Standard name
Human Ortholog
Description Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.08 0 0.06 0 – 0 0 0 0 0.06 0.11 0.17 0.06 0.1 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.1 0 0 0 0.36 0.09 – 0.36 0.26 0.39 0.42 0 0 0 0 0.05 0 0 0 0 0 0 0
Nucleus 0.95 0.9 0.97 0.92 0.93 0.81 0.9 – 0.85 0.85 0.82 0.8 0.92 0.88 0.8 0.81 0.73 0.77 0.89 0.91 0.84 0.81 0.71 0.6
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0 0.08 0 0.06 0.1
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.05 0 0 0 0 0 – 0 0 0 0 0 0 0 0.17 0.16 0.13 0 0 0 0.11 0.17 0.18
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 0 0 0 2 0 – 1 3 8 1 0 0 0 0 0 0 1 1 0 1 1 5
Bud Neck 0 0 0 0 0 0 0 – 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 4 2 – 4 5 10 12 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 7 2 1 14 10 14 11 – 10 14 15 13 12 52 79 15 14 11 1 1 0 0 2 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 1 0 1 6 6 5 0 0 0 0 2 0
Endosome 0 0 0 0 2 3 2 – 0 0 0 1 1 0 2 3 1 3 0 0 0 0 4 6
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 2
Mitochondria 1 11 2 1 2 80 29 – 103 89 162 175 0 1 2 6 7 4 1 0 1 0 2 5
Nucleus 209 98 78 153 254 180 292 – 243 289 340 337 200 410 370 194 107 90 199 101 88 158 297 246
Nuclear Periphery 0 0 0 0 5 1 3 – 4 2 1 4 0 9 11 0 0 1 1 0 0 0 1 7
Nucleolus 1 3 1 1 0 1 1 – 2 3 11 4 1 5 9 6 4 2 10 1 8 6 27 39
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 3 0 0 1 0 0 0 0 1 0
SpindlePole 0 0 0 1 0 1 5 – 0 6 1 2 0 1 2 1 0 2 0 1 0 0 3 6
Vac/Vac Membrane 5 5 0 1 7 7 5 – 6 8 7 11 2 5 9 40 23 15 6 4 3 21 69 74
Unique Cell Count 220 109 80 167 272 223 323 285 342 416 421 218 468 462 239 147 117 225 112 105 195 419 407
Labelled Cell Count 223 119 82 171 280 293 350 373 419 557 560 218 483 488 271 162 135 225 112 105 195 419 407


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 5.6 6.5 6.7 6.7 4.1 5.0 – 4.5 4.6 4.6 4.5 7.7 7.2 7.3 7.7 7.8 7.8 6.9 6.9 7.0
Std Deviation (1e-4) 1.2 1.0 1.6 1.5 1.5 1.0 0.9 – 1.0 0.9 1.2 1.0 1.6 1.9 2.0 1.8 1.9 2.1 1.4 1.5 1.8
Intensity Change (Log2) – – – 0.03 0.05 -0.67 -0.38 – -0.54 -0.52 -0.52 -0.52 0.24 0.14 0.15 0.23 0.26 0.26 0.08 0.09 0.11

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 – 0 0 0 0 0 2.8 3.7 0 2.4 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 1.9 – 0 0 0 0 0 0 0 0 0 0
Nucleus -1.8 -1.4 -3.6 -2.1 – -3.0 -3.1 -3.5 -3.8 -1.8 -2.6 -3.8 -3.6 -4.6 -4.0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 3.9 3.7 3.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.0669 1.2614 1.4038 1.8295 0.4763 0.9473 2.0977 3.0643 2.6901 2.5968 2.2078 2.6463 4.0499 5.3001 4.8562 4.7188 4.0378 4.7654
Actin 0.0453 0 0.0188 0.0824 0 0.0015 0.0017 0 0 0 0 0 0.001 0 0.0033 0 0 0.0016
Bud 0.0003 0 0.0003 0.0033 0 0.0001 0 0 0 0 0 0 0.0003 0 0 0.0001 0 0.0001
Bud Neck 0.0052 0.0008 0.0025 0.003 0.0005 0.0015 0.0004 0.0001 0.0001 0.0002 0.0001 0.0009 0.0006 0.0004 0.0003 0.0153 0.001 0.0019
Bud Periphery 0.0005 0.0002 0.0007 0.0075 0.0001 0.0001 0.0001 0 0.0001 0 0 0.0001 0.0007 0 0.0001 0.0001 0.0001 0.0002
Bud Site 0.001 0.0002 0.0016 0.0046 0.0001 0.0002 0.0002 0.0001 0.0001 0 0 0.0001 0.001 0.0003 0.0003 0.0009 0.0001 0.0004
Cell Periphery 0.0002 0.0005 0.0002 0.0006 0.0001 0 0 0 0.0001 0 0 0 0.0006 0 0 0.0001 0.0001 0.0001
Cytoplasm 0.0039 0.0002 0.001 0.0031 0.0001 0.0008 0.0013 0.0003 0.0001 0.0001 0.0002 0.0001 0.0011 0.0003 0.0004 0.0003 0.0002 0.0003
Cytoplasmic Foci 0.0039 0 0.0027 0.0047 0.0001 0.0007 0.0072 0 0 0 0 0 0.0015 0.0003 0.0006 0.0016 0.0005 0.0003
Eisosomes 0.0005 0 0.0001 0.0008 0 0 0 0 0 0 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0025 0.0001 0.0009 0.0055 0 0.0006 0.0007 0 0 0 0 0 0.0009 0 0.0002 0 0 0.0001
Endosome 0.0078 0.0003 0.0071 0.0282 0.0001 0.004 0.0047 0 0.0001 0 0.0001 0 0.0029 0 0.0011 0.0011 0.0001 0.0012
Golgi 0.0039 0 0.0026 0.0144 0 0.0004 0.0008 0 0 0 0 0 0.0006 0 0.0003 0.0003 0 0.0007
Lipid Particles 0.0063 0.0001 0.0047 0.0111 0 0.0007 0.0021 0 0 0 0 0 0.0039 0 0.0005 0.0008 0.0001 0.0009
Mitochondria 0.0021 0.0002 0.0026 0.0114 0.0001 0.0004 0.0005 0.0001 0.0005 0.0002 0.0001 0.0001 0.0025 0.0002 0.0005 0.0003 0.0002 0.0007
None 0.0032 0 0.0013 0.006 0 0.0008 0.0028 0 0 0 0.0001 0 0.0018 0.0001 0.0006 0.0001 0.0001 0.0001
Nuclear Periphery 0.0123 0.0042 0.0052 0.0238 0.0009 0.0198 0.0058 0.0029 0.001 0.001 0.0111 0.0005 0.0035 0.0014 0.0013 0.0011 0.0017 0.0028
Nucleolus 0.0374 0.0476 0.0269 0.0256 0.051 0.0589 0.0295 0.0447 0.0448 0.0396 0.0218 0.0577 0.0254 0.065 0.07 0.1425 0.0263 0.0827
Nucleus 0.8481 0.9384 0.901 0.7432 0.9093 0.8985 0.93 0.9477 0.9501 0.9579 0.9636 0.9352 0.9225 0.9272 0.917 0.7839 0.9167 0.8958
Peroxisomes 0.0058 0 0.0018 0.0028 0 0.0001 0.0006 0 0 0 0 0 0.0017 0 0.0004 0.0001 0 0.0003
Punctate Nuclear 0.0076 0.0008 0.0155 0.0075 0.0363 0.0099 0.0111 0.0035 0.0023 0.0006 0.0025 0.0052 0.0237 0.0046 0.0029 0.0507 0.0525 0.0093
Vacuole 0.0016 0.006 0.0014 0.0062 0.0009 0.0005 0.0003 0.0002 0.0005 0.0001 0.0001 0.0001 0.0027 0.0002 0.0002 0.0007 0.0003 0.0004
Vacuole Periphery 0.0009 0.0003 0.0011 0.0045 0.0001 0.0005 0.0002 0.0001 0.0002 0.0001 0.0001 0 0.0008 0.0001 0.0001 0.0001 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.8271 11.7426 17.427 17.3648 25.5466 5.6265 13.145 12.5925 15.2378 21.4497
Translational Efficiency 1.6827 1.8667 1.3668 0.9824 0.8892 4.0143 1.4342 1.1917 1.0005 1.2016

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1698 534 862 1695 1662 2469 2551 1445 3360 3003 3413 3140

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 799.83 833.87 999.33 1071.09 796.54 899.10 1051.51 1105.72 798.20 887.50 1038.33 1087.03
Standard Deviation 132.37 153.23 134.42 177.79 109.41 126.40 145.26 167.71 121.56 133.91 144.39 174.08
Intensity Change Log 2 — 0.060129 0.321268 0.421314 — 0.174735 0.400644 0.473167 — 0.118452 0.361420 0.447420

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000229 0.000539 0.000626 0.000672 0.000223 0.000208 0.000404 0.001351 0.000226 0.000267 0.000460 0.000985
Bud Neck 0.002817 0.007604 0.025411 0.021925 0.002891 0.009899 0.023931 0.040777 0.002854 0.009491 0.024305 0.030601
Bud Site 0.000773 0.001338 0.001792 0.001957 0.000425 0.002138 0.000703 0.006674 0.000601 0.001995 0.000979 0.004128
Cell Periphery 0.000143 0.000153 0.000093 0.000105 0.000108 0.000174 0.000060 0.000149 0.000126 0.000170 0.000068 0.000125
Cytoplasm 0.007777 0.006831 0.001147 0.004054 0.003099 0.003314 0.000428 0.011558 0.005463 0.003940 0.000609 0.007508
Cytoplasmic Foci 0.001502 0.001677 0.000033 0.001021 0.000332 0.000351 0.000006 0.003343 0.000923 0.000587 0.000013 0.002090
Eisosomes 0.000016 0.000023 0.000032 0.000023 0.000019 0.000020 0.000033 0.000033 0.000018 0.000020 0.000033 0.000027
Endoplasmic Reticulum 0.005919 0.008089 0.005036 0.004998 0.004873 0.006627 0.003506 0.006738 0.005402 0.006887 0.003892 0.005799
Endosome 0.000697 0.001159 0.000232 0.000885 0.000304 0.001010 0.000121 0.007583 0.000503 0.001037 0.000149 0.003967
Golgi 0.000393 0.000515 0.000062 0.001155 0.000341 0.000211 0.000034 0.004668 0.000367 0.000265 0.000041 0.002772
Lipid Particles 0.000466 0.000869 0.000078 0.000070 0.000350 0.000179 0.000017 0.000301 0.000409 0.000302 0.000033 0.000176
Mitochondria 0.000762 0.002101 0.001145 0.002916 0.000982 0.002756 0.000729 0.006155 0.000871 0.002639 0.000834 0.004407
Mitotic Spindle 0.000956 0.003572 0.000705 0.005067 0.000541 0.002471 0.000346 0.021454 0.000751 0.002666 0.000437 0.012608
None 0.010713 0.009045 0.001907 0.004361 0.003489 0.003864 0.000913 0.004196 0.007139 0.004785 0.001164 0.004285
Nuclear Periphery 0.000703 0.001108 0.000448 0.001282 0.000345 0.001144 0.000296 0.005246 0.000526 0.001138 0.000334 0.003106
Nuclear Periphery Foci 0.000487 0.002391 0.000151 0.000455 0.000317 0.000184 0.000042 0.002607 0.000403 0.000576 0.000070 0.001445
Nucleolus 0.020666 0.028005 0.018559 0.008762 0.020671 0.013277 0.019496 0.011116 0.020668 0.015896 0.019259 0.009845
Nucleus 0.943549 0.921265 0.941236 0.934678 0.959557 0.948672 0.948319 0.848061 0.951467 0.943798 0.946530 0.894818
Peroxisomes 0.000341 0.000887 0.000244 0.000131 0.000414 0.000518 0.000110 0.000614 0.000377 0.000584 0.000144 0.000353
Vacuole 0.000860 0.002260 0.000917 0.003934 0.000541 0.002317 0.000381 0.012740 0.000702 0.002307 0.000517 0.007986
Vacuole Periphery 0.000230 0.000568 0.000144 0.001547 0.000180 0.000667 0.000123 0.004634 0.000205 0.000650 0.000128 0.002967

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.44 -8.44 -9.44 -2.94 -0.89 0.44 -7.03 -7.70 -7.83 -6.56 -1.78 -11.97 -10.74 -10.07 -7.44
Bud Neck -4.06 -12.95 -18.96 -11.14 0.51 -7.53 -25.76 -22.69 -18.52 -11.99 -8.49 -28.66 -28.75 -20.57 -8.92
Bud Site -1.45 -2.22 -3.47 -1.68 -0.37 -4.04 -2.42 -8.73 -5.80 -8.26 -3.76 -2.30 -9.29 -4.74 -8.12
Cell Periphery -0.26 2.14 2.36 1.92 -0.19 -2.17 2.71 -0.99 1.72 -4.88 -1.74 4.00 1.25 2.65 -3.88
Cytoplasm 0.24 5.22 2.11 1.35 -4.48 -0.38 3.92 -5.15 -5.12 -7.68 1.52 6.71 -1.99 -3.72 -9.16
Cytoplasmic Foci -0.61 3.23 1.37 1.59 -1.83 0.09 3.18 -2.72 -2.78 -3.54 1.06 3.89 -0.51 -1.50 -3.86
Eisosomes -4.26 -10.19 -6.35 0.48 6.16 -0.18 -7.21 -7.88 -8.64 -1.88 -2.17 -11.85 -9.79 -7.25 2.56
Endoplasmic Reticulum -3.17 1.26 1.71 4.50 0.33 -4.01 4.68 -6.20 -1.80 -12.25 -4.01 5.76 -2.67 1.89 -9.68
Endosome -1.39 2.54 -0.05 1.41 -3.18 -2.91 3.68 -4.61 -3.64 -4.85 -2.38 3.76 -4.43 -2.84 -5.49
Golgi -0.42 1.48 -0.89 -0.64 -1.66 0.95 2.15 -3.21 -3.56 -3.86 0.78 2.52 -2.92 -3.36 -3.99
Lipid Particles -0.76 2.74 2.90 1.36 0.55 0.86 1.66 -0.19 -4.00 -9.64 0.53 3.13 1.57 0.78 -9.19
Mitochondria -1.18 -2.83 -4.61 -0.64 -3.35 -2.27 0.44 -4.94 -2.47 -6.32 -2.93 -0.14 -6.53 -1.80 -7.49
Mitotic Spindle -1.32 -0.25 -3.17 -0.65 -3.19 -2.50 0.71 -7.99 -7.22 -8.07 -2.55 0.56 -8.53 -6.86 -8.77
None 0.67 5.71 4.08 2.50 -2.68 -0.48 5.10 -1.24 -0.60 -6.10 2.28 7.36 3.25 0.81 -6.37
Nuclear Periphery -1.80 1.04 -4.64 -1.75 -5.14 -5.42 0.48 -6.33 -5.12 -6.37 -4.67 2.48 -7.50 -5.44 -7.95
Nuclear Periphery Foci -1.15 0.75 -0.22 1.12 -0.82 1.49 3.65 -4.27 -4.65 -5.04 -0.54 3.47 -3.87 -1.91 -5.30
Nucleolus -2.45 0.14 6.18 5.90 4.41 4.67 0.30 0.88 -3.46 0.66 3.80 0.33 4.82 1.19 4.37
Nucleus 3.24 1.66 3.49 -1.02 1.83 3.02 4.99 19.37 17.46 17.87 2.45 3.36 16.98 14.17 15.90
Peroxisomes -2.00 0.75 2.01 2.98 3.12 -0.32 3.15 -0.37 0.10 -3.17 -0.89 3.17 1.07 1.39 -2.58
Vacuole -1.77 -1.19 -4.48 -1.48 -4.19 -4.60 1.53 -9.72 -8.47 -9.82 -4.54 1.21 -10.58 -8.15 -10.75
Vacuole Periphery -1.88 1.99 -2.96 -1.80 -3.20 -4.10 1.71 -4.22 -3.26 -4.33 -4.37 2.87 -5.15 -3.58 -5.41
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Pop3

Pop3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pop3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available