Standard name
Human Ortholog
Description CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.33 0.31 0.44 0.52 0.28 0.32 0.22 0.3 0.27 0.22 0.35 0.28 0.41 0.4 0.34 0.31 0.36 0.28 0.63 0.45 0.53 0.57 0.64 0.58
Bud 0.09 0 0.12 0.11 0.16 0.12 0.07 0.07 0.12 0.08 0.06 0.09 0 0.12 0.19 0.07 0.08 0.1 0 0.07 0.07 0 0.06 0.12
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.14 0 0.06 0.08 0 0.06 0.05 0 0.05 0 0.08 0 0.09 0 0.1 0.06 0 0 0 0 0 0 0
Cytoplasm 0.36 0.35 0.23 0.16 0.2 0.19 0.23 0.2 0.22 0.17 0.25 0.16 0.29 0.37 0.34 0.19 0.23 0.22 0 0.17 0 0.08 0 0
Endoplasmic Reticulum 0.11 0.31 0.22 0.25 0.27 0.32 0.21 0.22 0.22 0.18 0.15 0.23 0.06 0.23 0.15 0 0 0 0.08 0.1 0.11 0.05 0.09 0
Endosome 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.06 0.06 0 0.05
Golgi 0.09 0.16 0.17 0.33 0.32 0.26 0.2 0.26 0.14 0.13 0.22 0.16 0.18 0.17 0.26 0.36 0.47 0.54 0.13 0.08 0.07 0 0.06 0
Mitochondria 0.2 0.08 0.16 0.14 0.06 0.34 0.32 0.29 0.43 0.52 0.41 0.46 0.35 0.05 0.19 0.07 0.08 0.13 0 0 0 0.07 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.11 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 0.05 0 0.05 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 15 16 56 74 52 58 64 91 61 62 28 44 7 31 16 94 58 25 50 37 83 18 54 59
Bud 4 1 15 16 30 21 19 22 27 22 5 14 0 9 9 21 13 9 2 6 11 1 5 11
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 1 1 2
Bud Site 1 0 0 1 0 0 2 0 0 3 1 1 0 0 0 2 1 0 – – – – – –
Cell Periphery 1 7 1 9 15 5 18 15 8 15 2 12 0 7 1 31 9 3 1 1 3 0 0 0
Cytoplasm 16 18 30 22 37 34 66 61 51 47 20 25 5 29 16 58 37 20 2 14 5 2 0 3
Endoplasmic Reticulum 5 16 28 35 51 58 60 67 49 52 12 36 1 18 7 11 5 3 6 8 17 1 7 4
Endosome 2 0 5 3 3 1 13 11 5 6 0 3 0 0 0 9 8 2 2 2 9 2 1 5
Golgi 4 8 22 47 59 47 59 78 32 38 18 25 3 13 12 109 76 49 10 6 11 1 4 3
Mitochondria 9 4 20 20 11 62 92 89 97 148 33 73 6 4 9 22 13 12 2 0 3 2 1 2
Nucleus 0 0 0 0 0 0 2 0 1 0 1 0 0 0 0 1 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 2 1 0 0 1 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 4 0 3 3 10 4 3 3 0 0 0 0 0 8 0 2 0 0 0 0 0 1
Peroxisomes 0 0 1 5 2 2 3 0 1 4 2 1 0 2 0 22 3 0 1 0 0 0 0 2
SpindlePole 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 39 18 3 0 0 1 0 3 2
Vac/Vac Membrane 0 0 1 0 4 2 13 16 5 15 1 4 0 0 1 15 12 4 0 2 5 0 0 0
Unique Cell Count 45 51 128 141 187 181 288 302 227 283 81 158 17 78 47 299 162 90 81 84 158 33 85 103
Labelled Cell Count 58 70 183 232 268 293 421 455 340 417 124 238 22 114 71 442 254 132 81 84 158 33 85 103


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.6 15.8 13.5 14.3 15.4 14.2 13.8 14.2 13.9 13.2 13.6 13.9 14.2 15.2 13.8 17.3 20.1 22.3 – 13.1 13.6
Std Deviation (1e-4) 2.9 3.1 3.0 2.8 3.0 3.0 3.8 3.4 3.4 3.5 4.2 4.1 2.6 3.6 3.8 6.0 7.0 7.3 – 3.2 3.3
Intensity Change (Log2) – – – 0.09 0.19 0.07 0.04 0.07 0.04 -0.03 0.01 0.05 0.07 0.17 0.03 0.36 0.58 0.73 – -0.04 0.02

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.4 -2.9 -2.1 -4.5 -2.7 -3.2 -4.5 -1.3 -2.8 -0.2 -0.6 -1.2 -2.4 -1.4 -2.4
Bud -0.1 1.1 0 -1.8 -1.5 0 -1.3 -1.3 -0.8 0 0 1.3 -1.6 -1.1 -0.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 2.9 0 2.5 0 0 0 0 2.8 0 0 0 3.4 0 0
Cytoplasm -1.6 -0.8 -1.0 -0.1 -0.8 -0.2 -1.6 0.2 -1.6 0 2.1 1.4 -0.9 -0.1 -0.2
Endoplasmic Reticulum 0.6 1.1 2.0 -0.2 0.1 -0.1 -0.8 -1.3 0.2 0 0.2 -1.0 -6.0 -5.0 -3.9
Endosome 0 0 0 0.3 0 0 0 0 0 0 0 0 0 0.4 0
Golgi 3.0 2.9 1.8 0.8 1.9 -0.8 -1.0 0.9 -0.3 0 -0.1 1.2 4.0 5.3 5.8
Mitochondria -0.3 -2.9 3.7 3.5 3.0 5.2 7.0 4.1 5.5 0 -2.3 0.6 -2.6 -2.0 -0.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 2.8 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 4.3 3.9 0
Vacuole 0 0 0 0 2.2 0 0 0 0 0 0 0 0 2.7 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.6564 10.9658 10.3493 11.7133 10.011 11.1886 10.104 11.5751 11.1926 10.9646 10.39 10.6406 12.8689 15.189 12.616 12.1203 11.4672 13.0456
Actin 0.6746 0.512 0.7389 0.905 0.8925 0.6986 0.6027 0.596 0.7167 0.8207 0.8334 0.7426 0.7704 0.4409 0.7356 0.7609 0.78 0.8161
Bud 0.0051 0.0069 0.0406 0.0073 0.006 0.0045 0.004 0.0095 0.0455 0.0131 0.0072 0.0045 0.0063 0.0075 0.0371 0.0404 0.0072 0.0025
Bud Neck 0.0049 0.0066 0.0037 0.0022 0.0012 0.0305 0.006 0.007 0.0042 0.0101 0.0003 0.0241 0.0039 0.0103 0.0026 0.0039 0.0022 0.0154
Bud Periphery 0.008 0.0072 0.0613 0.0192 0.0133 0.0068 0.0037 0.0063 0.0465 0.0163 0.0106 0.0049 0.0076 0.0061 0.0356 0.0573 0.0102 0.0026
Bud Site 0.0176 0.1536 0.0399 0.0038 0.0051 0.0051 0.0231 0.1659 0.0797 0.0086 0.0022 0.0098 0.0147 0.1486 0.0617 0.0232 0.0081 0.0031
Cell Periphery 0.0034 0.0092 0.0023 0.0011 0.0006 0.0029 0.0044 0.0045 0.002 0.0056 0.0002 0.0014 0.0024 0.0053 0.0018 0.0013 0.0008 0.0008
Cytoplasm 0.0174 0.1629 0.0145 0.0242 0.0024 0.0444 0.0632 0.1005 0.0183 0.0784 0.0013 0.0426 0.0802 0.2535 0.0469 0.0068 0.0033 0.0219
Cytoplasmic Foci 0.0384 0.0356 0.0209 0.0088 0.0054 0.0236 0.0388 0.0227 0.0124 0.0091 0.0068 0.0293 0.0204 0.0163 0.0229 0.0073 0.0267 0.0279
Eisosomes 0.0021 0.0012 0.0007 0.0005 0.0004 0.0012 0.0014 0.0007 0.0003 0.0003 0.0002 0.0007 0.0022 0.0016 0.0002 0.0003 0.0003 0.0005
Endoplasmic Reticulum 0.0124 0.0023 0.0005 0.0004 0.001 0.0043 0.0229 0.0052 0.009 0.0018 0.0003 0.002 0.0036 0.006 0.0027 0.0004 0.0009 0.0012
Endosome 0.0238 0.0194 0.009 0.0045 0.0158 0.0345 0.0686 0.0145 0.0163 0.0061 0.0429 0.0209 0.0116 0.0363 0.0138 0.0111 0.0327 0.0137
Golgi 0.0696 0.0492 0.0312 0.0208 0.0308 0.1042 0.0865 0.057 0.016 0.0151 0.088 0.1022 0.0515 0.0417 0.0195 0.0132 0.0678 0.0839
Lipid Particles 0.0285 0.0038 0.0029 0.0002 0.0015 0.0019 0.013 0.0029 0.0064 0.0026 0.0013 0.0014 0.0024 0.001 0.0061 0.0375 0.0215 0.0016
Mitochondria 0.0223 0.0156 0.0227 0.0011 0.0208 0.0295 0.0058 0.0015 0.0174 0.0006 0.0035 0.005 0.0086 0.0026 0.0034 0.0208 0.0037 0.0036
None 0.0075 0.0003 0.0002 0.0001 0.0002 0.0018 0.0029 0.0005 0.0004 0.0001 0 0.002 0.0054 0.0003 0.0014 0.0002 0.0026 0.0001
Nuclear Periphery 0.0071 0.0003 0.0001 0.0001 0.0003 0.0005 0.0089 0.0002 0.0009 0.0004 0.0001 0.0001 0.0011 0.004 0.0005 0.0003 0.0024 0.0001
Nucleolus 0.0017 0.0001 0.0002 0 0 0.0001 0.0006 0 0.0001 0.0001 0 0.0003 0 0.0002 0.0001 0.0011 0.0002 0
Nucleus 0.0029 0.0004 0.0002 0 0.0001 0.0003 0.0201 0.0002 0.0003 0.0005 0 0.0002 0.0005 0.0064 0.0003 0.0004 0.0003 0.0001
Peroxisomes 0.0127 0.0099 0.0086 0.0004 0.0009 0.0027 0.0077 0.0033 0.0045 0.001 0.0006 0.0032 0.0058 0.0006 0.0051 0.0087 0.0172 0.0044
Punctate Nuclear 0.018 0.0002 0.0001 0 0.0002 0.0002 0.0059 0.0002 0.0003 0.0002 0 0.0002 0.0003 0.001 0.0008 0.0003 0.0105 0.0001
Vacuole 0.019 0.0028 0.0009 0.0002 0.0009 0.0015 0.0074 0.0012 0.0022 0.0091 0.0004 0.0021 0.001 0.0074 0.0014 0.0035 0.0008 0.0003
Vacuole Periphery 0.003 0.0005 0.0005 0.0001 0.0005 0.001 0.0025 0.0002 0.0006 0.0004 0.0006 0.0003 0.0003 0.0025 0.0003 0.0011 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 170.9893 150.3584 130.0907 150.8286 152.0195 143.691 145.4036 145.6099 141.1244 173.0933
Translational Efficiency 2.0587 1.9454 1.7789 1.6371 1.8727 2.3735 1.7819 1.6108 1.8348 1.6851

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
121 290 474 1044 1109 1191 2313 580 1230 1481 2787 1624

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1147.58 1300.12 1728.28 1607.04 1227.79 1310.19 1628.72 1564.75 1219.90 1308.22 1645.65 1591.94
Standard Deviation 236.03 284.22 300.40 368.09 207.02 277.53 299.49 359.84 211.41 278.88 301.97 365.73
Intensity Change Log 2 — 0.180050 0.590742 0.485811 — 0.093712 0.407675 0.349868 — 0.136069 0.499020 0.417145

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.306256 0.278120 0.560608 0.550250 0.516507 0.398789 0.678114 0.450896 0.495824 0.375160 0.658130 0.514766
Bud Neck 0.015919 0.006428 0.022042 0.010229 0.011007 0.006525 0.011105 0.012555 0.011490 0.006506 0.012965 0.011060
Bud Site 0.160148 0.143356 0.137225 0.144730 0.147698 0.134398 0.114486 0.130169 0.148923 0.136152 0.118353 0.139530
Cell Periphery 0.005970 0.016712 0.008674 0.008709 0.016163 0.010078 0.009026 0.006125 0.015161 0.011377 0.008966 0.007786
Cytoplasm 0.029420 0.047346 0.011913 0.021666 0.029490 0.043831 0.017492 0.020215 0.029483 0.044519 0.016543 0.021147
Cytoplasmic Foci 0.199956 0.109817 0.035127 0.047464 0.055101 0.092192 0.033306 0.056216 0.069351 0.095644 0.033616 0.050590
Eisosomes 0.001755 0.002365 0.003781 0.004530 0.003848 0.002555 0.007881 0.002235 0.003642 0.002517 0.007184 0.003711
Endoplasmic Reticulum 0.007149 0.024721 0.018670 0.006477 0.025450 0.016240 0.005229 0.007424 0.023649 0.017900 0.007515 0.006815
Endosome 0.075608 0.100871 0.049365 0.055422 0.051637 0.079302 0.042247 0.107288 0.053995 0.083525 0.043458 0.073946
Golgi 0.094811 0.168775 0.067772 0.081356 0.088485 0.154713 0.031283 0.115273 0.089107 0.157467 0.037489 0.093469
Lipid Particles 0.027565 0.071795 0.064285 0.033826 0.034565 0.029563 0.027813 0.050695 0.033877 0.037833 0.034016 0.039850
Mitochondria 0.002834 0.005395 0.001318 0.004575 0.003611 0.006520 0.002380 0.007007 0.003534 0.006300 0.002200 0.005443
Mitotic Spindle 0.004534 0.002091 0.001792 0.004655 0.000941 0.001827 0.002726 0.006093 0.001294 0.001878 0.002567 0.005168
None 0.003776 0.000146 0.000064 0.000066 0.000105 0.000863 0.000055 0.000106 0.000466 0.000723 0.000057 0.000080
Nuclear Periphery 0.000071 0.000114 0.000097 0.000096 0.000033 0.000045 0.000033 0.000120 0.000037 0.000058 0.000044 0.000104
Nuclear Periphery Foci 0.001418 0.002472 0.000639 0.000530 0.000621 0.000294 0.000184 0.000614 0.000700 0.000721 0.000261 0.000560
Nucleolus 0.000067 0.000087 0.000007 0.000025 0.000009 0.000334 0.000006 0.000122 0.000015 0.000286 0.000006 0.000059
Nucleus 0.000148 0.000440 0.000174 0.000140 0.000193 0.000874 0.000141 0.000244 0.000188 0.000789 0.000147 0.000177
Peroxisomes 0.058142 0.010440 0.007676 0.008755 0.010996 0.012005 0.013232 0.009864 0.015634 0.011699 0.012287 0.009151
Vacuole 0.003225 0.005398 0.008035 0.011467 0.001875 0.005164 0.002824 0.012525 0.002007 0.005210 0.003710 0.011845
Vacuole Periphery 0.001227 0.003111 0.000734 0.005033 0.001665 0.003889 0.000436 0.004214 0.001622 0.003737 0.000487 0.004741

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.73 -6.92 -6.93 -12.07 0.54 7.78 -12.05 3.57 -2.70 13.28 8.61 -12.76 -1.09 -10.28 12.41
Bud Neck 2.60 -1.50 1.56 -3.01 4.75 4.22 -0.12 -0.96 -3.92 -0.94 4.92 -1.35 0.31 -5.16 1.84
Bud Site 0.67 0.89 0.61 -0.21 -0.61 1.50 4.10 1.54 0.33 -1.61 1.54 3.98 0.97 -0.62 -3.24
Cell Periphery -2.46 -0.99 -0.98 2.14 -0.01 3.33 4.28 5.77 2.94 2.62 2.15 4.08 4.62 2.67 1.19
Cytoplasm -2.06 2.60 1.00 3.49 -2.77 -3.31 3.69 1.88 4.68 -0.81 -3.85 4.34 2.17 6.06 -2.08
Cytoplasmic Foci 3.58 6.71 6.24 6.95 -2.23 -7.61 5.81 -0.29 6.17 -4.80 -5.07 8.28 3.83 10.14 -5.31
Eisosomes -0.90 -2.06 -2.68 -2.12 -0.61 3.49 -4.97 3.67 0.81 6.83 3.34 -5.06 -0.05 -1.86 4.00
Endoplasmic Reticulum -3.09 -2.26 0.15 4.91 4.61 3.61 9.16 7.64 5.20 -1.97 2.41 7.77 8.11 7.63 0.83
Endosome -1.72 2.01 1.56 5.50 -1.23 -6.77 2.76 -8.54 -4.09 -10.13 -7.46 3.22 -5.02 2.27 -8.46
Golgi -3.87 1.67 0.85 6.89 -1.71 -8.82 11.59 -2.96 4.15 -10.70 -9.93 10.84 -0.64 9.47 -11.93
Lipid Particles -4.24 -4.13 -0.84 4.30 4.39 1.32 1.95 -2.87 -3.89 -4.37 -1.10 -0.07 -1.59 -0.57 -1.76
Mitochondria -0.91 1.22 -1.23 0.30 -3.07 -2.39 1.86 -1.48 -0.18 -2.07 -2.44 2.21 -1.70 0.64 -3.22
Mitotic Spindle 1.83 2.08 -0.26 -2.66 -3.06 -2.88 -3.58 -3.00 -2.47 -1.82 -1.93 -2.97 -4.55 -3.88 -2.77
None 1.02 1.04 1.04 2.75 -0.00 -1.08 2.96 -0.14 1.07 -2.30 -0.38 1.17 1.10 1.13 -2.11
Nuclear Periphery -0.51 -0.77 -0.66 0.22 0.08 -0.53 -0.08 -3.89 -2.77 -4.29 -0.91 -0.81 -3.99 -1.85 -4.20
Nuclear Periphery Foci -0.51 0.99 1.12 1.02 0.68 1.44 1.95 0.01 -2.76 -3.90 -0.06 2.02 0.56 0.40 -3.32
Nucleolus -0.32 2.47 1.65 1.10 -1.82 -1.20 1.37 -1.99 0.79 -2.05 -1.23 2.69 -2.09 1.04 -2.52
Nucleus -1.52 -1.19 -0.04 1.52 1.28 -1.31 1.71 -0.74 1.20 -1.22 -1.43 1.36 0.07 1.43 -0.75
Peroxisomes 4.02 4.29 4.23 0.72 -0.57 -0.79 -1.57 0.72 1.38 2.02 2.36 1.97 3.96 2.30 2.62
Vacuole -1.45 -3.47 -4.46 -3.33 -1.80 -3.21 -2.03 -5.51 -3.50 -4.99 -3.66 -3.62 -7.66 -4.68 -6.32
Vacuole Periphery -2.32 1.38 -3.41 -1.49 -4.03 -2.92 2.88 -2.27 -0.26 -3.62 -3.23 2.94 -3.60 -1.06 -5.45
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog
Localization
Cell Percentages actin (61%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Srv2

Srv2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Srv2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available