Standard name | |
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Human Ortholog | |
Description | Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 5 | 6 | 140 | 109 | 63 | 66 | 71 | 62 | 35 | 79 | 69 | 114 | 64 | 78 | 48 | 17 | 50 | 19 | 2 | 7 | 49 | 33 | 52 | 43 |
Bud | 2 | 1 | 34 | 40 | 11 | 22 | 18 | 25 | 35 | 28 | 50 | 44 | 15 | 25 | 14 | 7 | 11 | 10 | 0 | 2 | 8 | 12 | 12 | 21 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 4 | 17 | 19 | 18 | 16 |
Bud Site | 0 | 0 | 1 | 2 | 1 | 2 | 1 | 4 | 3 | 6 | 5 | 6 | 0 | 1 | 0 | 2 | 5 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 1 | 49 | 34 | 27 | 32 | 36 | 31 | 27 | 39 | 42 | 88 | 58 | 48 | 74 | 9 | 50 | 27 | 1 | 0 | 21 | 9 | 33 | 31 |
Cytoplasm | 3 | 9 | 34 | 79 | 76 | 123 | 139 | 134 | 131 | 150 | 139 | 186 | 59 | 102 | 59 | 8 | 82 | 30 | 1 | 7 | 3 | 8 | 14 | 19 |
Endoplasmic Reticulum | 12 | 12 | 296 | 206 | 329 | 337 | 415 | 316 | 110 | 188 | 81 | 217 | 220 | 354 | 341 | 1 | 5 | 5 | 50 | 50 | 389 | 289 | 628 | 626 |
Endosome | 0 | 0 | 2 | 8 | 6 | 17 | 8 | 4 | 7 | 3 | 4 | 9 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 1 | 2 |
Golgi | 0 | 0 | 1 | 6 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 0 | 3 |
Mitochondria | 1 | 3 | 19 | 35 | 12 | 71 | 74 | 90 | 79 | 94 | 106 | 135 | 0 | 0 | 1 | 7 | 20 | 4 | 1 | 0 | 15 | 11 | 10 | 11 |
Nucleus | 0 | 0 | 0 | 1 | 0 | 2 | 2 | 7 | 0 | 0 | 1 | 0 | 0 | 2 | 4 | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 1 | 4 | 3 | 10 | 14 | 6 | 7 | 2 | 6 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 9 | 4 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 18 | 26 | 37 | 33 | 61 | 93 | 41 | 25 | 20 | 26 | 2 | 16 | 14 | 1 | 9 | 4 | 0 | 2 | 7 | 10 | 15 | 25 |
Unique Cell Count | 18 | 24 | 443 | 405 | 457 | 564 | 682 | 641 | 370 | 484 | 374 | 627 | 346 | 515 | 455 | 38 | 202 | 76 | 64 | 78 | 523 | 400 | 790 | 811 |
Labelled Cell Count | 24 | 32 | 597 | 553 | 569 | 710 | 839 | 790 | 478 | 621 | 523 | 836 | 421 | 629 | 558 | 54 | 245 | 102 | 64 | 78 | 523 | 400 | 790 | 811 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.5 | 10.2 | 9.9 | 10.0 | 10.0 | 8.9 | 8.7 | 8.9 | 8.5 | 8.2 | 8.0 | 8.3 | 11.3 | 11.5 | 12.6 | 8.2 | 9.7 | 12.2 | 12.6 | 12.9 | 12.2 |
Std Deviation (1e-4) | 2.0 | 2.3 | 2.0 | 1.9 | 1.9 | 1.7 | 1.7 | 1.7 | 1.7 | 1.6 | 1.6 | 1.6 | 1.8 | 2.0 | 2.4 | 1.8 | 2.3 | 6.1 | 2.2 | 2.3 | 2.2 |
Intensity Change (Log2) | – | – | – | 0.01 | 0.01 | -0.15 | -0.19 | -0.16 | -0.22 | -0.28 | -0.3 | -0.26 | 0.18 | 0.22 | 0.35 | -0.27 | -0.03 | 0.3 | 0.34 | 0.38 | 0.3 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | -1.5 | -6.4 | -7.8 | -8.9 | -9.1 | -7.6 | -5.5 | -4.3 | -5.1 | -4.2 | -6.1 | -7.8 | 1.7 | -1.8 | -1.2 |
Bud | 1.1 | -3.6 | -2.6 | -3.9 | -2.7 | 0.9 | -1.2 | 2.7 | -0.4 | -1.9 | -1.8 | -3.1 | 0 | -1.0 | 1.6 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | -1.3 | -2.8 | -3.1 | -3.6 | -3.9 | -1.8 | -1.6 | 0.1 | 1.4 | 2.3 | -0.9 | 2.3 | 0 | 4.5 | 5.6 |
Cytoplasm | 5.1 | 4.1 | 6.1 | 5.8 | 5.9 | 9.8 | 8.9 | 10.3 | 8.8 | 4.1 | 5.4 | 2.6 | 0 | 10.1 | 7.8 |
Endoplasmic Reticulum | -4.7 | 1.7 | -2.3 | -2.0 | -5.7 | -10.5 | -8.5 | -12.9 | -10.4 | -0.9 | 0.6 | 2.7 | -7.8 | -15.2 | -9.8 |
Endosome | 0 | 0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 2.6 | -1.4 | 4.6 | 3.9 | 5.2 | 7.4 | 7.0 | 9.5 | 7.9 | -3.9 | -4.7 | -4.1 | 0 | 2.8 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 1.5 | 2.5 | 1.3 | 3.1 | 5.6 | 3.8 | 0.8 | 0.9 | 0.1 | -3.1 | -0.8 | -0.8 | 0 | 0.2 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 6.2955 | 5.1644 | 6.0386 | 5.4542 | 5.1218 | 5.5069 | 4.9254 | 4.2826 | 5.2766 | 4.2914 | 4.8962 | 5.2499 | 3.8267 | 4.8739 | 4.6715 | 4.4067 | 3.955 | 5.5715 |
Actin | 0.0734 | 0.0354 | 0.0597 | 0.0485 | 0.0172 | 0.0429 | 0.0317 | 0.0818 | 0.1042 | 0.1341 | 0.0698 | 0.0703 | 0.063 | 0.0295 | 0.057 | 0.1156 | 0.1274 | 0.0305 |
Bud | 0.0098 | 0.0246 | 0.0871 | 0.0448 | 0.0167 | 0.009 | 0.0114 | 0.0022 | 0.0503 | 0.0108 | 0.0131 | 0.0023 | 0.003 | 0.0018 | 0.0298 | 0.0144 | 0.0045 | 0.0013 |
Bud Neck | 0.0343 | 0.0113 | 0.0138 | 0.0068 | 0.077 | 0.2911 | 0.0184 | 0.0071 | 0.0116 | 0.0307 | 0.0037 | 0.283 | 0.019 | 0.0114 | 0.0219 | 0.0049 | 0.0043 | 0.4779 |
Bud Periphery | 0.0455 | 0.0559 | 0.2865 | 0.2636 | 0.1238 | 0.0427 | 0.0363 | 0.0042 | 0.1864 | 0.1216 | 0.1449 | 0.0094 | 0.0111 | 0.0035 | 0.1329 | 0.1018 | 0.0408 | 0.0119 |
Bud Site | 0.074 | 0.1471 | 0.0799 | 0.0296 | 0.0068 | 0.0047 | 0.0322 | 0.1219 | 0.046 | 0.0053 | 0.002 | 0.0062 | 0.0797 | 0.2011 | 0.0321 | 0.02 | 0.0032 | 0.0013 |
Cell Periphery | 0.0723 | 0.033 | 0.0286 | 0.0373 | 0.0252 | 0.0266 | 0.0461 | 0.018 | 0.0258 | 0.0535 | 0.0396 | 0.0249 | 0.0518 | 0.059 | 0.0401 | 0.0536 | 0.036 | 0.028 |
Cytoplasm | 0.2255 | 0.3308 | 0.1443 | 0.1889 | 0.1551 | 0.2172 | 0.1991 | 0.2876 | 0.1404 | 0.281 | 0.2747 | 0.1619 | 0.2603 | 0.2782 | 0.2026 | 0.2021 | 0.4024 | 0.1669 |
Cytoplasmic Foci | 0.0315 | 0.0106 | 0.0075 | 0.0297 | 0.0095 | 0.0081 | 0.0423 | 0.0123 | 0.0167 | 0.0156 | 0.0128 | 0.0121 | 0.0117 | 0.0076 | 0.013 | 0.0042 | 0.0427 | 0.0035 |
Eisosomes | 0.0014 | 0.0009 | 0.0008 | 0.001 | 0.0013 | 0.0006 | 0.0012 | 0.0011 | 0.0008 | 0.0015 | 0.0011 | 0.0005 | 0.0025 | 0.0004 | 0.0007 | 0.0009 | 0.0014 | 0.0005 |
Endoplasmic Reticulum | 0.2708 | 0.2017 | 0.1675 | 0.1781 | 0.3792 | 0.262 | 0.4192 | 0.3245 | 0.3002 | 0.2209 | 0.304 | 0.3622 | 0.297 | 0.2502 | 0.3081 | 0.3359 | 0.1531 | 0.2421 |
Endosome | 0.0383 | 0.0259 | 0.0137 | 0.0132 | 0.0419 | 0.015 | 0.0184 | 0.0139 | 0.0227 | 0.0154 | 0.0217 | 0.0126 | 0.0164 | 0.0121 | 0.0181 | 0.0092 | 0.0777 | 0.0015 |
Golgi | 0.0161 | 0.0074 | 0.0064 | 0.0076 | 0.0161 | 0.0067 | 0.0152 | 0.0086 | 0.0215 | 0.0208 | 0.0081 | 0.013 | 0.0191 | 0.0053 | 0.0192 | 0.0116 | 0.0265 | 0.0019 |
Lipid Particles | 0.0244 | 0.0096 | 0.0042 | 0.013 | 0.0092 | 0.0053 | 0.034 | 0.0211 | 0.0233 | 0.0075 | 0.0117 | 0.0153 | 0.0204 | 0.0323 | 0.0167 | 0.0058 | 0.0315 | 0.0019 |
Mitochondria | 0.0069 | 0.002 | 0.0078 | 0.0034 | 0.0017 | 0.002 | 0.0042 | 0.0006 | 0.0054 | 0.0042 | 0.0035 | 0.0058 | 0.0069 | 0.0007 | 0.0088 | 0.0031 | 0.0144 | 0.0002 |
None | 0.0092 | 0.0681 | 0.054 | 0.0651 | 0.084 | 0.0407 | 0.0573 | 0.0682 | 0.018 | 0.0559 | 0.071 | 0.0069 | 0.1011 | 0.0731 | 0.0581 | 0.0918 | 0.0033 | 0.02 |
Nuclear Periphery | 0.0232 | 0.0106 | 0.0111 | 0.0069 | 0.0068 | 0.0088 | 0.0078 | 0.0105 | 0.0098 | 0.0075 | 0.0075 | 0.0037 | 0.0147 | 0.0129 | 0.0121 | 0.0133 | 0.0081 | 0.0035 |
Nucleolus | 0.003 | 0.0008 | 0.0009 | 0.0005 | 0.0003 | 0.0003 | 0.0009 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0.0002 | 0.0005 | 0.0003 | 0.0004 | 0.0002 | 0.0017 | 0.0001 |
Nucleus | 0.0054 | 0.0061 | 0.0044 | 0.0021 | 0.0019 | 0.0044 | 0.0018 | 0.0022 | 0.0019 | 0.0015 | 0.0016 | 0.0015 | 0.0022 | 0.0029 | 0.0038 | 0.0023 | 0.0038 | 0.0013 |
Peroxisomes | 0.0034 | 0.0004 | 0.0062 | 0.0396 | 0.0002 | 0.0005 | 0.0077 | 0.0003 | 0.0008 | 0.0007 | 0.0003 | 0.0017 | 0.0004 | 0.0002 | 0.0033 | 0.0002 | 0.0021 | 0.0001 |
Punctate Nuclear | 0.009 | 0.0013 | 0.0014 | 0.0069 | 0.0006 | 0.001 | 0.0019 | 0.0015 | 0.0007 | 0.0005 | 0.0013 | 0.0007 | 0.0008 | 0.0013 | 0.0009 | 0.0005 | 0.0016 | 0.0002 |
Vacuole | 0.0202 | 0.0151 | 0.012 | 0.0116 | 0.0237 | 0.009 | 0.0121 | 0.011 | 0.0115 | 0.0092 | 0.0065 | 0.0047 | 0.0157 | 0.0155 | 0.0183 | 0.0065 | 0.0109 | 0.0049 |
Vacuole Periphery | 0.0021 | 0.0013 | 0.002 | 0.0017 | 0.0021 | 0.0013 | 0.0011 | 0.0011 | 0.0017 | 0.0015 | 0.0009 | 0.0009 | 0.0027 | 0.0007 | 0.0021 | 0.0022 | 0.0027 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 42.5409 | 45.1594 | 37.0376 | 34.1983 | 32.749 | 38.0885 | 36.8489 | 41.0904 | 47.4133 | 42.7364 |
Translational Efficiency | 1.6192 | 1.1649 | 1.3467 | 1.3787 | 1.3989 | 1.6747 | 1.5507 | 1.3471 | 1.1485 | 1.1677 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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