Standard name
Human Ortholog
Description Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.06 0.11 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.06 0 0 0 0 0.07 0.07 0.05 0.08 0.11 0.22 0.18 0.11 0 0 0 0 0 0
Cytoplasm 0.1 0.19 0.15 0.17 0.15 0.13 0.14 0.17 0.11 0.17 0.2 0.14 0.07 0.15 0.17 0.39 0.39 0.42 0 0.05 0 0 0 0
Endoplasmic Reticulum 0.81 0.72 0.5 0.39 0.34 0.29 0.36 0.25 0.37 0.26 0.25 0.27 0.8 0.79 0.75 0.09 0 0.06 0.87 0.8 0.87 0.84 0.77 0.81
Endosome 0 0 0.05 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.09 0.29 0.51 0.26 0.47 0.46 0.45 0.64 0.59 0.52 0.57 0 0 0 0.17 0.21 0.14 0 0.06 0 0.06 0.06 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0 0.17 0.12 0.31 0.27 0.22 0.27 0.13 0.22 0.12 0.16 0.18 0.05 0 0.09 0.21 0.28 0 0 0 0 0.05 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 8 6 7 5 2 3 9 7 8 8 7 12 6 4 2 4 4 3 3 8 3 20 10
Bud 0 3 6 3 4 4 4 10 7 8 7 3 3 2 1 0 2 1 1 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 0 2 1
Bud Site 0 0 0 0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 0 7 8 9 20 17 14 12 18 25 34 25 13 25 5 13 4 0 0 1 4 10 14
Cytoplasm 15 23 35 37 38 42 63 87 32 72 68 66 33 26 37 9 28 15 5 7 2 5 7 4
Endoplasmic Reticulum 125 86 117 83 89 92 166 126 104 113 86 128 365 137 168 2 0 2 162 116 247 300 378 427
Endosome 0 0 11 7 21 9 9 12 1 4 4 4 3 1 0 0 1 0 1 0 1 1 3 7
Golgi 1 0 2 1 2 0 0 0 0 0 0 0 1 0 0 1 1 0 0 1 0 2 2 6
Mitochondria 2 11 69 109 67 150 211 223 181 256 176 264 0 0 0 4 15 5 5 8 7 21 30 20
Nucleus 2 0 0 3 0 2 0 8 1 2 1 3 7 1 2 0 1 0 0 0 0 0 0 0
Nuclear Periphery 1 5 5 2 6 3 21 14 17 16 7 20 8 0 1 0 1 0 0 2 2 8 4 4
Nucleolus 0 0 1 0 0 1 0 4 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 1 0 0 1 1 0 1 1 1 0 0 0 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 0 0 1 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0
Vac/Vac Membrane 17 5 39 25 80 85 103 132 36 94 40 73 80 9 1 2 15 10 4 5 2 8 23 26
Unique Cell Count 155 119 234 214 262 317 462 498 284 432 338 466 457 173 224 23 72 36 187 146 285 359 489 530
Labelled Cell Count 174 141 298 286 321 411 599 640 398 595 424 603 537 195 240 26 81 41 187 146 285 359 489 530


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.1 6.0 7.0 7.5 7.6 6.7 6.3 6.4 6.1 5.6 6.3 5.8 9.1 8.6 9.5 7.2 7.8 9.3 9.1 9.4 9.7
Std Deviation (1e-4) 1.0 0.8 1.4 1.4 1.5 1.6 1.2 1.4 1.3 1.2 2.6 1.3 1.1 1.2 1.4 1.9 1.6 3.0 1.6 1.8 1.5
Intensity Change (Log2) – – – 0.1 0.12 -0.06 -0.15 -0.13 -0.21 -0.32 -0.16 -0.28 0.38 0.28 0.44 0.03 0.16 0.41 0.37 0.41 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.4 -0.5 0 0 0 -0.1 0 -0.2 0 0 0.5 0 0 0 0
Bud 0 0 0 0 -0.5 -0.1 0 -0.4 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.4 0.3 1.8 0.5 -0.1 0.7 0.8 2.3 2.3 1.5 2.1 3.4 0 0 0
Cytoplasm 0.7 -0.1 -0.6 -0.5 0.9 -1.2 0.6 1.6 -0.3 -3.2 0 0.5 0 4.4 3.8
Endoplasmic Reticulum -2.4 -3.6 -5.0 -3.6 -6.6 -3.1 -6.2 -6.0 -5.9 8.1 6.0 5.5 -3.8 -7.6 -5.0
Endosome -0.8 1.5 -1.2 -2.1 -1.7 -3.3 -3.1 -2.6 -3.3 0 -2.4 -3.3 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.6 -1.0 4.2 4.1 3.9 7.8 7.3 5.4 6.8 -12.2 -7.8 -8.8 -1.2 -1.4 -2.0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0.1 0 1.6 0.5 2.2 1.1 0 1.4 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.5 3.6 2.8 1.7 2.9 -1.3 1.6 -1.6 -0.3 0.3 -3.5 -6.1 0 0.8 1.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.0002 5.207 4.9892 4.5465 4.1023 4.779 4.889 6.0446 5.6256 5.2558 4.6596 5.4625 5.9466 5.9405 5.4432 5.1365 5.6085 5.2117
Actin 0.0067 0.0024 0.0022 0.0265 0.0005 0.0045 0.032 0.0002 0.0085 0.0003 0.0044 0.0009 0 0.0009 0.0088 0.0043 0.0006 0.0003
Bud 0.0001 0.0002 0.0001 0.0003 0.0001 0 0.0004 0 0.0001 0 0 0 0 0.0001 0 0.0006 0 0
Bud Neck 0.0006 0.0005 0.0002 0.0278 0.0098 0.0009 0.0002 0.0001 0.0003 0.0009 0.0046 0.0003 0 0.0003 0.0015 0.0011 0.0002 0.0008
Bud Periphery 0.0002 0.0004 0.0001 0.001 0.0001 0.0001 0.0006 0.0001 0.0001 0.0002 0.0001 0.0001 0 0.0002 0.0001 0.0064 0 0
Bud Site 0.0002 0.0024 0.0005 0.0004 0.0003 0.0001 0.0016 0.0004 0.0011 0 0.0001 0 0 0.0091 0.0006 0.0008 0 0
Cell Periphery 0.0011 0.0038 0.0008 0.0015 0.0006 0.0006 0.0017 0.0035 0.0013 0.0013 0.0009 0.0002 0.0007 0.002 0.0029 0.016 0.0005 0.0006
Cytoplasm 0.0562 0.0989 0.0477 0.0237 0.0957 0.0661 0.019 0.0568 0.0341 0.0028 0.0466 0.0343 0.0074 0.0596 0.0477 0.029 0.019 0.0446
Cytoplasmic Foci 0.0087 0.0065 0.0099 0.0025 0.0013 0.003 0.0033 0.0043 0.0038 0.0001 0.0009 0.002 0.0001 0.0022 0.0023 0.0213 0.0016 0.0022
Eisosomes 0.0002 0.0003 0.0002 0.0003 0 0 0.0012 0 0.0001 0 0.0001 0 0 0.0001 0.0001 0.0005 0 0
Endoplasmic Reticulum 0.8285 0.7797 0.8774 0.8525 0.8291 0.8817 0.8472 0.8586 0.9211 0.9797 0.9273 0.9257 0.9714 0.8964 0.9106 0.8727 0.9576 0.9287
Endosome 0.0256 0.0316 0.0215 0.0158 0.0072 0.0112 0.0188 0.0222 0.0062 0.0021 0.0057 0.0166 0.0008 0.0066 0.009 0.0063 0.0042 0.0071
Golgi 0.0037 0.006 0.0044 0.0054 0.0004 0.001 0.0083 0.0013 0.0029 0.0003 0.0013 0.0018 0.0001 0.0013 0.0026 0.0042 0.0008 0.001
Lipid Particles 0.0058 0.0198 0.0126 0.0049 0.0012 0.003 0.0109 0.0176 0.0044 0.0008 0.0005 0.0021 0.0026 0.0034 0.0024 0.0215 0.0089 0.0028
Mitochondria 0.0014 0.0055 0.0006 0.0077 0.0002 0.0019 0.0013 0.0037 0.0007 0.0002 0.0003 0.0013 0 0.0003 0.0005 0.0009 0.0001 0.0002
None 0.0063 0.0094 0.0066 0.0016 0.0399 0.0027 0.0265 0.0117 0.0048 0.0001 0.0007 0.0015 0.0001 0.0027 0.0024 0.0008 0.0002 0.002
Nuclear Periphery 0.0312 0.0169 0.0097 0.0167 0.0071 0.0134 0.0177 0.0108 0.0043 0.008 0.0048 0.0089 0.0151 0.0086 0.0055 0.0029 0.0041 0.0067
Nucleolus 0.0002 0.0001 0 0.0003 0 0 0.0001 0 0 0 0 0 0 0 0 0.0002 0 0
Nucleus 0.0138 0.0031 0.0009 0.0036 0.0029 0.0017 0.0009 0.0024 0.0004 0.0005 0.0005 0.0006 0.0002 0.0006 0.0003 0.0002 0.0003 0.0005
Peroxisomes 0.0005 0.0001 0.0002 0.0006 0 0.0035 0.0005 0 0.0028 0 0 0 0 0 0.0001 0.0065 0 0
Punctate Nuclear 0.0045 0.0005 0.0004 0.0022 0.0003 0.0008 0.0004 0.0004 0.0009 0 0.0001 0.0003 0 0.0001 0.0001 0.002 0.0001 0.0002
Vacuole 0.0035 0.0107 0.0035 0.0036 0.0027 0.0031 0.0058 0.0053 0.0019 0.0023 0.0008 0.0023 0.0013 0.005 0.002 0.0014 0.0015 0.002
Vacuole Periphery 0.0012 0.0011 0.0006 0.0011 0.0003 0.0006 0.0014 0.0006 0.0002 0.0005 0.0002 0.0008 0.0002 0.0005 0.0003 0.0003 0.0001 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 46.9746 35.7383 34.4751 44.6868 38.4434 32.631 34.6293 42.4769 37.3433 50.94
Translational Efficiency 0.831 0.7234 0.8698 0.6533 0.6877 0.9661 0.8647 0.6158 0.8376 0.6293

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
133 383 1551 828 187 1463 247 1507 320 1846 1798 2335

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1255.73 950.99 1256.53 1271.45 931.35 935.92 1427.33 1203.94 1066.17 939.05 1279.99 1227.88
Standard Deviation 174.29 151.65 207.34 221.26 135.41 135.37 185.67 187.10 221.13 139.04 212.79 202.47
Intensity Change Log 2 — -0.401024 0.000919 0.017948 — 0.007062 0.615924 0.370368 — -0.212980 0.295303 0.178650

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001310 0.000621 0.000407 0.002033 0.003809 0.000455 0.000069 0.002230 0.002770 0.000489 0.000360 0.002161
Bud Neck 0.005243 0.001969 0.000668 0.001699 0.000410 0.000603 0.000370 0.001821 0.002419 0.000886 0.000627 0.001777
Bud Site 0.020639 0.002456 0.001547 0.009884 0.007666 0.001133 0.000111 0.008279 0.013058 0.001408 0.001349 0.008848
Cell Periphery 0.004976 0.000617 0.000326 0.002994 0.001129 0.000877 0.000463 0.001868 0.002728 0.000823 0.000345 0.002267
Cytoplasm 0.033575 0.047238 0.023063 0.016265 0.024520 0.056394 0.001637 0.028463 0.028284 0.054494 0.020120 0.024137
Cytoplasmic Foci 0.033588 0.019431 0.001339 0.004334 0.006465 0.010510 0.000034 0.008540 0.017738 0.012361 0.001159 0.007049
Eisosomes 0.000410 0.000125 0.000008 0.000143 0.000322 0.000390 0.000026 0.000178 0.000359 0.000335 0.000011 0.000165
Endoplasmic Reticulum 0.593029 0.832166 0.826401 0.894616 0.899842 0.860974 0.981828 0.822129 0.772323 0.854997 0.847753 0.847833
Endosome 0.025316 0.010522 0.010447 0.011364 0.003470 0.004200 0.003290 0.020019 0.012550 0.005512 0.009464 0.016950
Golgi 0.016151 0.009401 0.000727 0.003507 0.007934 0.010080 0.000180 0.010114 0.011349 0.009939 0.000652 0.007771
Lipid Particles 0.048105 0.021529 0.002838 0.015301 0.013844 0.021549 0.000766 0.018396 0.028084 0.021545 0.002553 0.017298
Mitochondria 0.000536 0.004885 0.000301 0.000708 0.001932 0.003433 0.000028 0.005170 0.001352 0.003734 0.000264 0.003588
Mitotic Spindle 0.012272 0.000509 0.001118 0.001531 0.000104 0.000624 0.000009 0.007743 0.005161 0.000600 0.000966 0.005540
None 0.000027 0.003766 0.000513 0.002214 0.000303 0.002809 0.000117 0.001426 0.000189 0.003008 0.000459 0.001706
Nuclear Periphery 0.005403 0.006568 0.049509 0.001635 0.007557 0.004114 0.002607 0.006205 0.006662 0.004623 0.043066 0.004584
Nuclear Periphery Foci 0.072402 0.015914 0.072223 0.020902 0.009337 0.011775 0.007321 0.037210 0.035548 0.012634 0.063307 0.031427
Nucleolus 0.000055 0.000397 0.000012 0.000015 0.000055 0.000056 0.000000 0.000061 0.000055 0.000127 0.000010 0.000045
Nucleus 0.006566 0.005805 0.001970 0.001154 0.005271 0.003018 0.000036 0.002253 0.005809 0.003596 0.001704 0.001863
Peroxisomes 0.001081 0.001468 0.000025 0.000189 0.003119 0.002347 0.000004 0.000496 0.002272 0.002164 0.000022 0.000387
Vacuole 0.113005 0.012826 0.006234 0.008377 0.002227 0.003278 0.001054 0.014293 0.048269 0.005259 0.005522 0.012195
Vacuole Periphery 0.006311 0.001788 0.000323 0.001136 0.000682 0.001380 0.000049 0.003107 0.003021 0.001465 0.000286 0.002408

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.85 2.53 -1.11 -2.53 -2.98 1.24 1.38 0.55 -4.65 -5.72 1.46 1.53 0.35 -5.33 -5.42
Bud Neck 2.15 3.20 2.38 0.03 -3.36 -0.76 0.12 -4.34 -3.92 -4.09 2.47 2.86 0.94 -3.42 -4.85
Bud Site 2.74 2.89 1.46 -4.00 -4.63 1.35 1.57 -0.21 -6.75 -7.86 2.96 2.96 0.92 -7.89 -7.78
Cell Periphery 1.34 1.43 0.54 -5.48 -6.34 0.77 2.08 -1.94 -3.66 -5.23 1.39 1.76 0.24 -6.14 -8.50
Cytoplasm -1.04 1.99 2.88 5.13 2.24 -5.78 5.10 -0.95 6.99 -12.00 -5.07 2.27 1.22 9.26 -1.91
Cytoplasmic Foci 1.89 4.66 4.20 3.92 -3.15 -1.67 3.29 -0.97 1.17 -9.42 1.68 5.19 3.31 3.63 -8.21
Eisosomes 1.70 2.43 1.57 -0.56 -4.75 -0.33 1.60 0.76 2.41 -4.48 0.17 2.72 1.46 2.44 -6.97
Endoplasmic Reticulum -7.02 -7.22 -8.91 -3.66 -6.54 2.29 -5.13 4.77 4.50 19.24 -4.66 -4.27 -4.06 1.55 0.52
Endosome 2.72 2.82 2.63 -0.50 -0.80 -1.01 0.19 -11.91 -11.93 -11.82 3.03 1.32 -1.78 -11.44 -7.19
Golgi 0.77 2.01 1.61 2.93 -3.24 -0.80 3.15 -0.76 -0.00 -7.08 0.28 3.11 0.92 1.69 -7.35
Lipid Particles 2.67 4.62 3.25 1.35 -5.82 -1.88 3.50 -1.29 0.98 -10.03 1.45 5.39 2.16 1.66 -10.63
Mitochondria -2.22 0.62 -0.40 2.11 -1.07 -1.33 1.86 -2.11 -1.43 -4.44 -2.90 1.74 -2.32 0.12 -4.36
Mitotic Spindle 1.92 1.81 1.72 -1.68 -0.69 -1.45 1.92 -5.24 -4.79 -5.31 1.79 1.63 0.05 -4.99 -4.28
None -1.41 -4.42 -1.64 0.52 -1.28 -4.07 1.16 -2.42 1.85 -2.95 -3.86 -2.04 -2.72 1.42 -2.25
Nuclear Periphery -0.47 -11.82 1.49 2.79 16.23 0.96 1.32 0.35 -2.03 -2.54 0.83 -10.63 0.82 -0.01 14.64
Nuclear Periphery Foci 4.70 0.27 4.21 -1.56 11.41 -0.87 0.60 -7.51 -7.98 -8.41 4.18 -4.11 0.80 -7.84 8.49
Nucleolus -1.07 2.39 2.19 1.24 -0.97 0.03 1.82 -0.21 -0.39 -4.91 -0.98 2.45 0.62 1.22 -4.22
Nucleus 0.52 2.27 2.58 2.79 1.52 0.70 1.57 0.88 1.34 -6.90 1.15 1.98 1.88 3.27 -0.67
Peroxisomes -0.77 2.58 2.17 3.98 -4.90 0.54 2.24 1.87 6.07 -4.83 0.12 2.70 2.25 7.23 -5.42
Vacuole 6.54 6.98 6.83 1.22 -1.80 -1.08 1.28 -7.15 -7.23 -8.79 6.12 6.07 5.13 -5.86 -5.84
Vacuole Periphery 1.22 1.65 1.41 1.32 -2.39 -1.56 3.10 -4.06 -2.51 -5.45 0.97 1.81 0.32 -1.88 -5.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant
Localization
Cell Percentages ER (95%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Alg12

Alg12


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Alg12-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available