Standard name
Human Ortholog
Description Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.05
Bud 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 – 0 0 0 0 0.06 0 0 0.08 0.08 0.15 0 0 0 0 0 0
Cytoplasm 0 0 – 0.05 0.05 0.06 0.07 – 0 0 0 0 0 0 0 0.36 0.31 0.2 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0.06 0 0.07 0 0 0
Golgi 0.1 0 – 0.05 0.35 0 0 – 0 0 0 0 0.19 0.14 0.25 0.31 0.38 0.25 0.06 0.08 0 0.07 0.07 0.1
Mitochondria 0.78 0.93 – 0.87 0.65 0.86 0.69 – 0.79 0.85 0.9 0.87 0.87 0.88 0.77 0.13 0.1 0 0.73 0.82 0.81 0.74 0.74 0.67
Nucleus 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Nuclear Periphery 0.07 0.08 – 0.07 0 0 0.07 – 0.08 0 0.06 0.07 0 0 0 0 0 0.05 0 0 0 0 0 0
Nucleolus 0.08 0 – 0 0 0.08 0.12 – 0.12 0.12 0.16 0.06 0.05 0 0 0 0 0.07 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0.06
SpindlePole 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.23 0.14 – 0.05 0.31 0.14 0.16 – 0.08 0.1 0.09 0.08 0.09 0.12 0.14 0.24 0.32 0.3 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 2 0 1 0 – 0 0 0 0 1 1 4 0 1 2 0 1 0 4 9 22
Bud 0 2 – 2 0 1 2 – 3 2 1 1 0 5 2 0 0 0 1 0 0 0 2 2
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 – 0 0 0 0 – 0 2 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 1 – 1 2 0 3 – 2 0 2 1 8 7 15 8 6 6 0 0 0 0 0 0
Cytoplasm 4 1 – 4 7 4 13 – 7 4 4 2 4 9 12 35 22 8 0 0 0 0 0 2
Endoplasmic Reticulum 0 3 – 0 3 0 1 – 1 0 0 0 2 6 9 3 1 1 0 0 0 1 1 3
Endosome 3 1 – 0 5 0 4 – 0 1 0 0 1 7 9 5 2 1 6 1 1 8 9 15
Golgi 9 1 – 4 50 1 5 – 2 2 1 2 26 51 104 30 27 10 6 8 0 14 27 42
Mitochondria 72 84 – 66 93 57 131 – 126 125 121 97 120 313 327 13 7 1 79 87 13 143 284 288
Nucleus 0 0 – 1 3 0 8 – 3 1 4 1 0 1 0 4 5 1 0 0 0 0 2 0
Nuclear Periphery 6 7 – 5 2 1 13 – 13 6 8 8 5 6 13 0 0 2 0 0 0 1 4 4
Nucleolus 7 2 – 2 4 5 23 – 19 18 22 7 7 3 2 1 3 3 0 0 0 1 3 2
Peroxisomes 0 0 – 0 0 0 1 – 0 0 0 1 4 5 8 2 0 1 4 0 0 13 22 23
SpindlePole 1 0 – 0 1 0 2 – 2 3 1 0 0 1 0 1 0 0 0 0 0 0 3 4
Vac/Vac Membrane 21 13 – 4 45 9 31 – 12 14 12 9 13 44 60 24 23 12 2 4 0 5 12 11
Unique Cell Count 92 90 76 144 66 191 159 147 135 111 138 354 422 98 72 40 108 106 16 194 386 429
Labelled Cell Count 127 115 91 215 79 237 190 178 176 129 191 459 565 126 97 48 108 106 16 194 386 429


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.0 8.4 – 7.7 9.3 6.0 8.2 – 7.0 7.1 6.7 7.8 10.7 9.5 10.4 12.9 13.6 14.2 9.2 9.2 9.6
Std Deviation (1e-4) 1.9 2.0 – 1.7 1.6 1.4 1.6 – 1.6 1.7 1.4 1.9 2.4 2.1 1.9 3.9 4.5 3.6 2.3 2.3 2.6
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700051015HU80HU120HU160051015rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.2999 7.0497 6.5004 5.9604 6.0249 6.6111 8.102 9.0967 8.778 8.441 8.0558 8.416 9.7397 11.0165 9.933 10.0794 9.1418 9.8299
Actin 0.023 0.0035 0.0019 0.0005 0.0026 0.0083 0.0234 0.0048 0.0031 0.0006 0.0003 0.0186 0.004 0.0069 0.0078 0.0002 0.0009 0.0005
Bud 0.0006 0.0001 0 0 0.0001 0 0.0003 0.0005 0.0027 0.0001 0 0.0004 0.0001 0.0006 0.0009 0 0.0001 0.0001
Bud Neck 0.0004 0.0001 0 0 0 0.0001 0.0004 0.0004 0.0003 0 0 0.0009 0.0001 0.0006 0.0002 0 0 0.0001
Bud Periphery 0.0008 0.0001 0.0001 0.0001 0.0001 0.0001 0.0005 0.0007 0.0044 0.0002 0 0.0006 0.0003 0.0012 0.0021 0.0001 0.0002 0.0002
Bud Site 0.0039 0.0001 0.0001 0 0.0001 0.0001 0.0007 0.0051 0.0088 0.0001 0 0.0004 0.0003 0.0032 0.0051 0 0 0.0001
Cell Periphery 0.0004 0.0002 0.0001 0.0001 0 0 0.0002 0.0009 0.0003 0.0001 0 0.0002 0.0001 0.0007 0.0009 0 0 0.0001
Cytoplasm 0.0004 0 0.0001 0 0 0.0014 0.0039 0.0001 0.0002 0 0 0.0004 0.0004 0.0001 0.0001 0 0.0001 0
Cytoplasmic Foci 0.0063 0.0011 0.0015 0.0004 0.0009 0.0007 0.0181 0.0065 0.0094 0.0009 0 0.005 0.0026 0.0041 0.0012 0.0001 0.0007 0.0005
Eisosomes 0.0008 0.0002 0.0002 0.0001 0.0001 0.0001 0.0003 0.0003 0.0001 0.0001 0.0001 0.0001 0.0003 0.0002 0.0003 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0009 0 0.0012 0 0 0.0002 0.0069 0.0001 0.0004 0.0002 0 0.0003 0.0002 0.0002 0.0001 0 0.0001 0.0001
Endosome 0.0169 0.0089 0.0032 0.0023 0.0022 0.0023 0.0325 0.0116 0.0146 0.0072 0.0001 0.0085 0.0095 0.0203 0.0047 0.0003 0.0389 0.005
Golgi 0.0209 0.0178 0.0056 0.003 0.0072 0.0057 0.0202 0.0203 0.0277 0.0043 0.0003 0.0069 0.0141 0.0224 0.0095 0.0006 0.016 0.0065
Lipid Particles 0.0262 0.0042 0.0028 0.0094 0.0043 0.0062 0.0265 0.0123 0.0082 0.0264 0.0001 0.0043 0.0448 0.0141 0.0039 0.004 0.0014 0.0099
Mitochondria 0.849 0.951 0.9645 0.9688 0.9797 0.9612 0.8241 0.9135 0.8935 0.9509 0.9978 0.9407 0.8881 0.8953 0.9429 0.9919 0.9295 0.9606
None 0.0032 0 0.0012 0 0 0.002 0.0011 0 0.0001 0.0001 0 0.0002 0.0002 0.0001 0.0001 0 0 0
Nuclear Periphery 0.0023 0 0.0023 0 0 0.0013 0.015 0.0001 0.0004 0.0019 0 0.0026 0.004 0.0002 0.0001 0 0.0001 0.0004
Nucleolus 0.0029 0.0011 0.0001 0.0003 0.0001 0.0003 0.0008 0.0005 0.0004 0.0003 0 0.0003 0.0006 0.0038 0.0002 0 0 0.0005
Nucleus 0.0012 0.0002 0.0001 0.0001 0 0.0014 0.0033 0.0001 0.0003 0.0002 0 0.0004 0.0091 0.0003 0.0001 0 0 0.0002
Peroxisomes 0.0242 0.005 0.0035 0.0011 0.0011 0.0021 0.0092 0.0086 0.0085 0.0011 0.0002 0.0027 0.0116 0.0121 0.0061 0.0011 0.0013 0.0014
Punctate Nuclear 0.0012 0 0.0001 0 0 0.0026 0.0032 0 0.0002 0.0003 0 0.0044 0.0008 0 0 0 0 0
Vacuole 0.0053 0.0021 0.0027 0.002 0.0003 0.0006 0.0038 0.0053 0.005 0.0014 0.0001 0.0009 0.0025 0.0059 0.0057 0.0002 0.0032 0.0048
Vacuole Periphery 0.0094 0.0042 0.0088 0.0118 0.0009 0.0034 0.0055 0.0083 0.0114 0.0036 0.0009 0.0012 0.0062 0.0078 0.008 0.0012 0.0072 0.0092

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 106.2538 96.4457 101.9285 104.3447 142.0015 109.4625 102.6874 98.7252 105.9305 101.0733
Translational Efficiency 1.2786 1.5758 1.3899 1.6083 1.2214 1.1337 1.2093 1.3505 1.1072 1.2301

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1904 615 2005 1141 1467 1741 740 1653 3371 2356 2745 2794

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 827.98 1067.29 1297.82 1314.56 836.83 1032.67 1016.34 1356.57 831.83 1041.71 1221.94 1339.41
Standard Deviation 195.12 199.41 229.34 216.50 115.68 161.35 234.84 234.67 165.37 172.77 262.46 228.36
Intensity Change Log 2 — 0.366284 0.648422 0.666912 — 0.303373 0.280377 0.696957 — 0.335004 0.475131 0.682093

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000754 0.008486 0.000642 0.007324 0.001544 0.001337 0.002544 0.002761 0.001097 0.003204 0.001155 0.004624
Bud Neck 0.001083 0.002760 0.001203 0.001367 0.000892 0.000798 0.022704 0.000832 0.000999 0.001310 0.006999 0.001051
Bud Site 0.001574 0.004538 0.002729 0.004337 0.003016 0.001713 0.046719 0.003011 0.002202 0.002450 0.014588 0.003553
Cell Periphery 0.000220 0.000801 0.000294 0.000490 0.000241 0.000189 0.004450 0.000733 0.000229 0.000349 0.001414 0.000634
Cytoplasm 0.000768 0.000557 0.000213 0.000842 0.000328 0.000373 0.015704 0.000365 0.000577 0.000421 0.004389 0.000560
Cytoplasmic Foci 0.006065 0.018394 0.008972 0.009888 0.009985 0.007922 0.029025 0.004670 0.007771 0.010655 0.014378 0.006801
Eisosomes 0.000029 0.000320 0.000094 0.000235 0.000045 0.000049 0.000226 0.000191 0.000036 0.000120 0.000130 0.000209
Endoplasmic Reticulum 0.000173 0.000622 0.000240 0.000404 0.000249 0.000166 0.001683 0.000255 0.000206 0.000285 0.000629 0.000316
Endosome 0.009208 0.017121 0.004400 0.006351 0.018627 0.012511 0.049707 0.003678 0.013307 0.013715 0.016614 0.004770
Golgi 0.011817 0.049042 0.032375 0.050913 0.017564 0.016664 0.034289 0.027691 0.014318 0.025116 0.032891 0.037174
Lipid Particles 0.003571 0.008990 0.002775 0.000811 0.003975 0.002243 0.009358 0.000492 0.003747 0.004004 0.004549 0.000622
Mitochondria 0.949381 0.845794 0.873032 0.884353 0.917724 0.931973 0.667694 0.931778 0.935605 0.909477 0.817677 0.912411
Mitotic Spindle 0.001121 0.002579 0.002724 0.003548 0.001152 0.002495 0.006431 0.002041 0.001134 0.002517 0.003723 0.002657
None 0.000439 0.000668 0.002289 0.000969 0.000289 0.000311 0.003661 0.000948 0.000373 0.000405 0.002659 0.000956
Nuclear Periphery 0.000076 0.000219 0.000928 0.000267 0.000127 0.000088 0.000824 0.000090 0.000098 0.000123 0.000900 0.000163
Nuclear Periphery Foci 0.000133 0.000216 0.000602 0.000167 0.000161 0.000143 0.001875 0.000132 0.000145 0.000162 0.000945 0.000146
Nucleolus 0.000222 0.000146 0.000448 0.000104 0.000095 0.000271 0.005447 0.000101 0.000167 0.000239 0.001795 0.000102
Nucleus 0.001155 0.000083 0.000113 0.000071 0.000084 0.000146 0.005063 0.000045 0.000689 0.000129 0.001448 0.000056
Peroxisomes 0.006948 0.025180 0.002506 0.006279 0.013385 0.006421 0.028746 0.003468 0.009749 0.011318 0.009580 0.004616
Vacuole 0.001659 0.006690 0.015946 0.007167 0.004174 0.006703 0.037419 0.005761 0.002753 0.006700 0.021735 0.006335
Vacuole Periphery 0.003604 0.006793 0.047476 0.014112 0.006344 0.007483 0.026432 0.010955 0.004797 0.007303 0.041803 0.012244

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.08 0.71 -5.49 0.60 -5.61 0.46 -1.86 -1.66 -2.09 -0.30 -4.42 -0.28 -5.49 -1.89 -5.52
Bud Neck -2.31 -0.26 -0.62 2.17 -0.55 0.33 -7.44 0.17 -0.24 7.47 -0.98 -6.98 -0.21 1.12 7.16
Bud Site -2.21 -1.39 -2.93 0.12 -1.46 1.33 -8.39 -0.10 -1.94 8.44 -0.37 -7.79 -2.11 -1.75 6.83
Cell Periphery -1.35 -0.65 -2.45 0.72 -1.60 0.88 -6.07 -3.85 -4.32 5.29 -0.97 -5.78 -4.48 -2.06 3.62
Cytoplasm 0.82 2.17 -0.12 -0.91 -2.14 -0.37 -5.28 -0.65 -0.07 5.26 0.98 -4.68 0.12 -0.98 4.74
Cytoplasmic Foci -6.12 -2.91 -2.78 3.74 -0.63 1.60 -6.22 4.51 3.26 8.24 -2.99 -5.87 1.15 3.88 6.58
Eisosomes -9.38 -8.86 -8.54 2.18 -5.62 -0.66 -10.24 -4.70 -4.57 1.00 -8.95 -12.64 -8.30 -3.95 -3.63
Endoplasmic Reticulum -2.86 -1.56 -3.28 1.29 -2.24 1.16 -7.94 -0.08 -2.03 8.32 -1.40 -6.82 -2.35 -0.56 5.02
Endosome -3.43 4.70 2.47 4.85 -2.45 3.22 -7.22 9.31 7.71 11.43 -0.31 -2.26 9.15 8.63 9.57
Golgi -7.29 -8.55 -9.16 -0.29 -3.99 0.40 -4.78 -3.39 -3.78 1.68 -5.42 -9.24 -9.38 -4.24 -1.49
Lipid Particles -2.58 0.90 3.51 4.17 4.33 1.57 -3.21 3.97 2.53 6.09 -0.28 -1.08 5.35 4.66 7.69
Mitochondria 9.11 12.14 8.48 -3.02 -1.32 -2.16 16.81 -2.11 0.08 -18.13 5.01 18.53 4.88 -0.48 -14.11
Mitotic Spindle -1.66 -2.39 -3.52 -0.93 -0.93 -2.17 -4.91 -2.56 0.66 3.96 -2.67 -4.62 -4.29 -0.26 1.69
None -1.97 -14.45 -5.03 -3.94 13.66 -0.46 -4.53 -10.17 -14.02 3.65 -0.46 -10.45 -8.88 -14.98 8.00
Nuclear Periphery -2.57 -6.51 -2.29 -0.49 4.30 1.15 -3.80 1.08 -0.16 4.05 -1.07 -7.43 -1.71 -1.06 6.58
Nuclear Periphery Foci -1.17 -4.25 -0.45 1.18 4.55 0.47 -4.57 0.32 0.10 4.57 -0.36 -6.29 -0.03 0.28 6.17
Nucleolus 0.78 -1.51 1.21 1.21 3.22 -1.48 -3.84 -0.18 1.45 3.83 -0.67 -4.16 1.12 1.57 4.37
Nucleus 2.10 2.04 2.12 0.26 1.04 -0.93 -5.03 1.34 1.60 5.07 1.93 -1.81 2.18 1.51 5.14
Peroxisomes -4.59 4.00 0.45 4.71 -3.08 3.77 -3.97 5.65 2.83 7.07 -1.05 0.08 4.80 5.04 4.16
Vacuole -3.52 -12.47 -5.50 -0.29 5.91 -2.64 -10.47 -1.61 0.79 9.78 -5.39 -15.55 -5.19 0.35 11.42
Vacuole Periphery -2.90 -16.79 -7.51 -4.28 11.40 -1.11 -8.71 -3.98 -2.89 6.46 -3.48 -18.29 -8.65 -4.94 13.80
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Rcf2

Rcf2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rcf2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available