Standard name
Human Ortholog
Description Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.3 0.2 0.18 0.16 0.06 0.08 0.05 0.05 0.05 0.05 0 0 – – – 0.15 0.2 0.18 0.26 0.15 0.32 0.23 0.2 0.22
Bud 0.13 0.16 0.11 0.11 0.13 0.12 0.08 0.06 0.08 0.09 0.07 0.06 – – – 0.07 0.05 0.09 0.17 0.19 0.13 0.36 0.21 0.29
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0.1 0.14 0.1 0.09 0.12 0.06
Bud Site 0.05 0.1 0.06 0 0.05 0 0 0 0 0 0 0 – – – 0 0.08 0 – – – – – –
Cell Periphery 0.06 0 0.09 0.05 0 0 0 0 0.05 0.05 0.07 0.05 – – – 0.05 0 0.06 0 0 0 0 0 0
Cytoplasm 0.53 0.55 0.53 0.56 0.53 0.5 0.48 0.47 0.4 0.37 0.4 0.35 – – – 0.67 0.6 0.58 0.32 0.34 0.25 0.08 0.25 0.21
Endoplasmic Reticulum 0 0 0 0.05 0 0.05 0 0.05 0 0.05 0 0 – – – 0.05 0 0.06 0 0 0.07 0 0.07 0
Endosome 0.05 0 0.09 0.06 0.13 0.08 0.05 0.05 0 0 0 0 – – – 0 0 0 0 0 0 0.07 0 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.07 0 0.07 0.05 0.25 0.36 0.33 0.46 0.54 0.55 0.59 – – – 0.06 0.09 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0.05 0 0.14 0.1 0.13 0.07 0.05 0 0 0 0 0 – – – 0 0.06 0 0 0 0 0 0 0
SpindlePole 0 0 0.05 0 0.06 0 0 0 0 0 0 0 – – – 0.08 0.1 0.09 0 0 0 0.05 0 0
Vac/Vac Membrane 0 0 0 0 0.05 0.05 0 0.08 0.09 0.06 0.06 0.05 – – – 0 0 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 117 69 50 30 15 33 22 23 21 29 19 20 – – – 49 64 36 129 60 107 5 8 8
Bud 52 55 29 21 32 48 35 30 34 48 31 35 – – – 24 17 17 83 76 43 9 9 11
Bud Neck 2 1 0 3 1 3 1 1 2 0 1 1 – – – 2 6 1 47 55 33 2 5 2
Bud Site 19 33 16 8 13 12 16 13 9 12 7 14 – – – 9 25 6 – – – – – –
Cell Periphery 25 8 24 10 4 11 16 13 19 29 31 27 – – – 18 9 11 5 2 6 0 0 0
Cytoplasm 209 186 146 104 129 207 213 234 166 207 171 189 – – – 223 197 116 157 137 83 2 10 8
Endoplasmic Reticulum 13 10 8 10 3 22 13 23 16 27 19 23 – – – 17 8 11 16 7 22 0 3 0
Endosome 20 13 26 12 32 33 22 25 17 11 11 15 – – – 10 12 6 21 17 11 1 0 2
Golgi 10 0 4 3 1 1 0 4 2 0 0 0 – – – 5 9 3 10 4 3 0 0 1
Mitochondria 10 24 5 14 11 101 160 164 187 303 236 316 – – – 20 28 2 5 12 7 0 1 0
Nucleus 2 0 1 0 0 2 0 2 0 1 0 1 – – – 1 3 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 4 4 2 2 2 3 – – – 0 0 0 1 0 0 1 0 0
Nucleolus 1 6 2 2 4 10 17 14 7 13 10 13 – – – 0 0 2 0 1 0 0 0 0
Peroxisomes 18 15 39 19 32 28 24 17 10 13 9 15 – – – 12 19 6 1 0 1 0 0 0
SpindlePole 13 7 13 7 15 7 10 11 7 7 7 15 – – – 25 32 17 6 10 5 1 0 1
Vac/Vac Membrane 9 7 6 1 12 21 13 38 36 36 24 28 – – – 14 8 11 1 12 1 0 1 0
Unique Cell Count 396 340 275 187 244 411 440 497 410 559 432 539 333 327 199 492 405 332 25 43 40
Labelled Cell Count 520 434 369 244 304 539 566 616 535 738 578 715 429 437 245 492 405 332 25 43 40


Ambiguous, Bud, Bud Neck, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.3 7.9 8.2 8.0 7.6 6.8 6.4 6.7 6.5 5.9 6.1 5.9 – – – 7.0 7.7 9.8 – – –
Std Deviation (1e-4) 1.2 1.1 1.7 1.5 1.1 1.3 1.3 1.3 1.3 1.2 1.7 1.2 – – – 1.2 1.4 1.7 – – –
Intensity Change (Log2) – – – -0.03 -0.12 -0.27 -0.35 -0.29 -0.33 -0.49 -0.44 -0.47 – – – -0.23 -0.1 0.25 – – –

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT30510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT10510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.6 -4.1 -4.0 -5.7 -6.2 -5.5 -6.0 -6.0 -7.0 – – – -1.2 0.4 0
Bud 0.2 0.9 0.5 -1.2 -2.3 -1.0 -0.9 -1.6 -2.0 – – – -1.5 -2.5 -0.7
Bud Neck 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud Site -0.7 -0.2 -1.9 -1.4 -2.2 -2.5 -2.8 -3.1 -2.3 – – – -1.9 0.9 -1.4
Cell Periphery -1.4 -3.6 -3.5 -2.9 -3.8 -2.2 -2.0 -0.8 -2.1 – – – -1.6 -3.2 -1.3
Cytoplasm 0.5 -0.1 -0.7 -1.2 -1.6 -3.2 -4.4 -3.5 -4.9 – – – 3.5 1.8 1.1
Endoplasmic Reticulum 1.3 -1.3 1.5 0 1.2 0.7 1.3 1.0 1.0 – – – 1.4 -0.4 1.4
Endosome -1.2 1.3 -0.7 -2.3 -2.4 -2.8 -4.9 -4.0 -4.1 – – – -3.4 -2.9 -2.8
Golgi 0 0 0 0 0 0 0 0 0 – – – 0 1.1 0
Mitochondria 3.0 1.8 8.1 10.7 10.0 12.5 14.7 14.4 15.7 – – – 2.6 3.6 0
Nucleus 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Nucleolus 0 0 0 2.5 2.0 0 0 0 1.7 – – – 0 0 0
Peroxisomes -1.3 -0.4 -3.2 -4.0 -5.5 -5.8 -6.7 -6.2 -6.2 – – – -4.7 -3.5 -4.1
SpindlePole -0.5 0.7 -2.3 -1.8 -1.9 -2.3 -3.1 -2.4 -1.4 – – – 1.4 2.4 1.7
Vacuole 0 1.7 1.9 0.6 3.1 3.5 2.6 2.2 2.0 – – – 1.4 0.2 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9474 5.0397 4.5419 4.3737 4.1666 4.534 5.3884 6.4863 6.3069 5.0048 6.0436 6.5267 6.6377 7.0366 6.8366 6.6628 6.562 6.9565
Actin 0.148 0.0822 0.1435 0.0887 0.1688 0.1276 0.1617 0.0407 0.155 0.1945 0.2781 0.1172 0.2191 0.0695 0.1575 0.195 0.2429 0.1676
Bud 0.043 0.0208 0.1364 0.1055 0.0415 0.006 0.0411 0.0283 0.1351 0.0654 0.0478 0.0077 0.0323 0.0475 0.1413 0.0779 0.0384 0.0075
Bud Neck 0.0356 0.0078 0.0072 0.0041 0.0044 0.4356 0.0547 0.0092 0.0152 0.0036 0.0728 0.4882 0.035 0.0054 0.012 0.0191 0.0724 0.493
Bud Periphery 0.0542 0.021 0.1371 0.1438 0.0374 0.0042 0.0509 0.0162 0.1782 0.123 0.0703 0.008 0.0492 0.0343 0.2018 0.1358 0.0718 0.0127
Bud Site 0.1399 0.35 0.0702 0.0136 0.0116 0.0097 0.1702 0.3382 0.0886 0.0732 0.0231 0.012 0.1417 0.3257 0.0978 0.0227 0.0282 0.0064
Cell Periphery 0.0048 0.0034 0.0032 0.0019 0.0009 0.0008 0.0034 0.0032 0.0019 0.0048 0.0017 0.0009 0.0052 0.0013 0.0023 0.0018 0.0019 0.0018
Cytoplasm 0.3429 0.4141 0.3425 0.4662 0.4462 0.2041 0.2948 0.4485 0.315 0.2878 0.3354 0.1881 0.381 0.4453 0.296 0.433 0.4079 0.1877
Cytoplasmic Foci 0.0691 0.0416 0.0309 0.0454 0.1236 0.1166 0.0952 0.0453 0.0405 0.0701 0.0531 0.1073 0.0569 0.0238 0.0435 0.0459 0.0444 0.0704
Eisosomes 0.0004 0.0002 0.0002 0.0001 0.0001 0.0004 0.0005 0.0001 0.0002 0.0007 0.0003 0.0002 0.0005 0.0001 0.0002 0.0002 0.0002 0.0003
Endoplasmic Reticulum 0.0299 0.0059 0.0057 0.0093 0.0076 0.0086 0.0069 0.0023 0.0025 0.0044 0.0121 0.0023 0.0131 0.0047 0.0023 0.003 0.0034 0.0036
Endosome 0.0495 0.0182 0.0393 0.0465 0.0707 0.0297 0.0394 0.0133 0.0202 0.0231 0.0197 0.0148 0.0167 0.0191 0.0139 0.021 0.0413 0.0123
Golgi 0.0271 0.0115 0.0232 0.0244 0.0408 0.0323 0.0257 0.0073 0.0125 0.0129 0.0322 0.0113 0.0191 0.0058 0.0131 0.0194 0.0205 0.0132
Lipid Particles 0.0063 0.0013 0.0024 0.001 0.0149 0.0021 0.0078 0.0007 0.001 0.0065 0.0097 0.0024 0.0023 0.0005 0.0005 0.0004 0.0002 0.0007
Mitochondria 0.0034 0.0037 0.012 0.007 0.0077 0.0029 0.0108 0.0011 0.0032 0.0443 0.003 0.0068 0.0028 0.0011 0.0039 0.0042 0.0029 0.0014
None 0.0239 0.0021 0.0204 0.0011 0.0025 0.003 0.0092 0.0135 0.0153 0.0157 0.0078 0.0087 0.0126 0.0034 0.003 0.0058 0.0144 0.003
Nuclear Periphery 0.004 0.0008 0.0015 0.003 0.0008 0.0005 0.0013 0.0003 0.0005 0.0017 0.0009 0.0026 0.0008 0.0027 0.0006 0.0007 0.0006 0.0002
Nucleolus 0.0017 0.0007 0.0009 0.0002 0.0002 0.0002 0.0005 0.0092 0.0004 0.0011 0.0098 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001 0.0002
Nucleus 0.0027 0.0016 0.0015 0.0023 0.0008 0.0006 0.0013 0.0039 0.0008 0.002 0.0017 0.0011 0.0008 0.0014 0.001 0.0009 0.0006 0.0004
Peroxisomes 0.0045 0.0077 0.0081 0.0131 0.0137 0.0098 0.016 0.0041 0.0086 0.051 0.0142 0.0175 0.0073 0.0027 0.0053 0.0072 0.0022 0.0109
Punctate Nuclear 0.0039 0.0013 0.0027 0.0008 0.0017 0.0031 0.0036 0.0011 0.0016 0.0034 0.0039 0.0011 0.0008 0.0008 0.0009 0.0008 0.0005 0.0051
Vacuole 0.0046 0.0037 0.0086 0.0183 0.0028 0.0017 0.0044 0.0133 0.0031 0.0092 0.002 0.001 0.0023 0.0039 0.0025 0.0039 0.0043 0.0012
Vacuole Periphery 0.0007 0.0004 0.0025 0.0037 0.0011 0.0005 0.0006 0.0004 0.0007 0.0017 0.0004 0.0005 0.0003 0.0007 0.0005 0.0011 0.001 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 35.0863 19.9006 24.0768 30.6741 32.628 39.1782 28.7605 26.866 31.2839 39.7773
Translational Efficiency 0.7898 0.7387 0.6787 0.6884 0.5889 0.6626 0.5248 0.6201 0.5956 0.5566

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2399 1440 644 1724 1318 98 2921 2171 3717 1538 3565 3895

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1004.74 925.40 1172.36 1097.62 884.59 981.39 1083.34 1113.45 962.14 928.97 1099.42 1106.44
Standard Deviation 110.19 179.81 136.64 152.13 125.14 122.93 144.63 143.79 129.20 177.26 147.25 147.75
Intensity Change Log 2 — -0.118673 0.222593 0.127556 — 0.149818 0.292405 0.331956 — 0.013271 0.255700 0.226870

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.016551 0.021168 0.066610 0.022510 0.019724 0.019543 0.018394 0.017585 0.017676 0.021065 0.027104 0.019765
Bud Neck 0.056245 0.043489 0.033183 0.025302 0.097431 0.058349 0.045119 0.034396 0.070849 0.044436 0.042963 0.030371
Bud Site 0.427248 0.384889 0.474530 0.295841 0.423026 0.354530 0.432168 0.312805 0.425751 0.382954 0.439820 0.305296
Cell Periphery 0.000306 0.000983 0.001063 0.000432 0.002630 0.002738 0.000302 0.000272 0.001130 0.001095 0.000439 0.000343
Cytoplasm 0.418955 0.272657 0.223411 0.485764 0.268686 0.291614 0.437956 0.513879 0.365672 0.273865 0.399200 0.501435
Cytoplasmic Foci 0.017229 0.151240 0.093230 0.057653 0.097712 0.137898 0.020863 0.038457 0.045767 0.150390 0.033935 0.046954
Eisosomes 0.000078 0.000368 0.000204 0.000130 0.001102 0.000795 0.000074 0.000091 0.000441 0.000395 0.000097 0.000108
Endoplasmic Reticulum 0.000125 0.001989 0.001343 0.000571 0.002176 0.001897 0.000266 0.000218 0.000853 0.001983 0.000461 0.000374
Endosome 0.006080 0.032823 0.013759 0.005846 0.024960 0.040805 0.002379 0.004845 0.012775 0.033332 0.004435 0.005288
Golgi 0.002757 0.028259 0.005339 0.002947 0.018660 0.021193 0.001337 0.003120 0.008396 0.027808 0.002060 0.003044
Lipid Particles 0.000190 0.004919 0.004460 0.002148 0.001930 0.002129 0.000532 0.000725 0.000807 0.004741 0.001242 0.001355
Mitochondria 0.001670 0.004474 0.000133 0.001856 0.007336 0.000945 0.000477 0.001319 0.003679 0.004249 0.000415 0.001557
Mitotic Spindle 0.008250 0.004978 0.003834 0.011457 0.001141 0.001487 0.004403 0.009499 0.005730 0.004755 0.004300 0.010365
None 0.000080 0.001698 0.000096 0.000156 0.000184 0.000227 0.000183 0.000094 0.000117 0.001605 0.000168 0.000122
Nuclear Periphery 0.000018 0.000056 0.000044 0.000131 0.000038 0.000034 0.000030 0.000050 0.000025 0.000055 0.000032 0.000086
Nuclear Periphery Foci 0.000048 0.000985 0.002461 0.000725 0.000336 0.000350 0.000107 0.000240 0.000150 0.000945 0.000532 0.000455
Nucleolus 0.000041 0.000559 0.000036 0.000083 0.000089 0.000101 0.000041 0.000099 0.000058 0.000530 0.000040 0.000092
Nucleus 0.001243 0.003580 0.003447 0.006192 0.001498 0.002483 0.005730 0.003474 0.001334 0.003510 0.005318 0.004677
Peroxisomes 0.016195 0.020447 0.023517 0.012256 0.011182 0.015089 0.011047 0.013598 0.014418 0.020105 0.013299 0.013004
Vacuole 0.025861 0.017566 0.048943 0.066457 0.017469 0.043387 0.018401 0.044312 0.022885 0.019211 0.023918 0.054114
Vacuole Periphery 0.000828 0.002873 0.000355 0.001543 0.002691 0.004406 0.000194 0.000922 0.001489 0.002970 0.000223 0.001197

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.81 -7.27 -1.40 0.64 6.73 0.03 0.87 1.57 0.45 0.87 -1.43 -4.10 0.06 1.48 4.18
Bud Neck 2.95 6.21 12.32 7.11 3.35 3.19 9.84 12.11 2.51 4.93 6.78 10.10 16.28 6.11 7.48
Bud Site 2.85 -2.32 18.63 12.82 13.81 2.00 1.73 13.42 2.29 14.63 3.59 0.69 22.61 12.57 21.02
Cell Periphery -4.68 -3.02 -1.50 4.09 2.68 -0.12 7.18 7.31 3.11 1.89 0.15 5.55 6.82 5.44 2.44
Cytoplasm 15.27 14.59 -7.32 -21.21 -19.52 -0.85 -18.98 -25.41 -8.31 -8.11 10.79 -5.51 -19.81 -26.97 -13.44
Cytoplasmic Foci -25.81 -13.63 -16.87 15.82 5.43 -2.26 17.72 12.19 5.47 -9.45 -20.20 4.77 -2.30 19.44 -7.66
Eisosomes -2.89 -5.29 -3.15 2.50 3.41 1.17 6.16 6.08 3.44 -1.43 0.41 5.73 5.67 3.11 -0.44
Endoplasmic Reticulum -5.80 -6.10 -5.63 4.32 3.88 0.30 4.13 4.40 2.00 1.06 -3.29 1.90 2.94 5.25 1.67
Endosome -11.99 -4.48 1.06 12.52 5.07 -2.07 11.85 10.48 4.82 -4.17 -9.31 9.55 9.21 13.56 -1.00
Golgi -14.98 -2.76 0.74 14.89 2.96 -0.37 14.99 12.33 2.81 -2.38 -11.46 12.92 9.73 15.07 -1.37
Lipid Particles -4.91 -5.06 -6.44 2.27 2.13 -0.32 4.78 3.97 1.98 -1.65 -4.35 -2.68 -4.38 3.37 -1.14
Mitochondria -4.70 5.73 0.40 4.38 -3.01 4.75 5.25 4.66 -0.48 -2.49 -0.84 6.50 4.35 5.26 -3.48
Mitotic Spindle 2.41 2.57 -0.85 -2.74 -2.87 -0.54 -5.11 -5.22 -4.24 -2.48 0.93 1.06 -2.72 -3.43 -3.69
None -4.27 -0.99 -7.03 3.99 -3.24 -0.32 -0.47 2.20 0.76 4.88 -4.19 -3.16 -1.22 4.13 2.69
Nuclear Periphery -2.41 -4.76 -2.21 -1.45 -1.43 0.13 -0.83 -0.96 -1.75 -0.29 -1.77 -2.92 -2.70 -1.42 -1.46
Nuclear Periphery Foci -2.68 -5.76 -8.84 0.18 3.88 -0.09 0.93 0.11 0.45 -4.72 -2.39 -4.18 -5.07 1.12 0.50
Nucleolus -2.30 0.45 -4.84 2.11 -6.19 -0.28 1.56 -0.33 0.08 -1.53 -2.25 1.05 -1.78 2.07 -2.50
Nucleus -2.96 -5.55 -15.50 -7.44 -7.50 -1.57 -8.99 -10.65 -3.70 5.43 -3.11 -9.51 -18.49 -5.21 2.69
Peroxisomes -2.28 -2.51 3.62 5.19 4.72 -0.68 0.51 -1.11 0.42 -1.76 -3.30 1.42 2.26 4.78 0.76
Vacuole 6.35 -5.29 -17.36 -21.87 -7.44 -3.21 -6.64 -17.51 -3.37 -12.58 4.22 -4.23 -22.30 -25.34 -18.18
Vacuole Periphery -5.63 2.00 -0.94 3.81 -2.45 -0.68 11.19 6.77 1.44 -3.20 -4.20 7.32 2.08 5.49 -4.01
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
Localization
Cell Percentages cytoplasm (59%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sec2

Sec2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available