Standard name
Human Ortholog
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.48 0.33 0.37 0.34 0.22 0.28 0.24 0.23 – 0.14 0.15 0.13 0.26 0.21 0.16 0.22 0.28 0.28 0.11 0.16 0.12 0.19 0.13 0.08
Bud 0.11 0.12 0.09 0.15 0.11 0.17 0.14 0.16 – 0.13 0.18 0.12 0.16 0.09 0 0.06 0.06 0 0 0 0 0.1 0.07 0.05
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.07 0.17 0.09 0.14 0.07 0.06
Bud Site 0.05 0 0 0.1 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.41 0.42 0.37 0.18 0.17 0.16 0.2 0.1 – 0.1 0.14 0.18 0.63 0.66 0.67 0.56 0.46 0.43 0.61 0.44 0.65 0.47 0.65 0.71
Cytoplasm 0.23 0.4 0.34 0.37 0.47 0.58 0.52 0.61 – 0.68 0.61 0.69 0.39 0.31 0.38 0.32 0.36 0.35 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0.07 0 0 – 0 0 0 0 0 0 0.09 0.05 0 0.09 0.06 0.06 0.05 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.06 0.08 0.08 0.16 0.17 0.16 – 0.18 0.24 0.2 0 0 0 0.13 0.06 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.12 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.08 0 0.1 0.08 0.1 0 0 0 – 0 0 0 0.08 0 0 0 0 0.08 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 105 122 113 56 39 78 86 80 – 41 59 50 16 15 21 71 95 100 35 81 43 26 24 17
Bud 25 46 27 25 19 46 49 56 – 40 71 46 10 6 6 18 21 14 3 13 4 13 13 10
Bud Neck 0 1 11 4 2 5 3 3 – 0 3 1 0 0 0 1 2 0 21 85 33 18 12 12
Bud Site 12 14 12 16 4 7 9 8 – 6 2 10 0 0 1 1 1 3 – – – – – –
Cell Periphery 90 155 112 30 31 45 71 34 – 30 55 69 39 46 90 183 153 151 190 216 243 65 118 151
Cytoplasm 51 147 102 62 84 160 186 212 – 205 236 267 24 22 51 104 119 122 3 22 2 0 0 3
Endoplasmic Reticulum 7 13 5 3 4 18 15 10 – 9 9 10 1 1 4 29 16 13 28 28 21 7 4 8
Endosome 9 0 2 3 4 1 0 3 – 0 0 0 0 0 0 3 2 1 3 4 0 0 0 0
Golgi 1 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 3 0 0 0
Mitochondria 7 9 17 14 15 45 61 56 – 54 93 79 0 0 1 42 19 20 7 12 5 2 3 3
Nucleus 2 1 0 1 1 0 2 1 – 1 0 1 0 0 1 3 2 8 0 0 0 0 0 0
Nuclear Periphery 2 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Nucleolus 2 0 1 0 0 0 0 0 – 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 7 0 8 7 21 5 6 5 – 3 0 3 0 0 0 0 0 0 0 0 0 0 1 0
SpindlePole 18 3 30 14 18 1 8 7 – 4 4 7 5 3 2 10 15 29 0 0 0 0 0 0
Vac/Vac Membrane 1 0 3 0 3 0 0 1 – 0 3 1 0 0 0 3 3 2 12 24 7 1 2 1
Unique Cell Count 219 369 304 166 179 276 360 350 301 388 389 62 70 135 327 334 351 312 495 373 138 184 215
Labelled Cell Count 339 512 443 235 245 411 496 476 393 537 544 95 93 177 468 448 463 312 495 373 138 184 215


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.7 6.6 5.8 5.1 5.8 4.7 4.7 5.0 – 4.4 4.3 4.5 7.9 8.1 8.6 7.6 8.4 9.1 9.3 10.4 11.7
Std Deviation (1e-4) 1.2 1.2 1.3 1.3 2.1 1.3 1.0 0.9 – 1.0 1.0 0.8 1.4 1.5 1.9 1.2 1.5 1.6 1.7 1.9 2.2
Intensity Change (Log2) – – – -0.19 -0.0 -0.31 -0.3 -0.2 – -0.41 -0.42 -0.35 0.45 0.48 0.57 0.4 0.54 0.65 0.68 0.84 1.02

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.7 -3.5 0 0 -4.0 – 0 0 0 -1.7 -2.5 -4.5 -4.3 -2.3 -2.4
Bud 2.0 0.6 0 0 2.7 – 0 0 0 1.7 -0.1 -1.6 -1.6 -1.2 -2.6
Bud Neck -0.7 0 0 0 -2.4 – 0 0 0 0 0 0 -3.0 -2.7 -3.6
Bud Site 2.5 -1.0 0 0 -1.2 – 0 0 0 0 0 0 -3.2 -3.3 -2.6
Cell Periphery -4.2 -4.5 0 0 -8.3 – 0 0 0 3.8 4.4 5.8 4.8 2.3 1.6
Cytoplasm 0.8 2.9 5.9 4.7 6.9 – 8.5 7.1 9.2 0.8 -0.3 0.9 -0.5 0.6 0.3
Endoplasmic Reticulum 0 0 0 0 1.0 – 0 0 0 0 0 0 4.0 2.2 1.6
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 1.2 1.2 0 0 4.2 – 0 0 0 0 0 -2.4 3.1 0.1 0.1
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0.9 4.1 0 0 -1.1 – 0 0 0 0 0 0 0 0 0
SpindlePole -0.5 0.1 0 0 -4.3 – 0 0 0 -0.4 -1.5 -3.1 -3.5 -2.6 -0.7
Vacuole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4425 5.1796 5.2677 4.8286 4.6272 4.7219 5.8874 6.4472 6.5189 6.5125 6.5872 6.568 5.9103 5.783 5.8827 6.2217 6.19 6.315
Actin 0.0107 0.0157 0.0182 0.0035 0.0044 0.0041 0.0125 0.0098 0.0087 0.0033 0.0035 0.0045 0.0135 0.0235 0.0235 0.0041 0.0282 0.0068
Bud 0.0072 0.0089 0.0199 0.0094 0.005 0.0034 0.0031 0.0034 0.0101 0.0037 0.0012 0.0025 0.0018 0.0027 0.0141 0.0039 0.0018 0.002
Bud Neck 0.0074 0.0078 0.0274 0.0315 0.01 0.077 0.0083 0.0105 0.0504 0.0751 0.058 0.0903 0.0041 0.0125 0.0299 0.0496 0.0158 0.0792
Bud Periphery 0.0666 0.0406 0.1619 0.1673 0.1013 0.051 0.042 0.0194 0.1129 0.1051 0.0298 0.0339 0.025 0.0185 0.1283 0.0877 0.0445 0.0354
Bud Site 0.0329 0.2329 0.0979 0.0174 0.0084 0.0114 0.0428 0.3332 0.1149 0.0135 0.0189 0.0099 0.0267 0.2981 0.0996 0.0105 0.0028 0.0069
Cell Periphery 0.547 0.2831 0.4272 0.4315 0.581 0.5226 0.6774 0.4391 0.5538 0.6458 0.731 0.6666 0.7287 0.387 0.5625 0.6865 0.6872 0.6627
Cytoplasm 0.2208 0.2863 0.163 0.2151 0.185 0.2068 0.1682 0.1517 0.1204 0.1202 0.137 0.1671 0.1543 0.2243 0.1188 0.1375 0.1942 0.1846
Cytoplasmic Foci 0.0028 0.0044 0.0031 0.0047 0.0012 0.0026 0.0008 0.0006 0.0009 0.0003 0.0005 0.0004 0.0013 0.0005 0.0005 0.0003 0.0005 0.0003
Eisosomes 0.0049 0.0039 0.0043 0.0007 0.0017 0.0011 0.0095 0.0038 0.0021 0.0022 0.0013 0.0014 0.0036 0.0064 0.0039 0.0005 0.0051 0.0011
Endoplasmic Reticulum 0.0127 0.01 0.0061 0.0116 0.0072 0.0056 0.0068 0.0068 0.004 0.0164 0.005 0.0045 0.0075 0.0043 0.0067 0.0048 0.0034 0.0024
Endosome 0.0124 0.0129 0.009 0.0131 0.0036 0.0067 0.0003 0.0002 0.0006 0.0001 0.0001 0.0001 0.0006 0.0002 0.0003 0.0002 0.0001 0.0001
Golgi 0.0012 0.0019 0.0009 0.0011 0.0004 0.0005 0.0006 0.0003 0.0006 0.0004 0.0003 0.0002 0.001 0.0005 0.0005 0.0002 0.0006 0.0002
Lipid Particles 0.003 0.003 0.0008 0.0011 0.0013 0.0023 0.0023 0.0012 0.0013 0.0029 0.0008 0.0012 0.0015 0.0009 0.0007 0.0004 0.0007 0.0005
Mitochondria 0.0008 0.0052 0.0008 0.0071 0.0003 0.0004 0.0002 0.0001 0.0006 0.0001 0.0002 0.0001 0.0038 0.0001 0.0001 0.0001 0.0001 0
None 0.0265 0.0261 0.0155 0.0394 0.0265 0.0187 0.0156 0.0123 0.0082 0.0006 0.0064 0.0092 0.0185 0.0139 0.0014 0.0008 0.0111 0.0104
Nuclear Periphery 0.0008 0.0014 0.0007 0.001 0.0005 0.0005 0.0005 0.0005 0.0004 0.0007 0.0002 0.0002 0.0005 0.0005 0.0004 0.0003 0.0002 0.0001
Nucleolus 0.0005 0.0013 0.0006 0.0008 0.0007 0.0008 0.0002 0.0003 0.0003 0.0002 0.0003 0.0002 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001
Nucleus 0.0008 0.0032 0.0016 0.0026 0.0022 0.0021 0.0004 0.0007 0.0007 0.0005 0.0005 0.0006 0.0002 0.0005 0.0006 0.0005 0.0002 0.0004
Peroxisomes 0.0002 0.0004 0.0001 0.0002 0 0.0001 0 0.0001 0.0012 0 0 0 0.0008 0 0.0003 0 0 0
Punctate Nuclear 0.0001 0.0007 0.0001 0.0001 0.0001 0.0004 0.0001 0.0001 0.0002 0.0001 0.0001 0 0.0001 0.0001 0.0002 0 0 0
Vacuole 0.0392 0.0489 0.0402 0.0379 0.0585 0.08 0.0082 0.0061 0.0076 0.0084 0.0049 0.0068 0.0063 0.0053 0.0073 0.0116 0.0035 0.0066
Vacuole Periphery 0.0015 0.0015 0.0007 0.0029 0.0006 0.0018 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0 0.0001 0.0002 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 93.045 71.1078 28.0768 26.2907 62.9204 51.7846 60.8486 44.7415 28.6996 77.6347
Translational Efficiency 0.5141 0.4177 0.2882 0.3556 0.5917 0.8027 0.3783 0.3608 0.4015 0.39

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
205 976 2673 481 300 1499 1031 1523 505 2475 3704 2004

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 933.37 868.35 955.30 1102.08 768.57 823.16 919.96 962.03 835.47 840.98 945.46 995.64
Standard Deviation 135.54 111.15 108.03 153.03 81.03 107.02 136.45 137.24 133.82 110.89 117.71 153.34
Intensity Change Log 2 — -0.104172 0.033505 0.239708 — 0.098996 0.259394 0.323905 — -0.008868 0.139910 0.278340

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.033234 0.026133 0.035363 0.029310 0.009555 0.018783 0.045064 0.036218 0.019168 0.021681 0.038063 0.034560
Bud Neck 0.065272 0.108182 0.169569 0.038602 0.172729 0.150211 0.098778 0.064634 0.129108 0.133637 0.149865 0.058385
Bud Site 0.217371 0.085022 0.192734 0.156991 0.061400 0.105336 0.139710 0.166081 0.124715 0.097325 0.177975 0.163899
Cell Periphery 0.145165 0.287881 0.170854 0.559432 0.189355 0.158730 0.319347 0.354552 0.171416 0.209660 0.212186 0.403727
Cytoplasm 0.215614 0.369861 0.285075 0.131514 0.411217 0.418490 0.190929 0.274713 0.331814 0.399314 0.258869 0.240342
Cytoplasmic Foci 0.026951 0.013996 0.010290 0.000930 0.021040 0.023275 0.010219 0.011457 0.023439 0.019616 0.010271 0.008930
Eisosomes 0.015944 0.047720 0.029160 0.022491 0.055192 0.039755 0.048127 0.021948 0.039260 0.042896 0.034440 0.022079
Endoplasmic Reticulum 0.006720 0.005550 0.014461 0.006626 0.002452 0.004209 0.024522 0.003986 0.004185 0.004738 0.017262 0.004619
Endosome 0.013092 0.003187 0.001559 0.000234 0.004926 0.004875 0.001314 0.003244 0.008241 0.004209 0.001491 0.002522
Golgi 0.011786 0.007202 0.001295 0.000244 0.008457 0.008584 0.002398 0.003080 0.009808 0.008039 0.001602 0.002399
Lipid Particles 0.001729 0.004066 0.003031 0.001309 0.011628 0.004762 0.002964 0.002291 0.007610 0.004487 0.003012 0.002055
Mitochondria 0.015721 0.002622 0.001371 0.000238 0.007846 0.009539 0.000418 0.001077 0.011043 0.006811 0.001106 0.000875
Mitotic Spindle 0.004602 0.000691 0.000216 0.000203 0.000139 0.000316 0.000234 0.001150 0.001951 0.000464 0.000221 0.000922
None 0.000054 0.000110 0.000439 0.000032 0.000176 0.000758 0.000445 0.000514 0.000126 0.000503 0.000441 0.000398
Nuclear Periphery 0.000367 0.000084 0.000106 0.000096 0.000120 0.000081 0.000178 0.000060 0.000220 0.000082 0.000126 0.000068
Nuclear Periphery Foci 0.000930 0.000880 0.000606 0.000568 0.000308 0.000236 0.000966 0.000723 0.000561 0.000490 0.000706 0.000686
Nucleolus 0.000045 0.000109 0.000080 0.000012 0.000205 0.000448 0.000069 0.000066 0.000140 0.000314 0.000077 0.000053
Nucleus 0.015930 0.007346 0.034280 0.004446 0.013212 0.013330 0.068040 0.008941 0.014315 0.010970 0.043677 0.007862
Peroxisomes 0.001305 0.005840 0.002175 0.000394 0.004642 0.006694 0.001578 0.001614 0.003288 0.006357 0.002009 0.001322
Vacuole 0.199264 0.022564 0.047144 0.046234 0.024962 0.030083 0.044601 0.043387 0.095718 0.027118 0.046436 0.044070
Vacuole Periphery 0.008904 0.000954 0.000189 0.000093 0.000438 0.001504 0.000100 0.000267 0.003875 0.001287 0.000165 0.000225

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.00 -1.07 0.17 -1.04 1.69 -3.74 -9.71 -9.76 -7.29 2.04 -1.48 -7.90 -6.30 -6.53 1.38
Bud Neck -4.59 -10.83 2.15 10.89 23.42 1.68 5.91 8.52 14.91 5.29 -0.75 -2.33 7.69 17.23 21.88
Bud Site 6.03 0.42 2.06 -6.58 3.24 -5.38 -8.04 -11.46 -8.24 -3.85 2.12 -5.95 -4.39 -11.07 1.99
Cell Periphery -8.37 -2.28 -18.69 -14.62 -23.65 2.14 -7.22 -10.37 -18.17 -3.82 -3.82 -3.77 -18.09 -20.01 -21.45
Cytoplasm -8.65 -4.23 4.64 21.65 16.96 -0.45 12.87 8.08 15.27 -8.68 -5.19 5.56 6.83 21.10 2.94
Cytoplasmic Foci 3.15 4.04 6.18 9.18 11.99 -0.57 3.16 2.84 5.74 -0.73 1.63 5.14 5.51 7.28 1.22
Eisosomes -9.84 -5.80 -2.37 7.34 2.57 2.83 1.62 6.27 8.23 8.57 -1.17 1.41 4.77 11.40 7.72
Endoplasmic Reticulum 0.41 -3.78 -0.11 -0.68 4.67 -2.15 -10.65 -2.15 0.27 10.02 -0.69 -10.71 -0.60 0.14 12.53
Endosome 3.12 3.69 4.13 8.26 11.82 0.07 4.28 1.77 2.66 -3.86 2.84 4.97 4.04 3.73 -2.87
Golgi 0.95 2.59 2.88 12.01 9.57 -0.06 4.83 3.85 5.02 -1.12 0.77 4.73 4.06 7.39 -1.64
Lipid Particles -2.82 -2.65 1.29 3.86 5.69 1.95 2.44 2.61 4.04 1.11 1.51 2.21 2.61 4.86 2.46
Mitochondria 2.04 2.27 2.47 4.00 10.31 -0.48 2.29 2.09 6.92 -2.80 1.18 3.11 3.18 7.54 1.21
Mitotic Spindle 1.30 1.50 1.51 1.08 0.29 -1.59 -1.42 -1.51 -1.26 -1.18 1.21 1.42 0.75 -0.84 -1.32
None -2.01 -4.23 2.17 4.74 4.68 -1.55 -1.97 -1.05 0.39 -0.22 -1.64 -3.36 -1.12 0.18 0.04
Nuclear Periphery 1.15 1.06 1.10 -0.76 1.26 1.71 -3.96 2.87 2.21 9.06 1.37 0.78 1.52 1.63 10.82
Nuclear Periphery Foci 0.37 2.35 2.41 0.65 0.39 1.62 -9.14 -1.23 -1.43 0.43 0.64 -0.86 -0.39 -0.72 -0.14
Nucleolus -0.89 -2.80 3.48 1.43 23.07 -0.47 0.83 0.92 1.05 0.48 -0.58 0.76 0.96 1.18 1.24
Nucleus 2.71 -4.03 3.32 2.57 18.75 -0.04 -11.71 2.86 3.93 12.58 2.29 -12.68 3.88 3.69 19.73
Peroxisomes -6.53 -2.29 2.40 8.95 9.22 -1.85 3.45 3.43 7.93 -0.32 -4.32 2.30 3.51 10.90 3.38
Vacuole 10.65 9.40 8.79 -4.90 -0.83 -1.84 -7.40 -5.90 -5.06 2.12 8.81 6.48 6.64 -7.54 0.95
Vacuole Periphery 2.28 2.58 2.61 1.37 3.19 -2.10 3.09 1.47 2.48 -3.56 1.72 2.69 2.64 2.72 -1.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication
Localization
Cell Percentages cell periphery (67%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-3

Wsc2

Wsc2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Wsc2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available