ORF
Human Ortholog
Description Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0.07 0.07 0.12 0 0 0 – – – 0.08 0 0 0 0 0
Bud – 0 0 0 0 0 0 0.05 0 0.06 0.06 0.06 0 0 0 – – – 0.14 0 0 0.05 0 0
Bud Neck – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 0.07 0.07 0.11 0.2 0 0 0 – – – 0.19 0 0 0.07 0 0.05
Cytoplasm – 0.96 0.99 0.99 0.95 0.92 0.81 0.75 0.74 0.57 0.56 0.55 0.97 0.97 0.94 – – – 0.18 0.79 0.74 0.61 0.68 0.67
Endoplasmic Reticulum – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria – 0 0 0 0.07 0.19 0.29 0.32 0.35 0.42 0.46 0.47 0 0 0 – – – 0.08 0.06 0.1 0.13 0.13 0.08
Nucleus – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0.15 0 0 0 0.05 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 1 1 0 0 0 3 13 9 15 15 32 0 7 9 – – – 4 5 7 6 3 8
Bud – 1 0 0 6 6 12 23 11 13 12 15 0 3 2 – – – 6 9 5 15 4 11
Bud Neck – 1 2 4 7 15 5 5 4 3 3 4 1 1 5 – – – 1 3 1 5 5 4
Bud Site – 1 1 0 0 1 1 2 2 1 0 2 0 0 0 – – – – – – – – –
Cell Periphery – 5 0 3 3 2 9 18 26 15 22 52 7 13 15 – – – 9 4 7 22 8 18
Cytoplasm – 329 274 291 307 361 352 381 260 125 117 141 303 504 437 – – – 9 284 202 195 213 239
Endoplasmic Reticulum – 1 1 0 0 0 1 0 0 1 4 1 0 0 3 – – – 1 2 0 4 4 4
Endosome – 0 0 0 0 0 0 0 0 0 0 0 0 2 1 – – – 1 3 2 1 4 3
Golgi – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 – – – 1 2 1 0 2 1
Mitochondria – 11 4 8 24 73 125 162 121 91 95 121 1 0 2 – – – 4 23 26 42 41 27
Nucleus – 0 0 1 0 1 5 1 0 1 1 1 3 2 0 – – – 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 2 6 2 4 3 0 0 0 – – – 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 – – – 0 0 0 2 0 0
Peroxisomes – 0 0 0 0 0 2 7 4 3 1 5 1 1 5 – – – 0 0 0 0 0 0
SpindlePole – 2 2 1 4 4 12 11 8 9 9 10 0 4 4 – – – 0 5 4 1 3 6
Vac/Vac Membrane – 1 0 1 0 0 0 6 3 2 1 4 0 0 2 – – – 7 5 2 14 14 27
Unique Cell Count 342 278 293 322 393 433 509 349 218 208 256 313 521 464 51 360 273 320 314 358
Labelled Cell Count 353 285 309 351 463 527 631 454 281 284 392 316 537 486 51 360 273 320 314 358


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 3.9 3.0 3.1 3.1 2.8 2.7 2.9 3.0 3.0 3.2 3.8 5.2 5.0 5.2 4.7 4.7 4.8 5.7 5.4 6.0
Std Deviation (1e-4) – 1.0 1.0 1.8 1.4 0.9 1.5 1.3 1.6 1.7 2.2 2.9 3.5 2.3 1.6 1.9 1.5 1.6 3.4 1.8 5.4
Intensity Change (Log2) – – – 0.01 0.01 -0.11 -0.15 -0.09 -0.0 -0.01 0.09 0.31 0.76 0.73 0.77 0.64 0.63 0.65 0.9 0.84 0.97

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.4991 -0.1176 0.2674 -0.7069 0.2817 0.0625 1.2018 2.9323 2.0741 2.6855 1.8363 1.8366 -1.8353 0.0869 -0.8227 -0.3651 -1.4648 -0.7649
Actin 0.0358 0.0125 0.0338 0.0042 0.042 0.0054 0.0397 0.0118 0.0192 0.0593 0.0162 0.0023 0.0101 0.0096 0.0011 0.0015 0.0011 0.0067
Bud 0.0026 0.0045 0.0086 0.0276 0.003 0.0077 0.0049 0.0152 0.0071 0.0039 0.0052 0.0114 0.006 0.0029 0.0021 0.0093 0.0006 0.0044
Bud Neck 0.002 0.0007 0.0013 0.0002 0.0008 0.0033 0.0042 0.002 0.001 0.0176 0.0001 0.0015 0.0003 0.0011 0.0011 0.0198 0.0146 0.001
Bud Periphery 0.0108 0.0195 0.0259 0.006 0.0077 0.033 0.0308 0.0442 0.0132 0.0551 0.0337 0.0402 0.0195 0.0111 0.0148 0.0504 0.009 0.023
Bud Site 0.0093 0.0221 0.0216 0.002 0.0025 0.0013 0.0153 0.0803 0.0278 0.0142 0.0009 0.0063 0.0112 0.0614 0.0149 0.0104 0.0155 0.0022
Cell Periphery 0.0049 0.0121 0.0182 0.0003 0.0002 0.0149 0.0084 0.0592 0.0372 0.0423 0.0322 0.0373 0.0131 0.0394 0.0372 0.0695 0.0114 0.0422
Cytoplasm 0.0438 0.0412 0.0296 0.0241 0.0132 0.0442 0.0342 0.0449 0.0444 0.0377 0.0122 0.0659 0.035 0.0775 0.0619 0.1032 0.0648 0.0715
Cytoplasmic Foci 0.0293 0.0089 0.0285 0.0088 0.0141 0.0105 0.0265 0.0039 0.0216 0.0149 0.0323 0.0082 0.0148 0.0021 0.0051 0.0043 0.0064 0.0025
Eisosomes 0.0067 0.0028 0.0013 0.0002 0.0002 0.0009 0.0014 0.0024 0.0006 0.0012 0.0005 0.0004 0.0032 0.0048 0.0007 0.0008 0.001 0.0019
Endoplasmic Reticulum 0.0064 0.0011 0.0044 0.0006 0.0047 0.0022 0.0044 0.0008 0.0021 0.0022 0.0007 0.0007 0.001 0.0007 0.0008 0.0009 0.0009 0.0028
Endosome 0.024 0.0037 0.0188 0.0038 0.0382 0.0064 0.0183 0.0005 0.0176 0.0036 0.0077 0.0032 0.0023 0.0001 0.0007 0.0005 0.0017 0.0004
Golgi 0.0101 0.0024 0.0072 0.0065 0.0369 0.0029 0.0045 0.0003 0.0083 0.0054 0.0051 0.0005 0.0051 0.0001 0.0002 0.0002 0.0001 0.0001
Lipid Particles 0.0278 0.0037 0.0068 0.0046 0.0063 0.0011 0.0075 0.0004 0.0082 0.0026 0.0117 0.0005 0.0023 0.0002 0.0005 0.0003 0.0011 0.0002
Mitochondria 0.0212 0.004 0.0158 0.0097 0.0104 0.0088 0.0083 0.0015 0.005 0.006 0.0036 0.0006 0.0019 0.0002 0.0008 0.0008 0.0005 0.0007
None 0.6932 0.853 0.7442 0.8858 0.7854 0.8478 0.7597 0.7186 0.7601 0.7114 0.7936 0.8079 0.8679 0.7861 0.8486 0.7245 0.8673 0.8352
Nuclear Periphery 0.0198 0.0003 0.0025 0.0004 0.004 0.0007 0.008 0.0003 0.0012 0.0005 0.0002 0.0006 0.0003 0.0002 0.0003 0.0003 0.0009 0.0003
Nucleolus 0.0028 0.0002 0.0023 0.0009 0.0002 0.001 0.0004 0.0011 0.0006 0.0009 0.0001 0.0002 0.0003 0.0002 0.0013 0.0005 0.0002 0.0002
Nucleus 0.0179 0.0006 0.0067 0.0035 0.0007 0.0019 0.0017 0.002 0.0008 0.001 0.0002 0.0006 0.0003 0.0004 0.0009 0.0006 0.0005 0.0007
Peroxisomes 0.0093 0.0051 0.0108 0.0093 0.004 0.0033 0.0143 0.0013 0.0107 0.0162 0.0424 0.0015 0.0023 0.0001 0.0004 0.0003 0.0004 0.0001
Punctate Nuclear 0.0067 0.0005 0.0078 0.0005 0.0011 0.0009 0.0018 0.0013 0.0013 0.0019 0.0009 0.0006 0.0024 0.0011 0.0057 0.0005 0.0008 0.0021
Vacuole 0.012 0.0008 0.003 0.0009 0.0131 0.0011 0.0036 0.0073 0.0114 0.0019 0.0003 0.0089 0.0005 0.0006 0.0007 0.0013 0.001 0.0017
Vacuole Periphery 0.0037 0.0001 0.0009 0.0003 0.0114 0.0005 0.0021 0.0006 0.0006 0.0002 0.0001 0.0007 0.0001 0 0.0001 0.0001 0.0002 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression – – – – – – – – – –
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression –
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2267 1701 1455 1217 2225 1864 1676 1480 4492 3565 3131 2697

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 648.63 667.37 741.20 789.44 663.11 681.30 767.21 827.38 655.80 674.65 755.12 810.26
Standard Deviation 69.63 86.82 107.59 134.70 78.71 85.29 90.66 126.39 74.62 86.31 99.74 131.56
Intensity Change Log 2 — 0.041091 0.192467 0.283434 — 0.039042 0.210373 0.319302 — 0.040056 0.201547 0.301677

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000428 0.001165 0.006954 0.007812 0.002269 0.005758 0.004470 0.009329 0.001340 0.003567 0.005625 0.008645
Bud Neck 0.028848 0.050865 0.019248 0.007029 0.027407 0.059505 0.007986 0.011445 0.028134 0.055382 0.013220 0.009453
Bud Site 0.007451 0.014464 0.040360 0.041065 0.026898 0.028915 0.025114 0.056227 0.017083 0.022020 0.032199 0.049385
Cell Periphery 0.000572 0.001446 0.005737 0.000339 0.004548 0.002087 0.003289 0.006123 0.002542 0.001781 0.004426 0.003513
Cytoplasm 0.435156 0.378673 0.341337 0.440856 0.430943 0.346574 0.370335 0.445222 0.433069 0.361890 0.356859 0.443252
Cytoplasmic Foci 0.233634 0.235671 0.028716 0.023653 0.202442 0.275834 0.009890 0.017890 0.218184 0.256671 0.018639 0.020491
Eisosomes 0.000822 0.001100 0.000655 0.000097 0.001366 0.001569 0.000809 0.001875 0.001091 0.001345 0.000737 0.001073
Endoplasmic Reticulum 0.000911 0.000648 0.001996 0.002007 0.001849 0.000666 0.002348 0.001354 0.001375 0.000658 0.002184 0.001649
Endosome 0.013693 0.016217 0.001637 0.010358 0.011939 0.028068 0.001260 0.001925 0.012824 0.022413 0.001435 0.005731
Golgi 0.004312 0.004081 0.000500 0.007478 0.003086 0.008723 0.000105 0.000393 0.003705 0.006508 0.000289 0.003590
Lipid Particles 0.015716 0.009209 0.006100 0.001320 0.014378 0.013535 0.000817 0.001012 0.015053 0.011471 0.003272 0.001151
Mitochondria 0.009164 0.016828 0.001439 0.006793 0.009475 0.025805 0.000614 0.001398 0.009318 0.021522 0.000997 0.003832
Mitotic Spindle 0.003872 0.003185 0.001248 0.077229 0.002092 0.005929 0.005700 0.012967 0.002990 0.004620 0.003631 0.041965
None 0.003194 0.001858 0.014099 0.007480 0.003322 0.001794 0.004766 0.005405 0.003257 0.001825 0.009103 0.006341
Nuclear Periphery 0.000362 0.000387 0.000805 0.001924 0.000564 0.000326 0.001863 0.001197 0.000462 0.000355 0.001371 0.001525
Nuclear Periphery Foci 0.000155 0.000136 0.000515 0.001453 0.000166 0.000216 0.000304 0.000465 0.000161 0.000178 0.000402 0.000911
Nucleolus 0.001382 0.001418 0.000788 0.000780 0.001519 0.001576 0.000459 0.000458 0.001450 0.001501 0.000612 0.000603
Nucleus 0.179683 0.167798 0.503643 0.239435 0.192405 0.101619 0.528249 0.345741 0.185985 0.133196 0.516815 0.297772
Peroxisomes 0.009981 0.017102 0.002909 0.002871 0.008356 0.024873 0.000581 0.001587 0.009176 0.021165 0.001663 0.002166
Vacuole 0.049626 0.076531 0.021173 0.112943 0.053618 0.064204 0.030800 0.076986 0.051603 0.070086 0.026326 0.093211
Vacuole Periphery 0.001038 0.001216 0.000142 0.007077 0.001359 0.002423 0.000241 0.001000 0.001197 0.001847 0.000195 0.003742

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.51 -4.02 -2.11 -1.57 1.56 -2.60 -0.76 -2.08 0.27 -1.39 -3.14 -3.73 -3.07 -0.74 0.23
Bud Neck -7.60 4.37 14.88 17.53 5.80 -10.14 12.32 10.98 16.89 -1.34 -12.63 11.06 17.70 23.96 3.69
Bud Site -3.97 -7.95 -5.36 -2.59 3.49 -0.57 2.58 -1.62 -1.22 -3.82 -2.49 -4.01 -4.43 -2.55 -0.37
Cell Periphery -1.21 -4.06 1.24 1.94 4.54 1.94 1.82 0.88 -0.94 -0.85 1.08 -1.23 0.86 -0.11 2.06
Cytoplasm 7.02 11.57 7.36 1.37 -2.66 10.39 11.95 5.10 -4.04 -5.66 12.41 16.67 8.76 -1.96 -5.97
Cytoplasmic Foci -0.41 42.32 46.93 41.42 5.40 -10.74 44.84 42.77 47.80 -5.72 -7.99 61.70 63.39 63.03 1.37
Eisosomes -0.49 0.84 3.32 2.09 5.03 -0.38 1.87 0.71 1.02 -0.94 -0.66 2.01 1.72 2.00 -0.05
Endoplasmic Reticulum 1.46 -1.92 -7.39 -10.43 -0.83 3.88 -2.08 -0.67 -10.45 2.00 4.07 -2.95 -4.80 -14.70 0.56
Endosome -1.93 15.80 8.35 8.52 -5.02 -10.86 15.61 14.89 19.84 -2.16 -9.58 22.26 16.05 20.64 -5.40
Golgi 0.49 8.77 1.37 1.06 -2.90 -7.58 13.05 11.61 11.95 -1.56 -5.63 13.83 4.78 8.60 -3.05
Lipid Particles 6.12 7.08 16.29 12.62 4.10 0.67 18.49 18.14 14.09 -3.52 4.49 15.57 24.12 18.63 3.81
Mitochondria -4.29 8.34 4.70 7.63 -2.21 -7.47 8.13 7.60 13.08 -3.23 -8.58 11.70 8.95 15.02 -2.78
Mitotic Spindle 0.51 2.25 -8.96 -9.14 -9.66 -2.81 -2.16 -3.94 -1.53 -2.00 -1.68 -0.39 -9.61 -8.76 -9.41
None 2.05 -6.20 -2.76 -4.10 4.62 2.67 -1.72 -1.28 -4.16 -0.05 3.32 -6.39 -2.79 -5.73 4.27
Nuclear Periphery -0.92 -12.81 -13.49 -13.30 -10.42 3.86 -4.01 -12.59 -17.00 0.71 3.01 -5.26 -18.31 -19.82 -3.37
Nuclear Periphery Foci 1.22 -2.35 -5.37 -5.47 -2.14 -1.00 -7.37 -5.99 -3.40 -2.14 -0.74 -3.74 -7.27 -6.50 -2.64
Nucleolus -0.30 2.23 2.50 3.42 0.61 0.02 3.54 3.51 6.81 0.03 -0.20 4.24 4.39 7.08 0.56
Nucleus 2.05 -36.22 -14.70 -15.33 17.83 17.35 -44.84 -22.63 -34.14 16.82 13.51 -57.46 -26.79 -34.91 24.17
Peroxisomes -5.26 7.03 9.56 13.33 1.93 -9.36 11.21 9.74 14.56 -1.68 -10.59 12.49 13.64 19.49 0.91
Vacuole -8.71 10.78 -20.72 -16.21 -23.97 -3.49 1.13 -15.13 -12.81 -15.15 -8.61 6.47 -25.38 -20.34 -27.68
Vacuole Periphery -1.65 12.70 -2.22 -2.03 -3.28 -4.64 9.33 2.80 5.72 -1.46 -5.01 14.30 -1.07 0.46 -3.58
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

YNL194C

YNL194C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ynl194c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available