Standard name
Human Ortholog
Description Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.24 0.19 0.14 0.13 0.11 0.16 0.07 0.07 0 0 0.06 0 0.07 0.05 0 0.17 0.21 0.11 0.05 0.05 0 0.14 0.15 0.09
Bud 0.2 0.17 0.23 0.14 0.28 0.22 0.19 0.15 0.11 0.11 0.17 0.11 0.07 0.06 0.07 0.11 0.12 0.08 0.36 0.35 0.34 0.13 0.13 0.09
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.16 0.15 0.2 0.18 0.1 0
Bud Site 0.08 0.14 0.14 0.12 0.1 0.1 0.07 0 0 0 0 0 0.06 0 0 0.09 0 0 – – – – – –
Cell Periphery 0.08 0 0 0 0 0 0 0 0.07 0.05 0.07 0.05 0 0.07 0.06 0 0.1 0.1 0 0 0 0 0 0
Cytoplasm 0.54 0.57 0.49 0.65 0.44 0.54 0.52 0.55 0.65 0.66 0.65 0.65 0.8 0.91 0.97 0.51 0.57 0.64 0.34 0.38 0.3 0.45 0.52 0.66
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0.12 0.11 0.06 0.15 0.19 0.21 0.28 0.28 0.31 0.3 0 0 0 0.05 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.05 0.09 0.06 0.07 0.06 0.06 0.06 0 0 0 0 0 0.06 0 0 0.06 0.05 0 0 0 0 0 0 0
SpindlePole 0.11 0.05 0.1 0.05 0.13 0.07 0.09 0.07 0 0 0 0 0 0 0 0.11 0.05 0.09 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 36 28 35 29 50 72 46 55 16 24 24 15 26 38 15 24 24 19 8 9 11 37 73 49
Bud 30 25 58 32 124 100 117 114 39 57 70 60 27 41 60 15 14 15 62 59 88 34 61 47
Bud Neck 3 0 11 0 13 8 15 20 6 3 2 9 0 1 0 2 7 4 28 24 53 46 47 21
Bud Site 12 21 34 28 46 46 45 27 13 24 10 16 21 9 4 12 2 6 – – – – – –
Cell Periphery 12 6 0 7 11 8 25 22 25 29 31 28 15 55 54 5 12 18 1 0 1 2 2 3
Cytoplasm 82 86 122 146 193 240 318 405 234 359 276 348 305 668 826 71 66 114 57 63 79 119 249 356
Endoplasmic Reticulum 0 2 1 1 2 0 10 5 2 3 2 7 3 2 2 10 5 5 0 1 1 4 8 16
Endosome 5 3 6 0 22 11 16 14 2 1 1 6 7 8 0 5 3 4 2 0 5 7 10 10
Golgi 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 2 3 1 0 0 0 1
Mitochondria 4 7 30 24 26 66 114 155 101 153 130 159 6 1 8 7 4 6 1 1 10 5 7 9
Nucleus 3 3 7 2 18 9 11 11 1 7 4 4 1 2 2 2 0 3 0 0 0 0 1 0
Nuclear Periphery 0 1 0 0 0 1 0 4 0 1 1 1 0 0 1 0 0 0 1 0 0 0 0 1
Nucleolus 2 1 1 2 8 7 21 31 8 11 5 13 2 0 0 1 2 7 0 0 0 0 0 0
Peroxisomes 7 13 16 15 25 25 35 16 10 16 7 7 24 9 6 9 6 7 0 0 1 0 0 0
SpindlePole 17 8 24 11 56 31 56 54 16 23 11 14 9 11 0 15 6 17 2 0 4 0 5 8
Vac/Vac Membrane 0 0 5 0 8 5 13 37 4 11 16 16 1 2 1 7 2 7 0 3 5 4 5 5
Unique Cell Count 153 150 247 226 440 448 615 736 358 540 424 532 379 737 855 139 116 179 173 169 264 266 477 538
Labelled Cell Count 216 204 350 297 602 629 842 970 477 722 590 703 447 847 979 187 153 234 173 169 264 266 477 538


Bud, Bud Neck, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.7 6.2 4.8 4.8 5.2 5.0 4.8 4.9 4.5 4.5 4.6 4.4 7.3 7.2 6.3 9.5 10.2 10.6 6.8 6.2 6.3
Std Deviation (1e-4) 1.3 1.0 0.7 1.1 1.1 1.1 1.1 1.0 0.8 0.9 1.0 1.0 1.4 1.0 0.8 1.7 1.8 1.8 1.0 1.0 1.1
Intensity Change (Log2) – – – -0.02 0.11 0.07 -0.01 0.03 -0.1 -0.1 -0.05 -0.12 0.61 0.58 0.4 0.98 1.08 1.14 0.49 0.37 0.38

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -1.1 0.7 0 -3.2 0 0 0 0 -3.0 -4.7 -8.3 0.8 1.6 -1.1
Bud 0 1.3 -0.3 0 -2.9 0 0 0 0 -5.8 -8.1 -7.4 -3.1 -2.5 -4.1
Bud Neck 0 -1.0 -2.1 0 -1.4 0 0 0 0 0 0 0 0 0.6 -1.2
Bud Site 0 -1.3 -1.4 0 -5.7 0 0 0 0 -3.6 -8.3 -10.1 -1.5 -3.6 -3.6
Cell Periphery 0 0 0 0 2.7 0 0 0 0 3.2 4.4 4.1 0 0 5.1
Cytoplasm 3.3 -1.4 1.1 0.6 1.5 3.9 4.6 4.0 4.3 8.2 14.1 18.9 0.3 1.3 2.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 1.6 0 0 -0.5 0 0 0 0 -0.5 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 -2.9 0.9 0 3.1 0 0 0 0 -5.5 -9.4 -8.5 -2.3 -2.7 -3.2
Nucleus 0 0.8 -0.7 -1.0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 2.9 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 -0.4 -0.5 0 -3.3 0 0 0 0 -0.1 -4.5 0 0 -0.5 -1.2
SpindlePole 0 1.2 -1.3 0 -1.2 0 0 0 0 -4.0 -6.0 -9.2 0.3 -1.5 -0.1
Vacuole 0 0 0 0.1 2.0 0 0 1.3 0.8 0 0 0 0 0 1.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.406 3.685 3.6392 3.4453 3.5714 4.1006 3.9697 4.5269 4.3335 4.0038 3.8419 4.7601 2.6203 2.4897 2.672 2.7332 2.419 3.0854
Actin 0.0503 0.0141 0.0148 0.019 0.0086 0.0278 0.0649 0.0091 0.0207 0.0685 0.0178 0.0186 0.0235 0.0075 0.0163 0.0543 0.0336 0.0264
Bud 0.0841 0.0905 0.3535 0.1127 0.044 0.018 0.1351 0.1223 0.3867 0.1325 0.0517 0.0132 0.099 0.1011 0.2869 0.1003 0.0703 0.0312
Bud Neck 0.0589 0.0088 0.0102 0.0059 0.0723 0.6317 0.0461 0.0053 0.0074 0.0017 0.0098 0.5585 0.0958 0.0056 0.0034 0.0016 0.019 0.601
Bud Periphery 0.1051 0.0565 0.41 0.3709 0.0705 0.0232 0.1438 0.0782 0.4115 0.3474 0.0971 0.0289 0.0883 0.0655 0.4053 0.2288 0.1726 0.0467
Bud Site 0.1663 0.3837 0.0705 0.0514 0.017 0.0185 0.205 0.338 0.0533 0.022 0.0457 0.0107 0.2365 0.414 0.0516 0.0282 0.047 0.0187
Cell Periphery 0.0045 0.0059 0.0049 0.0085 0.0058 0.0022 0.0059 0.0032 0.002 0.0048 0.0013 0.0007 0.0071 0.0037 0.0025 0.0057 0.0046 0.0018
Cytoplasm 0.2505 0.3757 0.1054 0.3768 0.707 0.1871 0.2079 0.3897 0.0755 0.2971 0.6678 0.2905 0.2865 0.3627 0.1764 0.4998 0.5084 0.1987
Cytoplasmic Foci 0.09 0.0135 0.0091 0.0114 0.0335 0.0361 0.0372 0.0061 0.012 0.0197 0.0187 0.0198 0.0456 0.0023 0.0067 0.0106 0.0772 0.0482
Eisosomes 0.0006 0.0001 0.0001 0.0001 0.0002 0.0001 0.0004 0.0001 0.0001 0.0002 0.0001 0.0001 0.0003 0.0001 0.0004 0.0002 0.0001 0
Endoplasmic Reticulum 0.0057 0.0027 0.0013 0.0049 0.0021 0.0022 0.0093 0.0006 0.0039 0.0036 0.0021 0.0032 0.0179 0.0024 0.0056 0.0039 0.0035 0.001
Endosome 0.0446 0.0039 0.0022 0.009 0.0046 0.0063 0.0331 0.0009 0.0028 0.0275 0.0187 0.0085 0.0084 0.0003 0.0052 0.0046 0.0098 0.0055
Golgi 0.0146 0.002 0.0014 0.0058 0.0013 0.0044 0.015 0.0009 0.002 0.02 0.0035 0.0035 0.0066 0.0002 0.0042 0.0042 0.0065 0.0031
Lipid Particles 0.0169 0.0004 0.0003 0.0005 0.0032 0.0031 0.0115 0.0005 0.002 0.0165 0.0114 0.0008 0.0061 0.0002 0.0007 0.0017 0.0014 0.0005
Mitochondria 0.0146 0.0004 0.0015 0.0035 0.0012 0.0028 0.0148 0.0012 0.0016 0.0091 0.002 0.0156 0.0016 0.0003 0.0168 0.0014 0.0022 0.0005
None 0.0252 0.028 0.0072 0.0048 0.0141 0.019 0.0144 0.0327 0.0053 0.0042 0.0043 0.0127 0.0234 0.0308 0.0136 0.0417 0.0088 0.0061
Nuclear Periphery 0.0088 0.0005 0.0005 0.001 0.0005 0.0044 0.0051 0.0002 0.0014 0.0019 0.0008 0.0033 0.0013 0.0003 0.0005 0.0008 0.0006 0.0001
Nucleolus 0.0033 0.0003 0.0003 0.0007 0.0004 0.0006 0.0011 0.0003 0.0003 0.0004 0.0007 0.0003 0.0036 0.0001 0.0001 0.0003 0.0007 0.0004
Nucleus 0.006 0.0015 0.0007 0.0022 0.0012 0.0011 0.0025 0.0012 0.0008 0.0016 0.0019 0.0033 0.0018 0.001 0.0005 0.0013 0.001 0.0006
Peroxisomes 0.0175 0.0033 0.0024 0.0004 0.0031 0.0052 0.0153 0.0061 0.007 0.0089 0.0291 0.0037 0.0215 0.0002 0.0006 0.0028 0.0105 0.007
Punctate Nuclear 0.0207 0.0012 0.0004 0.0006 0.0026 0.0029 0.0096 0.0003 0.0014 0.0014 0.0087 0.0009 0.0206 0.0002 0.0002 0.0011 0.0186 0.0006
Vacuole 0.0091 0.0067 0.003 0.0087 0.006 0.0026 0.0193 0.0028 0.0019 0.0095 0.006 0.0022 0.0039 0.0016 0.0021 0.0062 0.0033 0.0016
Vacuole Periphery 0.0025 0.0004 0.0003 0.001 0.0005 0.0007 0.0029 0.0002 0.0004 0.0016 0.0009 0.001 0.0005 0.0001 0.0003 0.0006 0.0003 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.4262 8.6769 9.8879 13.8123 17.9782 18.0161 15.7447 15.4377 15.62 23.1849
Translational Efficiency 0.8869 0.7242 0.5978 0.5591 0.5628 0.9057 0.5964 0.6526 0.6276 0.7051

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1359 399 875 1012 2138 1167 1456 89 3497 1566 2331 1101

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 778.08 945.34 1137.75 1051.11 826.21 827.70 1006.49 1084.53 807.51 857.67 1055.76 1053.81
Standard Deviation 87.74 131.82 127.37 120.14 106.53 154.53 112.57 131.35 102.38 157.64 134.33 121.42
Intensity Change Log 2 — 0.280915 0.548193 0.433923 — 0.002599 0.284752 0.392490 — 0.144290 0.418531 0.412734

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000629 0.002656 0.000735 0.005608 0.000555 0.001588 0.001092 0.004349 0.000583 0.001860 0.000958 0.005506
Bud Neck 0.099848 0.069813 0.029381 0.044818 0.097564 0.104141 0.091043 0.022587 0.098452 0.095395 0.067897 0.043021
Bud Site 0.454023 0.385761 0.256942 0.491747 0.356609 0.452501 0.449546 0.647519 0.394466 0.435496 0.377247 0.504339
Cell Periphery 0.001463 0.000547 0.000171 0.000296 0.000789 0.000843 0.000327 0.000431 0.001051 0.000768 0.000268 0.000307
Cytoplasm 0.320576 0.338994 0.552346 0.314501 0.423122 0.309714 0.303403 0.211546 0.383271 0.317174 0.396850 0.306178
Cytoplasmic Foci 0.064334 0.104282 0.044851 0.024802 0.059939 0.059608 0.017852 0.024226 0.061647 0.070990 0.027987 0.024755
Eisosomes 0.000219 0.000142 0.000023 0.000065 0.000078 0.000183 0.000060 0.000061 0.000133 0.000172 0.000046 0.000065
Endoplasmic Reticulum 0.001183 0.000425 0.000560 0.000262 0.000591 0.000364 0.000594 0.000441 0.000821 0.000380 0.000581 0.000277
Endosome 0.009300 0.017507 0.004765 0.005948 0.006605 0.014873 0.002112 0.000803 0.007653 0.015544 0.003108 0.005532
Golgi 0.003959 0.005575 0.000502 0.007453 0.002632 0.008327 0.000352 0.000165 0.003148 0.007626 0.000408 0.006864
Lipid Particles 0.001501 0.002884 0.000602 0.000389 0.000885 0.000798 0.000411 0.000309 0.001124 0.001329 0.000483 0.000382
Mitochondria 0.003602 0.001161 0.000057 0.000787 0.000952 0.005255 0.000242 0.000033 0.001982 0.004212 0.000173 0.000726
Mitotic Spindle 0.000577 0.002558 0.001864 0.008870 0.001368 0.002081 0.004581 0.000654 0.001061 0.002203 0.003561 0.008206
None 0.000960 0.000099 0.000510 0.000951 0.002001 0.000992 0.000830 0.000067 0.001596 0.000765 0.000710 0.000880
Nuclear Periphery 0.000025 0.000026 0.000096 0.000064 0.000027 0.000018 0.000132 0.000024 0.000026 0.000020 0.000118 0.000060
Nuclear Periphery Foci 0.000277 0.000418 0.003765 0.000492 0.000300 0.000136 0.000687 0.000511 0.000291 0.000208 0.001843 0.000494
Nucleolus 0.000197 0.000165 0.000119 0.000073 0.000438 0.000085 0.000124 0.000017 0.000344 0.000106 0.000122 0.000068
Nucleus 0.005075 0.002795 0.016621 0.005374 0.010324 0.004865 0.025224 0.003528 0.008284 0.004338 0.021995 0.005225
Peroxisomes 0.002719 0.009933 0.002692 0.004545 0.001883 0.005451 0.002372 0.005794 0.002208 0.006593 0.002492 0.004646
Vacuole 0.027611 0.053350 0.083097 0.082423 0.032256 0.027136 0.098869 0.076880 0.030451 0.033815 0.092949 0.081975
Vacuole Periphery 0.001923 0.000908 0.000301 0.000534 0.001081 0.001040 0.000146 0.000055 0.001408 0.001006 0.000205 0.000495

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.80 -1.07 -4.19 -1.71 -4.03 -2.67 -3.55 -2.05 -1.28 -1.57 -4.02 -3.69 -4.48 -2.79 -3.90
Bud Neck 3.30 12.97 12.62 4.99 -0.85 -0.89 5.15 13.91 12.29 9.43 0.59 11.11 18.15 12.81 7.46
Bud Site 3.58 16.03 9.27 3.02 -6.22 -7.45 1.10 -2.43 -0.16 -2.72 -3.60 10.30 5.37 7.51 -2.38
Cell Periphery 5.72 8.80 8.35 4.27 -3.51 -0.52 6.42 3.82 3.82 -0.73 2.71 10.83 10.84 6.95 0.39
Cytoplasm -1.07 -17.27 -3.28 -1.27 13.53 9.72 7.64 5.19 1.49 2.40 6.85 -4.36 2.65 -3.06 5.87
Cytoplasmic Foci -4.78 4.45 8.69 8.99 4.49 -0.01 14.47 4.24 3.98 -1.71 -2.62 13.56 11.19 10.54 -0.27
Eisosomes 2.50 8.96 6.84 3.32 -6.54 -3.45 1.05 0.78 3.68 0.18 -1.60 7.94 5.88 4.63 -2.25
Endoplasmic Reticulum 2.55 2.02 2.80 0.57 3.29 1.33 -2.41 0.37 -0.59 1.88 2.70 0.21 3.18 -0.06 6.29
Endosome -3.26 5.18 4.70 5.22 0.53 -4.95 9.02 9.74 8.38 2.77 -5.63 9.95 4.42 7.59 -1.20
Golgi -1.19 12.32 -0.18 0.63 -2.36 -5.82 14.57 15.36 8.49 3.80 -5.54 18.86 -0.52 2.20 -2.42
Lipid Particles -0.89 4.54 3.28 1.30 -0.78 0.48 2.40 0.58 0.16 -0.41 -0.53 5.04 2.23 1.22 -0.94
Mitochondria 2.03 3.24 2.78 1.65 -2.24 -3.43 2.58 3.43 4.26 4.31 -2.19 3.95 3.07 4.01 -1.55
Mitotic Spindle -1.77 -3.21 -4.67 -2.64 -3.41 -1.13 -2.99 -0.87 -0.75 -0.39 -2.21 -3.86 -4.33 -3.47 -2.57
None 6.85 3.32 0.52 -1.70 -0.62 1.99 3.36 6.95 2.10 4.99 2.30 4.06 2.29 0.17 0.24
Nuclear Periphery -0.39 -10.85 -10.93 -10.34 -3.53 1.51 -15.41 -3.15 -3.77 8.89 1.22 -17.95 -11.36 -11.93 2.89
Nuclear Periphery Foci -1.47 -9.82 -6.19 -3.54 8.08 3.38 -7.03 -2.75 -3.55 0.50 1.85 -11.54 -6.53 -7.38 7.04
Nucleolus -0.49 2.10 3.50 1.52 2.18 2.20 1.90 2.53 4.70 5.34 2.12 2.14 2.64 1.55 2.90
Nucleus 3.22 -12.64 -7.50 -10.44 5.27 4.27 -14.34 2.72 -0.64 14.25 4.15 -17.48 -4.29 -6.93 13.22
Peroxisomes -3.37 0.43 -0.99 3.06 -1.76 -5.91 -0.69 -0.81 0.45 -0.72 -5.82 -0.02 -2.27 3.48 -2.31
Vacuole -4.90 -12.91 -21.11 -15.72 -10.58 2.12 -21.57 -5.71 -5.88 -1.00 -1.68 -24.90 -21.74 -20.89 -7.25
Vacuole Periphery 2.10 3.68 3.47 2.45 -0.57 0.28 8.51 9.12 9.60 3.48 1.97 6.54 5.25 5.25 -1.39
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (55%), bud neck (23%), mixed (19%)
Cell Cycle Regulation Yes
cytoplasm - T/G1 (2e-10)
bud neck - S/G2 (7.2e-14)
Subcompartmental Group N/A

Caf120

Caf120


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Caf120-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available