Standard name
Human Ortholog
Description Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05
Bud 0 0 0.06 0 0 0 0 0.05 0 0.06 0.06 0.05 0 0 0 0.06 0 0.07 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.1 0.1 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0.06 0.07 0.05 0.08 0 0 0.05 0 0 0 0 0.14 0.11 0.06 0.14 0.15 0.12 0.06 0.05 0.06 0.1 0.07 0.08
Golgi 0 0 0.05 0.08 0.05 0 0 0 0 0 0 0 0.17 0.24 0.3 0.1 0.18 0.1 0 0.09 0 0.07 0.07 0.06
Mitochondria 0.93 0.88 0.7 0.88 0.75 0.86 0.91 0.83 0.9 0.87 0.89 0.89 0.7 0.59 0.59 0.05 0.06 0.05 0.76 0.7 0.71 0.57 0.54 0.55
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0.05 0.07 0 0.06 0.05 0.05 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0.06 0.08 0.07 0.08 0.08 0.1 0.13 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.05 0.06 0.16 0.15 0.08 0 0 0.06 0 0 0 0 0.17 0.23 0.24 0.44 0.35 0.48 0.07 0 0.12 0.1 0.17 0.13
SpindlePole 0 0 0.11 0.06 0 0 0.05 0.05 0 0.05 0 0 0.07 0 0 0.13 0.12 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0.18 0.08 0.05 0.1 0 0 0 0 0 0 0 0.1 0.1 0.08 0.11 0.11 0.09 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 3 2 2 1 0 1 1 2 1 2 2 4 0 0 2 4 5 4 4 13 20 25
Bud 5 11 16 8 5 10 23 22 18 22 18 14 2 4 0 16 4 13 0 3 0 5 6 15
Bud Neck 0 0 0 0 0 1 0 0 1 0 2 0 0 0 0 0 0 0 1 1 1 1 1 10
Bud Site 2 1 2 2 0 2 10 3 14 6 3 3 0 0 0 3 1 3 – – – – – –
Cell Periphery 4 12 14 9 4 6 4 1 4 3 0 1 9 8 11 30 13 18 0 0 0 0 0 3
Cytoplasm 4 6 5 3 8 11 9 11 6 9 6 6 5 7 6 18 8 11 0 1 1 0 0 0
Endoplasmic Reticulum 3 0 2 1 2 2 1 0 1 1 0 0 0 1 0 6 7 7 0 1 0 1 1 2
Endosome 7 23 19 14 28 15 13 20 2 3 0 2 38 41 24 38 19 22 23 19 19 32 27 42
Golgi 0 1 14 20 18 1 4 5 0 3 0 6 47 91 116 27 23 19 15 36 13 23 28 34
Mitochondria 331 339 195 235 251 410 531 360 385 322 280 246 192 221 232 14 8 9 275 277 225 197 210 303
Nucleus 2 3 1 0 3 3 6 10 2 4 2 3 2 0 0 8 2 0 0 1 0 0 0 1
Nuclear Periphery 11 6 9 3 17 35 26 27 23 19 24 14 5 5 1 3 4 0 3 2 3 3 4 2
Nucleolus 13 12 10 5 19 38 41 36 35 37 41 20 9 8 11 6 3 2 1 3 0 5 4 3
Peroxisomes 18 22 45 40 28 19 21 24 14 12 3 6 48 85 94 124 45 89 24 13 39 35 65 74
SpindlePole 14 7 31 16 4 16 29 20 12 17 8 6 18 13 13 36 15 23 2 1 2 11 10 16
Vac/Vac Membrane 31 70 23 12 32 16 24 13 11 8 4 3 27 36 32 31 14 16 5 24 2 5 6 7
Unique Cell Count 357 387 279 266 333 479 586 434 427 370 313 275 276 372 392 279 129 187 363 394 317 344 393 551
Labelled Cell Count 445 514 389 370 421 586 742 553 529 468 392 332 404 524 540 360 168 236 363 394 317 344 393 551


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.9 8.2 7.4 8.3 10.0 8.8 7.8 8.2 8.2 10.1 10.6 13.2 8.3 10.8 14.0 8.4 8.5 8.1 12.2 10.6 11.5
Std Deviation (1e-4) 2.2 4.1 3.9 4.1 3.2 3.8 3.4 3.4 4.5 5.8 6.4 7.6 2.3 3.7 6.1 3.0 2.9 2.5 16.9 12.9 14.8
Intensity Change (Log2) – – – 0.18 0.44 0.25 0.08 0.16 0.16 0.46 0.52 0.85 0.18 0.56 0.93 0.19 0.21 0.13 0.73 0.53 0.65

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud -1.6 -2.9 -2.7 -1.2 -0.4 -0.9 0.1 0 -0.3 -3.3 -3.4 -4.8 0 -1.1 0.5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 2.2 0 0 0 0 0 0 0 0 0
Cell Periphery -0.9 -2.8 -3.1 -4.2 -4.3 -3.4 -3.3 -4.0 -3.4 -1.0 -2.0 -1.5 2.5 1.9 1.9
Cytoplasm 0 0.5 0.5 0 0.7 0 0.6 0.1 0.3 0 0.1 0 2.8 0 2.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.8 0.7 -2.4 -3.3 -1.3 -4.8 -4.2 -4.7 -3.7 2.7 1.8 -0.4 2.7 2.6 1.9
Golgi 1.2 0.2 -4.6 -4.2 -3.1 -4.7 -3.3 -4.0 -1.8 4.5 6.7 7.9 2.1 4.2 2.1
Mitochondria 5.3 1.5 5.2 7.8 4.1 6.9 5.4 6.0 5.7 -0.1 -2.8 -2.8 -15.8 -12.0 -13.9
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.7 1.1 2.3 0.8 1.8 1.3 1.2 2.4 1.1 -1.1 -1.6 0 -1.8 0 0
Nucleolus -1.2 1.2 2.4 2.0 2.5 2.5 3.1 4.1 1.9 -0.2 -1.1 -0.6 -1.0 0 0
Peroxisomes -0.4 -2.9 -5.8 -6.5 -4.7 -6.0 -5.7 -6.8 -5.7 0.4 2.1 2.5 7.3 4.2 7.4
SpindlePole -2.1 -5.3 -4.3 -3.3 -3.3 -4.5 -3.1 -4.2 -4.2 -1.9 -3.8 -4.0 0.7 0.2 0.4
Vacuole -1.8 0.6 -2.9 -2.5 -3.1 -3.4 -3.6 -4.1 -4.0 0.6 0.6 0 1.1 0.9 0.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 30.1714 34.6875 32.0918 29.5816 27.8095 34.0157 49.4011 42.4697 44.6575 42.6657 43.9458 42.5558 39.3623 40.9821 40.8039 36.7091 34.7338 39.3281
Actin 0.0046 0.0092 0.0053 0.0003 0.0025 0.0047 0.0007 0.0011 0.0003 0.0001 0.0005 0.0002 0.002 0.0007 0.002 0.0027 0.0019 0.0001
Bud 0.0006 0.0012 0.0005 0 0.0002 0.0002 0 0 0 0.0001 0.0001 0 0.0002 0.0001 0.0001 0 0 0
Bud Neck 0.0001 0.0003 0.0014 0 0.0004 0.0004 0 0 0 0 0 0 0.0001 0.0001 0.0001 0 0 0
Bud Periphery 0.0004 0.0017 0.0012 0 0.0003 0.0004 0 0 0 0.0002 0.0004 0 0.0004 0.0001 0.0002 0.0001 0 0
Bud Site 0.0015 0.0025 0.0017 0.0002 0.0012 0.0003 0 0 0 0 0 0 0.0005 0.0018 0.0003 0 0.0001 0
Cell Periphery 0.0007 0.0039 0.0008 0.0003 0.0007 0.0009 0.0003 0.0004 0.0007 0.0002 0.0001 0.0001 0.0012 0.0006 0.002 0.0002 0.0003 0.0001
Cytoplasm 0.0011 0.0001 0.0023 0.0021 0.0011 0.0002 0 0 0 0 0 0 0.001 0.0001 0.0002 0.0001 0.0002 0
Cytoplasmic Foci 0.0151 0.0008 0.012 0.0196 0.0089 0.0004 0.0001 0 0.0001 0 0 0 0.0033 0.0007 0.0034 0.0003 0.0035 0.0001
Eisosomes 0.0007 0.0015 0.0022 0.0001 0.0003 0.0012 0.0007 0.0009 0.0014 0.0001 0.0017 0.0009 0.0017 0.0005 0.0003 0.0019 0.0004 0.0002
Endoplasmic Reticulum 0.0005 0.0009 0.0002 0.0006 0.0009 0.0006 0 0 0 0 0 0 0.0008 0 0.0002 0.0001 0.0002 0
Endosome 0.0078 0.0025 0.0035 0.0018 0.0047 0.0037 0.0003 0.0003 0.0002 0 0.0002 0.0003 0.0025 0.0014 0.0019 0.002 0.0023 0.0002
Golgi 0.0103 0.0075 0.0075 0.0009 0.0033 0.012 0.0024 0.0013 0.0006 0 0.0004 0.0041 0.0027 0.0053 0.0036 0.0042 0.0013 0.0016
Lipid Particles 0.0137 0.0213 0.0089 0.0061 0.0228 0.0116 0.0039 0.0018 0.0058 0.0001 0.0003 0.0019 0.0152 0.0056 0.0053 0.0078 0.0164 0.0061
Mitochondria 0.8876 0.8759 0.9039 0.918 0.9154 0.9277 0.9696 0.9713 0.9687 0.9979 0.9939 0.9836 0.9108 0.9484 0.9571 0.9544 0.9555 0.9751
None 0.0018 0.0001 0.0028 0.0023 0.0006 0.0002 0 0 0 0 0 0 0.0011 0 0.0003 0 0.0009 0
Nuclear Periphery 0.003 0.0005 0.0008 0.0025 0.0022 0.0015 0.0001 0 0.0001 0 0 0 0.0031 0.0003 0.0008 0.0006 0.0025 0
Nucleolus 0.0087 0.0063 0.0108 0.0009 0.005 0.0014 0.0026 0.0002 0.0002 0 0 0.0001 0.0108 0.0013 0.0032 0.0001 0.0073 0.0004
Nucleus 0.002 0.0006 0.0021 0.0009 0.0017 0.0006 0.0001 0.0001 0.0001 0 0 0 0.004 0.0004 0.0008 0.0001 0.0005 0
Peroxisomes 0.0059 0.0023 0.0057 0.0007 0.0053 0.0008 0.0004 0.0005 0.0004 0.0001 0.0003 0.0002 0.0024 0.0018 0.001 0.0006 0.0021 0.0002
Punctate Nuclear 0.004 0 0.0013 0.0137 0.0092 0.0003 0 0 0 0 0 0 0.0036 0.0034 0.0004 0 0.002 0
Vacuole 0.0048 0.0131 0.0061 0.0019 0.004 0.0032 0.0021 0.0024 0.0033 0.0002 0.0003 0.0004 0.0045 0.0043 0.0048 0.002 0.0007 0.0006
Vacuole Periphery 0.025 0.048 0.019 0.0271 0.0094 0.0276 0.0168 0.0197 0.0179 0.001 0.0015 0.0081 0.0281 0.0231 0.012 0.0226 0.0019 0.0153

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 159.958 202.1935 144.6296 192.5414 192.8618 295.3002 542.4042 461.1817 451.6179 366.8166
Translational Efficiency 1.7501 1.7562 2.1538 1.9171 1.8417 2.0281 1.8195 2.1663 1.8746 1.8966

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1398 380 2682 1272 1980 1897 656 1222 3378 2277 3338 2494

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 867.40 1150.48 1030.05 1450.32 921.49 989.10 1655.16 1784.71 899.10 1016.03 1152.90 1614.16
Standard Deviation 180.64 263.57 530.42 514.35 224.53 219.41 755.65 636.04 209.20 235.21 632.44 600.91
Intensity Change Log 2 — 0.407467 0.247945 0.741602 — 0.102148 0.844930 0.953649 — 0.258263 0.585970 0.854714

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002986 0.005675 0.009454 0.011269 0.002146 0.005131 0.026801 0.007963 0.002494 0.005222 0.012863 0.009649
Bud Neck 0.001448 0.002174 0.008539 0.002781 0.000526 0.001422 0.004855 0.004416 0.000907 0.001547 0.007815 0.003582
Bud Site 0.003451 0.004625 0.037742 0.007773 0.002875 0.003531 0.004536 0.011621 0.003113 0.003713 0.031216 0.009659
Cell Periphery 0.000376 0.000170 0.000907 0.000368 0.000278 0.000178 0.000356 0.000811 0.000319 0.000176 0.000799 0.000585
Cytoplasm 0.000604 0.001156 0.008258 0.001225 0.000339 0.000846 0.000681 0.001958 0.000449 0.000898 0.006769 0.001584
Cytoplasmic Foci 0.012878 0.045256 0.022396 0.014383 0.009845 0.020533 0.033998 0.011421 0.011100 0.024659 0.024676 0.012931
Eisosomes 0.000079 0.000262 0.000238 0.000519 0.000121 0.000144 0.001555 0.000826 0.000103 0.000164 0.000497 0.000670
Endoplasmic Reticulum 0.000178 0.000265 0.000461 0.000219 0.000120 0.000193 0.000914 0.000441 0.000144 0.000205 0.000550 0.000328
Endosome 0.022204 0.024221 0.055469 0.009187 0.009376 0.020619 0.019873 0.009424 0.014685 0.021220 0.048473 0.009303
Golgi 0.017429 0.067501 0.028431 0.023647 0.015817 0.035829 0.134308 0.023995 0.016484 0.041115 0.049238 0.023818
Lipid Particles 0.007317 0.008757 0.003311 0.003331 0.003878 0.005633 0.031471 0.006599 0.005301 0.006154 0.008845 0.004932
Mitochondria 0.893694 0.781419 0.727892 0.883656 0.934031 0.870125 0.685102 0.873949 0.917337 0.855321 0.719483 0.878900
Mitotic Spindle 0.002478 0.003250 0.027930 0.006691 0.000870 0.001942 0.005233 0.003631 0.001535 0.002161 0.023470 0.005192
None 0.000277 0.000577 0.000778 0.001205 0.000494 0.000389 0.002240 0.001972 0.000404 0.000421 0.001065 0.001581
Nuclear Periphery 0.000073 0.000188 0.000585 0.000722 0.000073 0.000096 0.001933 0.000779 0.000073 0.000111 0.000850 0.000750
Nuclear Periphery Foci 0.000179 0.000275 0.000544 0.000329 0.000108 0.000229 0.000773 0.000520 0.000137 0.000237 0.000589 0.000423
Nucleolus 0.000078 0.000392 0.000816 0.000252 0.000335 0.000555 0.000945 0.001524 0.000229 0.000528 0.000842 0.000876
Nucleus 0.000052 0.000087 0.001555 0.000069 0.000081 0.000362 0.000245 0.000548 0.000069 0.000316 0.001298 0.000304
Peroxisomes 0.028478 0.046348 0.028604 0.015838 0.015567 0.026937 0.009095 0.010426 0.020910 0.030176 0.024770 0.013186
Vacuole 0.002752 0.004652 0.022348 0.005875 0.001416 0.002448 0.012420 0.012735 0.001969 0.002816 0.020397 0.009236
Vacuole Periphery 0.002989 0.002753 0.013741 0.010660 0.001705 0.002859 0.022666 0.014441 0.002236 0.002841 0.015495 0.012513

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.57 -5.83 -4.82 -2.96 -0.91 -3.73 -7.16 -4.33 -1.94 5.16 -4.06 -9.43 -6.54 -3.66 2.19
Bud Neck -1.25 -8.68 -2.33 -1.09 6.81 -3.22 -5.98 -5.09 -3.74 0.36 -2.23 -11.16 -5.77 -4.20 5.70
Bud Site -0.56 -15.16 -2.87 -1.42 12.15 -0.59 -1.20 -4.03 -3.82 -3.10 -0.67 -15.44 -4.97 -4.43 10.30
Cell Periphery 2.19 -3.75 0.05 -1.91 3.63 1.05 -0.79 -3.60 -5.29 -3.42 2.07 -4.30 -2.70 -5.18 1.84
Cytoplasm -1.93 -9.89 -2.17 -0.20 8.68 -2.67 -2.37 -2.93 -1.95 -2.17 -2.73 -10.13 -3.69 -2.03 7.60
Cytoplasmic Foci -6.41 -5.60 -0.80 6.05 4.44 -6.21 -7.72 -1.08 4.77 6.99 -8.26 -9.96 -1.55 6.72 8.01
Eisosomes -4.58 -2.98 -6.41 -3.27 -3.24 -1.53 -5.34 -9.16 -8.85 2.62 -4.58 -5.73 -10.96 -9.65 -2.01
Endoplasmic Reticulum -1.41 -6.63 -1.32 0.73 5.48 -2.02 -6.60 -4.00 -3.10 3.34 -2.11 -9.65 -4.29 -2.69 4.06
Endosome -0.52 -10.81 5.90 4.24 18.04 -6.15 -4.55 -0.09 5.47 4.19 -3.75 -15.43 4.24 7.19 18.48
Golgi -6.80 -5.07 -2.31 5.86 1.86 -7.72 -13.73 -2.80 3.45 12.37 -10.07 -13.73 -3.72 6.23 9.32
Lipid Particles -0.63 2.76 2.67 2.83 0.01 -1.57 -6.43 -1.79 -0.61 5.58 -0.78 -3.07 0.38 1.09 3.26
Mitochondria 6.47 18.64 1.22 -5.82 -17.15 8.98 17.36 7.12 -0.29 -12.02 9.40 28.81 6.48 -3.06 -20.80
Mitotic Spindle -0.84 -14.90 -3.48 -2.86 10.60 -2.64 -3.54 -2.93 -1.83 0.89 -1.49 -16.31 -4.82 -4.05 11.86
None -4.58 -7.47 -11.67 -7.31 -4.59 1.27 -9.39 -10.60 -12.28 1.27 -0.28 -9.30 -14.34 -14.65 -5.57
Nuclear Periphery -3.97 -3.74 -4.41 -3.58 -0.65 -0.87 -4.68 -4.05 -3.94 2.66 -2.12 -5.72 -5.94 -5.63 0.58
Nuclear Periphery Foci -1.11 -3.66 -2.00 -0.63 2.11 -0.75 -3.62 -3.66 -2.43 1.28 -0.88 -4.93 -4.10 -2.11 1.76
Nucleolus -1.73 -4.81 -4.39 0.76 3.70 -0.13 -0.97 -1.91 -1.74 -0.93 -0.67 -2.57 -2.00 -1.03 -0.09
Nucleus -1.10 -4.72 -1.04 0.58 4.68 -1.67 -1.29 -2.71 -0.82 -1.39 -1.80 -4.75 -2.73 0.08 3.79
Peroxisomes -2.57 -0.08 3.73 4.51 4.65 -3.93 2.53 2.21 6.05 -0.57 -3.48 -1.83 3.87 6.69 5.84
Vacuole -1.06 -15.03 -3.71 -0.69 12.35 -3.09 -8.32 -7.74 -6.97 -0.18 -1.91 -18.08 -8.83 -7.44 8.94
Vacuole Periphery 0.41 -10.36 -5.82 -6.15 1.99 -2.87 -10.21 -7.83 -6.98 3.15 -1.61 -15.11 -9.93 -9.12 2.25
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Idh1

Idh1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Idh1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available