Standard name
Human Ortholog
Description Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0.14 0 0.15 0.14 0.14 0.22
Bud 0 0 – – – 0 – 0 – – – 0.06 0 0 0.05 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0.05 0 0 0.07 0 0.06
Bud Site 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – – – 0.05 – 0 – – – 0 0 0 0 0.05 0.1 0.09 0.1 0.12 0.05 0.14 0.13 0.17
Cytoplasm 0.89 0.96 – – – 0.84 – 0.75 – – – 0.59 0.97 0.97 0.98 0.84 0.79 0.84 0.34 0.53 0.36 0.41 0.47 0.29
Endoplasmic Reticulum 0 0 – – – 0 – 0 – – – 0 0 0 0 0.08 0 0.07 0 0 0 0 0 0
Endosome 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Golgi 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 – – – 0.19 – 0.32 – – – 0.58 0 0 0 0.05 0 0.06 0.22 0.12 0.36 0.12 0.12 0.15
Nucleus 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.07 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0
Vac/Vac Membrane 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 – – – 0 – 0 – – – 1 0 3 1 4 3 3 31 2 5 17 26 55
Bud 0 0 – – – 1 – 3 – – – 5 1 5 10 6 2 1 1 1 0 1 3 3
Bud Neck 4 0 – – – 0 – 0 – – – 1 1 0 0 4 2 0 10 1 0 8 6 15
Bud Site 0 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 7 2 – – – 2 – 4 – – – 2 5 1 7 9 10 10 22 9 2 16 24 42
Cytoplasm 168 45 – – – 31 – 69 – – – 47 134 233 216 139 79 90 74 43 14 50 88 75
Endoplasmic Reticulum 1 2 – – – 1 – 2 – – – 0 0 0 0 13 1 7 9 0 0 1 1 4
Endosome 0 0 – – – 0 – 1 – – – 0 0 0 0 3 5 1 5 2 0 4 2 4
Golgi 1 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 1 0 0 0 2 1
Mitochondria 1 0 – – – 7 – 29 – – – 46 2 2 6 8 1 6 47 9 13 14 21 38
Nucleus 4 0 – – – 0 – 0 – – – 1 0 0 0 1 2 0 0 0 0 0 0 0
Nuclear Periphery 13 0 – – – 0 – 0 – – – 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – – – 0 – 0 – – – 0 0 0 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 – – – 0 – 0 – – – 0 0 1 0 0 2 2 0 0 0 0 0 1
SpindlePole 1 0 – – – 0 – 1 – – – 3 0 0 0 6 5 7 1 0 0 1 0 0
Vac/Vac Membrane 0 1 – – – 0 – 0 – – – 0 1 0 0 2 6 0 6 1 0 2 4 7
Unique Cell Count 189 47 37 92 79 138 241 221 165 100 107 218 81 39 123 186 257
Labelled Cell Count 201 50 42 109 106 144 245 240 195 119 127 218 81 39 123 186 257


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 3.9 – – – 3.2 – 3.1 – – – 2.8 3.9 4.2 3.7 5.8 6.9 6.0 4.1 4.2 4.6
Std Deviation (1e-4) 0.7 1.3 – – – 1.0 – 1.2 – – – 1.5 1.1 1.1 1.2 2.1 4.6 2.0 1.3 1.6 1.5
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP220RAP380RAP7000510HU80HU120HU1600510rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.6489 2.0495 1.9582 1.5822 1.1377 1.9796 0.8998 1.1158 1.3226 1.1211 0.64 1.4084 0.8708 1.3901 1.4039 1.0057 0.8307 1.7512
Actin 0.0015 0.0024 0.0146 0.0009 0.0002 0.0022 0.0593 0.0079 0.0086 0.0009 0.0067 0.001 0.1362 0.0073 0.0017 0.0034 0.0002 0.007
Bud 0.0028 0.0006 0.0009 0.0003 0 0.0001 0.0003 0.0019 0.0005 0.0003 0.0002 0 0.0029 0.0063 0.0008 0.0001 0 0.0005
Bud Neck 0.0055 0.0016 0.0179 0.0035 0.0003 0.0027 0.0104 0.0021 0.0106 0.0048 0.0386 0.0024 0.0013 0.001 0.0041 0.0163 0.0001 0.0231
Bud Periphery 0.0061 0.0017 0.0048 0.001 0.0002 0.0003 0.0009 0.0035 0.0017 0.0003 0.0012 0.0001 0.0071 0.0314 0.0019 0.0004 0 0.0022
Bud Site 0.0419 0.0354 0.0155 0.0021 0.0001 0.0001 0.0068 0.0377 0.0397 0.0026 0.0022 0.0001 0.1063 0.0667 0.0095 0.0005 0 0.0004
Cell Periphery 0.0141 0.0128 0.0194 0.0096 0.0027 0.0014 0.0043 0.0142 0.0096 0.003 0.0091 0.0005 0.0027 0.0025 0.0038 0.0047 0.0001 0.0019
Cytoplasm 0.4795 0.4997 0.5406 0.6041 0.4284 0.6051 0.1446 0.3903 0.4141 0.3909 0.3603 0.5256 0.1795 0.2677 0.179 0.3131 0.2766 0.3482
Cytoplasmic Foci 0.0199 0.0093 0.005 0.0056 0.0013 0.0058 0.0208 0.011 0.0123 0.0245 0.0393 0.0127 0.0471 0.0084 0.0053 0.0218 0.0024 0.0038
Eisosomes 0.0017 0.0005 0.0006 0.0002 0.0002 0.0002 0.0008 0.0008 0.0005 0.0003 0.0006 0 0.0005 0.0008 0.0006 0.0014 0 0.0003
Endoplasmic Reticulum 0.0034 0.005 0.0031 0.0035 0.0013 0.0019 0.0094 0.0018 0.0024 0.0051 0.0007 0.001 0.013 0.002 0.0023 0.0026 0.0006 0.0012
Endosome 0.0029 0.0009 0.0004 0.0011 0.0001 0.0009 0.0147 0.0052 0.0076 0.018 0.0003 0.0111 0.0238 0.0005 0.0228 0.0007 0.0004 0.0016
Golgi 0.0013 0.0005 0.0005 0.0004 0 0.0002 0.0138 0.0005 0.0144 0.0025 0.0005 0.002 0.015 0.0003 0.0006 0.0005 0 0.0002
Lipid Particles 0.0054 0.001 0.0009 0.0012 0.0002 0.0007 0.0345 0.0004 0.0014 0.0005 0.0002 0.0054 0.1236 0.0004 0.0017 0.0008 0 0.0001
Mitochondria 0.0017 0.0002 0.0003 0.0002 0 0.0001 0.0024 0.0002 0.0037 0.0003 0.0002 0.0013 0.0028 0.0008 0.0004 0.0002 0.0001 0.0002
None 0.4042 0.4253 0.3731 0.3637 0.5642 0.3771 0.6385 0.5181 0.4596 0.5417 0.5377 0.4121 0.2917 0.6011 0.7348 0.632 0.7189 0.6079
Nuclear Periphery 0.0002 0.0003 0.0002 0.0002 0.0001 0.0001 0.0164 0.0002 0.0004 0.0003 0 0.0126 0.0012 0.0002 0.0007 0.0002 0.0001 0.0001
Nucleolus 0.0009 0.0002 0.0001 0.0001 0.0001 0.0001 0.0014 0.0001 0.0005 0.0001 0.0001 0.0003 0.0008 0.0003 0.0003 0.0001 0 0.0001
Nucleus 0.0012 0.0006 0.0005 0.0004 0.0002 0.0003 0.0086 0.0005 0.0013 0.0006 0.0002 0.0042 0.0006 0.0004 0.0006 0.0003 0.0001 0.0003
Peroxisomes 0.003 0.0001 0.0002 0.0001 0 0.0001 0.0082 0.0003 0.0069 0.0003 0.001 0.0026 0.0387 0.0009 0.0003 0.0002 0 0.0001
Punctate Nuclear 0.0009 0.0004 0.0004 0.0002 0 0.0002 0.0017 0.0002 0.0005 0.0003 0.0004 0.0041 0.004 0.0005 0.0006 0.0003 0.0001 0.0001
Vacuole 0.0018 0.0016 0.0011 0.0015 0.0006 0.0004 0.0016 0.003 0.0035 0.0023 0.0005 0.0004 0.0009 0.0005 0.0272 0.0005 0.0003 0.0005
Vacuole Periphery 0.0001 0 0 0.0001 0 0 0.0005 0.0001 0.0002 0.0002 0 0.0003 0.0004 0 0.001 0 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.6696 11.4944 12.8931 18.7919 16.8649 15.8396 21.6898 21.6167 18.1873 24.4824
Translational Efficiency 0.2215 0.432 0.3582 0.2663 0.2956 0.3537 0.284 0.2117 0.3218 0.2658

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1988 14 134 154 1408 1086 304 60 3396 1100 438 214

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 629.26 725.54 988.14 875.26 639.17 728.95 913.67 843.57 633.37 728.91 936.45 866.37
Standard Deviation 72.58 116.56 107.91 86.80 84.08 93.13 87.64 93.64 77.71 93.46 100.36 89.90
Intensity Change Log 2 — 0.205399 0.651059 0.476055 — 0.189620 0.515473 0.400308 — 0.197469 0.584329 0.438383

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000317 0.000440 0.011834 0.017636 0.001901 0.002642 0.001854 0.016105 0.000974 0.002614 0.004907 0.017207
Bud Neck 0.026452 0.009283 0.009381 0.011132 0.038914 0.047336 0.007610 0.005310 0.031619 0.046852 0.008152 0.009500
Bud Site 0.009083 0.004873 0.040347 0.047430 0.009586 0.022444 0.021271 0.013632 0.009292 0.022220 0.027107 0.037954
Cell Periphery 0.000446 0.000329 0.005039 0.001054 0.001160 0.000879 0.001678 0.003747 0.000742 0.000872 0.002706 0.001809
Cytoplasm 0.481395 0.369352 0.168000 0.282833 0.438316 0.405812 0.228263 0.402019 0.463535 0.405348 0.209827 0.316249
Cytoplasmic Foci 0.171274 0.363071 0.088867 0.092434 0.251376 0.249435 0.061185 0.125098 0.204485 0.250881 0.069654 0.101592
Eisosomes 0.000761 0.000219 0.001203 0.000537 0.003738 0.001481 0.000566 0.002802 0.001995 0.001465 0.000761 0.001172
Endoplasmic Reticulum 0.000980 0.000571 0.024780 0.003403 0.002352 0.001106 0.007624 0.002049 0.001549 0.001099 0.012872 0.003023
Endosome 0.010332 0.014986 0.009961 0.015474 0.009786 0.020591 0.004829 0.008476 0.010106 0.020520 0.006399 0.013512
Golgi 0.002203 0.005184 0.000396 0.001008 0.007165 0.010174 0.000245 0.000701 0.004260 0.010111 0.000291 0.000922
Lipid Particles 0.011343 0.020853 0.010277 0.005947 0.022903 0.013525 0.008814 0.007003 0.016136 0.013618 0.009261 0.006243
Mitochondria 0.005234 0.025031 0.000301 0.004397 0.007316 0.010356 0.004838 0.000314 0.006097 0.010543 0.003450 0.003253
Mitotic Spindle 0.001017 0.000557 0.000216 0.005530 0.000181 0.012215 0.000591 0.001845 0.000670 0.012066 0.000477 0.004497
None 0.006215 0.016656 0.000428 0.000765 0.002398 0.002631 0.001557 0.000836 0.004633 0.002809 0.001212 0.000785
Nuclear Periphery 0.000338 0.000370 0.001536 0.000829 0.000301 0.000404 0.001242 0.000545 0.000323 0.000404 0.001332 0.000750
Nuclear Periphery Foci 0.000246 0.000538 0.008195 0.002128 0.000361 0.000529 0.002302 0.001031 0.000294 0.000529 0.004105 0.001821
Nucleolus 0.001305 0.003602 0.000488 0.000467 0.001290 0.001429 0.000487 0.000223 0.001299 0.001457 0.000487 0.000398
Nucleus 0.211216 0.085599 0.351085 0.143145 0.147695 0.120434 0.512333 0.168934 0.184880 0.119991 0.463001 0.150376
Peroxisomes 0.005011 0.020470 0.002310 0.024271 0.017921 0.022018 0.001836 0.023626 0.010364 0.021999 0.001981 0.024090
Vacuole 0.054095 0.056378 0.265133 0.336736 0.034470 0.052381 0.130626 0.215496 0.045959 0.052432 0.171776 0.302743
Vacuole Periphery 0.000735 0.001637 0.000225 0.002843 0.000871 0.002179 0.000247 0.000210 0.000791 0.002172 0.000241 0.002105

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin NaN NaN NaN NaN NaN -0.79 0.34 -1.29 -1.19 -1.32 -1.86 -2.66 -1.85 -1.50 -1.23
Bud Neck NaN NaN NaN NaN NaN -1.97 10.71 12.67 12.32 1.80 -4.18 13.55 13.47 11.16 0.32
Bud Site NaN NaN NaN NaN NaN -4.80 -1.59 -0.91 2.33 0.81 -5.16 -3.08 -2.81 -0.72 -0.63
Cell Periphery NaN NaN NaN NaN NaN 2.12 -1.63 -1.05 -1.22 -0.82 -1.14 -4.72 -1.40 -1.12 1.49
Cytoplasm NaN NaN NaN NaN NaN 3.33 18.19 2.29 1.32 -4.09 6.78 28.76 10.32 6.80 -3.78
Cytoplasmic Foci NaN NaN NaN NaN NaN 0.25 25.86 7.17 6.96 -3.14 -6.69 25.10 12.62 15.30 -2.08
Eisosomes NaN NaN NaN NaN NaN 4.93 7.49 1.05 -0.43 -1.07 1.98 6.05 2.29 1.16 -0.59
Endoplasmic Reticulum NaN NaN NaN NaN NaN 2.71 -5.58 -0.02 -2.91 5.63 1.75 -10.31 -5.39 -6.42 7.66
Endosome NaN NaN NaN NaN NaN -6.57 5.13 0.71 4.51 -1.13 -6.60 4.52 0.11 3.96 -1.34
Golgi NaN NaN NaN NaN NaN -2.29 14.76 12.01 7.77 -1.11 -4.77 15.32 11.95 7.93 -1.82
Lipid Particles NaN NaN NaN NaN NaN 6.39 6.79 8.49 4.08 0.93 2.32 4.91 8.91 6.12 1.91
Mitochondria NaN NaN NaN NaN NaN -1.76 1.19 6.23 7.54 0.98 -3.06 1.62 3.01 4.72 0.27
Mitotic Spindle NaN NaN NaN NaN NaN -5.05 -1.27 -1.03 3.51 -0.81 -4.80 0.59 -1.74 3.06 -1.90
None NaN NaN NaN NaN NaN -0.31 1.70 2.84 2.11 1.17 2.02 6.05 7.03 2.60 1.00
Nuclear Periphery NaN NaN NaN NaN NaN -1.32 -14.72 -3.02 -1.94 4.72 -1.09 -17.14 -7.36 -5.26 3.47
Nuclear Periphery Foci NaN NaN NaN NaN NaN -1.32 -7.40 -3.78 -0.87 4.57 -1.62 -10.57 -5.03 -3.07 3.62
Nucleolus NaN NaN NaN NaN NaN -0.38 1.54 2.04 3.98 3.60 -0.65 3.48 3.88 3.62 1.40
Nucleus NaN NaN NaN NaN NaN 4.30 -21.39 -1.79 -2.65 8.48 11.51 -19.19 0.89 -3.37 14.16
Peroxisomes NaN NaN NaN NaN NaN -1.80 11.28 -0.05 0.31 -1.49 -6.08 12.10 -0.78 1.30 -2.37
Vacuole NaN NaN NaN NaN NaN -6.17 -12.24 -7.04 -6.41 -2.58 -2.35 -16.04 -15.53 -15.15 -7.25
Vacuole Periphery NaN NaN NaN NaN NaN -3.07 4.20 4.05 4.76 0.05 -3.42 6.57 -0.45 1.13 -1.16
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p
Localization
Cell Percentages cytoplasm (16%), ER (5%), mixed (41%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sip3

Sip3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sip3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available