Standard name
Human Ortholog
Description Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.07 0.28 0.21 0.23 0.19 – 0.23 0.18 0.21 0.23 0 0 0 0.07 0.08 0 0 0 0 0 0 0
Cytoplasm 0.98 1.0 0.99 0.98 0.95 0.92 0.88 – 0.78 0.87 0.81 0.76 0.98 0.99 0.99 0.94 0.96 0.97 0.93 0.96 0.95 0.93 0.91 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0.09 – 0.12 0 0.07 0.11 0 0 0 0 0 0 0 0 0 0 0.05 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0.05 0 0.13 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 7 – 5 4 5 8 0 0 0 0 0 1 0 0 1 1 1 1
Bud 0 1 0 2 2 4 4 – 5 8 1 8 1 4 1 0 0 0 0 0 0 0 0 2
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 4 24 77 80 70 107 – 74 62 45 79 6 27 8 31 17 7 0 0 0 0 1 2
Cytoplasm 42 263 337 266 372 278 487 – 251 307 178 264 541 820 824 410 213 185 58 253 326 400 582 744
Endoplasmic Reticulum 0 0 5 6 16 11 47 – 38 13 16 37 11 7 10 10 9 3 0 1 3 16 30 18
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 2 1 0 0 0 0 0 2 1
Mitochondria 0 1 0 0 0 0 13 – 17 14 28 16 1 1 2 6 1 1 0 1 1 0 2 1
Nucleus 1 0 2 3 0 2 3 – 0 0 1 0 1 0 2 5 7 3 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 2 0 0 0 0 – 1 1 1 11 0 3 5 14 5 4 1 4 3 6 6 6
Unique Cell Count 43 264 341 272 390 301 552 321 352 219 347 551 830 836 435 223 191 63 264 343 431 642 791
Labelled Cell Count 43 269 370 354 470 366 668 391 409 275 423 561 863 853 478 254 204 63 264 343 431 642 791


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.2 13.4 13.5 12.5 13.6 11.3 10.9 – 9.7 9.0 8.6 9.7 13.0 13.1 12.6 16.5 17.3 17.2 11.9 12.7 13.5
Std Deviation (1e-4) 3.4 2.2 1.8 1.6 1.7 1.8 1.6 – 1.7 1.6 1.6 1.5 1.8 2.1 2.3 3.8 4.0 3.6 1.6 1.7 2.0
Intensity Change (Log2) – – – -0.11 0.01 -0.25 -0.31 – -0.47 -0.58 -0.65 -0.47 -0.05 -0.05 -0.1 0.29 0.36 0.35 -0.18 -0.08 0.0


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 7.1 5.2 5.8 5.1 – 5.8 4.2 4.7 5.8 -4.8 -2.9 -5.8 0 0.3 -1.6
Cytoplasm -1.0 -2.7 -4.1 -5.8 – -8.4 -6.0 -7.5 -9.0 -0.7 0 -0.4 -3.3 -2.5 -1.6
Endoplasmic Reticulum 0 2.1 1.8 4.4 – 5.4 1.8 3.5 5.0 0.6 0 0 0.8 1.9 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 4.3 3.7 6.8 4.0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 2.5 0 0 0 2.6 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.5059 9.1961 8.5494 9.3463 8.2086 8.4733 6.003 8.5533 6.8453 6.6417 6.3201 7.4472 6.3073 9.7336 7.9364 7.2607 6.4825 8.4281
Actin 0.0263 0.0105 0.0035 0.001 0.0214 0.0021 0.0152 0.0001 0.0095 0.0001 0.0296 0.0048 0.0258 0.0001 0.0018 0.001 0.0045 0.0002
Bud 0.0008 0.0002 0.0002 0.0003 0.0392 0.0002 0.0008 0.0002 0.0009 0.0003 0.0021 0.0002 0.0005 0.0001 0.0003 0.0022 0.0005 0
Bud Neck 0.0098 0.0003 0.0004 0.0003 0.0018 0.001 0.0035 0.0002 0.0011 0.0002 0.0013 0.0006 0.001 0.0001 0.0002 0.001 0.001 0.0005
Bud Periphery 0.0008 0.0002 0.0001 0.0001 0.0113 0.0002 0.0008 0 0.0006 0 0.0058 0.0003 0.0007 0 0.0001 0.0026 0.0004 0
Bud Site 0.0023 0.0031 0.0005 0.0004 0.0019 0.002 0.0038 0.0015 0.0022 0.0001 0.0031 0.0002 0.0024 0.0001 0.0003 0.0003 0.0011 0
Cell Periphery 0.0008 0.001 0.0003 0.0001 0.0009 0.0001 0.0003 0.0001 0.0001 0 0.0004 0 0.0004 0 0.0001 0.0001 0.0001 0
Cytoplasm 0.7852 0.9616 0.9287 0.9758 0.809 0.9366 0.7925 0.9874 0.8894 0.9382 0.8487 0.953 0.8268 0.9891 0.9507 0.9493 0.894 0.9764
Cytoplasmic Foci 0.0311 0.0051 0.0069 0.0065 0.0234 0.0046 0.0275 0.0031 0.0221 0.0066 0.0074 0.0051 0.0208 0.0011 0.0061 0.0094 0.0196 0.003
Eisosomes 0.0003 0.0001 0 0 0.0001 0 0.0002 0 0.0001 0 0.0003 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.0407 0.0031 0.0092 0.0027 0.0042 0.017 0.0121 0.0012 0.0038 0.0109 0.0046 0.0044 0.0197 0.0066 0.0075 0.0028 0.0022 0.0069
Endosome 0.0235 0.0035 0.0031 0.0056 0.0285 0.0088 0.0644 0.0034 0.0283 0.0231 0.0189 0.0105 0.0296 0.0005 0.0144 0.0144 0.0337 0.0031
Golgi 0.0068 0.0006 0.0013 0.0004 0.022 0.0021 0.0223 0.0002 0.0114 0.0007 0.0223 0.0055 0.0078 0.0001 0.0017 0.0014 0.0093 0.0004
Lipid Particles 0.0083 0.0014 0.0033 0.0001 0.0006 0.0017 0.0082 0 0.0028 0.0003 0.0046 0.0017 0.0167 0 0.0011 0.0002 0.0047 0.0054
Mitochondria 0.0023 0.0009 0.0011 0.0001 0.0051 0.0012 0.0208 0 0.0103 0.0002 0.0353 0.004 0.0039 0 0.0013 0.0042 0.0033 0.0011
None 0.0176 0.0038 0.0016 0.002 0.0245 0.0111 0.0044 0.0011 0.0019 0.0018 0.0037 0.0009 0.012 0.0011 0.0019 0.0016 0.0026 0.0005
Nuclear Periphery 0.0154 0.0003 0.0031 0.0006 0.0007 0.0021 0.0034 0.0001 0.0011 0.002 0.0011 0.0042 0.0078 0.0002 0.0062 0.0007 0.0031 0.0004
Nucleolus 0.0006 0.0001 0.0001 0 0.0002 0.001 0.0002 0 0.0002 0 0.0007 0.0001 0.0008 0 0.0002 0.0002 0.0005 0
Nucleus 0.0042 0.0005 0.0134 0.0009 0.0011 0.0024 0.0031 0.0005 0.0032 0.0012 0.0014 0.0009 0.0031 0.0004 0.0022 0.0017 0.0017 0.0005
Peroxisomes 0.0123 0.0013 0.0217 0.0001 0.0011 0.0004 0.0044 0 0.0044 0 0.0026 0.0016 0.0092 0 0.0002 0.0006 0.0032 0.0007
Punctate Nuclear 0.0062 0.0002 0.0003 0.0002 0.0002 0.004 0.0021 0 0.002 0.0001 0.0004 0.0005 0.006 0 0.0003 0.0002 0.0105 0.0001
Vacuole 0.0037 0.002 0.001 0.0026 0.0023 0.0011 0.0073 0.0009 0.0038 0.0126 0.0037 0.0009 0.0036 0.0003 0.0024 0.0049 0.0032 0.0005
Vacuole Periphery 0.0011 0.0001 0.0002 0.0003 0.0006 0.0003 0.0026 0.0001 0.001 0.0016 0.0017 0.0005 0.0011 0 0.0011 0.0013 0.0008 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.4845 10.8073 14.4968 16.9396 11.756 13.477 15.5504 20.1399 16.2135 19.9744
Translational Efficiency 0.9707 1.3471 1.0548 0.8951 1.2583 1.4506 1.3694 1.0704 1.2808 1.0473

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1153 1299 1914 1651 1363 1882 1881 185 2516 3181 3795 1836

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1172.81 1269.04 1080.02 1097.98 1241.00 1296.24 1214.50 1233.18 1209.75 1285.13 1146.68 1111.60
Standard Deviation 182.30 207.80 668.69 134.88 190.50 205.47 158.05 171.24 189.85 206.86 492.36 144.81
Intensity Change Log 2 — 0.113768 -0.118911 -0.095118 — 0.062830 -0.031141 -0.009120 — 0.087804 -0.073120 -0.050264

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000351 0.000179 0.000422 0.001109 0.000386 0.000375 0.000454 0.003725 0.000370 0.000295 0.000438 0.001373
Bud Neck 0.000410 0.000375 0.002365 0.003293 0.000346 0.000708 0.001090 0.003638 0.000375 0.000572 0.001733 0.003328
Bud Site 0.017970 0.007749 0.012551 0.030717 0.012207 0.015491 0.011407 0.055708 0.014848 0.012330 0.011984 0.033235
Cell Periphery 0.000412 0.000141 0.000054 0.000077 0.000451 0.000207 0.000108 0.000328 0.000433 0.000180 0.000081 0.000102
Cytoplasm 0.886682* 0.896591* 0.812326* 0.649687* 0.889094* 0.864310* 0.801252* 0.578063* 0.887989* 0.877492* 0.806837* 0.642470*
Cytoplasmic Foci 0.059706 0.058281 0.032532 0.050867 0.059970 0.073474 0.057203 0.092307 0.059849 0.067270 0.044760 0.055043
Eisosomes 0.000007 0.000004 0.000009 0.000015 0.000006 0.000010 0.000010 0.000040 0.000006 0.000007 0.000010 0.000018
Endoplasmic Reticulum 0.002949 0.002243 0.000099 0.000411 0.004950 0.001184 0.000278 0.000434 0.004033 0.001617 0.000188 0.000413
Endosome 0.002510 0.002518 0.002178 0.008146 0.002532 0.003155 0.002650 0.020870 0.002522 0.002895 0.002412 0.009428
Golgi 0.005652 0.003533 0.000540 0.005261 0.007188 0.007116 0.000738 0.072632 0.006484 0.005653 0.000638 0.012049
Lipid Particles 0.000816 0.001132 0.000447 0.000939 0.001533 0.001190 0.001006 0.001605 0.001205 0.001166 0.000724 0.001007
Mitochondria 0.000743 0.000172 0.000435 0.001011 0.000337 0.000459 0.000231 0.008909 0.000523 0.000341 0.000334 0.001807
Mitotic Spindle 0.000694 0.000680 0.004768 0.024197 0.001044 0.001116 0.001121 0.012382 0.000884 0.000938 0.002960 0.023007
None 0.000958 0.001374 0.004555 0.000586 0.000807 0.001649 0.000996 0.001103 0.000876 0.001537 0.002791 0.000638
Nuclear Periphery 0.000065 0.000030 0.000053 0.000155 0.000021 0.000010 0.000048 0.000097 0.000041 0.000018 0.000051 0.000149
Nuclear Periphery Foci 0.001174 0.002170 0.000710 0.001619 0.001509 0.000723 0.002966 0.001838 0.001355 0.001314 0.001828 0.001641
Nucleolus 0.000042 0.000078 0.000104 0.000291 0.000035 0.000137 0.000105 0.000046 0.000038 0.000113 0.000105 0.000267
Nucleus 0.003091 0.006128 0.017048 0.015290 0.002978 0.004827 0.011912 0.007262 0.003030 0.005358 0.014503 0.014481
Peroxisomes 0.000232 0.000187 0.001142 0.002258 0.000181 0.000555 0.001068 0.005670 0.000204 0.000405 0.001105 0.002602
Vacuole 0.012103 0.014720 0.107034 0.200304* 0.011084 0.021932 0.105086 0.127395 0.011551 0.018987 0.106068 0.192957
Vacuole Periphery 0.003432 0.001713 0.000628 0.003766 0.003341 0.001372 0.000268 0.005947 0.003382 0.001511 0.000449 0.003986

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.34 0.01 -1.22 -2.20 -1.16 0.14 -0.02 -2.77 -2.77 -2.68 1.55 0.01 -1.84 -2.26 -1.73
Bud Neck 0.64 -7.89 -7.05 -7.13 -0.75 -7.37 -15.30 -5.10 -4.10 -2.81 -5.88 -11.53 -7.89 -7.02 -2.53
Bud Site 7.32 4.69 -0.11 -6.29 -4.18 -3.01 0.97 -3.84 -3.24 -4.01 2.78 4.38 -2.90 -4.55 -5.41
Cell Periphery 9.03 12.43 12.14 9.98 -1.94 5.70 8.35 5.02 0.57 -2.80 9.37 13.58 13.62 14.17 0.60
Cytoplasm -1.48 19.11 32.53 34.86 15.50 4.39 20.30 16.06 14.98 10.44 2.67 27.86 38.29 37.10 19.63
Cytoplasmic Foci 0.33 8.31 5.01 4.62 -4.12 -3.79 0.84 -1.25 0.87 -1.72 -2.91 6.48 5.49 8.39 -0.17
Eisosomes 5.65 -5.17 -7.31 -13.06 -3.55 -4.53 -8.76 -7.12 -5.64 -5.37 -1.61 -9.76 -10.68 -8.91 -5.28
Endoplasmic Reticulum 0.76 3.33 3.17 4.84 -3.51 4.08 5.31 5.27 3.58 -0.59 3.66 6.23 6.10 6.05 -1.98
Endosome -0.08 1.65 -2.94 -3.03 -4.47 -1.94 0.15 -2.38 -2.02 -2.41 -1.45 1.47 -3.82 -3.12 -4.62
Golgi 4.34 13.86 4.99 2.05 -2.87 0.14 17.96 -1.35 -1.36 -2.27 1.81 22.71 3.02 2.02 -3.45
Lipid Particles -2.29 3.56 -0.34 1.93 -3.07 2.09 3.01 -2.38 -3.55 -3.96 0.31 4.38 2.00 1.64 -1.77
Mitochondria 1.11 0.92 0.59 -1.83 -1.09 -0.50 1.15 -1.29 -1.19 -1.43 0.67 1.24 -0.26 -1.20 -2.06
Mitotic Spindle -0.12 -2.86 -5.99 -5.99 -4.15 -0.15 0.05 -2.14 -2.13 -2.15 -0.22 -2.23 -6.23 -6.22 -5.42
None -1.42 -1.74 1.64 4.41 2.24 -2.19 0.28 0.78 2.42 0.35 -2.53 -1.63 2.18 3.95 2.34
Nuclear Periphery 0.63 -0.70 -2.12 -10.31 -6.81 1.53 -6.64 -6.24 -6.75 -4.65 0.90 -1.86 -5.33 -15.15 -9.18
Nuclear Periphery Foci -3.75 3.21 -1.78 2.72 -4.82 5.54 -6.64 -4.17 -7.46 0.71 0.19 -4.18 -1.57 -1.58 2.27
Nucleolus -1.95 -10.19 -3.50 -2.56 -2.12 -1.74 -11.29 -2.10 1.53 7.05 -2.09 -15.41 -3.60 -1.35 -2.09
Nucleus -5.83 -19.43 -21.79 -15.98 0.48 -8.05 -25.06 -5.89 -4.48 2.62 -9.10 -28.66 -23.22 -19.22 -1.77
Peroxisomes 1.94 -3.59 -3.12 -3.26 -1.04 -7.95 -1.74 -2.26 -1.85 -1.47 -6.89 -3.05 -3.78 -3.03 -1.32
Vacuole -1.98 -34.64 -41.76 -40.77 -13.81 -7.26 -34.53 -14.22 -13.68 -7.85 -6.97 -48.72 -44.31 -42.70 -18.07
Vacuole Periphery 1.69 3.81 2.03 0.21 -2.07 3.07 4.96 1.57 -0.06 -1.19 3.31 6.14 2.71 -0.02 -2.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Npr1

Npr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Npr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available