.67 -5.69 12.98 14.60 -11.94 -0.99 -17.00 11.63 17.88 -19.57 -3.84 -18.00 17.83
Peroxisomes -2.44 7.09 7.78 4.78 2.40 -2.57 4.95 3.14 5.41 -2.74 -1.75 8.83 6.58 6.50 -2.15
Vacuole -5.00 -8.81 -7.83 -4.58 -2.11 2.07 -10.64 -14.35 -15.66 4.02 0.53 -13.77 -16.23 -15.61 4.40
Vacuole Periphery -0.79 3.88 4.78 1.77 7.44 0.87 3.34 0.15 -0.48 -2.18 0.60 5.17 0.20 -0.14 -2.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (86%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YMR315W

YMR315W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ymr315w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available