Standard name
Human Ortholog
Description Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0.07 0.07 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.09 0.06 0.05 0.06 0.05 0 0.05 0 0.06 0.18 0.16 0.06 0.05 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.13 0 0 0 0 0.09 0.24 0.17 0.28 0.22 0.27 0.14 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.89 0.89 0.93 0.89 0.84 0.84 0.72 0.77 0.74 0.74 0.72 0.75 0.89 0.8 0.81 0.84 0.89 0.89 0.84 0.82 0.83 0.71 0.67 0.66
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.33 0.33 0.08 0.14 0.08 0.19 0.3 0.25 0.33 0.32 0.36 0.31 0 0.05 0 0.09 0.12 0.17 0.08 0.1 0.1 0.18 0.17 0.21
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0
Bud 0 0 0 0 0 0 1 3 1 3 3 0 1 0 0 1 0 1 1 0 1 1 3 3
Bud Neck 0 0 0 0 0 0 0 4 1 2 1 2 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 1 1 1 4 13 11 19 18 10 15 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 3 6 8 23 15 15 18 13 7 16 13 15 51 41 20 16 8 1 1 1 3 1 3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 1 0 1 0 1 0 0 3 3 2 0 0 0 1 1 1
Endosome 0 0 2 0 0 1 0 0 0 0 0 0 0 2 2 2 2 1 1 0 0 1 3 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 0 0 0 1 0
Mitochondria 25 2 3 7 4 23 77 51 79 54 81 44 5 0 1 5 4 8 0 0 1 1 1 2
Nucleus 165 100 194 169 227 211 232 232 210 182 218 233 229 234 204 302 279 237 158 94 186 153 176 189
Nuclear Periphery 2 0 1 0 1 1 1 0 3 2 2 0 1 1 1 4 2 0 1 0 0 1 0 0
Nucleolus 61 37 17 27 22 48 95 74 94 79 109 97 10 14 9 33 39 46 14 11 22 39 43 61
Peroxisomes 0 0 1 0 1 0 0 0 0 0 0 0 0 0 1 4 0 1 0 0 0 0 0 0
SpindlePole 0 0 6 1 3 3 3 2 0 5 1 4 2 4 5 6 1 0 1 1 0 2 4 6
Vac/Vac Membrane 0 0 0 0 4 1 1 2 1 1 2 3 4 3 1 9 2 3 2 4 6 5 21 12
Unique Cell Count 186 112 208 189 270 251 321 301 284 245 303 312 256 291 253 360 315 265 188 115 224 216 264 288
Labelled Cell Count 257 142 231 213 286 307 438 397 422 353 444 411 268 309 265 390 348 309 188 115 224 216 264 288


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 8.2 6.8 6.5 7.8 5.9 5.4 5.6 5.5 5.6 5.3 5.8 7.6 8.1 7.9 11.5 11.1 10.8 8.2 8.1 8.7
Std Deviation (1e-4) 1.1 1.8 1.2 1.3 2.9 1.7 1.5 1.4 1.8 2.2 2.0 1.6 2.4 3.0 2.9 2.7 3.0 3.0 2.4 3.0 2.3
Intensity Change (Log2) – – – -0.06 0.2 -0.21 -0.33 -0.28 -0.32 -0.29 -0.36 -0.23 0.16 0.24 0.22 0.76 0.7 0.66 0.26 0.26 0.35


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 2.5 0 3.4 3.6 0 2.8 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 2.6 1.6 1.0 1.6 1.0 0 1.3 0.8 1.5 5.1 4.7 1.5 1.2 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.6 7.1 5.6 7.8 6.6 7.6 4.9 0 0 0 0 0 0
Nucleus -1.4 -3.1 -3.0 -6.0 -4.9 -5.5 -5.4 -6.0 -5.4 -1.4 -4.1 -3.9 -3.2 -1.8 -1.5
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.9 0 3.3 5.9 4.8 6.5 6.2 7.2 6.2 -2.0 -1.5 -2.1 0.4 1.5 2.9
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 -0.6 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5393 2.1365 2.0515 1.3547 1.0507 1.6778 3.6333 3.15 3.2052 3.0275 3.1049 3.1071 3.5728 2.4575 2.2809 2.65 3.0535 2.5559
Actin 0.0106 0.0017 0.0009 0 0.0435 0 0.0112 0 0.0017 0 0.0043 0 0.0103 0 0.0051 0.0068 0.0057 0.0019
Bud 0.0004 0.0001 0 0 0.0004 0 0.0003 0 0.0001 0 0.0003 0 0.0003 0 0.0003 0.0002 0.0003 0
Bud Neck 0.001 0.0004 0.0003 0.0001 0.0006 0.0004 0.0013 0 0.0005 0 0.0013 0.0003 0.0008 0 0.0005 0.0004 0.0005 0.0004
Bud Periphery 0.0009 0.0001 0.0001 0.0001 0.0016 0 0.001 0 0.0002 0 0.001 0 0.0005 0 0.0007 0.0003 0.0008 0.0001
Bud Site 0.0073 0.0024 0.0003 0.0002 0.0007 0 0.0011 0 0.0007 0 0.0012 0 0.0021 0 0.0006 0.0005 0.0007 0.0001
Cell Periphery 0.0005 0 0 0.0001 0.0003 0 0.0005 0 0.0001 0 0.0003 0 0.0002 0 0.0002 0 0.0002 0
Cytoplasm 0.0051 0.0001 0.0069 0.0014 0.0003 0.0004 0.0013 0 0.0011 0 0.0004 0 0.0032 0 0.0011 0.0001 0.0001 0.0002
Cytoplasmic Foci 0.0031 0.0001 0.0035 0.0016 0.0048 0 0.0054 0 0.0027 0 0.0048 0.0002 0.0113 0 0.0009 0.0069 0.0026 0.0016
Eisosomes 0.0003 0 0 0 0.0006 0 0.0002 0 0.0001 0 0.0001 0 0.0002 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0041 0 0.0005 0.0005 0.0006 0 0.0011 0 0.0009 0 0.0008 0 0.0012 0 0.0009 0.0001 0.0003 0.0004
Endosome 0.0154 0 0.0043 0.0219 0.0102 0.0003 0.0094 0 0.0039 0 0.0057 0.0004 0.0145 0 0.003 0.0027 0.0079 0.0039
Golgi 0.0023 0.0001 0.0008 0.0038 0.0075 0 0.002 0 0.0007 0 0.0027 0.0002 0.0044 0 0.0011 0.0046 0.0071 0.001
Lipid Particles 0.0032 0 0.0042 0.0003 0.0158 0 0.0164 0 0.0059 0 0.0085 0.0028 0.0163 0 0.0009 0.0107 0.0155 0.0021
Mitochondria 0.0031 0 0.0017 0.0035 0.0114 0.0001 0.0062 0 0.0015 0 0.0023 0.0007 0.0058 0 0.0114 0.0024 0.0136 0.0003
None 0.0032 0 0.0006 0.0005 0.0008 0.0007 0.0066 0 0.0014 0 0.0006 0 0.002 0 0.0004 0.0002 0.0003 0.0002
Nuclear Periphery 0.016 0.0006 0.0079 0.0041 0.0054 0.0031 0.0072 0.0008 0.0066 0.0003 0.0119 0.0005 0.011 0.0007 0.0024 0.001 0.0029 0.0049
Nucleolus 0.0464 0.0167 0.019 0.0299 0.0737 0.0996 0.0423 0.027 0.0152 0.0189 0.1592 0.0877 0.043 0.0203 0.0274 0.0137 0.1664 0.0913
Nucleus 0.857 0.9758 0.937 0.9256 0.7812 0.8923 0.8628 0.9668 0.9503 0.98 0.7766 0.9037 0.8556 0.967 0.9318 0.8961 0.7679 0.8844
Peroxisomes 0.0005 0 0.0036 0.0001 0.0228 0 0.0028 0 0.0023 0 0.0021 0.0005 0.0041 0 0.0007 0.0114 0.003 0.004
Punctate Nuclear 0.0146 0.0018 0.0075 0.0042 0.0138 0.0027 0.0166 0.0053 0.0023 0.0008 0.013 0.0026 0.0107 0.0118 0.0082 0.0417 0.0023 0.0026
Vacuole 0.0031 0 0.0005 0.0011 0.002 0.0001 0.0032 0 0.0011 0 0.0022 0.0001 0.0015 0 0.0014 0.0001 0.0009 0.0002
Vacuole Periphery 0.0018 0 0.0006 0.0007 0.0021 0.0001 0.0012 0 0.0008 0 0.0009 0 0.0008 0 0.001 0.0001 0.0011 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3.4374 10.2427 9.8807 10.8602 9.6563 17.1775 8.2851 11.8828 15.5068 11.2695
Translational Efficiency 18.8806 4.8403 5.2498 6.1947 5.2606 3.6386 4.8019 3.7165 3.1135 4.3552

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
82 489 1853 1544 1109 2256 1200 832 1191 2745 3053 2376

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 925.12 922.60 1122.62 1122.49 835.20 912.58 1083.77 1146.49 841.39 914.36 1107.35 1130.89
Standard Deviation 141.24 176.36 168.30 180.97 132.96 139.04 159.94 200.68 135.48 146.44 166.15 188.45
Intensity Change Log 2 — -0.003935 0.279157 0.278990 — 0.127829 0.375865 0.457030 — 0.060084 0.325850 0.366206

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000460 0.000970 0.000787 0.000891 0.000622 0.000420 0.000777 0.001568 0.000611 0.000518 0.000783 0.001128
Bud Neck 0.002886 0.013874 0.029111 0.024979 0.009383 0.011049 0.016574 0.026964 0.008936 0.011553 0.024183 0.025674
Bud Site 0.000323 0.002970 0.001381 0.001954 0.001286 0.001638 0.000965 0.004926 0.001220 0.001875 0.001218 0.002995
Cell Periphery 0.000018 0.000206 0.000039 0.000069 0.000084 0.000076 0.000030 0.000114 0.000079 0.000099 0.000035 0.000084
Cytoplasm 0.000029 0.001138 0.000157 0.001512 0.001531 0.000949 0.000090 0.001478 0.001428 0.000982 0.000131 0.001500
Cytoplasmic Foci 0.000016 0.000877 0.000016 0.000766 0.001430 0.000513 0.000013 0.001858 0.001333 0.000578 0.000015 0.001148
Eisosomes 0.000037 0.000049 0.000058 0.000043 0.000037 0.000055 0.000058 0.000045 0.000037 0.000054 0.000058 0.000043
Endoplasmic Reticulum 0.002326 0.003123 0.001294 0.001901 0.002808 0.003015 0.001906 0.001957 0.002775 0.003034 0.001534 0.001921
Endosome 0.000042 0.001148 0.000049 0.000693 0.000578 0.000804 0.000053 0.002854 0.000541 0.000865 0.000051 0.001449
Golgi 0.000049 0.000377 0.000110 0.001316 0.000334 0.000365 0.000087 0.002596 0.000314 0.000367 0.000101 0.001764
Lipid Particles 0.000035 0.000196 0.000016 0.000059 0.000498 0.000134 0.000025 0.000354 0.000466 0.000145 0.000019 0.000162
Mitochondria 0.000534 0.001283 0.001549 0.002795 0.002127 0.001424 0.001041 0.005359 0.002017 0.001399 0.001349 0.003693
Mitotic Spindle 0.000068 0.002822 0.000689 0.006790 0.003217 0.004258 0.001054 0.016395 0.003000 0.004002 0.000833 0.010153
None 0.000776 0.005429 0.001449 0.001722 0.001913 0.001989 0.001064 0.006936 0.001835 0.002602 0.001298 0.003548
Nuclear Periphery 0.000031 0.000135 0.000125 0.001208 0.000199 0.000392 0.000084 0.001176 0.000188 0.000346 0.000109 0.001197
Nuclear Periphery Foci 0.000029 0.000656 0.000029 0.000545 0.000326 0.000244 0.000044 0.000561 0.000305 0.000318 0.000035 0.000551
Nucleolus 0.059313 0.082861 0.059442 0.040185 0.076526 0.064068 0.056289 0.047178 0.075341 0.067416 0.058203 0.042634
Nucleus 0.932107* 0.878945* 0.902356* 0.907206* 0.895442* 0.906162* 0.918443* 0.868889* 0.897966* 0.901314* 0.908679* 0.893789*
Peroxisomes 0.000743 0.001217 0.000932 0.000675 0.000863 0.000632 0.000974 0.001643 0.000855 0.000736 0.000949 0.001014
Vacuole 0.000109 0.001297 0.000236 0.002498 0.000457 0.001113 0.000294 0.004138 0.000433 0.001146 0.000259 0.003072
Vacuole Periphery 0.000070 0.000425 0.000174 0.002195 0.000340 0.000700 0.000133 0.003013 0.000321 0.000651 0.000158 0.002482

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.77 -8.35 -9.11 -0.40 -1.85 3.24 -3.11 -5.72 -7.10 -4.89 1.65 -4.22 -7.07 -10.04 -5.23
Bud Neck -6.40 -26.74 -19.45 -6.82 1.89 -1.60 -7.90 -11.72 -11.21 -7.29 -2.98 -18.84 -17.54 -15.92 -3.16
Bud Site -3.07 -12.84 -7.24 1.14 -1.94 -0.52 0.87 -4.34 -3.94 -4.88 -1.42 -0.65 -4.58 -2.77 -5.27
Cell Periphery -2.72 -4.68 -5.98 1.88 -3.63 0.48 2.93 -1.47 -2.85 -6.67 -0.85 2.53 -0.53 0.56 -6.94
Cytoplasm -3.32 -3.27 -2.39 -0.79 -2.20 0.65 2.60 0.39 -0.49 -6.15 0.61 2.54 0.11 -0.61 -3.30
Cytoplasmic Foci -1.25 -1.27 -1.52 0.42 -1.50 1.53 2.33 0.71 -1.21 -2.61 1.38 2.32 1.16 -0.37 -2.69
Eisosomes -2.51 -6.37 -1.60 1.70 9.34 -6.24 -9.46 -5.66 0.45 2.49 -6.63 -12.55 -4.87 2.99 8.87
Endoplasmic Reticulum -2.34 3.86 1.35 4.17 -6.22 -0.70 4.19 1.05 1.72 -2.87 -1.06 7.04 3.46 4.87 -5.98
Endosome -1.19 -1.56 -2.74 0.64 -2.65 -0.80 2.25 -1.77 -1.38 -2.83 -1.05 2.25 -1.21 -0.14 -3.78
Golgi -2.44 -9.99 -1.92 -1.18 -1.74 -0.14 2.16 -2.16 -2.07 -2.64 -0.30 1.91 -2.24 -2.06 -2.87
Lipid Particles -1.77 1.32 -1.24 1.48 -2.06 1.25 1.66 0.65 -1.27 -2.37 1.19 1.68 1.22 0.10 -2.82
Mitochondria -6.46 -13.57 -11.07 -7.17 -5.49 0.92 1.39 -2.36 -3.57 -4.05 0.87 0.72 -2.21 -5.36 -6.02
Mitotic Spindle -2.06 -4.21 -5.58 -3.22 -4.89 -0.30 1.94 -5.18 -5.14 -6.05 -0.37 1.99 -5.62 -5.71 -7.73
None -2.40 -1.77 -4.05 1.75 -1.39 -0.03 2.51 -2.12 -2.11 -2.76 -1.29 1.60 -1.95 -0.75 -3.14
Nuclear Periphery -4.72 -10.91 -3.67 -3.30 -3.27 -1.44 3.36 -5.87 -4.23 -6.49 -1.43 2.14 -4.82 -3.78 -5.15
Nuclear Periphery Foci -1.57 -0.49 -2.45 0.50 -2.41 0.57 3.32 -0.82 -1.31 -3.52 -0.07 3.43 -0.75 -0.64 -3.58
Nucleolus -2.35 -0.97 1.25 6.86 5.86 3.33 4.07 1.64 -0.91 -1.77 2.25 2.95 5.55 4.34 3.49
Nucleus 4.90 4.57 4.07 -1.75 -0.50 -2.21 -3.61 6.60 8.52 9.43 -0.84 -0.36 4.34 6.04 5.94
Peroxisomes -2.83 -3.31 -0.14 3.22 4.47 1.24 -0.85 -3.58 -5.01 -3.58 0.72 -1.41 -1.56 -3.35 -0.48
Vacuole -2.58 -8.59 -3.30 -0.92 -2.97 -2.07 0.57 -3.87 -3.04 -3.99 -2.51 0.79 -4.52 -2.79 -4.89
Vacuole Periphery -3.63 -12.94 -3.13 -2.37 -2.89 -1.83 3.21 -1.89 -1.37 -2.15 -2.00 2.61 -3.23 -2.32 -3.61
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Ies2

Ies2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ies2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available