Standard name
Human Ortholog
Description Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.07 0.17 0.16 0 0 0 0 0 0 0 0 0 0.13 0.08 0 0 0 0 0 0.08 0.05 0 0 0
Bud 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.05 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.18 0.18 0.25 0 0 0 0 0 0 0 0 0 0.17 0.17 0.09 0 0 0 0.06 0.05 0.17 0.07 0 0
Cytoplasm 0.17 0.22 0.14 0.18 0.13 0.26 0.38 0.54 0.63 0.52 0.62 0.65 0.24 0.62 0.81 0.14 0.17 0.17 0 0 0 0 0 0
Endoplasmic Reticulum 0.49 0.51 0.42 0.14 0 0 0 0 0 0 0 0 0.33 0.11 0 0.07 0.05 0 0.24 0.31 0.27 0.35 0.23 0.14
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.12 0.07 0 0 0.11 0.06 0.05 0 0 0 0 0.08 0 0 0 0 0 0 0
Nucleus 0.08 0 0 0.21 0.25 0.23 0.2 0.09 0.09 0.08 0.07 0.05 0.07 0 0 0.47 0.4 0.35 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.05 0.18 0.5 0.73 0.6 0.6 0.47 0.39 0.43 0.41 0.41 0.16 0.08 0.07 0.49 0.44 0.5 0.52 0.41 0.4 0.47 0.62 0.72
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 12 23 35 3 0 0 1 2 0 2 2 2 73 48 24 0 4 2 9 14 14 6 9 7
Bud 7 6 2 1 0 2 0 4 0 4 4 10 15 15 10 0 0 0 3 1 2 3 3 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 4 12 17 0 0 0 11 12 12 5 4 5
Bud Site 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 32 24 56 3 0 0 0 5 4 2 9 11 97 98 68 2 6 4 14 9 44 18 9 2
Cytoplasm 31 29 30 24 30 89 161 267 183 165 295 342 136 360 641 16 26 16 5 4 2 3 6 6
Endoplasmic Reticulum 87 67 94 19 3 8 3 4 9 0 3 9 182 62 29 8 7 4 55 55 73 85 84 59
Endosome 0 1 3 5 5 3 4 5 1 6 0 5 6 5 6 2 2 1 3 2 1 0 13 13
Golgi 1 0 6 3 1 0 0 0 1 0 0 0 5 2 0 2 2 5 1 1 3 2 2 3
Mitochondria 2 2 5 0 9 40 31 12 13 34 31 26 0 0 0 1 12 1 2 0 4 4 5 7
Nucleus 15 2 5 28 56 78 83 44 26 26 35 24 37 23 9 53 61 34 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 1 0 1 1 1 3 1 1 0 0 0 0 0 0 0 0 0 0 1 3
Nucleolus 0 0 1 1 0 3 1 1 0 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 1 0 2 1 0 0 0 2 0 0 0 5 25 8 26 1 1 0 0 0 0 0 0 0
Vac/Vac Membrane 20 6 40 67 165 201 253 235 113 138 197 217 91 45 52 55 67 48 119 73 108 115 231 312
Unique Cell Count 178 132 222 134 226 337 419 499 289 319 479 527 556 584 790 112 151 96 228 180 269 246 374 433
Labelled Cell Count 208 160 280 155 270 424 538 582 351 382 577 655 671 678 882 140 188 115 228 180 269 246 374 433


Cell Periphery, Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.2 11.9 12.9 12.3 11.1 8.1 7.3 7.8 7.6 6.6 7.2 7.6 9.9 7.5 7.0 10.0 10.5 14.4 10.5 9.3 9.1
Std Deviation (1e-4) 2.2 2.7 3.3 2.9 3.6 3.5 3.0 3.0 2.8 2.7 2.5 2.6 1.8 1.2 2.3 2.6 3.2 4.2 2.0 1.8 2.0
Intensity Change (Log2) – – – -0.07 -0.23 -0.68 -0.82 -0.73 -0.76 -0.96 -0.84 -0.77 -0.39 -0.79 -0.88 -0.38 -0.3 0.16 -0.3 -0.47 -0.5

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -4.0 -6.2 -7.5 -8.1 -8.6 -7.0 -6.9 -8.5 -8.9 -1.0 -3.1 -7.2 -4.4 -4.1 -3.5
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -5.7 -8.1 -9.7 -10.8 -10.8 -8.3 -9.1 -9.9 -10.1 -2.5 -2.7 -6.7 -5.3 -5.4 -4.4
Cytoplasm 1.1 -0.1 3.6 6.6 10.1 11.3 9.1 11.9 12.8 3.4 12.2 18.8 0.2 1.0 0.7
Endoplasmic Reticulum -5.5 -10.5 -12.0 -14.0 -15.0 -11.0 -12.8 -14.9 -14.7 -2.5 -10.2 -15.6 -6.6 -8.0 -6.8
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 1.1 4.1 2.7 0.1 1.4 3.7 2.4 1.7 0 0 0 0 2.6 0
Nucleus 5.9 7.0 6.8 6.1 3.2 3.2 2.9 2.7 1.5 2.5 1.2 0 10.3 9.5 8.3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 2.5 0 1.9 0 0 0
Vacuole 6.4 11.7 9.7 10.2 7.4 5.2 6.1 6.0 6.1 -0.6 -4.3 -5.2 5.9 5.5 5.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.1864 2.2961 2.426 1.7684 2.9625 2.2944 3.4673 3.964 3.6411 3.3717 3.1246 3.1756 1.63 3.6436 3.395 3.206 2.0313 3.0375
Actin 0.0273 0.0032 0.016 0.0163 0.0002 0.0003 0.0317 0.002 0.0072 0.0042 0.0057 0.0038 0.0002 0.0001 0.0089 0.0019 0.0001 0.0008
Bud 0.0016 0.0025 0.005 0.0007 0.0005 0.0011 0.0013 0.0019 0.004 0.0042 0.0012 0.0018 0.0002 0.0008 0.0008 0.0038 0.0004 0.0005
Bud Neck 0.0033 0.0038 0.0084 0.0023 0.0035 0.0104 0.0091 0.0072 0.0251 0.0342 0.0029 0.0352 0.0017 0.0045 0.0098 0.0023 0.0012 0.0411
Bud Periphery 0.0045 0.0053 0.0097 0.0026 0.0013 0.0066 0.0037 0.0031 0.0149 0.0462 0.0056 0.0092 0.0003 0.0012 0.0026 0.018 0.002 0.0015
Bud Site 0.0061 0.0571 0.0319 0.0036 0.0031 0.0017 0.0115 0.0942 0.0459 0.0148 0.0027 0.0019 0.0017 0.017 0.0348 0.0049 0.0012 0.0018
Cell Periphery 0.0238 0.0259 0.0134 0.0033 0.0041 0.0305 0.0611 0.028 0.0233 0.0233 0.0196 0.011 0.0027 0.0177 0.0255 0.0326 0.0059 0.0233
Cytoplasm 0.1138 0.2247 0.2047 0.1768 0.156 0.2296 0.232 0.2524 0.2312 0.1292 0.1785 0.3103 0.1165 0.2208 0.3266 0.3384 0.1603 0.2494
Cytoplasmic Foci 0.0596 0.0412 0.0452 0.0326 0.0457 0.0274 0.0808 0.0468 0.0516 0.0342 0.0844 0.0716 0.0761 0.0312 0.0494 0.0317 0.0689 0.0801
Eisosomes 0.0003 0.0002 0.0004 0.0021 0 0.0001 0.0013 0.0002 0.0002 0 0.0001 0.0001 0 0 0.0003 0 0.0001 0
Endoplasmic Reticulum 0.0307 0.0128 0.0127 0.0047 0.0078 0.0124 0.0186 0.0159 0.0184 0.0105 0.0223 0.0048 0.0156 0.0141 0.0275 0.0114 0.0083 0.0104
Endosome 0.2143 0.1419 0.1499 0.1672 0.227 0.1101 0.187 0.1479 0.1816 0.186 0.2433 0.1094 0.1733 0.1211 0.1806 0.1806 0.3507 0.1436
Golgi 0.02 0.0065 0.0117 0.0033 0.0112 0.0027 0.0145 0.0065 0.0094 0.0393 0.0087 0.0076 0.019 0.0041 0.0083 0.0057 0.0096 0.0033
Lipid Particles 0.0518 0.026 0.0332 0.0048 0.0084 0.0105 0.0648 0.0292 0.0335 0.0526 0.0527 0.0478 0.1343 0.0325 0.0409 0.1258 0.0332 0.0483
Mitochondria 0.0155 0.0025 0.0091 0.0022 0.0025 0.0044 0.0143 0.0131 0.0186 0.0044 0.0082 0.0013 0.0013 0.0006 0.0014 0.0007 0.0049 0.0005
None 0.118 0.1338 0.1321 0.2368 0.0654 0.1021 0.0571 0.1185 0.0759 0.0104 0.0099 0.1218 0.1415 0.1242 0.0808 0.0073 0.1114 0.1198
Nuclear Periphery 0.0199 0.0033 0.0055 0.0019 0.0142 0.0022 0.0125 0.0023 0.0034 0.0026 0.018 0.0008 0.0026 0.002 0.0028 0.0029 0.0014 0.0027
Nucleolus 0.0019 0.0033 0.0044 0.0011 0.0054 0.0011 0.0016 0.0022 0.0018 0.0019 0.0014 0.0011 0.0007 0.0033 0.0012 0.0006 0.0006 0.0009
Nucleus 0.0046 0.0089 0.0062 0.0033 0.0278 0.0035 0.0126 0.0034 0.0031 0.0045 0.0068 0.0023 0.0017 0.0109 0.0025 0.0019 0.0012 0.0019
Peroxisomes 0.0156 0.0018 0.0041 0.0021 0.0016 0.0009 0.0132 0.0015 0.0024 0.0016 0.0051 0.0063 0.007 0.0004 0.0139 0.0005 0.0007 0.0015
Punctate Nuclear 0.019 0.0014 0.0136 0.0005 0.0064 0.0003 0.0023 0.0007 0.0009 0.0005 0.0048 0.0009 0.0011 0.0007 0.0011 0.0005 0.0004 0.0012
Vacuole 0.238 0.2856 0.2696 0.3185 0.3954 0.4295 0.1649 0.2175 0.2378 0.3871 0.3075 0.2443 0.2973 0.3889 0.1747 0.2227 0.2317 0.2554
Vacuole Periphery 0.0104 0.0083 0.0133 0.0134 0.0124 0.0126 0.0043 0.0056 0.0097 0.0084 0.0106 0.0068 0.0052 0.0039 0.0056 0.0056 0.006 0.0118

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.9176 21.2847 11.2222 10.0201 18.2787 5.0099 15.7159 10.1294 8.9787 17.3223
Translational Efficiency 0.9859 0.7902 0.7846 0.6003 0.6367 1.5726 0.6518 0.5913 0.5986 0.6562

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
147 513 1345 1198 2354 1544 1791 1632 2501 2057 3136 2830

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1071.87 1161.95 1150.37 1128.40 1058.23 1149.12 1418.34 1287.35 1059.03 1152.32 1303.41 1220.06
Standard Deviation 154.13 204.37 194.94 244.20 162.64 190.55 213.37 221.40 162.18 194.17 244.72 244.29
Intensity Change Log 2 — 0.116418 0.101968 0.074149 — 0.118876 0.422550 0.282751 — 0.117640 0.270123 0.181550

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.012020 0.003490 0.019886 0.014017 0.001244 0.001863 0.010746 0.005261 0.001877 0.002269 0.014666 0.008968
Bud Neck 0.031475 0.045636 0.051344 0.014535 0.071168 0.024847 0.036268 0.009482 0.068835 0.030031 0.042734 0.011621
Bud Site 0.056950 0.066157 0.131462 0.160512 0.027917 0.048548 0.058925 0.047864 0.029623 0.052939 0.090036 0.095551
Cell Periphery 0.143890 0.716418 0.387613 0.520937 0.522176 0.780016 0.669374 0.820643 0.499942 0.764155 0.548530 0.693771
Cytoplasm 0.165397 0.096069 0.205566 0.231806 0.074942 0.082407 0.050187 0.089165 0.080259 0.085814 0.116827 0.149548
Cytoplasmic Foci 0.037167 0.001364 0.010425 0.007618 0.002264 0.002297 0.001226 0.001789 0.004315 0.002064 0.005171 0.004257
Eisosomes 0.007114 0.001458 0.004295 0.001437 0.001294 0.000717 0.003544 0.001234 0.001636 0.000902 0.003866 0.001320
Endoplasmic Reticulum 0.012752 0.011252 0.044392 0.005831 0.045131 0.012170 0.025701 0.003040 0.043227 0.011941 0.033717 0.004222
Endosome 0.020068 0.003226 0.006387 0.002686 0.007077 0.002550 0.004518 0.001571 0.007840 0.002719 0.005320 0.002043
Golgi 0.022589 0.001261 0.003237 0.003625 0.001752 0.002137 0.001515 0.003238 0.002976 0.001919 0.002254 0.003402
Lipid Particles 0.006253 0.005902 0.036375 0.013046 0.011132 0.001476 0.061336 0.002332 0.010845 0.002580 0.050631 0.006868
Mitochondria 0.004901 0.000536 0.000401 0.001069 0.001488 0.001524 0.000399 0.001607 0.001688 0.001277 0.000400 0.001379
Mitotic Spindle 0.002544 0.001645 0.000344 0.000345 0.000146 0.000427 0.000773 0.000336 0.000287 0.000731 0.000589 0.000340
None 0.000026 0.000022 0.000168 0.000072 0.000022 0.000021 0.000031 0.000028 0.000023 0.000021 0.000090 0.000046
Nuclear Periphery 0.000923 0.000485 0.000545 0.000197 0.000401 0.000528 0.002249 0.000213 0.000431 0.000517 0.001518 0.000206
Nuclear Periphery Foci 0.005272 0.000883 0.002619 0.000745 0.001057 0.000693 0.001358 0.000183 0.001305 0.000740 0.001899 0.000421
Nucleolus 0.000043 0.000040 0.000063 0.000036 0.000295 0.000265 0.000072 0.000031 0.000280 0.000209 0.000068 0.000033
Nucleus 0.009086 0.000368 0.003004 0.000977 0.000839 0.000520 0.000713 0.000468 0.001324 0.000482 0.001696 0.000683
Peroxisomes 0.001740 0.003033 0.003685 0.001630 0.009644 0.002660 0.004300 0.000691 0.009179 0.002753 0.004036 0.001088
Vacuole 0.457017 0.039668 0.087235 0.016849 0.217994 0.032861 0.065637 0.009151 0.232043 0.034559 0.074900 0.012410
Vacuole Periphery 0.002773 0.001087 0.000953 0.002027 0.002020 0.001475 0.001127 0.001675 0.002064 0.001378 0.001052 0.001824

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.54 -3.18 -0.90 -8.13 3.50 -2.36 -9.77 -5.78 -4.80 4.67 -1.34 -16.05 -10.84 -10.13 5.76
Bud Neck -2.20 -3.67 3.08 6.45 13.31 13.67 9.89 20.69 7.36 11.62 11.90 8.29 20.60 9.38 17.50
Bud Site -0.84 -6.68 -8.85 -10.06 -3.48 -5.24 -7.75 -5.38 0.13 2.29 -6.45 -16.70 -17.01 -9.18 -1.17
Cell Periphery -24.21 -11.34 -16.68 11.51 -9.50 -28.99 -15.97 -32.31 -4.10 -14.91 -31.43 -5.71 -21.50 7.75 -15.89
Cytoplasm 4.18 -2.72 -4.25 -12.57 -2.54 -1.51 6.11 -2.63 -1.14 -7.37 -1.24 -7.99 -13.15 -11.38 -5.77
Cytoplasmic Foci 6.28 4.65 5.12 -5.94 1.92 -0.06 2.42 0.77 0.73 -1.01 3.61 -1.21 0.10 -3.44 1.30
Eisosomes 3.40 1.60 3.42 0.08 8.61 4.35 -9.37 0.35 -4.24 9.84 4.44 -9.79 1.70 -3.84 13.02
Endoplasmic Reticulum 0.38 -8.44 2.37 2.96 12.47 14.35 7.32 19.87 7.63 12.71 14.76 3.78 19.30 7.37 17.57
Endosome 4.78 4.02 5.16 0.42 5.32 6.53 3.68 9.31 1.77 5.27 7.42 3.93 10.00 1.29 7.50
Golgi 2.67 2.41 2.34 -2.26 -0.38 -0.53 0.57 -1.35 -0.91 -1.65 1.34 1.12 -0.52 -1.70 -1.54
Lipid Particles 0.10 -10.33 -3.24 -2.80 7.05 8.95 -12.08 6.99 -1.00 14.38 7.60 -14.42 3.01 -4.09 15.93
Mitochondria 1.63 1.69 1.41 -1.46 -1.95 -0.07 4.25 -0.26 -0.15 -3.12 0.95 4.51 0.77 -0.25 -3.68
Mitotic Spindle 0.26 1.14 1.14 1.05 -0.05 -6.16 -18.25 -1.92 0.83 4.18 -1.34 -2.77 -0.47 1.22 4.00
None 0.22 -1.43 -3.20 -3.30 0.96 0.20 -1.86 -1.13 -1.30 0.85 0.16 -1.57 -3.67 -3.77 1.01
Nuclear Periphery 0.56 0.48 0.96 3.77 8.25 -3.37 -14.91 7.82 8.51 16.46 -1.59 -12.62 4.72 9.25 17.61
Nuclear Periphery Foci 1.41 0.84 1.46 1.02 12.02 2.31 -2.04 6.36 6.35 22.64 2.44 -2.61 3.97 4.42 19.96
Nucleolus 0.14 -3.32 1.00 0.69 7.17 0.14 4.25 5.05 1.14 7.05 0.44 4.29 5.01 1.14 9.48
Nucleus 2.35 1.65 2.19 -6.52 9.38 2.40 1.83 4.76 0.37 3.45 3.43 -1.54 2.73 -1.99 9.81
Peroxisomes -1.78 -4.46 0.21 2.02 5.81 9.14 6.78 12.89 5.64 9.00 8.99 7.40 12.33 5.24 10.73
Vacuole 15.14 13.46 16.04 6.32 19.88 39.95 32.04 47.55 10.57 22.80 41.61 32.48 48.46 11.85 29.96
Vacuole Periphery 1.43 1.60 0.50 -1.24 -1.52 1.58 4.56 0.83 -0.43 -1.43 2.33 5.45 0.57 -1.03 -2.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
Localization
Cell Percentages cell periphery (43%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-3

Aqr1

Aqr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aqr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available