Standard name
Human Ortholog
Description Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 0.49 0.51 0.79 0.37 0.47 0.42 0.52 – 0.57 0.66 0.59 0.68 0.48 0.49 0.08 0.07 0.09 0.05 0.11 0.13 0.18 0.15 0.13
Endoplasmic Reticulum – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome – 0 0 0 0.06 0 0 0 – 0 0 0 0 0.09 0.09 0 0 0 0 0.08 0.05 0 0 0.06
Golgi – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 0 0.1 0.05 0.13 0.12 0.13 0.1 – 0.08 0.11 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus – 0 0 0 0.06 0.08 0.07 0 – 0 0 0 0 0 0 0.31 0.34 0.3 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 0.56 0.53 0.26 0.58 0.49 0.49 0.47 – 0.45 0.38 0.45 0.36 0.5 0.52 0.74 0.79 0.77 0.72 0.73 0.7 0.71 0.67 0.71
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 1 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 1 0 3 3
Bud – 0 0 2 0 0 3 5 – 1 8 1 0 0 0 0 0 0 0 8 1 3 8 10
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 1 1 0 0 0 0 0 0 0 2 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 1 – 3 1 1 1 0 0 2 0 0 0 0 0 0 0 0
Cytoplasm – 174 68 143 80 112 138 173 – 226 219 243 167 221 245 36 24 31 1 41 19 48 58 54
Endoplasmic Reticulum – 4 1 1 0 4 3 2 – 4 2 1 8 4 4 19 18 13 0 1 0 1 5 1
Endosome – 15 5 5 13 1 0 1 – 2 0 1 5 39 46 8 1 6 1 30 8 7 17 23
Golgi – 0 2 0 0 0 0 0 – 0 0 1 0 0 1 0 0 2 0 4 2 0 4 1
Mitochondria – 9 14 10 29 29 42 32 – 31 36 40 0 1 1 11 3 3 0 5 4 5 18 11
Nucleus – 11 0 2 12 18 24 14 – 9 10 12 6 15 12 134 116 103 1 5 0 2 3 4
Nuclear Periphery – 2 0 0 3 2 12 4 – 6 7 4 0 0 1 7 2 1 0 2 1 0 1 1
Nucleolus – 0 0 0 1 0 2 0 – 1 0 0 0 2 0 1 0 1 0 0 0 0 2 1
Peroxisomes – 1 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 1 0 1 0 – 0 0 0 0 3 0 1 1 1 0 1 1 2 3 4
Vac/Vac Membrane – 198 71 48 124 116 161 158 – 179 127 183 89 228 264 321 272 259 23 280 103 194 270 300
Unique Cell Count 354 134 182 215 236 330 333 395 330 409 247 457 503 433 346 338 32 387 148 273 403 423
Labelled Cell Count 414 161 212 263 282 386 390 462 410 487 277 514 575 540 437 420 32 387 148 273 403 423


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 5.2 4.5 4.3 5.3 5.3 5.5 5.7 – 5.9 5.6 6.2 5.9 6.2 6.3 8.9 8.9 9.0 6.0 6.4 6.4
Std Deviation (1e-4) – 1.2 1.6 1.7 1.6 1.2 1.5 1.4 – 1.7 1.4 1.9 1.3 1.4 1.4 2.3 2.4 2.4 1.2 1.7 1.5
Intensity Change (Log2) – – – -0.05 0.26 0.26 0.31 0.35 – 0.41 0.34 0.47 0.41 0.46 0.51 0.99 0.99 1.01 0.43 0.51 0.52


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 5.2 -2.5 -0.6 -1.8 0.2 – 1.3 3.1 1.8 3.2 -0.5 -0.4 -11.1 -10.9 -10.0
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 0 2.2 0
Endosome 0 1.0 0 0 0 – 0 0 0 0 1.9 2.1 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.8 0.5 0.7 -0.3 – -0.9 0.1 -0.2 0 0 0 -3.9 0 0
Nucleus 0 0 3.3 3.2 0 – 0 0 0 0 0 0 7.4 7.7 7.2
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole -4.8 0.9 -0.7 -0.8 -1.1 – -1.5 -2.9 -1.7 -3.2 -0.6 -0.1 4.6 5.6 5.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.1524 0.4369 0.149 -0.1243 0.5206 -0.0279 2.8494 2.5868 2.8919 2.1804 2.9689 3.0103 -0.2002 0.9351 0.3989 0.2308 -0.5287 0.2887
Actin 0.0261 0.0002 0.0033 0.0051 0.0311 0.0055 0.0226 0.0008 0.004 0 0.0233 0.0031 0.0011 0.0001 0.0002 0 0.0001 0.0001
Bud 0.0014 0.0028 0.0063 0.0058 0.0071 0.0007 0.0017 0.0058 0.0054 0.0012 0.0039 0.0017 0.0007 0.0062 0.0007 0.0002 0.0004 0.0005
Bud Neck 0.0018 0.0011 0.002 0.0007 0.0027 0.0018 0.0043 0.0014 0.0026 0.0007 0.0019 0.0024 0.001 0.0009 0.0008 0.0004 0.0016 0.0016
Bud Periphery 0.0013 0.0027 0.0056 0.0115 0.0278 0.0011 0.0024 0.0102 0.0127 0.0023 0.0155 0.0032 0.0015 0.0027 0.001 0.0003 0.0007 0.0012
Bud Site 0.0028 0.0111 0.0152 0.0023 0.0055 0.0006 0.0057 0.0138 0.0079 0.0007 0.0024 0.001 0.0019 0.0089 0.0019 0.0004 0.0011 0.0015
Cell Periphery 0.0007 0.0011 0.0008 0.0003 0.0044 0.0004 0.0013 0.0011 0.0014 0.0004 0.0007 0.0005 0.001 0.0011 0.0007 0.0003 0.0006 0.0005
Cytoplasm 0.0774 0.1293 0.104 0.0778 0.0839 0.1422 0.0899 0.0788 0.0824 0.0591 0.0918 0.0897 0.0656 0.0958 0.0652 0.0911 0.1346 0.0586
Cytoplasmic Foci 0.084 0.0462 0.0479 0.0801 0.0603 0.0679 0.0524 0.0532 0.0499 0.0381 0.0615 0.0615 0.05 0.0398 0.0459 0.0224 0.0242 0.0407
Eisosomes 0.0003 0.0001 0.0001 0.0001 0.0004 0.0001 0.0005 0 0.0002 0.0001 0.0004 0 0.0001 0 0.0002 0 0 0
Endoplasmic Reticulum 0.0057 0.0044 0.0034 0.0022 0.0023 0.0024 0.0074 0.0031 0.0056 0.0025 0.0045 0.003 0.0059 0.0048 0.0043 0.0017 0.0061 0.0029
Endosome 0.199 0.127 0.1936 0.2788 0.1567 0.1903 0.2147 0.2048 0.2199 0.2104 0.2532 0.2537 0.2619 0.1944 0.2651 0.2248 0.3379 0.2886
Golgi 0.0159 0.0019 0.0045 0.0161 0.0329 0.0039 0.0093 0.0055 0.0049 0.0017 0.0167 0.0047 0.0052 0.0023 0.0046 0.0031 0.0066 0.0038
Lipid Particles 0.0396 0.0105 0.0101 0.0088 0.0524 0.0104 0.0169 0.0028 0.007 0.0018 0.0154 0.0068 0.0162 0.0095 0.0104 0.0019 0.0088 0.0082
Mitochondria 0.0191 0.005 0.0234 0.0307 0.0503 0.0058 0.0164 0.0062 0.0146 0.0061 0.0213 0.0079 0.0065 0.0021 0.0047 0.0008 0.0039 0.0072
None 0.2742 0.3666 0.2913 0.2297 0.1913 0.212 0.2068 0.1536 0.1789 0.2857 0.1363 0.1548 0.1302 0.1261 0.1704 0.1137 0.0083 0.0835
Nuclear Periphery 0.0135 0.0082 0.0045 0.0032 0.0021 0.0035 0.0097 0.0034 0.0086 0.0046 0.0054 0.0051 0.0086 0.0107 0.0046 0.0029 0.0055 0.0066
Nucleolus 0.0038 0.0042 0.0075 0.0018 0.0031 0.0038 0.0045 0.0044 0.007 0.0016 0.0046 0.0022 0.0054 0.0041 0.003 0.0009 0.002 0.0025
Nucleus 0.0212 0.0126 0.0176 0.007 0.0044 0.0086 0.0087 0.0089 0.0111 0.0054 0.0073 0.0079 0.0181 0.0122 0.0069 0.0031 0.005 0.0084
Peroxisomes 0.0175 0.0012 0.0031 0.0111 0.0185 0.0099 0.004 0.0016 0.0022 0.0008 0.0068 0.0042 0.0071 0.0022 0.0021 0.0002 0.0006 0.0017
Punctate Nuclear 0.0042 0.0021 0.0043 0.0011 0.002 0.0061 0.0039 0.0023 0.0029 0.0009 0.0167 0.002 0.0031 0.0015 0.0014 0.0005 0.0005 0.0028
Vacuole 0.1732 0.2313 0.2189 0.189 0.2274 0.2841 0.2826 0.3878 0.3204 0.3344 0.2652 0.3284 0.3518 0.4151 0.3453 0.4541 0.3912 0.4022
Vacuole Periphery 0.0171 0.0304 0.0326 0.0368 0.0334 0.0388 0.0343 0.0505 0.0506 0.0417 0.0451 0.0563 0.0569 0.0594 0.0606 0.077 0.0604 0.0769

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.3018 20.9633 25.3803 27.1114 22.4033 38.24 29.2838 26.3528 38.3202 30.5124
Translational Efficiency 0.9404 1.1319 0.9586 1.3824 1.471 1.0875 1.2117 1.9206 1.0685 1.1653

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1828 1798 581 1330 1589 1503 2585 1689 3417 3301 3166 3019

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 666.39 690.26 817.75 953.25 658.66 691.77 807.17 912.04 662.80 690.95 809.11 930.19
Standard Deviation 83.77 118.45 106.03 173.75 99.30 97.58 126.89 147.65 91.40 109.44 123.40 160.98
Intensity Change Log 2 — 0.050773 0.295293 0.516488 — 0.070759 0.293339 0.469563 — 0.060742 0.294322 0.493353

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000055 0.000102 0.000386 0.000320 0.000050 0.000191 0.000466 0.000421 0.000052 0.000142 0.000451 0.000377
Bud Neck 0.015201 0.026341 0.013738 0.020205 0.016650 0.033562 0.023522 0.022458 0.015874 0.029629 0.021726 0.021466
Bud Site 0.006995 0.012616 0.005879 0.048447 0.004385 0.016588 0.024912 0.031008 0.005781 0.014424 0.021419 0.038691
Cell Periphery 0.000078 0.000125 0.000120 0.000120 0.000103 0.000182 0.000218 0.000144 0.000089 0.000151 0.000200 0.000133
Cytoplasm 0.384020* 0.306635* 0.202841* 0.143390* 0.363703* 0.235724* 0.479244* 0.206514* 0.374572* 0.274348* 0.428520* 0.178705*
Cytoplasmic Foci 0.148417 0.108872 0.018334 0.034894 0.146882 0.190801* 0.013061 0.035307 0.147703 0.146175 0.014028 0.035125
Eisosomes 0.000069 0.000064 0.000056 0.000014 0.000091 0.000111 0.000021 0.000029 0.000079 0.000085 0.000027 0.000022
Endoplasmic Reticulum 0.001419 0.001538 0.005463 0.001322 0.001244 0.001333 0.001691 0.001421 0.001337 0.001444 0.002383 0.001377
Endosome 0.045788 0.053026 0.020621 0.094706 0.050544 0.102922 0.008869 0.093901 0.048000 0.075745 0.011026 0.094256
Golgi 0.001573 0.002099 0.000227 0.007292 0.001503 0.006724 0.000457 0.004186 0.001540 0.004205 0.000415 0.005554
Lipid Particles 0.006358 0.006034 0.002848 0.001169 0.006170 0.009123 0.000951 0.002081 0.006271 0.007440 0.001299 0.001680
Mitochondria 0.002641 0.005567 0.000883 0.002900 0.002425 0.012237 0.002558 0.002689 0.002540 0.008604 0.002250 0.002782
Mitotic Spindle 0.002760 0.004662 0.002124 0.025940 0.001191 0.004344 0.019830 0.019264 0.002030 0.004517 0.016581 0.022205
None 0.001541 0.004809 0.003453 0.000771 0.003191 0.001442 0.004775 0.002287 0.002308 0.003276 0.004532 0.001619
Nuclear Periphery 0.000644 0.001020 0.005021 0.001074 0.000503 0.000468 0.003078 0.001432 0.000578 0.000768 0.003434 0.001274
Nuclear Periphery Foci 0.000274 0.000559 0.001975 0.001542 0.000338 0.000306 0.000483 0.000719 0.000304 0.000443 0.000756 0.001081
Nucleolus 0.001161 0.003900 0.006565 0.001513 0.002024 0.001846 0.001810 0.003283 0.001563 0.002964 0.002683 0.002503
Nucleus 0.068545 0.073677 0.473848* 0.016772 0.075334 0.043383 0.257560* 0.063628 0.071702 0.059883 0.297252* 0.042986
Peroxisomes 0.002061 0.004190 0.000978 0.003762 0.003271 0.012343 0.000779 0.004609 0.002624 0.007902 0.000815 0.004236
Vacuole 0.304532* 0.375044* 0.231146* 0.557486* 0.315427* 0.316941* 0.152355 0.479629* 0.309598* 0.348588* 0.166814 0.513928*
Vacuole Periphery 0.005869 0.009123 0.003496 0.036363 0.004973 0.009433 0.003362 0.024991 0.005452 0.009264 0.003386 0.030001

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.88 -1.68 -4.60 -3.66 0.61 -6.87 -2.48 -1.85 -0.96 -0.04 -7.85 -2.93 -2.94 -1.96 0.24
Bud Neck -6.02 0.53 -3.17 2.48 -2.96 -7.39 -5.27 -3.49 4.28 1.65 -9.48 -5.77 -4.87 4.60 1.33
Bud Site -4.63 0.37 -10.91 -8.98 -10.33 -7.26 -9.85 -10.38 -3.96 -3.20 -8.57 -8.50 -14.81 -9.35 -7.59
Cell Periphery -3.33 -3.56 -2.47 1.25 1.22 -2.54 -3.97 -0.89 1.86 2.44 -3.69 -5.08 -2.01 2.06 3.13
Cytoplasm 8.15 16.34 21.32 13.45 1.56 13.28 -7.72 12.63 -0.42 22.22 14.76 -2.29 23.35 9.05 25.18
Cytoplasmic Foci 7.95 32.87 29.58 21.32 -5.96 -6.94 32.76 26.43 30.41 -11.62 0.24 48.35 39.61 36.03 -14.14
Eisosomes 0.80 1.52 14.77 10.08 10.12 -3.15 15.99 14.47 15.83 -2.61 -1.53 16.90 20.04 17.60 5.32
Endoplasmic Reticulum -0.59 -10.71 0.14 0.51 9.59 -0.57 -5.91 -1.11 -0.50 5.51 -0.83 -10.99 -0.42 0.26 8.83
Endosome -2.56 8.68 -6.85 -4.81 -12.60 -12.23 19.12 -6.14 5.57 -19.82 -11.09 24.94 -9.27 0.66 -25.89
Golgi -1.05 6.45 -3.77 -3.00 -5.38 -6.16 5.14 -2.85 3.55 -5.14 -5.70 7.61 -4.71 0.25 -7.32
Lipid Particles 0.57 6.34 10.56 9.28 5.33 -3.87 12.99 9.41 10.07 -3.58 -2.32 15.48 13.71 13.34 -1.77
Mitochondria -4.02 5.42 0.52 3.89 -2.81 -6.35 0.43 0.21 6.45 -0.18 -7.49 1.94 0.56 7.57 -0.99
Mitotic Spindle -1.23 -0.24 -7.84 -7.20 -7.77 -2.52 -9.29 -7.63 -6.06 -0.78 -2.48 -8.82 -10.81 -9.36 -3.77
None -3.69 -3.46 2.13 4.59 5.16 2.17 -1.23 1.32 -1.06 4.07 -1.55 -3.96 1.67 3.17 7.27
Nuclear Periphery -2.59 -10.23 -4.93 -2.94 7.86 0.43 -19.60 -7.27 -7.66 8.98 -2.26 -21.53 -8.54 -7.15 12.62
Nuclear Periphery Foci -3.79 -5.53 -6.33 -4.79 1.91 0.37 -4.28 -4.73 -5.23 -1.07 -2.97 -7.45 -7.90 -6.24 -1.11
Nucleolus -6.05 -5.83 -3.41 4.41 4.99 0.32 -0.74 -2.38 -2.49 -2.12 -4.22 -5.44 -3.54 0.64 0.83
Nucleus -1.46 -30.03 11.92 11.76 32.94 8.52 -36.71 0.60 -6.94 35.33 4.28 -47.69 5.91 1.82 49.79
Peroxisomes -6.13 6.80 -1.83 2.28 -4.46 -8.11 6.36 -0.69 7.34 -5.70 -9.61 8.58 -1.84 7.24 -7.25
Vacuole -7.39 4.89 -23.50 -16.00 -21.77 -0.07 16.44 -14.77 -14.64 -33.58 -5.46 19.24 -26.47 -20.63 -44.96
Vacuole Periphery -4.18 5.26 -11.41 -9.41 -13.16 -6.23 5.31 -10.26 -6.69 -12.21 -7.20 7.54 -15.20 -11.38 -17.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
Localization
Cell Percentages vacuole (36%), cytoplasm (9%), mixed (47%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Bxi1

Bxi1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bxi1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available