Standard name
Human Ortholog
Description CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.33 0.31 0.44 0.52 0.28 0.32 0.22 0.3 0.27 0.22 0.35 0.28 0.41 0.4 0.34 0.31 0.36 0.28 0.63 0.45 0.53 0.57 0.64 0.58
Bud 0.09 0 0.12 0.11 0.16 0.12 0.07 0.07 0.12 0.08 0.06 0.09 0 0.12 0.19 0.07 0.08 0.1 0 0.07 0.07 0 0.06 0.12
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.14 0 0.06 0.08 0 0.06 0.05 0 0.05 0 0.08 0 0.09 0 0.1 0.06 0 0 0 0 0 0 0
Cytoplasm 0.36 0.35 0.23 0.16 0.2 0.19 0.23 0.2 0.22 0.17 0.25 0.16 0.29 0.37 0.34 0.19 0.23 0.22 0 0.17 0 0.08 0 0
Endoplasmic Reticulum 0.11 0.31 0.22 0.25 0.27 0.32 0.21 0.22 0.22 0.18 0.15 0.23 0.06 0.23 0.15 0 0 0 0.08 0.1 0.11 0.05 0.09 0
Endosome 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.06 0.06 0 0.05
Golgi 0.09 0.16 0.17 0.33 0.32 0.26 0.2 0.26 0.14 0.13 0.22 0.16 0.18 0.17 0.26 0.36 0.47 0.54 0.13 0.08 0.07 0 0.06 0
Mitochondria 0.2 0.08 0.16 0.14 0.06 0.34 0.32 0.29 0.43 0.52 0.41 0.46 0.35 0.05 0.19 0.07 0.08 0.13 0 0 0 0.07 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.11 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 0.05 0 0.05 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 15 16 56 74 52 58 64 91 61 62 28 44 7 31 16 94 58 25 50 37 83 18 54 59
Bud 4 1 15 16 30 21 19 22 27 22 5 14 0 9 9 21 13 9 2 6 11 1 5 11
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 1 1 2
Bud Site 1 0 0 1 0 0 2 0 0 3 1 1 0 0 0 2 1 0 – – – – – –
Cell Periphery 1 7 1 9 15 5 18 15 8 15 2 12 0 7 1 31 9 3 1 1 3 0 0 0
Cytoplasm 16 18 30 22 37 34 66 61 51 47 20 25 5 29 16 58 37 20 2 14 5 2 0 3
Endoplasmic Reticulum 5 16 28 35 51 58 60 67 49 52 12 36 1 18 7 11 5 3 6 8 17 1 7 4
Endosome 2 0 5 3 3 1 13 11 5 6 0 3 0 0 0 9 8 2 2 2 9 2 1 5
Golgi 4 8 22 47 59 47 59 78 32 38 18 25 3 13 12 109 76 49 10 6 11 1 4 3
Mitochondria 9 4 20 20 11 62 92 89 97 148 33 73 6 4 9 22 13 12 2 0 3 2 1 2
Nucleus 0 0 0 0 0 0 2 0 1 0 1 0 0 0 0 1 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 2 1 0 0 1 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 4 0 3 3 10 4 3 3 0 0 0 0 0 8 0 2 0 0 0 0 0 1
Peroxisomes 0 0 1 5 2 2 3 0 1 4 2 1 0 2 0 22 3 0 1 0 0 0 0 2
SpindlePole 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 39 18 3 0 0 1 0 3 2
Vac/Vac Membrane 0 0 1 0 4 2 13 16 5 15 1 4 0 0 1 15 12 4 0 2 5 0 0 0
Unique Cell Count 45 51 128 141 187 181 288 302 227 283 81 158 17 78 47 299 162 90 81 84 158 33 85 103
Labelled Cell Count 58 70 183 232 268 293 421 455 340 417 124 238 22 114 71 442 254 132 81 84 158 33 85 103


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.6 15.8 13.5 14.3 15.4 14.2 13.8 14.2 13.9 13.2 13.6 13.9 14.2 15.2 13.8 17.3 20.1 22.3 – 13.1 13.6
Std Deviation (1e-4) 2.9 3.1 3.0 2.8 3.0 3.0 3.8 3.4 3.4 3.5 4.2 4.1 2.6 3.6 3.8 6.0 7.0 7.3 – 3.2 3.3
Intensity Change (Log2) – – – 0.09 0.19 0.07 0.04 0.07 0.04 -0.03 0.01 0.05 0.07 0.17 0.03 0.36 0.58 0.73 – -0.04 0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.4 -2.9 -2.1 -4.5 -2.7 -3.2 -4.5 -1.3 -2.8 -0.2 -0.6 -1.2 -2.4 -1.4 -2.4
Bud -0.1 1.1 0 -1.8 -1.5 0 -1.3 -1.3 -0.8 0 0 1.3 -1.6 -1.1 -0.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 2.9 0 2.5 0 0 0 0 2.8 0 0 0 3.4 0 0
Cytoplasm -1.6 -0.8 -1.0 -0.1 -0.8 -0.2 -1.6 0.2 -1.6 0 2.1 1.4 -0.9 -0.1 -0.2
Endoplasmic Reticulum 0.6 1.1 2.0 -0.2 0.1 -0.1 -0.8 -1.3 0.2 0 0.2 -1.0 -6.0 -5.0 -3.9
Endosome 0 0 0 0.3 0 0 0 0 0 0 0 0 0 0.4 0
Golgi 3.0 2.9 1.8 0.8 1.9 -0.8 -1.0 0.9 -0.3 0 -0.1 1.2 4.0 5.3 5.8
Mitochondria -0.3 -2.9 3.7 3.5 3.0 5.2 7.0 4.1 5.5 0 -2.3 0.6 -2.6 -2.0 -0.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 2.8 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 4.3 3.9 0
Vacuole 0 0 0 0 2.2 0 0 0 0 0 0 0 0 2.7 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.6564 10.9658 10.3493 11.7133 10.011 11.1886 10.104 11.5751 11.1926 10.9646 10.39 10.6406 12.8689 15.189 12.616 12.1203 11.4672 13.0456
Actin 0.6746 0.512 0.7389 0.905 0.8925 0.6986 0.6027 0.596 0.7167 0.8207 0.8334 0.7426 0.7704 0.4409 0.7356 0.7609 0.78 0.8161
Bud 0.0051 0.0069 0.0406 0.0073 0.006 0.0045 0.004 0.0095 0.0455 0.0131 0.0072 0.0045 0.0063 0.0075 0.0371 0.0404 0.0072 0.0025
Bud Neck 0.0049 0.0066 0.0037 0.0022 0.0012 0.0305 0.006 0.007 0.0042 0.0101 0.0003 0.0241 0.0039 0.0103 0.0026 0.0039 0.0022 0.0154
Bud Periphery 0.008 0.0072 0.0613 0.0192 0.0133 0.0068 0.0037 0.0063 0.0465 0.0163 0.0106 0.0049 0.0076 0.0061 0.0356 0.0573 0.0102 0.0026
Bud Site 0.0176 0.1536 0.0399 0.0038 0.0051 0.0051 0.0231 0.1659 0.0797 0.0086 0.0022 0.0098 0.0147 0.1486 0.0617 0.0232 0.0081 0.0031
Cell Periphery 0.0034 0.0092 0.0023 0.0011 0.0006 0.0029 0.0044 0.0045 0.002 0.0056 0.0002 0.0014 0.0024 0.0053 0.0018 0.0013 0.0008 0.0008
Cytoplasm 0.0174 0.1629 0.0145 0.0242 0.0024 0.0444 0.0632 0.1005 0.0183 0.0784 0.0013 0.0426 0.0802 0.2535 0.0469 0.0068 0.0033 0.0219
Cytoplasmic Foci 0.0384 0.0356 0.0209 0.0088 0.0054 0.0236 0.0388 0.0227 0.0124 0.0091 0.0068 0.0293 0.0204 0.0163 0.0229 0.0073 0.0267 0.0279
Eisosomes 0.0021 0.0012 0.0007 0.0005 0.0004 0.0012 0.0014 0.0007 0.0003 0.0003 0.0002 0.0007 0.0022 0.0016 0.0002 0.0003 0.0003 0.0005
Endoplasmic Reticulum 0.0124 0.0023 0.0005 0.0004 0.001 0.0043 0.0229 0.0052 0.009 0.0018 0.0003 0.002 0.0036 0.006 0.0027 0.0004 0.0009 0.0012
Endosome 0.0238 0.0194 0.009 0.0045 0.0158 0.0345 0.0686 0.0145 0.0163 0.0061 0.0429 0.0209 0.0116 0.0363 0.0138 0.0111 0.0327 0.0137
Golgi 0.0696 0.0492 0.0312 0.0208 0.0308 0.1042 0.0865 0.057 0.016 0.0151 0.088 0.1022 0.0515 0.0417 0.0195 0.0132 0.0678 0.0839
Lipid Particles 0.0285 0.0038 0.0029 0.0002 0.0015 0.0019 0.013 0.0029 0.0064 0.0026 0.0013 0.0014 0.0024 0.001 0.0061 0.0375 0.0215 0.0016
Mitochondria 0.0223 0.0156 0.0227 0.0011 0.0208 0.0295 0.0058 0.0015 0.0174 0.0006 0.0035 0.005 0.0086 0.0026 0.0034 0.0208 0.0037 0.0036
None 0.0075 0.0003 0.0002 0.0001 0.0002 0.0018 0.0029 0.0005 0.0004 0.0001 0 0.002 0.0054 0.0003 0.0014 0.0002 0.0026 0.0001
Nuclear Periphery 0.0071 0.0003 0.0001 0.0001 0.0003 0.0005 0.0089 0.0002 0.0009 0.0004 0.0001 0.0001 0.0011 0.004 0.0005 0.0003 0.0024 0.0001
Nucleolus 0.0017 0.0001 0.0002 0 0 0.0001 0.0006 0 0.0001 0.0001 0 0.0003 0 0.0002 0.0001 0.0011 0.0002 0
Nucleus 0.0029 0.0004 0.0002 0 0.0001 0.0003 0.0201 0.0002 0.0003 0.0005 0 0.0002 0.0005 0.0064 0.0003 0.0004 0.0003 0.0001
Peroxisomes 0.0127 0.0099 0.0086 0.0004 0.0009 0.0027 0.0077 0.0033 0.0045 0.001 0.0006 0.0032 0.0058 0.0006 0.0051 0.0087 0.0172 0.0044
Punctate Nuclear 0.018 0.0002 0.0001 0 0.0002 0.0002 0.0059 0.0002 0.0003 0.0002 0 0.0002 0.0003 0.001 0.0008 0.0003 0.0105 0.0001
Vacuole 0.019 0.0028 0.0009 0.0002 0.0009 0.0015 0.0074 0.0012 0.0022 0.0091 0.0004 0.0021 0.001 0.0074 0.0014 0.0035 0.0008 0.0003
Vacuole Periphery 0.003 0.0005 0.0005 0.0001 0.0005 0.001 0.0025 0.0002 0.0006 0.0004 0.0006 0.0003 0.0003 0.0025 0.0003 0.0011 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 170.9893 150.3584 130.0907 150.8286 152.0195 143.691 145.4036 145.6099 141.1244 173.0933
Translational Efficiency 2.0587 1.9454 1.7789 1.6371 1.8727 2.3735 1.7819 1.6108 1.8348 1.6851

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
121 290 474 1044 1109 1191 2313 580 1230 1481 2787 1624

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1147.58 1300.12 1728.28 1607.04 1227.79 1310.19 1628.72 1564.75 1219.90 1308.22 1645.65 1591.94
Standard Deviation 236.03 284.22 300.40 368.09 207.02 277.53 299.49 359.84 211.41 278.88 301.97 365.73
Intensity Change Log 2 — 0.180050 0.590742 0.485811 — 0.093712 0.407675 0.349868 — 0.136069 0.499020 0.417145

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.306256* 0.278120* 0.560608* 0.550250* 0.516507* 0.398789* 0.678114* 0.450896* 0.495824* 0.375160* 0.658130* 0.514766*
Bud Neck 0.015919 0.006428 0.022042 0.010229 0.011007 0.006525 0.011105 0.012555 0.011490 0.006506 0.012965 0.011060
Bud Site 0.160148* 0.143356* 0.137225* 0.144730* 0.147698* 0.134398* 0.114486* 0.130169* 0.148923* 0.136152* 0.118353* 0.139530*
Cell Periphery 0.005970 0.016712 0.008674 0.008709 0.016163 0.010078 0.009026 0.006125 0.015161 0.011377 0.008966 0.007786
Cytoplasm 0.029420 0.047346 0.011913 0.021666 0.029490 0.043831 0.017492 0.020215 0.029483 0.044519 0.016543 0.021147
Cytoplasmic Foci 0.199956* 0.109817 0.035127 0.047464 0.055101 0.092192 0.033306 0.056216 0.069351 0.095644 0.033616 0.050590
Eisosomes 0.001755 0.002365 0.003781 0.004530 0.003848 0.002555 0.007881 0.002235 0.003642 0.002517 0.007184 0.003711
Endoplasmic Reticulum 0.007149 0.024721 0.018670 0.006477 0.025450 0.016240 0.005229 0.007424 0.023649 0.017900 0.007515 0.006815
Endosome 0.075608 0.100871 0.049365 0.055422 0.051637 0.079302 0.042247 0.107288 0.053995 0.083525 0.043458 0.073946
Golgi 0.094811 0.168775* 0.067772 0.081356 0.088485 0.154713* 0.031283 0.115273* 0.089107 0.157467* 0.037489 0.093469
Lipid Particles 0.027565 0.071795 0.064285 0.033826 0.034565 0.029563 0.027813 0.050695 0.033877 0.037833 0.034016 0.039850
Mitochondria 0.002834 0.005395 0.001318 0.004575 0.003611 0.006520 0.002380 0.007007 0.003534 0.006300 0.002200 0.005443
Mitotic Spindle 0.004534 0.002091 0.001792 0.004655 0.000941 0.001827 0.002726 0.006093 0.001294 0.001878 0.002567 0.005168
None 0.003776 0.000146 0.000064 0.000066 0.000105 0.000863 0.000055 0.000106 0.000466 0.000723 0.000057 0.000080
Nuclear Periphery 0.000071 0.000114 0.000097 0.000096 0.000033 0.000045 0.000033 0.000120 0.000037 0.000058 0.000044 0.000104
Nuclear Periphery Foci 0.001418 0.002472 0.000639 0.000530 0.000621 0.000294 0.000184 0.000614 0.000700 0.000721 0.000261 0.000560
Nucleolus 0.000067 0.000087 0.000007 0.000025 0.000009 0.000334 0.000006 0.000122 0.000015 0.000286 0.000006 0.000059
Nucleus 0.000148 0.000440 0.000174 0.000140 0.000193 0.000874 0.000141 0.000244 0.000188 0.000789 0.000147 0.000177
Peroxisomes 0.058142 0.010440 0.007676 0.008755 0.010996 0.012005 0.013232 0.009864 0.015634 0.011699 0.012287 0.009151
Vacuole 0.003225 0.005398 0.008035 0.011467 0.001875 0.005164 0.002824 0.012525 0.002007 0.005210 0.003710 0.011845
Vacuole Periphery 0.001227 0.003111 0.000734 0.005033 0.001665 0.003889 0.000436 0.004214 0.001622 0.003737 0.000487 0.004741

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.73 -6.92 -6.93 -12.07 0.54 7.78 -12.05 3.57 -2.70 13.28 8.61 -12.76 -1.09 -10.28 12.41
Bud Neck 2.60 -1.50 1.56 -3.01 4.75 4.22 -0.12 -0.96 -3.92 -0.94 4.92 -1.35 0.31 -5.16 1.84
Bud Site 0.67 0.89 0.61 -0.21 -0.61 1.50 4.10 1.54 0.33 -1.61 1.54 3.98 0.97 -0.62 -3.24
Cell Periphery -2.46 -0.99 -0.98 2.14 -0.01 3.33 4.28 5.77 2.94 2.62 2.15 4.08 4.62 2.67 1.19
Cytoplasm -2.06 2.60 1.00 3.49 -2.77 -3.31 3.69 1.88 4.68 -0.81 -3.85 4.34 2.17 6.06 -2.08
Cytoplasmic Foci 3.58 6.71 6.24 6.95 -2.23 -7.61 5.81 -0.29 6.17 -4.80 -5.07 8.28 3.83 10.14 -5.31
Eisosomes -0.90 -2.06 -2.68 -2.12 -0.61 3.49 -4.97 3.67 0.81 6.83 3.34 -5.06 -0.05 -1.86 4.00
Endoplasmic Reticulum -3.09 -2.26 0.15 4.91 4.61 3.61 9.16 7.64 5.20 -1.97 2.41 7.77 8.11 7.63 0.83
Endosome -1.72 2.01 1.56 5.50 -1.23 -6.77 2.76 -8.54 -4.09 -10.13 -7.46 3.22 -5.02 2.27 -8.46
Golgi -3.87 1.67 0.85 6.89 -1.71 -8.82 11.59 -2.96 4.15 -10.70 -9.93 10.84 -0.64 9.47 -11.93
Lipid Particles -4.24 -4.13 -0.84 4.30 4.39 1.32 1.95 -2.87 -3.89 -4.37 -1.10 -0.07 -1.59 -0.57 -1.76
Mitochondria -0.91 1.22 -1.23 0.30 -3.07 -2.39 1.86 -1.48 -0.18 -2.07 -2.44 2.21 -1.70 0.64 -3.22
Mitotic Spindle 1.83 2.08 -0.26 -2.66 -3.06 -2.88 -3.58 -3.00 -2.47 -1.82 -1.93 -2.97 -4.55 -3.88 -2.77
None 1.02 1.04 1.04 2.75 -0.00 -1.08 2.96 -0.14 1.07 -2.30 -0.38 1.17 1.10 1.13 -2.11
Nuclear Periphery -0.51 -0.77 -0.66 0.22 0.08 -0.53 -0.08 -3.89 -2.77 -4.29 -0.91 -0.81 -3.99 -1.85 -4.20
Nuclear Periphery Foci -0.51 0.99 1.12 1.02 0.68 1.44 1.95 0.01 -2.76 -3.90 -0.06 2.02 0.56 0.40 -3.32
Nucleolus -0.32 2.47 1.65 1.10 -1.82 -1.20 1.37 -1.99 0.79 -2.05 -1.23 2.69 -2.09 1.04 -2.52
Nucleus -1.52 -1.19 -0.04 1.52 1.28 -1.31 1.71 -0.74 1.20 -1.22 -1.43 1.36 0.07 1.43 -0.75
Peroxisomes 4.02 4.29 4.23 0.72 -0.57 -0.79 -1.57 0.72 1.38 2.02 2.36 1.97 3.96 2.30 2.62
Vacuole -1.45 -3.47 -4.46 -3.33 -1.80 -3.21 -2.03 -5.51 -3.50 -4.99 -3.66 -3.62 -7.66 -4.68 -6.32
Vacuole Periphery -2.32 1.38 -3.41 -1.49 -4.03 -2.92 2.88 -2.27 -0.26 -3.62 -3.23 2.94 -3.60 -1.06 -5.45
Standard name
Human Ortholog
Description CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog
Localization
Cell Percentages actin (61%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Srv2

Srv2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Srv2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available