Standard name
Human Ortholog
Description Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p, and in the heat shock response; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; other members of the HDA1 histone deacetylase complex are Hda2p and Hda3p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.09 0.06 0 0.06 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.1 0.08 0 0 0 0.13 0.15 0.08 0.34 0.37 0.4 0.15 0 0 0 0 0.06 0.13 0 0 0 0 0 0
Nucleus 0.91 0.92 0.97 0.93 0.93 0.87 0.86 0.85 0.77 0.77 0.66 0.75 0.93 0.85 0.89 0.95 0.9 0.81 0.85 0.91 0.91 0.77 0.71 0.74
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.12 0.08 0 0 0 0.07 0.11 0.07 0.19 0.16 0.14 0.19 0.07 0.11 0.2 0 0.05 0.05 0.07 0 0 0.11 0.12 0.12
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0.07 0.08 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 0 3 2 6 2 9 12 7 7 0 0 0 0 1 0 5 2 6 0 1 0
Bud Neck 0 0 2 0 2 1 3 2 0 0 3 4 0 0 0 0 0 0 0 1 0 0 1 0
Bud Site 1 0 1 0 2 12 12 4 20 17 7 11 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 5 4 4 26 18 18 20 28 9 10 20 17 7 15 9 4 6 9 0 2 0 0 0 0
Endoplasmic Reticulum 0 0 0 2 2 0 1 0 0 0 0 0 0 0 0 2 0 2 0 0 0 0 1 0
Endosome 0 0 1 1 0 1 2 0 0 1 0 0 0 0 0 0 1 1 3 3 3 1 2 1
Golgi 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 1 0
Mitochondria 33 36 4 14 17 118 166 59 259 285 304 121 5 2 4 4 6 11 2 2 3 0 0 0
Nucleus 296 391 622 536 640 799 958 644 590 586 499 606 149 148 142 104 92 70 288 419 627 66 127 124
Nuclear Periphery 4 3 1 4 1 5 6 2 5 13 10 13 1 3 0 2 3 0 0 0 0 0 0 0
Nucleolus 39 36 7 8 23 65 128 51 145 122 107 153 12 20 32 4 5 4 24 9 13 9 22 19
Peroxisomes 0 0 0 0 0 0 0 0 1 0 0 0 0 2 2 0 0 0 0 0 0 0 0 2
SpindlePole 0 1 7 1 7 10 16 16 4 8 4 12 0 1 1 1 0 2 2 1 4 0 2 0
Vac/Vac Membrane 3 7 10 4 8 11 11 16 1 5 16 23 3 2 0 0 1 6 8 17 21 5 14 14
Unique Cell Count 324 426 643 576 686 915 1116 758 769 765 752 807 160 175 160 110 102 86 340 463 686 86 180 168
Labelled Cell Count 381 479 660 597 724 1042 1329 824 1043 1059 977 967 177 193 190 121 115 105 340 463 686 86 180 168


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 7.1 7.0 6.7 6.6 5.6 5.6 6.3 5.0 5.0 5.0 5.8 7.5 7.9 7.1 10.0 9.6 7.4 7.0 7.0 7.3
Std Deviation (1e-4) 1.2 1.9 1.1 1.3 1.3 1.1 1.0 1.2 1.0 1.1 1.3 1.3 1.7 2.2 1.6 2.2 2.4 1.9 1.8 1.7 1.4
Intensity Change (Log2) – – – -0.06 -0.08 -0.32 -0.33 -0.16 -0.49 -0.5 -0.5 -0.28 0.1 0.16 0.02 0.51 0.45 0.08 -0.01 -0.01 0.05

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 3.2 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 2.5 0 0 3.8 3.4 0 2.5 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4.4 2.9 2.2 2.0 3.8 1.1 1.3 2.9 2.4 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.6 2.7 8.9 9.7 6.4 15.9 17.0 17.9 9.7 0 0 0 0 0 0
Nucleus -2.9 -2.9 -6.5 -7.3 -7.4 -10.7 -10.8 -14.2 -11.4 -2.1 -6.1 -4.2 -1.1 -3.1 -6.1
Nuclear Periphery 0 0 0 0 0 0 2.9 2.5 2.8 0 0 0 0 0 0
Nucleolus 0.5 2.8 5.6 7.9 5.3 10.7 9.6 8.9 10.8 0 6.8 10.0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 -0.1 0 0.6 1.5 -1.2 -0.1 -1.2 0.7 0 0 0 0 0 0
Vacuole -1.4 -0.6 -0.6 -1.1 0.8 -3.0 -1.6 0.8 1.6 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.0905 3.7797 3.3781 3.4805 3.1115 3.2839 4.9701 4.9125 4.7143 4.7479 3.6414 4.1604 5.1284 4.302 3.8305 3.9789 3.7337 3.6317
Actin 0.0241 0 0.0053 0 0.0239 0.0031 0.0015 0 0.0004 0 0.0038 0.0001 0.0114 0 0.0017 0.0025 0.0003 0.0097
Bud 0.0005 0 0.0002 0 0.0008 0 0.0002 0 0.0003 0 0.0001 0 0.0001 0 0.0001 0.0002 0.0003 0
Bud Neck 0.0017 0 0.0001 0.0001 0.0011 0.0004 0.0002 0 0.0002 0.0001 0.0003 0.0005 0.0009 0 0.0001 0.0001 0.0015 0.0004
Bud Periphery 0.0005 0 0.0002 0 0.0014 0.0001 0.0003 0 0.0007 0.0001 0.0002 0.0001 0.0002 0 0.0002 0.0003 0.0013 0.0001
Bud Site 0.0039 0 0.0005 0 0.0033 0 0.001 0.0001 0.0009 0.0001 0.0007 0 0.001 0 0.0003 0.0011 0.001 0.0001
Cell Periphery 0.0001 0 0 0 0.0002 0 0.0002 0 0.0003 0 0.0001 0 0.0001 0 0.0001 0 0.0005 0
Cytoplasm 0.0047 0 0.0011 0 0.0002 0.0002 0.0018 0.0004 0.0008 0 0.0008 0 0.0017 0 0.0004 0.0006 0.0007 0
Cytoplasmic Foci 0.01 0 0.0029 0 0.0089 0.0004 0.0068 0.0059 0.0037 0 0.0066 0.0002 0.0067 0 0.0017 0.0233 0.0016 0.0007
Eisosomes 0.0002 0 0 0 0.0003 0.0001 0.0001 0 0 0 0.0001 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0027 0 0.0003 0 0.0006 0.0004 0.002 0 0.0004 0 0.0007 0.0002 0.0024 0 0.0009 0.0002 0.0022 0
Endosome 0.0104 0 0.004 0 0.0148 0.0036 0.0088 0.006 0.0032 0 0.0077 0.0004 0.0064 0 0.0046 0.0054 0.0089 0.0014
Golgi 0.0039 0 0.002 0 0.0189 0.0012 0.0015 0.0005 0.0011 0 0.0015 0.0002 0.0024 0 0.0011 0.0027 0.0012 0.0015
Lipid Particles 0.0113 0 0.0022 0 0.018 0.0024 0.0042 0.0002 0.0048 0 0.0162 0.0016 0.0058 0 0.0041 0.007 0.0075 0.0023
Mitochondria 0.0024 0 0.0031 0 0.0209 0.0012 0.0105 0.0001 0.0084 0.0002 0.0011 0.005 0.0011 0.0001 0.0021 0.0024 0.0024 0.0012
None 0.0048 0 0.0018 0 0.0005 0.0005 0.0016 0.0001 0.0006 0 0.002 0 0.0007 0 0.0003 0.0008 0.0003 0
Nuclear Periphery 0.0143 0.0002 0.0021 0.0001 0.002 0.0087 0.0053 0.0002 0.0088 0.0002 0.0126 0.002 0.0053 0.0001 0.0026 0.0027 0.0084 0.0001
Nucleolus 0.0321 0.0174 0.0137 0.0347 0.1882 0.0729 0.0365 0.0189 0.0232 0.0333 0.1293 0.0779 0.024 0.0162 0.0094 0.0109 0.1727 0.0538
Nucleus 0.829 0.9821 0.9533 0.9649 0.6759 0.9021 0.9094 0.9666 0.9329 0.9658 0.7995 0.9071 0.9198 0.9834 0.9673 0.9021 0.7751 0.9263
Peroxisomes 0.0087 0 0.0007 0 0.0074 0.0006 0.0004 0.0002 0.003 0 0.0032 0.0001 0.0031 0 0.0003 0.0089 0.0004 0.0018
Punctate Nuclear 0.0321 0.0001 0.0051 0.0002 0.0104 0.0012 0.0031 0.0007 0.0017 0.0001 0.0122 0.0041 0.0058 0.0001 0.0008 0.0285 0.0033 0.0003
Vacuole 0.0015 0 0.0007 0 0.0011 0.0003 0.003 0.0001 0.0023 0 0.0008 0.0002 0.0007 0 0.0014 0.0002 0.0083 0.0001
Vacuole Periphery 0.001 0 0.0005 0 0.0013 0.0004 0.0014 0 0.0022 0 0.0006 0.0002 0.0003 0 0.0007 0.0002 0.0021 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.0866 15.8118 17.9446 23.6961 19.2232 11.9586 18.5735 21.898 24.9319 22.3476
Translational Efficiency 1.0256 1.0161 1.0299 0.8774 0.8013 1.1961 0.8358 0.7344 0.6551 0.7608

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
382 1234 168 157 2005 1065 106 31 2387 2299 274 188

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 757.49 942.32 1319.47 1378.05 836.55 945.95 1310.14 1344.06 823.90 944.00 1315.86 1372.45
Standard Deviation 100.51 143.73 180.12 188.31 118.51 140.77 182.21 220.08 119.39 142.38 180.99 194.31
Intensity Change Log 2 — 0.314990 0.800660 0.863329 — 0.177312 0.647197 0.684074 — 0.244377 0.722161 0.772038

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000216 0.000568 0.001485 0.001161 0.000233 0.000626 0.001122 0.000834 0.000230 0.000595 0.001345 0.001107
Bud Neck 0.001505 0.006445 0.011730 0.022231 0.004791 0.008108 0.012544 0.009162 0.004266 0.007215 0.012045 0.020076
Bud Site 0.000274 0.000733 0.001363 0.005220 0.000340 0.001615 0.001196 0.000638 0.000330 0.001142 0.001298 0.004464
Cell Periphery 0.000039 0.000065 0.000041 0.000140 0.000053 0.000113 0.000043 0.000030 0.000051 0.000087 0.000042 0.000122
Cytoplasm 0.006003 0.001039 0.000125 0.001186 0.000539 0.001008 0.000287 0.000187 0.001413 0.001025 0.000188 0.001021
Cytoplasmic Foci 0.003307 0.001001 0.000078 0.000134 0.000361 0.000710 0.000077 0.000016 0.000833 0.000867 0.000077 0.000114
Eisosomes 0.000016 0.000040 0.000088 0.000052 0.000026 0.000041 0.000071 0.000047 0.000024 0.000040 0.000082 0.000052
Endoplasmic Reticulum 0.001467 0.003309 0.002499 0.001601 0.002921 0.004960 0.002071 0.001212 0.002688 0.004074 0.002333 0.001537
Endosome 0.000119 0.000530 0.000066 0.000126 0.000155 0.000507 0.000090 0.000036 0.000149 0.000519 0.000075 0.000111
Golgi 0.000144 0.001159 0.000137 0.000100 0.000077 0.000729 0.000096 0.000048 0.000088 0.000960 0.000121 0.000091
Lipid Particles 0.000844 0.000468 0.000069 0.000062 0.000324 0.000403 0.000090 0.000016 0.000408 0.000438 0.000078 0.000055
Mitochondria 0.000443 0.002097 0.001865 0.002272 0.000646 0.003769 0.001513 0.001782 0.000613 0.002872 0.001729 0.002191
Mitotic Spindle 0.005745 0.006317 0.000463 0.011174 0.000879 0.003453 0.000501 0.000265 0.001658 0.004990 0.000478 0.009375
None 0.006396 0.001875 0.000689 0.002102 0.001697 0.001623 0.001035 0.000582 0.002449 0.001759 0.000823 0.001851
Nuclear Periphery 0.000108 0.000345 0.000122 0.000507 0.000238 0.000235 0.000151 0.000177 0.000217 0.000294 0.000133 0.000453
Nuclear Periphery Foci 0.000113 0.000465 0.000032 0.000246 0.000150 0.000203 0.000074 0.000012 0.000144 0.000344 0.000048 0.000207
Nucleolus 0.019199 0.032102 0.050251 0.019506 0.029226 0.029822 0.027394 0.026517 0.027622 0.031046 0.041408 0.020662
Nucleus 0.953463 0.939675 0.923864 0.929933 0.956674 0.939123 0.948249 0.957080 0.956160 0.939419 0.933298 0.934410
Peroxisomes 0.000355 0.000657 0.003838 0.000923 0.000248 0.001055 0.001651 0.000826 0.000265 0.000842 0.002992 0.000907
Vacuole 0.000193 0.000629 0.000982 0.001128 0.000213 0.001331 0.001605 0.000398 0.000210 0.000954 0.001223 0.001008
Vacuole Periphery 0.000050 0.000481 0.000211 0.000195 0.000209 0.000566 0.000139 0.000134 0.000184 0.000520 0.000184 0.000185

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.91 -10.79 -6.67 -5.41 -0.55 -5.02 -6.57 -5.96 -2.02 3.02 -7.81 -12.67 -7.21 -5.42 -0.15
Bud Neck -8.12 -7.69 -5.85 -4.84 -3.50 -4.48 -5.25 -2.38 -1.15 1.11 -5.91 -7.91 -5.51 -4.79 -3.21
Bud Site -2.84 -7.08 -2.46 -2.32 -1.95 -2.96 -3.38 -2.17 1.41 2.06 -3.83 -6.78 -2.49 -2.15 -1.83
Cell Periphery -1.61 -0.72 -2.34 -1.80 -2.20 -1.98 -1.15 1.29 2.42 1.80 -2.25 -0.88 -2.09 -1.02 -1.83
Cytoplasm 2.41 2.88 2.50 0.33 -2.35 -1.19 -0.66 1.83 2.18 1.09 0.92 1.96 1.51 0.70 -0.64
Cytoplasmic Foci 1.14 1.75 1.69 1.95 -0.95 -0.98 0.60 1.50 2.70 1.21 -0.24 1.95 1.87 2.74 -0.19
Eisosomes -4.93 -11.74 -7.76 -4.12 2.36 -5.51 -6.75 -3.31 -1.10 3.36 -5.59 -12.62 -7.28 -4.49 2.78
Endoplasmic Reticulum -8.37 -4.10 -3.14 1.75 0.56 -6.25 0.02 6.17 9.59 3.39 -6.92 -0.77 0.88 4.98 1.26
Endosome -2.50 1.28 -1.10 2.05 -2.19 -2.44 -0.72 3.35 3.20 1.46 -3.37 -0.02 -0.38 3.06 -0.25
Golgi -1.86 -0.37 -1.09 1.69 -1.55 -1.30 -1.41 0.18 1.32 1.55 -2.33 -1.83 -2.36 2.02 -1.10
Lipid Particles 0.58 1.48 1.34 1.64 -1.73 -0.09 0.15 1.67 2.36 1.40 -0.04 1.23 1.58 2.34 0.54
Mitochondria -2.19 -8.96 -7.54 -1.42 -3.32 -2.57 -5.91 -4.96 1.46 0.17 -3.25 -9.81 -7.81 -0.22 -3.22
Mitotic Spindle -0.10 1.46 -1.09 -1.11 -1.83 -1.73 -1.02 -0.84 -0.40 -0.14 -2.44 -0.40 -1.79 -1.30 -1.67
None 2.54 3.21 2.39 -0.53 -3.53 0.19 0.75 1.75 0.98 1.01 1.47 3.74 1.05 -0.48 -2.68
Nuclear Periphery -2.11 -2.11 -4.43 -2.14 -4.00 -0.00 -1.09 -0.63 -0.63 0.14 -1.01 -0.44 -3.52 -2.71 -3.29
Nuclear Periphery Foci -1.98 1.59 -0.63 1.21 -1.38 0.47 -0.32 1.50 1.26 1.22 -0.59 0.60 0.42 1.05 -0.16
Nucleolus -4.78 -5.42 -1.13 1.31 3.82 -0.11 -0.11 -0.15 -0.13 -0.09 -1.96 -3.95 0.33 1.01 3.12
Nucleus 1.61 3.70 3.29 2.66 0.82 4.05 2.54 0.74 -0.25 -0.72 4.99 5.50 3.93 2.52 0.85
Peroxisomes -1.69 -5.98 -3.45 -2.50 4.02 -2.23 -5.72 -1.87 0.92 3.36 -2.86 -7.33 -3.99 -1.39 4.29
Vacuole -1.97 -5.39 -4.62 -3.77 -2.53 -2.31 -1.31 -2.31 1.76 1.25 -3.00 -1.75 -4.73 -2.88 0.31
Vacuole Periphery -3.40 -6.92 -3.90 1.65 -0.50 -1.97 0.47 1.30 2.45 1.55 -2.99 -0.63 -0.91 2.48 -0.58
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p, and in the heat shock response; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; other members of the HDA1 histone deacetylase complex are Hda2p and Hda3p
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Hda1

Hda1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hda1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available