Standard name
Human Ortholog
Description Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0.07 0 0 0 0.05 0.07 0.07 0.07 0.08 0.09 0 0.06 0 0.05 0.06 0.05 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.97 0.95 0.93 0.86 0.71 0.73 0.69 0.66 0.67 0.66 0.99 0.99 0.99 0.96 0.96 0.95 0.97 0.97 0.94 0.96 0.96 0.97
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0.08 0.08 0 0.05 0 0 0 0.05 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.2 0.31 0.22 0.26 0.32 0.32 0.32 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 0 0 0.06 0 0 0 0 0 0 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 2 0 4 6 11 4 9 12 9 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 4 1 3 3 12 7 11 9 19 18 0 0 1 0 0 0 0 0 1 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2 3 22 11 6 18 31 45 34 37 32 46 9 28 14 6 9 7 0 0 1 0 0 0
Cytoplasm 174 129 314 278 334 375 439 505 317 327 280 327 322 444 543 124 137 122 166 140 309 237 386 350
Endoplasmic Reticulum 1 3 6 0 7 13 27 25 37 40 15 25 2 6 5 6 7 6 0 0 8 0 2 0
Endosome 0 0 0 0 0 0 1 5 0 1 0 1 0 0 0 0 0 0 0 0 0 0 1 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 1 0 0 1 0 0 0
Mitochondria 0 0 2 10 18 87 195 153 120 158 133 158 0 0 1 2 3 0 1 0 1 0 1 2
Nucleus 1 0 0 0 1 2 3 1 0 1 1 1 1 1 2 0 1 0 1 0 0 2 1 0
Nuclear Periphery 0 0 0 0 1 1 3 1 0 1 0 1 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 1 2 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 0 0 1 8 9 4 23 40 17 16 23 14 0 0 0 1 2 7 0 1 0 2 4 1
Unique Cell Count 175 130 324 292 361 436 621 691 460 497 418 493 324 449 546 129 142 129 172 145 330 247 401 362
Labelled Cell Count 178 136 349 310 379 507 741 795 540 599 515 601 335 479 567 139 161 143 172 145 330 247 401 362


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.0 17.0 14.0 12.2 10.9 9.4 8.9 9.2 8.7 8.4 8.2 8.2 15.5 16.0 15.4 17.7 17.4 19.7 14.4 14.8 15.8
Std Deviation (1e-4) 1.9 2.1 1.7 1.6 1.8 1.5 1.7 1.8 1.8 1.8 1.7 1.7 2.7 2.5 2.2 5.0 4.7 4.1 2.4 2.7 2.8
Intensity Change (Log2) -0.2 -0.36 -0.58 -0.65 -0.61 -0.69 -0.73 -0.78 -0.77 0.15 0.2 0.14 0.34 0.31 0.49 0.04 0.08 0.17

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 3.1 0 0 0 0 0 0 0
Bud 0 0 0 0.8 0 1.2 0.6 2.6 2.1 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.7 -3.4 -1.6 -1.1 -0.2 0.3 0.4 0.5 1.3 -2.4 -0.3 -3.0 -0.9 -0.2 -0.5
Cytoplasm -1.1 -2.5 -5.1 -9.5 -9.0 -9.7 -10.5 -10.1 -10.4 2.3 2.0 3.0 -0.4 -0.2 -1.2
Endoplasmic Reticulum 0 0.1 1.0 2.0 1.5 3.7 3.8 1.4 2.4 0 -0.6 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.5 3.4 8.2 11.1 8.9 9.7 11.0 10.9 11.1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.1 4.1 3.1 2.9 4.0 2.6 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.0065 13.5474 11.9633 10.9782 11.3637 11.9796 9.3789 12.9115 12.1728 10.6985 11.038 11.7975 9.0515 11.9813 10.3185 10.4525 8.4739 10.8888
Actin 0.0002 0.0001 0.0007 0.0002 0.0001 0.0004 0.0058 0.0002 0.0101 0.0066 0.0007 0.0002 0.0348 0.0009 0.0031 0.0176 0.0297 0.0104
Bud 0.0001 0.0001 0.0013 0.0002 0.0001 0.0001 0.0007 0.0001 0.0003 0.0007 0.0007 0.0001 0.0005 0.0003 0.0004 0.0005 0.0004 0.0001
Bud Neck 0.0002 0.0001 0.0002 0.0004 0.0006 0.0006 0.0009 0.0001 0.0004 0.0003 0.0004 0.0008 0.0007 0.0001 0.0007 0.0004 0.0005 0.0004
Bud Periphery 0 0 0.0006 0 0 0.0001 0.0009 0 0.0002 0.0008 0.0015 0.0001 0.0006 0.0001 0.0004 0.0001 0.0005 0.0001
Bud Site 0.0002 0.0002 0.0017 0.0001 0 0 0.0008 0.0001 0.0005 0.0027 0.0006 0.0001 0.0016 0.001 0.001 0.0002 0.0012 0.0001
Cell Periphery 0 0 0.0001 0 0 0 0.0003 0 0 0.0012 0.0001 0 0.0002 0 0.0002 0 0.0001 0
Cytoplasm 0.9571 0.9886 0.9744 0.9409 0.9707 0.9758 0.8351 0.9941 0.9581 0.9267 0.8931 0.9611 0.8551 0.9806 0.9247 0.9471 0.7834 0.9563
Cytoplasmic Foci 0.0131 0.0021 0.0035 0.0072 0.0046 0.0042 0.0291 0.0013 0.0049 0.0062 0.0034 0.0077 0.0113 0.0044 0.0141 0.012 0.0442 0.0041
Eisosomes 0 0 0 0 0 0 0.0001 0 0 0.0001 0 0 0.0004 0 0.0001 0 0.0002 0.0001
Endoplasmic Reticulum 0.0069 0.0023 0.0027 0.0044 0.0157 0.0076 0.0092 0.0008 0.0013 0.002 0.003 0.0093 0.0068 0.001 0.0068 0.0033 0.0017 0.003
Endosome 0.0115 0.0021 0.0079 0.0356 0.0044 0.0067 0.0411 0.0012 0.0074 0.0105 0.0411 0.0097 0.0213 0.0031 0.0143 0.0075 0.0176 0.0074
Golgi 0.0007 0.0001 0.0019 0.001 0.0002 0.0007 0.0074 0.0001 0.0065 0.0068 0.0026 0.0005 0.0111 0.0025 0.0018 0.0022 0.0142 0.0012
Lipid Particles 0.0007 0 0 0 0 0 0.0076 0 0.0008 0.0192 0.0009 0.0001 0.0116 0.0001 0.0049 0 0.0224 0.0015
Mitochondria 0.0002 0.0001 0.0007 0.0004 0.0001 0.0008 0.0233 0.0002 0.0046 0.0037 0.0198 0.0056 0.0164 0.0032 0.0047 0.0004 0.0424 0.0006
None 0.0018 0.0008 0.0008 0.0006 0.0006 0.0006 0.0059 0.0004 0.0005 0.0006 0.0008 0.0006 0.0026 0.0005 0.0048 0.0005 0.0019 0.003
Nuclear Periphery 0.0008 0.0008 0.0005 0.0008 0.0006 0.0004 0.007 0.0002 0.0005 0.0011 0.0078 0.0007 0.0091 0.0002 0.0021 0.0008 0.0023 0.0046
Nucleolus 0.0006 0 0 0 0 0 0.0006 0 0 0.0001 0.0002 0 0.0003 0 0.0005 0 0.0002 0.0006
Nucleus 0.0012 0.0009 0.001 0.0015 0.0012 0.0008 0.0047 0.0006 0.0011 0.0021 0.0028 0.0014 0.0037 0.0006 0.0021 0.0013 0.0011 0.0024
Peroxisomes 0.0002 0 0 0 0 0 0.0066 0 0.0013 0.0051 0.0002 0.0003 0.006 0.0006 0.0081 0.0024 0.0269 0.0003
Punctate Nuclear 0.0027 0.0001 0.0004 0.0001 0.0001 0.0001 0.0043 0 0.0001 0.0004 0.0004 0.0002 0.0017 0 0.0013 0.0001 0.008 0.0023
Vacuole 0.0013 0.0012 0.0011 0.005 0.0008 0.0008 0.0059 0.0004 0.001 0.0023 0.0129 0.0012 0.0028 0.0005 0.0029 0.0027 0.0008 0.0008
Vacuole Periphery 0.0002 0.0002 0.0003 0.0014 0.0002 0.0003 0.0027 0.0001 0.0003 0.0006 0.007 0.0004 0.0014 0.0001 0.001 0.0008 0.0004 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 26.611 33.9837 34.0434 36.4164 19.7156 18.0474 33.9313 35.6566 27.9943 34.5608
Translational Efficiency 2.0903 1.7324 1.5477 1.557 2.1996 2.4422 1.582 1.4535 1.6586 1.5777

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2102 336 258 1206 1838 485 335 731 3940 821 593 1937

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1374.03 1418.36 1658.04 1461.69 1298.40 1353.51 1721.39 1574.35 1338.75 1380.05 1693.83 1504.21
Standard Deviation 203.47 227.91 202.80 258.25 199.72 198.32 229.82 315.62 205.22 213.33 220.72 286.53
Intensity Change Log 2 0.045810 0.271065 0.089224 0.059971 0.406839 0.278021 0.052707 0.338628 0.184039

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000118 0.000267 0.000756 0.000605 0.000130 0.000142 0.001110 0.000646 0.000124 0.000193 0.000956 0.000621
Bud Neck 0.000162 0.000512 0.004089 0.001203 0.000201 0.000248 0.003094 0.001713 0.000180 0.000356 0.003527 0.001396
Bud Site 0.007153 0.014700 0.023363 0.024849 0.008577 0.006934 0.024209 0.023880 0.007817 0.010112 0.023841 0.024484
Cell Periphery 0.000172 0.000425 0.000725 0.002015 0.000174 0.000095 0.000733 0.001939 0.000173 0.000230 0.000730 0.001987
Cytoplasm 0.920782 0.880248 0.630617 0.864774 0.887612 0.908603 0.825600 0.844912 0.905308 0.896998 0.740768 0.857278
Cytoplasmic Foci 0.044106 0.059206 0.075600 0.016569 0.060521 0.052498 0.056658 0.022406 0.051763 0.055243 0.064899 0.018772
Eisosomes 0.000002 0.000003 0.000010 0.000004 0.000002 0.000002 0.000008 0.000006 0.000002 0.000003 0.000008 0.000005
Endoplasmic Reticulum 0.001753 0.002605 0.003231 0.000749 0.002823 0.001144 0.000745 0.000851 0.002252 0.001742 0.001827 0.000787
Endosome 0.001344 0.003655 0.018666 0.002957 0.002723 0.002450 0.005914 0.003867 0.001987 0.002943 0.011462 0.003301
Golgi 0.007710 0.006555 0.004799 0.005224 0.007490 0.004262 0.005006 0.004226 0.007608 0.005201 0.004916 0.004847
Lipid Particles 0.000842 0.003296 0.009910 0.006546 0.000620 0.000861 0.006815 0.008538 0.000738 0.001858 0.008162 0.007298
Mitochondria 0.000872 0.000258 0.000015 0.000049 0.000291 0.000077 0.000011 0.000067 0.000601 0.000151 0.000013 0.000056
Mitotic Spindle 0.000640 0.000790 0.002994 0.001932 0.001300 0.000510 0.003028 0.001271 0.000948 0.000625 0.003013 0.001683
None 0.000798 0.000410 0.000113 0.000302 0.000632 0.000408 0.000403 0.000484 0.000721 0.000409 0.000277 0.000371
Nuclear Periphery 0.000016 0.000310 0.000134 0.000023 0.000016 0.000012 0.000065 0.000052 0.000016 0.000134 0.000095 0.000034
Nuclear Periphery Foci 0.000673 0.003808 0.007981 0.001901 0.000693 0.000848 0.006691 0.003235 0.000682 0.002060 0.007252 0.002404
Nucleolus 0.000050 0.000171 0.000082 0.000060 0.000030 0.000028 0.000047 0.000094 0.000040 0.000087 0.000062 0.000073
Nucleus 0.002558 0.002513 0.006489 0.004361 0.003089 0.003820 0.009099 0.005608 0.002806 0.003285 0.007964 0.004832
Peroxisomes 0.000118 0.000419 0.000733 0.000316 0.000113 0.000144 0.000413 0.000534 0.000116 0.000256 0.000552 0.000398
Vacuole 0.005514 0.016030 0.207257 0.060719 0.015243 0.014959 0.048710 0.073707 0.010053 0.015398 0.117690 0.065621
Vacuole Periphery 0.004617 0.003816 0.002436 0.004841 0.007721 0.001955 0.001640 0.001963 0.006065 0.002717 0.001987 0.003755

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.65 -7.22 -7.85 -4.75 1.31 -0.58 -6.57 -6.22 -5.96 2.74 -3.27 -8.90 -10.00 -8.13 3.18
Bud Neck -4.55 -11.83 -11.79 -6.34 8.62 -1.34 -9.65 -9.06 -8.70 4.06 -4.64 -14.99 -14.43 -11.69 9.15
Bud Site -4.46 -7.96 -9.46 -4.26 -0.48 2.03 -6.32 -6.23 -6.81 0.44 -2.68 -9.64 -11.26 -8.83 0.00
Cell Periphery -1.55 -5.37 -7.70 -5.40 -4.93 4.18 -7.22 -5.87 -6.16 -3.77 -0.83 -8.87 -9.69 -8.78 -6.28
Cytoplasm 4.04 17.11 10.06 2.02 -13.13 -2.75 6.86 6.34 7.54 -2.01 1.40 16.66 11.14 6.83 -10.84
Cytoplasmic Foci -3.00 -6.63 12.77 8.77 12.92 1.74 0.50 12.95 6.84 7.81 -1.05 -4.18 18.72 11.38 14.61
Eisosomes -1.76 -9.72 -6.31 -1.38 6.91 0.86 -6.26 -5.09 -5.67 1.66 -0.97 -10.85 -7.61 -5.55 5.92
Endoplasmic Reticulum -0.76 -0.60 3.06 1.74 1.23 2.85 4.05 2.98 0.67 -0.18 0.92 0.83 4.35 1.97 1.14
Endosome -3.31 -9.23 -4.15 0.86 8.15 0.33 -4.32 -1.64 -1.33 2.38 -1.76 -9.99 -3.72 -0.50 8.16
Golgi 1.19 5.22 4.31 1.43 -0.90 5.40 2.85 3.60 0.37 0.50 4.56 4.89 5.55 0.91 -0.18
Lipid Particles -1.71 -9.85 -7.29 -2.09 3.11 -0.70 -8.87 -8.24 -7.57 -1.31 -1.79 -13.13 -10.82 -6.44 1.39
Mitochondria 1.50 2.45 2.36 1.01 -5.08 1.54 2.04 1.64 0.44 -1.50 2.09 2.98 2.77 1.13 -3.12
Mitotic Spindle -0.64 -4.27 -2.01 -1.83 1.67 1.84 -2.30 0.16 -1.37 2.32 1.37 -4.19 -1.57 -2.34 2.52
None 1.68 3.09 2.24 1.34 -3.41 2.33 2.90 1.14 -0.34 -0.56 2.38 3.64 2.70 0.69 -1.37
Nuclear Periphery -1.31 -8.95 -1.74 1.27 8.79 2.20 -8.12 -1.72 -1.93 1.26 -1.28 -11.59 -2.28 1.06 6.88
Nuclear Periphery Foci -2.01 -6.68 -8.38 1.13 5.53 -0.61 -9.96 -6.10 -5.09 4.66 -2.09 -11.19 -9.44 -0.78 7.90
Nucleolus -0.88 -1.41 -0.48 0.81 2.15 0.60 -4.67 -7.29 -7.42 -4.74 -0.81 -1.82 -2.43 0.23 -1.05
Nucleus 0.26 -7.41 -6.40 -6.25 3.76 -2.15 -7.23 -4.52 -3.51 2.91 -2.05 -9.81 -7.24 -5.65 4.99
Peroxisomes -2.62 -4.79 -7.23 0.88 3.10 -1.68 -6.07 -5.68 -5.16 -1.23 -2.90 -7.08 -8.64 -2.43 2.13
Vacuole -3.06 -13.97 -16.76 -9.99 9.67 0.10 -8.47 -13.00 -12.01 -2.82 -2.44 -15.09 -20.70 -15.78 6.74
Vacuole Periphery 0.44 3.17 -0.03 -0.46 -3.40 5.05 5.67 6.04 0.24 -0.53 3.42 6.30 3.39 -0.95 -3.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Dom34

Dom34


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dom34-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available