Standard name
Human Ortholog
Description Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0.06 0 0 0 0 0 0 0 0 – – 0 0.07 0 0.08 0.07 0.07 0.05 0 0 0.07
Bud 0 0 0 0 0 0 0 0 0.05 0 0.05 0.05 – – 0 0 0 0 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 0 0 0 0 0 – – 0 0.05 0 0 0 0 0 0 0 0
Cytoplasm 0.75 0.85 0.93 0.76 0.74 0.45 0.39 0.39 0.25 0.28 0.18 0.25 – – 1.0 0.74 0.63 0.7 0.22 0.37 0.3 0.2 0.19 0.33
Endoplasmic Reticulum 0 0 0 0 0 0.1 0.06 0 0.05 0 0.08 0 – – 0 0.08 0.07 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0.09 0.06 0.1 0.13 0.07 0.13 0 0 – – 0 0 0.12 0.07 0.08 0 0 0 0.05 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.27 0.06 0 0.09 0.07 0.3 0.35 0.42 0.61 0.51 0.8 0.64 – – 0 0 0.1 0.05 0.48 0.35 0.44 0.45 0.44 0.33
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0 0.05 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.05 0.05 0.05 0 0.06 0.07 0.06 0 0 0.05 – – 0 0.05 0.06 0.06 0 0 0 0 0.05 0
Vac/Vac Membrane 0 0 0 0 0.06 0.09 0.08 0.07 0 0.09 0 0.05 – – 0 0.05 0.06 0 0 0.05 0.07 0.05 0.06 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 1 0 8 1 7 8 6 2 4 4 2 – – 0 22 7 24 16 18 4 0 2 5
Bud 7 3 0 2 2 7 11 9 11 9 13 12 – – 0 5 6 4 3 7 0 0 1 5
Bud Neck 0 2 0 4 1 1 3 0 1 3 1 0 – – 0 4 3 1 4 7 2 0 1 1
Bud Site 0 0 0 0 0 0 1 1 1 1 1 1 – – 0 0 1 0 – – – – – –
Cell Periphery 2 2 2 1 7 5 5 2 4 4 0 4 – – 1 15 7 9 1 3 0 0 0 0
Cytoplasm 144 192 39 99 140 96 113 93 59 74 49 67 – – 26 218 162 207 55 104 26 4 11 28
Endoplasmic Reticulum 4 9 0 1 1 21 18 3 12 4 22 9 – – 0 24 19 17 7 1 2 0 1 1
Endosome 1 3 1 3 17 13 30 31 16 34 5 11 – – 0 11 31 20 19 11 2 0 3 1
Golgi 0 1 0 0 1 0 1 1 1 0 0 0 – – 0 0 0 1 3 2 0 0 0 0
Mitochondria 52 13 1 12 14 64 103 102 142 136 216 168 – – 0 13 25 14 119 96 38 9 27 29
Nucleus 0 0 0 0 1 2 1 0 2 1 1 0 – – 0 2 4 6 0 2 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 2 0 0 0 1 0 – – 0 0 0 0 0 1 0 0 0 0
Nucleolus 0 0 0 0 0 2 0 1 0 0 0 0 – – 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 2 0 1 4 1 3 3 0 4 0 2 – – 0 0 5 0 1 0 0 0 0 1
SpindlePole 4 1 2 6 9 5 18 17 14 11 6 14 – – 0 15 16 17 4 5 1 0 2 0
Vac/Vac Membrane 1 4 0 2 12 19 23 17 7 24 10 14 – – 1 15 16 13 6 13 5 1 3 6
Unique Cell Count 192 226 42 130 190 213 293 240 234 267 269 264 26 294 257 297 251 280 88 21 62 88
Labelled Cell Count 218 233 45 139 210 243 340 286 272 309 329 304 28 345 302 333 251 280 88 21 62 88


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 4.7 5.2 5.5 6.2 5.3 5.3 5.6 4.8 5.0 4.4 4.8 – – 7.9 6.2 6.0 5.8 – 8.8 7.1
Std Deviation (1e-4) 0.6 0.9 0.9 1.6 1.7 1.3 1.1 1.2 1.3 1.0 1.3 0.9 – – 3.7 1.1 1.1 1.0 – 4.4 3.3
Intensity Change (Log2) – – – 0.06 0.25 0.02 0.03 0.1 -0.13 -0.06 -0.25 -0.14 – – 0.59 0.24 0.2 0.14 – 0.75 0.45

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.3802 0.4135 0.5834 -0.0035 0.3274 0.4102 -0.2062 -0.0179 0.099 0.3089 0.1527 0.0055 -0.8698 -0.3873 -0.6413 -0.219 -0.5689 -0.565
Actin 0.0338 0.0127 0.0312 0.0099 0.0144 0.0115 0.0405 0.0075 0.0269 0.0377 0.0279 0.0192 0.0088 0.0049 0.0067 0.0366 0.0125 0.0043
Bud 0.0048 0.0179 0.0048 0.0096 0.0142 0.0041 0.0014 0.0012 0.0093 0.0019 0.0016 0.0014 0.0014 0.0032 0.0022 0.0031 0.0022 0.0039
Bud Neck 0.0069 0.0045 0.0128 0.0043 0.004 0.0241 0.0061 0.002 0.0046 0.0042 0.0014 0.0224 0.0093 0.0011 0.0037 0.0011 0.0013 0.026
Bud Periphery 0.0067 0.0142 0.012 0.032 0.0154 0.0064 0.0029 0.0016 0.0219 0.0038 0.0045 0.0037 0.0021 0.0028 0.0034 0.0061 0.0045 0.0027
Bud Site 0.0179 0.0645 0.0271 0.035 0.0104 0.0036 0.0177 0.0142 0.0197 0.0021 0.0026 0.004 0.0113 0.0267 0.017 0.0015 0.003 0.0019
Cell Periphery 0.002 0.0033 0.0037 0.0014 0.001 0.0008 0.0026 0.0017 0.0015 0.0006 0.0005 0.0009 0.0014 0.0011 0.0012 0.0004 0.0004 0.0004
Cytoplasm 0.2203 0.3039 0.2473 0.2036 0.1463 0.2957 0.203 0.3273 0.259 0.3145 0.2131 0.2967 0.2349 0.3518 0.3315 0.2743 0.2567 0.3403
Cytoplasmic Foci 0.1144 0.108 0.13 0.1244 0.161 0.1306 0.1549 0.0942 0.1191 0.0921 0.1212 0.1436 0.1137 0.1057 0.093 0.1081 0.1264 0.1255
Eisosomes 0.0012 0.0012 0.001 0.0004 0.0004 0.0004 0.0009 0.0004 0.0006 0.0004 0.0005 0.0004 0.0007 0.0002 0.0007 0.0002 0.0004 0.0003
Endoplasmic Reticulum 0.0141 0.007 0.0077 0.0055 0.0078 0.0058 0.0079 0.0032 0.0049 0.0064 0.0045 0.0046 0.0096 0.0034 0.0048 0.0045 0.003 0.0041
Endosome 0.104 0.0718 0.0931 0.111 0.0936 0.0515 0.0826 0.0381 0.0655 0.0734 0.0575 0.0505 0.09 0.0752 0.0567 0.1051 0.0573 0.0763
Golgi 0.0194 0.0173 0.024 0.0194 0.0225 0.0092 0.0195 0.0098 0.0213 0.0158 0.0278 0.0175 0.0141 0.0087 0.0104 0.021 0.0126 0.011
Lipid Particles 0.0179 0.0094 0.0127 0.0132 0.0128 0.008 0.0284 0.0012 0.0119 0.034 0.0222 0.0179 0.0108 0.0033 0.0043 0.0086 0.0062 0.0059
Mitochondria 0.0556 0.0226 0.0433 0.0477 0.0289 0.0238 0.0121 0.0093 0.044 0.1049 0.0811 0.0366 0.015 0.0078 0.0226 0.036 0.0266 0.0175
None 0.3309 0.3123 0.2762 0.3244 0.4189 0.3822 0.3427 0.4716 0.3433 0.2388 0.3494 0.337 0.4488 0.3797 0.4205 0.3487 0.4575 0.3571
Nuclear Periphery 0.0096 0.002 0.0047 0.0118 0.0084 0.0042 0.0097 0.0007 0.0026 0.0053 0.0009 0.0031 0.002 0.0013 0.001 0.0023 0.0009 0.0015
Nucleolus 0.0017 0.0019 0.0023 0.0051 0.0015 0.0011 0.0016 0.0004 0.0011 0.0007 0.0005 0.0005 0.0016 0.0008 0.0007 0.0006 0.0003 0.0009
Nucleus 0.0029 0.0056 0.0057 0.0116 0.0061 0.0037 0.0048 0.0013 0.0036 0.0017 0.0012 0.0015 0.0023 0.0022 0.0025 0.002 0.0012 0.0027
Peroxisomes 0.0179 0.0049 0.0253 0.0111 0.013 0.0158 0.0365 0.009 0.0259 0.0481 0.0739 0.029 0.0072 0.0037 0.0077 0.0203 0.0182 0.0088
Punctate Nuclear 0.0043 0.0069 0.0147 0.0052 0.0074 0.0105 0.0093 0.0008 0.0038 0.0019 0.002 0.0028 0.0041 0.0085 0.0025 0.0036 0.0018 0.0017
Vacuole 0.0107 0.0067 0.0155 0.0087 0.0088 0.0049 0.0116 0.0038 0.0073 0.0081 0.0038 0.0046 0.0094 0.0065 0.0058 0.0123 0.0056 0.0054
Vacuole Periphery 0.0029 0.0015 0.0049 0.0048 0.003 0.0019 0.0033 0.0007 0.002 0.0036 0.0019 0.002 0.0015 0.0014 0.0015 0.0035 0.0013 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.3292 16.7751 22.8211 23.9398 16.2201 22.506 24.4525 28.6193 29.3801 28.4999
Translational Efficiency 0.3155 0.4057 0.2683 0.2703 0.307 0.4121 0.3084 0.225 0.2691 0.2258

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1729 563 797 1268 1672 627 68 1350 3401 1190 865 2618

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 633.61 659.55 959.80 814.96 710.06 717.41 959.64 852.97 671.19 690.04 959.79 834.56
Standard Deviation 66.85 101.16 113.82 120.42 86.39 94.10 112.87 98.41 86.03 101.69 113.75 111.26
Intensity Change Log 2 — 0.057887 0.599139 0.363134 — 0.014857 0.434552 0.264554 — 0.035308 0.514507 0.311880

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000787 0.000938 0.000927 0.018306 0.000488 0.001479 0.005078 0.002487 0.000640 0.001223 0.001253 0.010148
Bud Neck 0.060976 0.075079 0.009105 0.029427 0.016106 0.055003 0.006985 0.028467 0.038917 0.064501 0.008939 0.028932
Bud Site 0.017406 0.044921 0.015588 0.122357 0.014642 0.043020 0.037117 0.058947 0.016047 0.043920 0.017281 0.089659
Cell Periphery 0.000231 0.000745 0.000222 0.000484 0.000191 0.000273 0.000484 0.000141 0.000211 0.000496 0.000242 0.000307
Cytoplasm 0.257154 0.122340 0.478627 0.245824 0.423693 0.160281 0.336383 0.235755 0.339028 0.142331 0.467445 0.240632
Cytoplasmic Foci 0.375316 0.282001 0.088471 0.174504 0.350038 0.292011 0.189200 0.193735 0.362889 0.287275 0.096390 0.184421
Eisosomes 0.000381 0.000393 0.000072 0.000275 0.000162 0.000325 0.000215 0.000133 0.000273 0.000357 0.000084 0.000202
Endoplasmic Reticulum 0.001624 0.000830 0.006664 0.003654 0.002540 0.000803 0.011202 0.002177 0.002075 0.000816 0.007021 0.002893
Endosome 0.042692 0.081587 0.017383 0.032643 0.015448 0.094859 0.034876 0.061319 0.029298 0.088580 0.018758 0.047430
Golgi 0.021847 0.047968 0.001072 0.015846 0.013174 0.046900 0.007654 0.010836 0.017583 0.047405 0.001589 0.013262
Lipid Particles 0.026507 0.013567 0.005945 0.004285 0.011470 0.009803 0.015368 0.005583 0.019114 0.011584 0.006686 0.004955
Mitochondria 0.043687 0.172354 0.000644 0.012287 0.019921 0.117290 0.000644 0.010909 0.032003 0.143341 0.000644 0.011577
Mitotic Spindle 0.003051 0.006558 0.008354 0.038870 0.002828 0.019467 0.004947 0.051394 0.002941 0.013360 0.008086 0.045328
None 0.002715 0.002649 0.002110 0.001632 0.002471 0.001700 0.000532 0.000496 0.002595 0.002149 0.001986 0.001046
Nuclear Periphery 0.000287 0.000233 0.001777 0.000335 0.000296 0.000204 0.000761 0.000855 0.000292 0.000218 0.001697 0.000603
Nuclear Periphery Foci 0.000310 0.000538 0.007016 0.000892 0.000651 0.000224 0.009750 0.001211 0.000477 0.000373 0.007231 0.001057
Nucleolus 0.001939 0.002864 0.000914 0.000728 0.001132 0.001251 0.000672 0.001374 0.001542 0.002014 0.000895 0.001061
Nucleus 0.058214 0.029519 0.182078 0.039930 0.074239 0.022323 0.098806 0.034535 0.066093 0.025727 0.175532 0.037148
Peroxisomes 0.029512 0.066844 0.002437 0.099478 0.011265 0.060311 0.024908 0.041199 0.020541 0.063402 0.004203 0.069426
Vacuole 0.051249 0.037371 0.169504 0.153930 0.036058 0.063523 0.206667 0.252435 0.043781 0.051150 0.172425 0.204725
Vacuole Periphery 0.004114 0.010700 0.001088 0.004312 0.003186 0.008951 0.007751 0.006012 0.003658 0.009778 0.001612 0.005189

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.54 -0.93 -10.33 -10.36 -10.27 -2.02 -2.57 -7.33 -1.36 1.59 -1.98 -3.21 -11.17 -9.97 -10.07
Bud Neck -2.25 16.28 9.92 8.14 -9.16 -9.03 5.96 -5.75 6.39 -10.55 -6.79 14.40 5.85 10.30 -10.83
Bud Site -6.86 0.95 -19.40 -10.83 -19.17 -7.64 -3.08 -11.54 -1.74 -2.13 -10.23 -0.57 -22.03 -9.42 -19.46
Cell Periphery -2.58 0.33 -2.93 1.46 -3.19 -2.14 -4.31 2.66 4.64 5.56 -2.94 -1.51 -1.76 2.18 -0.88
Cytoplasm 14.50 -16.68 1.06 -12.17 16.36 24.19 3.04 19.25 -6.98 2.53 26.74 -9.26 14.17 -13.21 18.29
Cytoplasmic Foci 8.36 42.72 29.26 11.85 -12.85 5.65 8.52 22.96 12.00 0.11 9.98 47.54 36.79 16.90 -14.96
Eisosomes -0.29 17.21 4.88 3.10 -8.87 -2.98 -1.87 3.95 3.72 3.22 -2.35 17.40 6.22 4.78 -8.80
Endoplasmic Reticulum 2.75 -10.59 -3.74 -5.86 5.94 4.48 -3.65 0.93 -4.54 3.81 5.16 -10.80 -2.55 -7.38 9.05
Endosome -6.53 11.62 5.52 9.01 -5.67 -14.84 -2.99 -13.91 7.25 -2.95 -14.78 7.13 -5.99 11.48 -11.57
Golgi -6.42 16.41 5.26 8.69 -9.39 -9.09 1.53 3.72 10.30 -0.45 -10.84 18.58 6.55 13.42 -10.35
Lipid Particles 5.75 12.98 14.36 5.72 2.90 1.09 -1.00 6.51 3.15 2.60 5.51 12.21 15.47 6.34 2.95
Mitochondria -11.32 16.17 11.79 14.64 -9.88 -11.84 11.04 5.32 13.37 -7.79 -15.98 19.40 12.63 19.67 -12.31
Mitotic Spindle -1.89 -2.62 -10.07 -8.10 -8.10 -5.31 -0.98 -11.49 -5.66 -9.82 -5.52 -2.96 -15.24 -9.17 -12.01
None 0.02 1.25 1.67 1.21 0.76 0.90 8.81 6.66 1.19 -1.02 0.59 1.94 3.79 1.68 1.91
Nuclear Periphery 1.11 -14.13 -4.29 -4.09 12.50 1.85 -4.08 -6.74 -7.54 -2.05 2.14 -14.32 -7.61 -8.48 8.04
Nuclear Periphery Foci -0.90 -12.16 -6.51 -0.64 10.93 4.42 -4.22 -3.22 -5.22 3.85 0.15 -12.59 -5.41 -3.23 11.08
Nucleolus -1.83 3.57 3.77 3.38 0.18 -0.48 2.59 -1.21 -0.78 -3.57 -1.80 3.57 2.00 2.90 -1.92
Nucleus 6.92 -17.94 2.73 -4.19 18.86 13.83 -1.44 9.40 -5.44 3.37 14.53 -17.09 8.44 -6.76 20.08
Peroxisomes -6.87 17.05 -11.87 -2.81 -18.52 -11.59 -1.14 -10.16 5.14 -1.45 -12.52 14.07 -14.76 0.73 -21.22
Vacuole 3.89 -19.01 -21.45 -22.59 0.30 -6.37 -7.49 -35.79 -27.97 -1.85 -2.56 -21.61 -40.16 -35.23 -4.94
Vacuole Periphery -3.93 8.68 0.72 3.95 -3.29 -6.02 -0.63 -2.30 3.83 0.33 -6.51 4.45 -0.97 5.42 -4.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
Localization
Cell Percentages cytoplasm (32%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

App1

App1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (App1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available