ORF
Human Ortholog
Description Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0 0.05 0 0 0 0 0 0 0.1 0.13 0.15 0.15 0.06 0.15 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.15 0.16 0.11 0.13 0.26 0.21 0.24 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.97 0.93 0.94 0.95 0.91 0.86 0.83 0.83 0.81 0.79 0.82 0.78 0.9 0.85 0.81 0.82 0.86 0.8 0.95 0.92 0.88 0.87 0.75 0.63
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.07 0.12 0.17 0.13 0.17 0.15 0.2 0 0 0 0 0 0 0 0 0 0 0 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0 0 0 0.07 0.16 0.25
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 2 0
Bud 0 0 0 0 0 1 4 4 1 2 2 1 0 2 0 0 0 0 0 1 0 0 6 3
Bud Neck 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 1 0 0 0 4 21 19 10 10 17 19 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 2 9 11 10 17 20 15 16 16 7 10 33 82 100 17 5 11 0 0 1 4 3 4
Endoplasmic Reticulum 0 0 3 0 2 0 0 0 0 0 0 0 0 0 0 2 0 2 1 0 0 0 1 2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 1 3 9 0 0 0 0 0 2 2 4 6
Golgi 0 0 3 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 4 1 3 1
Mitochondria 15 4 0 1 14 49 76 59 56 140 85 101 1 0 3 1 1 2 0 1 3 1 3 6
Nucleus 185 92 296 189 308 281 404 449 344 418 332 333 293 554 538 94 67 57 181 103 277 312 505 388
Nuclear Periphery 0 1 2 0 3 4 14 16 17 5 3 6 5 19 10 0 0 0 0 0 0 0 2 3
Nucleolus 2 3 4 4 10 22 56 92 54 91 60 84 0 5 7 2 0 1 0 0 7 4 21 36
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 1 0 1 0 1 3 10 0 1 0 0 1 0 0 6 3
Vac/Vac Membrane 0 3 3 0 4 1 9 6 6 9 1 9 2 10 10 5 5 5 2 2 10 24 107 151
Unique Cell Count 191 99 315 200 337 328 486 543 425 532 407 425 327 651 667 114 78 71 190 112 316 359 673 613
Labelled Cell Count 205 106 320 205 351 379 605 661 505 691 508 563 336 678 697 121 79 78 190 112 316 359 673 613


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 8.9 8.2 7.6 7.2 6.3 5.9 6.0 6.0 5.7 5.6 5.5 9.9 9.8 9.0 11.3 11.0 11.0 9.6 9.9 10.3
Std Deviation (1e-4) 1.2 1.9 1.7 1.7 2.1 2.0 1.7 1.6 1.8 1.8 1.5 1.5 2.4 4.4 2.4 2.9 2.6 3.2 1.8 1.9 2.0
Intensity Change (Log2) – – – -0.11 -0.19 -0.38 -0.47 -0.45 -0.44 -0.52 -0.54 -0.58 0.28 0.27 0.14 0.47 0.43 0.43 0.23 0.28 0.34


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 3.7 3.4 0 0 3.7 3.8 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.5 0.1 1.5 0.9 -0.1 0.7 0.1 -1.0 -0.4 3.7 4.9 5.7 4.6 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.7 7.1 7.4 6.1 6.7 10.0 8.6 9.3 0 0 0 0 0 0
Nucleus 0.3 -1.3 -3.5 -4.5 -4.7 -5.1 -6.0 -4.9 -5.9 -2.0 -4.0 -5.4 -3.7 -2.4 -3.7
Nuclear Periphery 0 0 0 2.2 2.3 2.9 0 0 0 0 2.3 0 0 0 0
Nucleolus 0 1.5 3.5 5.4 7.0 5.7 7.1 6.3 7.7 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 1.2 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.3518 2.9023 2.6271 2.5067 1.8003 2.6537 4.6532 4.5999 4.4118 4.1735 3.8692 4.285 4.0467 4.0359 3.4478 3.9219 3.5832 3.5231
Actin 0.0002 0 0 0 0 0 0.015 0.0001 0.0026 0.0001 0.0118 0.0053 0.0051 0 0.0093 0.0046 0.0053 0.0062
Bud 0.0001 0 0 0 0 0 0.0005 0 0.0003 0.0002 0.0004 0.0001 0.0004 0 0.0003 0.0002 0.0003 0.0001
Bud Neck 0.0005 0.0001 0.0001 0.0002 0.0001 0.0006 0.0014 0.0001 0.0019 0.0007 0.0009 0.0011 0.0015 0 0.0018 0.0002 0.0006 0.0022
Bud Periphery 0.0003 0 0 0 0 0.0001 0.0016 0.0001 0.0007 0.0013 0.0014 0.0002 0.0013 0 0.0008 0.0005 0.0016 0.0002
Bud Site 0.0007 0 0 0 0 0 0.0012 0.0002 0.0032 0.0004 0.0006 0.0003 0.0014 0.0001 0.0022 0.0004 0.0004 0.0001
Cell Periphery 0.0001 0 0 0 0 0 0.0005 0 0.0001 0.001 0.0003 0 0.0006 0 0.0004 0 0.0004 0.0001
Cytoplasm 0.0006 0.0007 0.0001 0.0002 0 0.0001 0.0059 0.0003 0.0013 0.0003 0.0008 0.0003 0.004 0.0001 0.0019 0.0009 0.0011 0.0002
Cytoplasmic Foci 0.0005 0.0003 0.0001 0 0 0 0.0097 0.0027 0.0112 0.0001 0.0041 0.0024 0.0073 0 0.0113 0.0028 0.0025 0.0004
Eisosomes 0 0 0 0 0 0 0.0002 0 0.0001 0 0.0003 0 0.0001 0 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0001 0 0 0.0001 0 0 0.0051 0 0.0009 0.001 0.0051 0.0003 0.0031 0 0.002 0.0004 0.0034 0.0005
Endosome 0.0005 0.0001 0.0001 0.0003 0 0 0.0174 0.0017 0.0123 0.0033 0.0202 0.0051 0.0151 0 0.0111 0.0034 0.0148 0.003
Golgi 0.0001 0 0 0 0 0 0.0045 0.0018 0.0033 0.0003 0.0143 0.0031 0.0024 0 0.0035 0.0016 0.003 0.0014
Lipid Particles 0.0003 0.0001 0.0002 0.0002 0 0 0.0159 0.0001 0.009 0.0003 0.0347 0.004 0.015 0 0.0185 0.0112 0.0078 0.0053
Mitochondria 0.0009 0.0001 0.0001 0.0001 0.0001 0.0001 0.0081 0.0004 0.0147 0.001 0.051 0.0009 0.0072 0.0002 0.0041 0.0041 0.0233 0.0041
None 0.001 0.0053 0.0001 0.0001 0 0.0007 0.0027 0 0.0015 0 0.0006 0.0001 0.0026 0 0.0014 0.001 0.0009 0.0003
Nuclear Periphery 0.0029 0.0028 0.0057 0.0213 0.0019 0.0009 0.0211 0.002 0.0095 0.0012 0.0303 0.0009 0.0224 0.0007 0.0178 0.0095 0.0262 0.0056
Nucleolus 0.0366 0.0371 0.0387 0.029 0.0398 0.0655 0.0136 0.0151 0.0135 0.0098 0.0266 0.0512 0.0188 0.0138 0.022 0.0115 0.0322 0.049
Nucleus 0.9488 0.933 0.9519 0.9323 0.9566 0.9289 0.8535 0.9746 0.8973 0.9576 0.7787 0.9221 0.8699 0.9848 0.8708 0.9356 0.8521 0.9189
Peroxisomes 0.0001 0 0 0 0 0 0.0087 0.0003 0.0047 0 0.0012 0.0009 0.0035 0 0.0063 0.006 0.0021 0.0002
Punctate Nuclear 0.0049 0.0202 0.0024 0.0159 0.0015 0.0028 0.0055 0.0003 0.0062 0.0004 0.0103 0.0013 0.0092 0.0002 0.009 0.0047 0.0112 0.001
Vacuole 0.0007 0.0001 0.0001 0.0001 0 0.0002 0.0052 0.0001 0.0039 0.0188 0.0024 0.0002 0.0054 0.0001 0.004 0.0007 0.0038 0.0005
Vacuole Periphery 0.0002 0.0001 0.0002 0.0001 0 0.0001 0.0026 0.0002 0.0017 0.0022 0.0039 0.0001 0.0035 0 0.0015 0.0008 0.0066 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.0486 16.0181 18.1419 22.3257 20.7867 22.6214 19.3924 20.4239 20.5715 23.3146
Translational Efficiency 1.0162 1.2831 0.9849 0.9718 1.1525 1.1087 1.0604 0.8734 0.8952 0.9437

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1794 220 1494 1441 1942 911 1401 1424 3736 1131 2895 2865

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 896.72 1101.30 1131.82 1025.53 902.14 1049.43 1026.98 1112.31 899.54 1059.52 1081.08 1068.66
Standard Deviation 138.35 175.18 174.44 220.58 133.67 156.98 161.94 174.90 135.97 161.99 176.47 203.86
Intensity Change Log 2 — 0.296478 0.335915 0.193640 — 0.218183 0.186985 0.302136 — 0.257744 0.263147 0.249071

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000257 0.000757 0.000578 0.000713 0.000234 0.000450 0.000606 0.000813 0.000245 0.000510 0.000592 0.000763
Bud Neck 0.005501 0.012169 0.016588 0.022027 0.003363 0.010968 0.009967 0.033922 0.004389 0.011201 0.013384 0.027939
Bud Site 0.000568 0.003707 0.000835 0.002128 0.000392 0.001442 0.001073 0.004552 0.000476 0.001883 0.000950 0.003333
Cell Periphery 0.000406 0.000086 0.000058 0.000199 0.000208 0.000123 0.000135 0.000231 0.000303 0.000116 0.000095 0.000215
Cytoplasm 0.001107 0.000642 0.000251 0.005120 0.001092 0.000762 0.003303 0.006031 0.001099 0.000739 0.001728 0.005572
Cytoplasmic Foci 0.000082 0.001761 0.000011 0.000338 0.000244 0.002196 0.000327 0.000623 0.000166 0.002112 0.000164 0.000480
Eisosomes 0.000037 0.000035 0.000044 0.000028 0.000036 0.000032 0.000037 0.000027 0.000037 0.000032 0.000040 0.000028
Endoplasmic Reticulum 0.008051 0.004229 0.003146 0.005022 0.007591 0.005525 0.004359 0.004886 0.007812 0.005273 0.003733 0.004954
Endosome 0.000252 0.001471 0.000080 0.000853 0.000331 0.001588 0.000494 0.002502 0.000293 0.001565 0.000281 0.001673
Golgi 0.000039 0.001639 0.000032 0.000789 0.000251 0.001124 0.000159 0.002276 0.000149 0.001224 0.000093 0.001528
Lipid Particles 0.000091 0.000174 0.000029 0.000045 0.000151 0.000273 0.000098 0.000141 0.000122 0.000254 0.000062 0.000093
Mitochondria 0.000887 0.001216 0.001109 0.001894 0.000549 0.001587 0.001095 0.005061 0.000711 0.001515 0.001102 0.003468
Mitotic Spindle 0.000747 0.007028 0.000339 0.004257 0.000441 0.005778 0.001084 0.018902 0.000588 0.006021 0.000699 0.011536
None 0.001537 0.001256 0.000677 0.004373 0.001339 0.001523 0.006774 0.002940 0.001434 0.001471 0.003628 0.003660
Nuclear Periphery 0.000517 0.000258 0.000218 0.001469 0.000422 0.000383 0.000308 0.002966 0.000468 0.000359 0.000262 0.002213
Nuclear Periphery Foci 0.000166 0.000106 0.000034 0.000508 0.000333 0.000094 0.000125 0.001333 0.000253 0.000097 0.000078 0.000918
Nucleolus 0.007319 0.009487 0.006981 0.007608 0.007362 0.008276 0.008482 0.008196 0.007341 0.008511 0.007707 0.007900
Nucleus 0.970543* 0.950793* 0.968172* 0.938163* 0.974593* 0.955251* 0.959458* 0.898015* 0.972649* 0.954384* 0.963955* 0.918208*
Peroxisomes 0.000112 0.000910 0.000213 0.000143 0.000125 0.000567 0.000191 0.000179 0.000119 0.000634 0.000202 0.000161
Vacuole 0.001410 0.001769 0.000506 0.003010 0.000749 0.001420 0.001103 0.004619 0.001066 0.001488 0.000795 0.003810
Vacuole Periphery 0.000371 0.000507 0.000099 0.001315 0.000192 0.000637 0.000821 0.001784 0.000278 0.000612 0.000449 0.001548

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.30 -8.52 -11.67 -0.05 -3.57 -5.25 -13.12 -8.98 -6.34 -4.24 -5.04 -14.76 -13.24 -5.70 -5.45
Bud Neck -2.34 -11.88 -12.16 -4.07 -4.98 -8.38 -11.64 -18.53 -13.23 -13.84 -7.37 -16.62 -21.95 -13.57 -13.61
Bud Site -2.22 -2.56 -5.44 0.89 -4.43 -2.61 -4.52 -6.72 -4.08 -5.26 -3.32 -5.19 -8.52 -2.74 -6.75
Cell Periphery 1.58 1.74 1.10 -1.57 -2.27 1.52 1.54 0.48 -0.52 -0.46 1.83 2.11 1.20 -1.07 -1.69
Cytoplasm 0.77 1.69 -3.53 -4.23 -4.72 0.65 -3.61 -4.20 -4.48 -1.89 0.80 -1.65 -5.45 -6.04 -4.64
Cytoplasmic Foci -1.32 1.36 -1.62 1.15 -2.46 -2.18 -0.25 -0.61 2.06 -0.41 -2.58 0.18 -1.33 2.36 -1.73
Eisosomes 0.30 -1.90 2.17 1.66 9.11 0.54 -0.31 0.67 0.25 4.06 0.82 -1.20 1.59 1.12 9.41
Endoplasmic Reticulum 6.36 10.19 5.65 -1.33 -5.17 4.04 7.58 4.67 0.21 -2.91 6.13 12.83 7.35 0.39 -5.86
Endosome -1.52 4.43 -2.28 0.85 -3.06 -2.10 -0.71 -3.26 0.01 -2.70 -2.51 0.24 -3.95 0.73 -3.84
Golgi -1.17 0.39 -1.88 0.70 -1.89 -1.60 0.42 -1.81 -0.33 -2.10 -2.18 0.48 -2.46 0.36 -2.78
Lipid Particles -0.63 1.56 0.93 0.93 -2.65 -0.72 0.41 -0.32 0.63 -2.43 -1.02 0.97 0.05 1.13 -3.18
Mitochondria -0.98 -1.14 -4.11 -2.59 -5.86 -2.58 -3.06 -4.80 -3.12 -3.96 -2.36 -2.86 -5.97 -3.27 -4.98
Mitotic Spindle -1.58 0.83 -3.19 0.81 -3.57 -3.01 -2.06 -6.13 -3.17 -5.30 -3.32 -1.41 -6.90 -1.59 -6.34
None 0.50 2.84 -2.88 -3.03 -4.03 -0.41 -4.54 -4.28 -2.53 2.94 -0.15 -3.54 -4.34 -3.45 -0.29
Nuclear Periphery 1.63 2.12 -3.57 -4.67 -4.97 -0.12 0.25 -3.96 -3.97 -4.05 0.70 1.90 -5.16 -5.44 -5.77
Nuclear Periphery Foci 0.67 1.99 -2.52 -2.87 -3.49 1.62 1.29 -1.75 -2.41 -2.30 1.76 2.03 -2.56 -3.36 -3.46
Nucleolus -1.49 -0.17 -2.71 -0.63 -2.49 -1.26 -1.97 -5.53 -4.02 -4.00 -1.69 -1.66 -6.06 -3.46 -4.73
Nucleus 2.21 1.99 9.86 1.66 9.24 4.80 6.58 16.51 9.91 12.05 5.03 6.49 18.96 8.55 15.16
Peroxisomes -1.52 -4.00 -2.58 1.42 2.06 -1.45 -2.99 -3.89 1.03 -1.73 -1.95 -4.90 -4.61 1.60 0.27
Vacuole -0.57 1.94 -2.79 -1.90 -4.01 -2.26 -2.51 -7.31 -4.94 -5.58 -1.70 -0.04 -6.56 -4.65 -6.71
Vacuole Periphery -0.49 1.60 -1.90 -1.42 -2.88 -2.34 -1.26 -3.21 -1.40 -0.82 -1.90 -0.57 -3.49 -1.79 -2.35
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

YNL035C

YNL035C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ynl035c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available