Standard name
Human Ortholog
Description Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.06 0.05 0.06 0 0 0.07 0 0 0.05 0 0 0 0.09 0.09 0.06 0 0 0 0 0 0
Cytoplasm 0.97 0.96 0.94 0.91 0.91 0.78 0.71 0.64 0.61 0.62 0.59 0.62 0.96 0.98 0.98 0.9 0.91 0.95 0.9 0.89 0.86 0.85 0.86 0.89
Endoplasmic Reticulum 0 0 0.08 0.05 0 0.07 0.09 0.12 0.1 0.12 0 0.11 0 0 0 0 0 0 0.05 0 0.08 0.11 0.08 0.07
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.17 0.2 0.24 0.32 0.21 0.42 0.24 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.05 0.05 0.06 0 0.05 0.05 0.07 0 0 0 0.06 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 2 2 1 2 8 12 3 8 13 0 2 1 1 0 0 0 0 0 0 1 1
Bud 2 0 1 0 1 1 1 2 6 6 13 3 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 2 7 12 12 13 8 8 22 5 7 15 3 10 14 17 21 12 0 0 0 0 0 0
Cytoplasm 413 165 224 181 241 180 207 145 180 158 147 170 267 316 322 162 207 175 386 155 210 218 327 334
Endoplasmic Reticulum 7 7 19 9 11 16 27 28 31 31 10 29 11 9 8 6 5 5 22 4 18 27 31 25
Endosome 0 0 0 1 0 0 0 0 0 0 0 1 0 1 0 0 0 0 2 0 0 0 1 1
Golgi 3 0 1 0 0 4 0 0 0 1 0 0 0 1 0 0 1 1 2 0 0 0 1 2
Mitochondria 2 2 1 4 9 39 59 55 95 55 105 65 0 0 0 0 2 2 3 1 4 1 2 2
Nucleus 0 0 2 0 0 1 1 1 2 1 1 0 0 2 1 2 2 0 0 1 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 2 5 8 11 14 14 8 14 12 18 2 0 1 11 11 3 4 5 4 3 6 2
Unique Cell Count 426 172 239 198 264 232 291 228 296 256 251 273 277 322 328 181 227 185 427 174 246 257 380 374
Labelled Cell Count 432 176 257 214 284 266 319 262 357 275 303 314 283 341 347 199 249 199 427 174 246 257 380 374


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.0 16.5 12.0 11.8 11.5 9.9 9.3 9.3 8.7 8.9 8.4 9.2 13.9 14.3 14.4 20.3 20.8 19.1 13.8 13.5 14.7
Std Deviation (1e-4) 1.7 2.6 2.0 2.0 1.5 1.8 1.6 1.6 1.6 1.7 1.8 1.8 1.9 2.0 1.9 4.1 4.5 4.6 2.1 2.2 2.2
Intensity Change (Log2) – – – -0.02 -0.07 -0.28 -0.37 -0.38 -0.46 -0.43 -0.52 -0.38 0.21 0.25 0.26 0.75 0.79 0.67 0.19 0.16 0.28


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 3.1 0 0 3.4 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 3.2 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.6 0.9 1.4 -0.1 0.4 2.3 -0.7 -0.1 1.4 0 0.1 0.8 2.8 2.9 1.8
Cytoplasm -0.9 -1.0 -5.0 -6.6 -8.0 -8.8 -8.5 -9.1 -8.4 1.4 2.7 2.8 -1.6 -1.0 0.4
Endoplasmic Reticulum -1.4 -1.8 -0.4 0.5 1.6 1.0 1.5 -1.9 1.0 -1.9 -2.8 -3.0 -2.0 -2.8 -2.3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.4 7.2 7.9 9.5 7.4 11.1 7.9 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 2.6 2.7 3.1 0 2.9 2.6 3.4 0 0 0 3.1 2.6 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 12.0283 14.7448 13.454 11.7628 11.2831 13.2081 9.3554 13.1845 11.7859 9.9609 9.8367 11.683 12.289 15.534 13.6906 13.0337 12.5784 14.1237
Actin 0.0071 0.0013 0.0014 0.0036 0.0098 0.0023 0.0139 0.0035 0.0098 0.0061 0.0019 0.0173 0.0052 0.0003 0.019 0.0025 0.02 0.0026
Bud 0.0008 0.0019 0.0005 0.0008 0.0006 0.0004 0.0079 0.0003 0.0005 0.0016 0.0003 0.0005 0.0007 0.0002 0.0004 0.0011 0.0007 0.0002
Bud Neck 0.0008 0.0003 0.0005 0.0006 0.0005 0.0012 0.0014 0.0001 0.0006 0.0009 0.0005 0.0045 0.0012 0.0002 0.0006 0.001 0.0011 0.0011
Bud Periphery 0.0009 0.0009 0.0002 0.0004 0.0002 0.0003 0.0035 0.0001 0.0002 0.0008 0.0002 0.0004 0.0007 0 0.0003 0.001 0.0006 0.0002
Bud Site 0.0008 0.0013 0.0007 0.0008 0.0005 0.0002 0.0042 0.0006 0.0013 0.001 0.0003 0.0003 0.0008 0.0003 0.0007 0.0034 0.0017 0.0001
Cell Periphery 0.0007 0.0003 0.0003 0.0001 0.0001 0.0002 0.0011 0.0001 0.0002 0.0002 0.0001 0.0002 0.0004 0.0002 0.0002 0.0004 0.0001 0.0002
Cytoplasm 0.7612 0.9168 0.886 0.6872 0.7614 0.8221 0.7155 0.958 0.8752 0.8003 0.6871 0.7879 0.7667 0.9563 0.8709 0.799 0.8218 0.8319
Cytoplasmic Foci 0.0199 0.0101 0.0149 0.0421 0.0309 0.0212 0.0276 0.0064 0.0147 0.0205 0.022 0.0149 0.0224 0.0052 0.012 0.0169 0.018 0.0139
Eisosomes 0.0001 0 0 0.0002 0.0001 0 0.0009 0 0 0.0001 0.0001 0.0001 0 0 0.0001 0.0001 0.0002 0
Endoplasmic Reticulum 0.0842 0.0229 0.0297 0.017 0.0257 0.0455 0.0512 0.0055 0.0301 0.0135 0.0052 0.0776 0.0841 0.0212 0.0257 0.021 0.0075 0.0824
Endosome 0.0599 0.0255 0.0432 0.1419 0.0868 0.0678 0.0845 0.0119 0.044 0.0872 0.1039 0.0636 0.0516 0.0104 0.039 0.079 0.0707 0.0468
Golgi 0.016 0.0046 0.0069 0.0101 0.0104 0.0117 0.0204 0.002 0.0068 0.0139 0.0359 0.0137 0.0128 0.0013 0.0054 0.0051 0.0091 0.0061
Lipid Particles 0.0042 0.0001 0.0014 0.0302 0.0079 0.0012 0.0063 0.0003 0.0005 0.0201 0.0024 0.0008 0.0066 0.0001 0.0015 0.0022 0.0082 0.0009
Mitochondria 0.0151 0.0072 0.0018 0.0125 0.0081 0.0118 0.0155 0.0061 0.0016 0.0068 0.1236 0.0067 0.0085 0.0005 0.0045 0.0148 0.0043 0.0043
None 0.0024 0.0006 0.0007 0.0028 0.0036 0.0012 0.0069 0.0006 0.0006 0.0007 0.001 0.0007 0.0021 0.0003 0.0032 0.0007 0.0046 0.0006
Nuclear Periphery 0.005 0.0012 0.0016 0.0058 0.0036 0.0019 0.0085 0.0006 0.0018 0.0026 0.0013 0.0026 0.006 0.0007 0.004 0.0074 0.0068 0.002
Nucleolus 0.0001 0 0 0.0001 0.0002 0.0001 0.0009 0 0 0.0001 0 0 0.0003 0 0.0001 0.0004 0.0005 0
Nucleus 0.0019 0.0007 0.0009 0.002 0.0012 0.0014 0.0028 0.0005 0.0009 0.0012 0.0007 0.0011 0.002 0.0006 0.0016 0.0044 0.0039 0.0009
Peroxisomes 0.0016 0.0001 0.0003 0.0038 0.0268 0.0027 0.0041 0.0011 0.0007 0.0038 0.001 0.0003 0.0126 0 0.0008 0.0016 0.0025 0.0004
Punctate Nuclear 0.0014 0.0001 0.0005 0.001 0.0119 0.0002 0.0008 0.0001 0.0001 0.0018 0.0001 0.0002 0.0018 0 0.0005 0.0004 0.0039 0.0003
Vacuole 0.0127 0.003 0.0061 0.027 0.0069 0.004 0.0178 0.0017 0.0083 0.013 0.0087 0.0045 0.0104 0.0017 0.0078 0.0296 0.0109 0.0033
Vacuole Periphery 0.0031 0.001 0.0023 0.0101 0.0031 0.0025 0.0046 0.0004 0.0021 0.0038 0.0037 0.0022 0.0028 0.0004 0.0017 0.008 0.003 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.5857 38.6814 23.4845 29.4655 25.5011 29.4865 31.7775 24.5973 28.4976 30.6383
Translational Efficiency 1.5357 1.0543 1.7323 1.2402 1.4579 1.6913 1.4291 1.7072 1.6127 1.3206

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
42 897 1606 159 1283 2043 203 98 1325 2940 1809 257

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1379.91 1236.06 1433.21 1539.04 1138.60 1342.77 1620.21 1799.30 1146.25 1310.21 1454.19 1638.28
Standard Deviation 237.15 216.96 203.93 252.83 161.59 196.87 228.82 271.79 169.86 209.07 215.13 289.30
Intensity Change Log 2 — -0.158825 0.054676 0.157457 — 0.237951 0.508920 0.660175 — 0.034146 0.277856 0.406560

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.004891 0.000418 0.000258 0.000705 0.000350 0.000435 0.001470 0.001338 0.000494 0.000430 0.000394 0.000946
Bud Neck 0.007666 0.000535 0.001180 0.004598 0.000404 0.000341 0.004185 0.004986 0.000634 0.000400 0.001517 0.004746
Bud Site 0.113720* 0.027295 0.014118 0.044461 0.025844 0.016277 0.048588 0.046626 0.028629 0.019639 0.017986 0.045286
Cell Periphery 0.003767 0.000635 0.000334 0.001581 0.000547 0.000237 0.001464 0.005334 0.000649 0.000358 0.000461 0.003012
Cytoplasm 0.221821* 0.711841* 0.637591* 0.416994* 0.573288* 0.718645* 0.686001* 0.655168* 0.562147* 0.716569* 0.643023* 0.507815*
Cytoplasmic Foci 0.270114* 0.135922 0.066327 0.100102 0.264750* 0.160875 0.089591 0.084310 0.264920* 0.153262 0.068938 0.094080
Eisosomes 0.000069 0.000006 0.000004 0.000016 0.000011 0.000005 0.000011 0.000011 0.000013 0.000005 0.000005 0.000014
Endoplasmic Reticulum 0.027598 0.016455 0.014258 0.012291 0.042147 0.011554 0.011585 0.003374 0.041686 0.013049 0.013958 0.008891
Endosome 0.031283 0.012203 0.016376 0.032979 0.012909 0.009140 0.019984 0.013112 0.013491 0.010074 0.016781 0.025404
Golgi 0.056027 0.024456 0.009255 0.016998 0.028197 0.022473 0.017449 0.018311 0.029079 0.023078 0.010174 0.017499
Lipid Particles 0.011378 0.002785 0.003979 0.014156 0.002080 0.001232 0.014708 0.025671 0.002375 0.001706 0.005183 0.018547
Mitochondria 0.001806 0.000406 0.000099 0.000136 0.001529 0.001355 0.000025 0.000015 0.001538 0.001066 0.000091 0.000090
Mitotic Spindle 0.004019 0.001142 0.003872 0.002563 0.001256 0.003427 0.006149 0.004500 0.001344 0.002730 0.004127 0.003301
None 0.000355 0.000942 0.000161 0.000162 0.000160 0.000229 0.000162 0.000174 0.000166 0.000447 0.000161 0.000167
Nuclear Periphery 0.001936 0.000401 0.000278 0.000595 0.000039 0.000036 0.000218 0.000105 0.000099 0.000147 0.000272 0.000408
Nuclear Periphery Foci 0.029809 0.003775 0.004554 0.009346 0.000735 0.000732 0.015613 0.006497 0.001657 0.001661 0.005795 0.008260
Nucleolus 0.012407 0.000141 0.000081 0.000168 0.000028 0.000103 0.000032 0.000081 0.000420 0.000115 0.000076 0.000135
Nucleus 0.035933 0.002725 0.004189 0.004252 0.001276 0.001756 0.004865 0.003517 0.002374 0.002051 0.004264 0.003972
Peroxisomes 0.002238 0.000287 0.000221 0.001297 0.000270 0.000275 0.000421 0.001223 0.000332 0.000278 0.000244 0.001269
Vacuole 0.111791 0.033973 0.202166* 0.325364* 0.017987 0.029436 0.072568 0.116763 0.020960 0.030820 0.187623 0.245820*
Vacuole Periphery 0.051372 0.023657 0.020699 0.011237 0.026196 0.021438 0.004912 0.008884 0.026994 0.022115 0.018927 0.010340

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.86 1.93 1.71 -2.48 -3.89 -0.44 -5.65 -3.75 -2.75 0.48 0.37 1.04 -3.25 -2.94 -4.43
Bud Neck 1.95 1.82 1.06 -6.33 -5.32 1.76 -7.51 -6.15 -6.22 -1.41 1.90 -4.44 -7.97 -8.92 -6.68
Bud Site 3.59 4.17 2.82 -2.89 -5.41 5.73 -3.80 -3.14 -4.73 0.30 4.95 5.47 -3.64 -5.99 -6.29
Cell Periphery 1.73 1.91 1.19 -2.66 -3.67 8.04 -4.98 -1.89 -2.04 -1.49 4.18 2.65 -2.40 -2.73 -2.62
Cytoplasm -11.95 -10.18 -4.21 10.94 8.26 -14.10 -5.25 -2.20 2.75 1.32 -15.79 -7.17 2.75 10.35 6.50
Cytoplasmic Foci 3.03 4.87 3.99 3.75 -3.16 14.43 20.05 16.20 7.61 0.60 16.47 31.07 19.36 8.37 -3.10
Eisosomes 3.03 3.11 2.53 -5.24 -6.33 6.17 -0.13 -0.72 -4.10 -0.55 6.48 6.81 -1.17 -6.85 -7.11
Endoplasmic Reticulum 1.03 1.30 1.38 0.89 0.47 8.70 7.29 11.06 4.86 2.71 8.49 8.19 7.05 1.36 1.49
Endosome 3.23 2.49 -0.23 -6.11 -4.87 4.72 -2.64 0.00 -1.74 2.09 4.33 -3.56 -4.95 -6.64 -3.48
Golgi 2.90 4.53 3.70 3.05 -2.77 4.36 5.07 3.39 1.77 0.15 4.78 17.51 5.86 3.31 -2.97
Lipid Particles 1.72 1.49 -0.48 -5.99 -5.39 5.23 -6.35 -5.44 -5.64 -2.18 2.78 -7.44 -7.90 -8.27 -6.48
Mitochondria 1.25 1.55 1.38 0.65 -0.77 0.25 2.55 2.57 3.43 1.40 0.74 2.53 2.35 3.00 -0.57
Mitotic Spindle 1.26 0.13 0.41 -2.01 0.62 -2.50 -3.49 -1.29 -0.96 -0.52 -2.05 -3.64 -1.64 -1.11 -0.58
None -1.43 1.85 1.56 2.23 -0.01 -2.41 -0.04 -0.63 0.53 -0.57 -2.64 0.28 -0.11 2.25 -0.22
Nuclear Periphery 1.35 1.51 1.18 -0.37 -0.82 0.45 -3.21 -2.13 -2.21 1.56 -0.50 -3.85 -1.35 -1.06 -0.56
Nuclear Periphery Foci 2.28 2.21 1.77 -2.81 -2.44 -0.01 -7.83 -6.19 -6.16 4.26 0.15 -7.48 -4.87 -5.11 -1.96
Nucleolus 1.92 1.92 1.91 -0.45 -1.98 -1.11 -1.04 -2.74 0.07 -2.55 1.49 1.67 1.39 -0.52 -2.23
Nucleus 2.59 2.48 2.47 -2.03 -0.19 -2.84 -8.28 -4.75 -3.87 1.20 1.00 -2.89 -2.39 -4.52 0.11
Peroxisomes 3.13 3.22 1.47 -4.21 -4.48 -0.23 -2.70 -5.45 -5.41 -4.40 1.79 2.77 -5.70 -6.09 -6.28
Vacuole 2.90 -2.43 -5.15 -12.46 -5.14 -6.03 -6.24 -5.87 -5.28 -2.68 -4.59 -29.59 -13.35 -12.82 -3.55
Vacuole Periphery 2.26 2.59 3.49 5.62 5.66 2.33 10.90 3.81 2.92 -0.66 2.46 4.27 6.90 5.88 4.19
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Caf40

Caf40


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Caf40-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available