Standard name
Human Ortholog
Description Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.97 0.96 0.95 0.85 0.82 0.78 – 0.69 0.7 0.63 0.67 0.98 0.99 1.0 0.89 0.9 0.94 0.96 0.94 0.92 0.91 0.85 0.73
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0.06
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.16 0 – 0.21 0.17 0.25 0.22 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.19 0.06 0.21 – 0.16 0.15 0.18 0.14 0 0 0 0.12 0.13 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 1 0 – 1 0 0 0 0 0 0 0 2 0 1 2 2 1 1 2
Bud 0 0 0 0 0 4 0 – 2 5 6 7 0 0 0 0 0 0 4 0 1 2 3 4
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 1 – 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 4 2 4 2 6 – 5 3 2 2 2 0 3 7 12 5 0 0 0 0 0 0
Cytoplasm 401 451 279 225 182 256 320 – 229 309 257 300 204 252 292 257 260 224 386 430 264 174 203 172
Endoplasmic Reticulum 1 6 1 4 1 2 7 – 0 2 4 6 0 1 0 13 5 4 0 2 2 0 5 7
Endosome 0 0 2 0 1 1 3 – 2 10 16 9 0 0 0 13 5 4 0 4 1 0 10 13
Golgi 1 2 0 0 0 0 0 – 0 0 0 0 1 0 0 2 1 2 1 2 2 1 0 4
Mitochondria 0 3 1 1 2 50 12 – 69 77 101 99 0 0 0 2 0 0 0 2 2 3 2 2
Nucleus 2 0 0 3 3 3 10 – 6 12 8 5 3 1 2 2 3 2 1 3 2 2 1 2
Nuclear Periphery 0 0 0 0 0 0 1 – 0 0 0 3 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 1 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 2 0 2 1 1 0 1 6 0 0 1 1 0 1 8
Vac/Vac Membrane 7 2 10 8 40 18 85 – 53 66 74 63 1 1 1 36 39 17 0 3 3 2 1 7
Unique Cell Count 408 463 291 237 215 312 410 331 441 409 450 208 255 293 288 289 239 402 456 288 193 240 236
Labelled Cell Count 412 466 297 243 234 337 445 367 486 468 497 212 256 298 333 334 259 402 456 288 193 240 236


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.7 8.3 8.9 9.2 9.4 6.3 7.6 – 6.4 6.4 6.1 6.0 9.2 9.1 8.8 10.3 11.1 10.1 8.0 8.1 8.3
Std Deviation (1e-4) 1.5 1.6 1.6 1.7 1.6 1.6 1.5 – 1.4 1.3 1.0 1.1 1.6 1.7 1.8 1.9 1.8 2.0 1.8 1.9 2.2
Intensity Change (Log2) – – – 0.05 0.08 -0.5 -0.23 – -0.48 -0.49 -0.55 -0.58 0.05 0.03 -0.01 0.21 0.32 0.18 -0.16 -0.14 -0.11

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0.9 2.0 0
Cytoplasm -0.5 -4.4 -5.4 -6.6 – -8.6 -8.6 -10.2 -9.4 1.4 2.1 3.1 -3.0 -2.8 -1.1
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 3.3 0 0
Endosome 0 0 0 0 – 0 0 2.7 0 0 0 0 2.9 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.9 2.5 – 8.1 7.3 9.0 8.4 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 5.7 1.4 6.6 – 5.2 5.0 5.9 4.7 0 -2.5 -2.8 4.0 4.4 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.6219 1.8887 0.961 1.4106 1.3819 1.6205 2.189 3.5389 2.8218 3.6948 3.1674 3.1894 5.2034 7.2721 5.5616 4.7223 5.6382 5.7968
Actin 0.0098 0.0062 0.0211 0.0226 0.0027 0.001 0.0046 0.0008 0.0037 0.0334 0.0425 0.0018 0.0014 0.0012 0.0094 0.0004 0.0005 0.0066
Bud 0.0006 0.0006 0.0016 0.001 0.0007 0.0002 0.0003 0.0014 0.0004 0.0006 0.0028 0.0099 0.0001 0.0006 0.0012 0.0001 0.0003 0.0001
Bud Neck 0.003 0.0004 0.0007 0.0076 0.0012 0.0011 0.0003 0.0002 0.0005 0.0008 0.0003 0.0317 0.0002 0.0002 0.0033 0.0002 0.0003 0.001
Bud Periphery 0.001 0.0006 0.0011 0.0018 0.0008 0.0001 0.0003 0.0006 0.0003 0.0005 0.0016 0.0054 0.0001 0.0003 0.0013 0 0.0002 0
Bud Site 0.0015 0.0113 0.0098 0.005 0.0017 0.0001 0.0007 0.0073 0.0016 0.0014 0.001 0.0004 0.0002 0.0019 0.0008 0.0001 0.0002 0.0001
Cell Periphery 0.0002 0.0002 0.0002 0.0006 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0001 0 0 0
Cytoplasm 0.6068 0.778 0.7044 0.6775 0.5961 0.8658 0.6414 0.8762 0.7134 0.841 0.5036 0.7303 0.7318 0.8757 0.7777 0.9572 0.7881 0.8481
Cytoplasmic Foci 0.0407 0.0118 0.0225 0.0349 0.0783 0.0117 0.0135 0.0037 0.0162 0.0163 0.0573 0.0088 0.0052 0.0043 0.0101 0.0043 0.0074 0.0108
Eisosomes 0.0005 0 0.0001 0.0004 0 0 0.0001 0 0 0.0002 0.0001 0 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0088 0.0027 0.0069 0.0016 0.0029 0.0042 0.0035 0.0018 0.008 0.001 0.013 0.0026 0.004 0.0012 0.0022 0.0018 0.0031 0.0023
Endosome 0.0379 0.0095 0.014 0.0415 0.0591 0.0136 0.0436 0.0009 0.0076 0.0147 0.1482 0.0259 0.0032 0.001 0.0027 0.0012 0.0047 0.0045
Golgi 0.0083 0.0041 0.0086 0.0286 0.0218 0.0017 0.0189 0.0001 0.0089 0.0271 0.054 0.0049 0.0002 0.0002 0.0007 0.0002 0.0005 0.0005
Lipid Particles 0.0126 0.0028 0.0032 0.0137 0.0045 0.0003 0.0032 0 0.0005 0.0051 0.0019 0.0072 0.0004 0.0001 0.0003 0 0.0001 0.0004
Mitochondria 0.0086 0.0005 0.0038 0.0666 0.0106 0.0014 0.0054 0.0001 0.0006 0.0108 0.0239 0.0109 0.0002 0.0002 0.0015 0.0001 0.0004 0.0002
None 0.2402 0.163 0.1876 0.0771 0.1109 0.0913 0.2562 0.1038 0.2316 0.0354 0.1137 0.1447 0.2444 0.1088 0.1775 0.0316 0.1856 0.1122
Nuclear Periphery 0.0056 0.0008 0.002 0.0009 0.0427 0.0012 0.0018 0.0005 0.0009 0.0006 0.0035 0.0023 0.0019 0.0004 0.0011 0.0005 0.001 0.0015
Nucleolus 0.0005 0.0001 0.0001 0.0002 0.0009 0.0001 0.0001 0 0.0001 0.0001 0.0007 0.0002 0.0001 0 0.0001 0 0 0.0001
Nucleus 0.0037 0.0021 0.0022 0.0025 0.0132 0.0034 0.0017 0.0014 0.0016 0.0023 0.0037 0.0038 0.002 0.0022 0.0034 0.0015 0.0057 0.0087
Peroxisomes 0.0025 0.002 0.0037 0.008 0.0427 0.0003 0.001 0.0001 0.0013 0.0061 0.0007 0.0037 0.0002 0.0005 0.0046 0 0.0001 0.0003
Punctate Nuclear 0.0022 0.0017 0.0042 0.0015 0.0037 0.0009 0.0008 0.0003 0.0011 0.0006 0.0184 0.0007 0.0031 0.0003 0.0009 0.0002 0.0004 0.0018
Vacuole 0.0036 0.0012 0.0018 0.0037 0.0031 0.0013 0.0018 0.0006 0.0013 0.0015 0.0052 0.0032 0.001 0.0007 0.0009 0.0004 0.0012 0.0006
Vacuole Periphery 0.0015 0.0001 0.0004 0.0026 0.0023 0.0005 0.0007 0.0001 0.0002 0.0005 0.0036 0.0014 0.0002 0.0001 0.0002 0.0001 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.3138 19.1 19.2348 21.0465 29.6807 18.3036 25.5194 22.81 22.3553 29.2907
Translational Efficiency 1.8235 1.3341 1.1217 1.3199 0.8782 1.7425 1.1812 0.9586 1.2207 1.2527

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1761 717 74 1125 1128 2256 2383 1263 2889 2973 2457 2388

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 840.02 984.32 972.96 791.89 825.91 990.08 858.74 809.79 834.51 988.69 862.18 801.36
Standard Deviation 109.86 160.13 140.30 128.25 121.05 146.33 111.77 129.08 114.57 149.80 114.41 129.00
Intensity Change Log 2 — 0.228704 0.211957 -0.085124 — 0.261561 0.056237 -0.028437 — 0.245087 0.136855 -0.056742

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000294 0.000777 0.000358 0.004291 0.000247 0.000384 0.000184 0.001828 0.000276 0.000479 0.000189 0.002989
Bud Neck 0.006829 0.003091 0.003106 0.012715 0.002457 0.005666 0.005659 0.010282 0.005122 0.005045 0.005582 0.011428
Bud Site 0.010732 0.025355 0.003022 0.070840 0.005128 0.015585 0.008360 0.058854 0.008544 0.017941 0.008199 0.064501
Cell Periphery 0.000095 0.000105 0.000360 0.000477 0.000094 0.000054 0.000110 0.000247 0.000095 0.000066 0.000118 0.000355
Cytoplasm 0.649683 0.748006 0.435832 0.408065 0.714304 0.756280 0.454996 0.490748 0.674914 0.754284 0.454419 0.451796
Cytoplasmic Foci 0.159749 0.102053 0.016270 0.027906 0.111805 0.074876 0.004914 0.029711 0.141030 0.081430 0.005256 0.028860
Eisosomes 0.000052 0.000024 0.000073 0.000071 0.000038 0.000020 0.000019 0.000058 0.000047 0.000021 0.000020 0.000064
Endoplasmic Reticulum 0.001720 0.001095 0.004031 0.003660 0.000986 0.000536 0.001566 0.001592 0.001433 0.000671 0.001640 0.002566
Endosome 0.006779 0.007668 0.003643 0.019106 0.007369 0.005527 0.001310 0.008866 0.007009 0.006043 0.001380 0.013690
Golgi 0.002693 0.002474 0.000135 0.010161 0.001190 0.001804 0.000831 0.003424 0.002106 0.001966 0.000810 0.006598
Lipid Particles 0.002228 0.001100 0.002360 0.001936 0.001774 0.000768 0.000510 0.001500 0.002051 0.000848 0.000566 0.001705
Mitochondria 0.001535 0.000312 0.000293 0.005462 0.000482 0.002494 0.001126 0.004414 0.001123 0.001968 0.001101 0.004908
Mitotic Spindle 0.001758 0.002387 0.002652 0.049772 0.001395 0.011165 0.005133 0.041445 0.001617 0.009048 0.005059 0.045368
None 0.002641 0.004182 0.015489 0.005352 0.003576 0.005073 0.008308 0.005704 0.003006 0.004858 0.008524 0.005538
Nuclear Periphery 0.000276 0.000101 0.000914 0.001514 0.000185 0.000154 0.001544 0.001142 0.000240 0.000141 0.001525 0.001317
Nuclear Periphery Foci 0.001775 0.002774 0.005650 0.001416 0.002396 0.000680 0.000534 0.000913 0.002018 0.001185 0.000689 0.001150
Nucleolus 0.000566 0.000658 0.000717 0.000814 0.000699 0.000473 0.000281 0.001349 0.000618 0.000518 0.000294 0.001097
Nucleus 0.090271 0.046780 0.386471 0.255598 0.080920 0.060628 0.470262 0.214807 0.086619 0.057288 0.467738 0.234024
Peroxisomes 0.001927 0.003333 0.000319 0.003816 0.001604 0.002898 0.000132 0.001873 0.001801 0.003003 0.000138 0.002788
Vacuole 0.056827 0.046921 0.118121 0.110137 0.062931 0.053851 0.033820 0.116220 0.059210 0.052179 0.036359 0.113354
Vacuole Periphery 0.001571 0.000806 0.000185 0.006890 0.000421 0.001083 0.000401 0.005024 0.001122 0.001016 0.000395 0.005903

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.21 -1.99 -3.82 -2.44 -3.51 -1.22 0.65 -2.14 -1.77 -2.26 -2.37 1.78 -4.15 -3.32 -4.39
Bud Neck 5.71 3.13 -2.64 -7.38 -4.54 -4.86 -3.97 -7.65 -3.81 -3.99 0.04 -0.25 -6.31 -6.22 -5.05
Bud Site -4.80 6.18 -6.62 -1.93 -8.83 -6.91 -0.63 -8.39 -5.33 -8.10 -6.68 2.52 -10.30 -6.21 -11.12
Cell Periphery -1.40 -2.31 -5.52 -5.00 0.36 8.26 0.02 -6.08 -10.11 -5.84 7.89 -0.83 -7.61 -9.59 -6.77
Cytoplasm -8.06 8.71 31.35 32.59 1.05 -4.69 38.70 28.26 35.66 -3.57 -11.68 43.18 40.59 51.17 -0.02
Cytoplasmic Foci 8.17 29.42 31.93 15.11 -0.79 7.56 25.86 20.29 17.66 -10.55 15.17 43.81 37.15 24.05 -13.96
Eisosomes 6.66 -3.05 -5.00 -13.10 1.16 6.38 4.36 -7.53 -15.34 -14.27 9.85 7.26 -7.69 -20.66 -18.59
Endoplasmic Reticulum 2.71 -4.41 -6.14 -8.48 1.22 3.39 -11.71 -6.87 -9.17 1.80 5.20 -7.67 -7.73 -12.61 -2.12
Endosome -0.68 2.91 -0.35 0.21 -2.29 2.37 8.57 2.32 0.30 -5.79 1.81 12.09 1.13 -0.29 -7.36
Golgi 0.41 8.15 -0.60 -0.76 -3.75 -1.14 1.75 -0.69 0.24 -2.14 0.61 5.09 -0.48 -0.87 -3.73
Lipid Particles 2.52 -0.28 1.32 -1.91 0.97 5.07 6.63 1.54 -4.20 -6.32 6.29 8.94 2.28 -5.37 -10.07
Mitochondria 6.13 6.68 -2.05 -5.30 -5.50 -3.28 -2.67 -3.40 -0.17 -2.56 -1.69 0.91 -3.54 -1.06 -3.95
Mitotic Spindle -1.19 0.16 -8.31 -8.00 -7.86 -5.43 -3.82 -7.75 -4.92 -6.45 -5.62 -4.07 -11.26 -7.71 -9.16
None -1.62 -1.14 -5.41 -1.58 0.62 -1.63 -5.25 -1.81 -0.07 3.42 -2.96 -8.27 -4.96 -0.88 3.66
Nuclear Periphery 2.13 -6.19 -17.70 -20.97 -10.43 1.10 -31.55 -18.89 -19.08 3.43 1.88 -26.75 -24.08 -27.98 -0.58
Nuclear Periphery Foci -2.43 -3.62 1.09 4.39 4.06 8.75 9.11 6.89 -1.00 -0.67 3.37 4.99 3.93 0.75 -1.82
Nucleolus -0.30 0.54 -0.55 0.03 -0.99 0.78 1.54 -0.98 -2.26 -3.25 0.73 2.88 -1.29 -2.10 -4.38
Nucleus 11.49 -8.12 -26.00 -31.25 1.70 5.57 -70.52 -24.79 -28.41 27.20 11.35 -73.48 -35.57 -41.62 29.75
Peroxisomes -2.19 11.04 1.08 2.49 -2.66 -1.99 4.20 1.27 3.16 -3.47 -2.63 10.40 1.94 3.62 -4.50
Vacuole 0.92 -5.17 -22.01 -21.14 -0.65 1.75 -0.08 -17.14 -18.94 -17.62 1.01 -3.13 -28.02 -28.33 -24.37
Vacuole Periphery 2.25 4.78 -0.93 -2.06 -2.98 -3.01 1.83 -3.55 -2.33 -3.85 0.62 4.55 -2.58 -2.93 -4.70
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
Localization
Cell Percentages cytoplasm (94%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Nrk1

Nrk1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nrk1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available