Standard name
Human Ortholog
Description Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.13 0.11 0.07 0.05 0 0 0 0 0 0 0 0 0.05 0 0 0.09 0 0.13 0 0.07 0.09 0.07 0 0
Bud 0 0 0 0 0 0 0 0 0.05 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.06 0.08 0.05 0.05 0 0 0 0 0 0 0 0.06 0 0.08 0.11 0 0 0 0 0 0 0
Cytoplasm 0.32 0.38 0.3 0.33 0.43 0.3 0.27 0.24 0.25 0.2 0.19 0.16 0.58 0.63 0.69 0.7 0.74 0.58 0.08 0.09 0 0.08 0.11 0.13
Endoplasmic Reticulum 0.42 0.62 0.57 0.38 0.25 0.18 0.1 0.07 0.13 0 0.09 0.07 0.31 0.36 0.26 0.08 0 0 0.53 0.62 0.7 0.5 0.59 0.59
Endosome 0.09 0 0 0.07 0.11 0.06 0.08 0.1 0.06 0 0 0 0 0 0 0 0 0.07 0.1 0 0 0 0 0
Golgi 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.13 0.09 0.09 0.08 0 0
Mitochondria 0.1 0.08 0.06 0.24 0.22 0.54 0.61 0.63 0.65 0.81 0.8 0.83 0 0 0 0.08 0.05 0.16 0.06 0.05 0 0.15 0.12 0.09
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0 0 0 0.05 0 0 0.06 0 0.06 0 0 0.05 0 0 0 0.08 0.07 0 0 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 38 23 19 13 5 2 3 1 8 0 4 5 44 24 24 14 0 6 14 16 28 19 19 20
Bud 4 2 2 5 5 14 22 13 20 9 18 24 6 4 0 3 0 0 3 2 0 1 4 5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 2 1 6 2 1 0 4 2 1 2 4 4
Bud Site 0 0 0 0 0 0 2 2 5 2 1 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 4 15 23 18 17 14 13 8 8 9 13 31 56 30 12 4 0 1 0 3 2 11 14
Cytoplasm 96 80 77 93 153 94 133 151 90 86 67 74 470 606 638 111 28 26 26 20 5 23 53 78
Endoplasmic Reticulum 124 131 145 106 89 56 52 42 46 18 32 31 249 344 238 12 1 1 188 150 216 144 290 345
Endosome 26 2 11 20 41 20 41 63 22 6 2 8 22 3 10 5 0 3 33 10 9 11 6 9
Golgi 18 3 8 12 4 3 0 0 0 1 0 0 2 1 2 1 0 4 47 20 26 23 11 10
Mitochondria 29 17 15 67 78 171 305 392 237 341 282 388 4 0 1 12 2 7 20 11 10 43 61 49
Nucleus 1 0 0 1 1 0 1 0 0 2 1 0 2 4 2 1 2 0 0 0 0 0 0 1
Nuclear Periphery 0 0 0 0 0 1 3 5 7 6 3 3 0 0 2 0 0 0 0 1 0 0 0 1
Nucleolus 0 0 0 0 0 1 1 8 2 3 2 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 5 0 3 5 14 3 5 0 5 0 0 0 0 0 0 2 0 2 3 1 1
SpindlePole 5 0 2 4 1 3 8 13 3 5 2 9 7 2 4 12 0 2 2 0 0 0 2 1
Vac/Vac Membrane 17 3 6 6 19 8 16 37 11 25 6 9 37 9 28 6 3 3 7 4 2 11 22 30
Unique Cell Count 297 213 254 282 359 317 496 620 367 422 351 467 808 963 925 159 38 45 356 242 309 292 494 582
Labelled Cell Count 361 265 300 355 414 393 606 754 462 517 429 575 876 1054 985 191 41 52 356 242 309 292 494 582


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.4 7.5 7.0 6.8 6.0 5.2 4.9 5.0 5.0 4.3 4.6 4.5 7.2 7.4 7.4 5.9 6.3 7.8 7.7 7.6 7.8
Std Deviation (1e-4) 0.7 0.8 1.0 1.4 1.1 1.2 1.4 1.1 1.0 0.9 0.9 0.8 0.7 0.7 0.8 1.3 1.1 1.4 1.1 1.1 1.2
Intensity Change (Log2) – – – -0.02 -0.21 -0.42 -0.49 -0.47 -0.49 -0.71 -0.61 -0.63 0.05 0.08 0.1 -0.24 -0.15 0.17 0.15 0.12 0.16

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 -3.8 -4.3 -5.3 -6.6 -3.2 0 0 0 -1.2 -3.8 -3.7 0.5 0 0
Bud 0 0 2.6 2.7 0 3.1 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.0 -0.5 -0.3 -2.1 -2.9 -2.4 0 0 0 -1.4 -0.1 -2.0 0.7 0 0
Cytoplasm 0.7 3.1 -0.2 -1.0 -1.8 -1.6 -2.9 -3.2 -4.6 7.7 9.3 11.2 7.8 5.2 3.6
Endoplasmic Reticulum -4.5 -8.1 -9.8 -13.7 -16.5 -11.8 0 0 0 -7.6 -6.2 -9.5 -10.1 -6.3 -6.8
Endosome 1.4 3.1 1.0 2.0 2.8 0.9 0 0 0 -1.3 0 0 -0.6 0 0
Golgi 0.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 5.7 5.4 12.2 14.6 15.4 14.6 0 0 0 0 0 0 0.7 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 3.7 0 0
Vacuole -0.2 1.8 0.1 0.7 2.2 0.5 2.1 -0.6 -0.4 1.6 0 0.6 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.4594 3.9038 3.853 3.5233 4.0454 3.8896 5.455 5.3569 5.3114 4.9741 5.2497 5.2081 4.983 5.1646 5.0733 5.8852 5.3058 5.3841
Actin 0.0202 0.0163 0.0254 0.0069 0.005 0.0192 0.0834 0.0369 0.0119 0.0238 0.0592 0.0209 0.0329 0.0076 0.0055 0.0122 0.0075 0.0242
Bud 0.0009 0.0009 0.0014 0.0019 0.0002 0.0004 0.0012 0.0004 0.0004 0.0007 0.0005 0.0002 0.0003 0.0003 0.0002 0.0004 0.0002 0.0002
Bud Neck 0.0044 0.001 0.0015 0.0074 0.0006 0.0047 0.0014 0.0008 0.0011 0.0014 0.0011 0.018 0.0005 0.0008 0.0005 0.0012 0.0006 0.0091
Bud Periphery 0.0011 0.0007 0.0019 0.0037 0.0002 0.0005 0.0024 0.0004 0.001 0.0013 0.0006 0.0002 0.0003 0.0002 0.0004 0.0004 0.0002 0.0003
Bud Site 0.0231 0.0182 0.0236 0.012 0.0002 0.0028 0.0017 0.0108 0.0057 0.0018 0.0017 0.0004 0.0015 0.0044 0.0008 0.0009 0.0003 0.0003
Cell Periphery 0.0025 0.0022 0.0028 0.0011 0.0003 0.0007 0.0022 0.0044 0.005 0.0012 0.0002 0.0006 0.0035 0.002 0.0037 0.0026 0.0006 0.0022
Cytoplasm 0.2535 0.442 0.3415 0.1637 0.343 0.3012 0.1535 0.3002 0.3554 0.4684 0.0949 0.32 0.1965 0.2391 0.2789 0.2893 0.3207 0.347
Cytoplasmic Foci 0.0978 0.0851 0.046 0.1129 0.1004 0.0952 0.0877 0.0716 0.0513 0.0794 0.167 0.1111 0.0408 0.0956 0.0313 0.0372 0.0901 0.0585
Eisosomes 0.0006 0.0002 0.0004 0.0002 0.0001 0.0002 0.0006 0.0004 0.0003 0.0002 0.0004 0.0001 0.0004 0.0001 0.0002 0.0003 0.0001 0.0001
Endoplasmic Reticulum 0.1333 0.1412 0.3062 0.1769 0.1339 0.1447 0.2336 0.2583 0.3871 0.1525 0.1257 0.2468 0.5046 0.3908 0.5324 0.2111 0.2329 0.3071
Endosome 0.1773 0.1525 0.1131 0.2651 0.2383 0.2114 0.1404 0.1292 0.0567 0.1115 0.3061 0.1471 0.0944 0.1401 0.0656 0.2348 0.1693 0.1014
Golgi 0.0665 0.0525 0.0308 0.11 0.0582 0.1343 0.0906 0.0771 0.0278 0.0757 0.1265 0.0902 0.0663 0.0644 0.0345 0.068 0.0735 0.0923
Lipid Particles 0.0693 0.0166 0.0215 0.0274 0.0147 0.0285 0.0597 0.0227 0.0344 0.0064 0.0313 0.0144 0.0203 0.0248 0.0219 0.0204 0.0646 0.018
Mitochondria 0.0155 0.0059 0.012 0.0372 0.0074 0.0254 0.0118 0.0015 0.0119 0.0038 0.0201 0.0059 0.0162 0.0026 0.0021 0.0123 0.0039 0.0103
None 0.03 0.0369 0.0367 0.0054 0.0832 0.0111 0.0151 0.0712 0.0283 0.057 0.0063 0.0113 0.0077 0.0058 0.011 0.0946 0.0156 0.016
Nuclear Periphery 0.021 0.0085 0.0089 0.006 0.0028 0.004 0.0499 0.0054 0.0082 0.0054 0.0043 0.0027 0.0066 0.0072 0.0049 0.0027 0.0056 0.0031
Nucleolus 0.0015 0.0004 0.0006 0.0062 0.0001 0.0002 0.0004 0.0001 0.0002 0.0001 0.0001 0 0 0.0001 0.0001 0.0001 0.0001 0
Nucleus 0.0195 0.0027 0.0024 0.0018 0.0014 0.0015 0.0073 0.001 0.0013 0.0016 0.0006 0.0007 0.0007 0.0019 0.0007 0.0007 0.001 0.0007
Peroxisomes 0.0394 0.0043 0.0086 0.0368 0.0027 0.0067 0.0143 0.0024 0.0055 0.0012 0.046 0.0054 0.0017 0.0046 0.0006 0.0006 0.0049 0.0037
Punctate Nuclear 0.0112 0.0028 0.0021 0.0011 0.0011 0.001 0.0289 0.0012 0.0013 0.0009 0.0033 0.0006 0.0006 0.0018 0.0007 0.0008 0.0016 0.0006
Vacuole 0.0083 0.0078 0.0106 0.0127 0.0041 0.0046 0.0062 0.0035 0.0042 0.0048 0.0023 0.0026 0.0033 0.0047 0.0036 0.0068 0.0052 0.004
Vacuole Periphery 0.0032 0.0014 0.0019 0.0038 0.0021 0.002 0.0076 0.0007 0.0008 0.001 0.0016 0.001 0.0009 0.0009 0.0005 0.0026 0.0015 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.5317 7.0533 13.2859 14.8042 12.1972 5.4594 14.5375 16.2913 12.9492 17.0696
Translational Efficiency 0.899 1.4617 0.675 0.6037 0.8648 1.9945 0.7169 0.5749 0.719 0.5881

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
105 387 183 1482 2151 1717 2300 1562 2256 2104 2483 3044

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 983.42 836.55 1025.23 1016.66 816.50 875.37 994.26 1045.56 824.27 868.23 996.54 1031.49
Standard Deviation 134.67 148.10 108.56 134.88 97.73 117.69 114.56 138.04 105.77 124.76 114.41 137.27
Intensity Change Log 2 — -0.233356 0.060068 0.047958 — 0.100440 0.284170 0.356751 — -0.072318 0.166058 0.196265

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002644 0.006700 0.004695 0.021603 0.002377 0.002579 0.002321 0.024451 0.002390 0.003337 0.002496 0.023064
Bud Neck 0.009599 0.005270 0.005735 0.013985 0.004230 0.005625 0.010236 0.013408 0.004480 0.005560 0.009904 0.013689
Bud Site 0.040746 0.012758 0.015281 0.049681 0.004541 0.009611 0.015439 0.041972 0.006227 0.010190 0.015427 0.045725
Cell Periphery 0.002663 0.001076 0.001209 0.002313 0.000936 0.000959 0.000780 0.003691 0.001016 0.000980 0.000811 0.003020
Cytoplasm 0.151914 0.125496 0.239589 0.191968 0.198596 0.156515 0.284693 0.174284 0.196423 0.150810 0.281369 0.182894
Cytoplasmic Foci 0.174011 0.232670 0.103428 0.135366 0.168087 0.182261 0.102500 0.133295 0.168362 0.191533 0.102569 0.134303
Eisosomes 0.002872 0.001147 0.000255 0.001431 0.002134 0.001472 0.000451 0.002595 0.002168 0.001412 0.000436 0.002028
Endoplasmic Reticulum 0.043885 0.221931 0.160814 0.167049 0.246853 0.247870 0.138753 0.245313 0.237407 0.243099 0.140379 0.207210
Endosome 0.092754 0.070785 0.039581 0.056485 0.025940 0.046763 0.040995 0.048253 0.029050 0.051181 0.040891 0.052261
Golgi 0.012937 0.123984 0.002247 0.026369 0.145486 0.141157 0.010651 0.046310 0.139317 0.137999 0.010032 0.036601
Lipid Particles 0.032557 0.104448 0.039812 0.083371 0.128315 0.127934 0.076020 0.106729 0.123858 0.123614 0.073351 0.095357
Mitochondria 0.002646 0.009066 0.000254 0.005855 0.020625 0.020886 0.002108 0.003193 0.019788 0.018712 0.001971 0.004489
Mitotic Spindle 0.003308 0.003899 0.003672 0.020790 0.000746 0.003433 0.014940 0.009399 0.000865 0.003518 0.014109 0.014945
None 0.000039 0.001593 0.000375 0.000620 0.002643 0.001799 0.000965 0.000254 0.002522 0.001761 0.000921 0.000432
Nuclear Periphery 0.000640 0.000837 0.007422 0.001488 0.000815 0.000883 0.010525 0.000530 0.000807 0.000875 0.010296 0.000996
Nuclear Periphery Foci 0.006585 0.004875 0.104606 0.022784 0.001857 0.003285 0.037651 0.014808 0.002077 0.003578 0.042585 0.018691
Nucleolus 0.000181 0.000386 0.000277 0.000340 0.000318 0.000374 0.000699 0.000204 0.000311 0.000376 0.000667 0.000270
Nucleus 0.025638 0.008220 0.059684 0.027832 0.015886 0.009471 0.102735 0.019258 0.016340 0.009241 0.099562 0.023432
Peroxisomes 0.007899 0.011080 0.003339 0.010643 0.013602 0.010603 0.005009 0.010531 0.013336 0.010690 0.004886 0.010585
Vacuole 0.382778 0.046326 0.207044 0.157159 0.012704 0.020161 0.141479 0.099721 0.029928 0.024974 0.146311 0.127685
Vacuole Periphery 0.003701 0.007454 0.000682 0.002869 0.003308 0.006360 0.001052 0.001800 0.003326 0.006561 0.001024 0.002320

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.96 -0.95 -8.82 -5.31 -5.27 -0.52 0.18 -10.74 -10.62 -10.75 -1.94 -0.30 -14.41 -13.34 -14.18
Bud Neck 1.53 1.20 -1.96 -7.79 -6.69 -1.73 -9.20 -9.56 -7.09 -2.70 -1.56 -8.81 -12.37 -9.63 -4.11
Bud Site 2.36 2.14 -0.70 -9.26 -8.54 -3.91 -7.13 -13.80 -11.10 -8.85 -3.07 -6.00 -18.28 -15.40 -12.42
Cell Periphery 0.90 0.78 0.17 -3.90 -2.88 -0.12 1.27 -6.93 -6.94 -7.84 0.14 1.40 -7.16 -7.89 -9.30
Cytoplasm 1.60 -3.05 -2.06 -6.71 2.05 7.10 -12.30 3.55 -2.91 14.54 8.25 -12.49 2.10 -6.34 14.61
Cytoplasmic Foci -3.39 3.53 1.90 9.16 -3.54 -2.59 14.16 6.50 8.49 -5.82 -4.51 14.66 7.63 12.02 -7.52
Eisosomes 0.68 1.10 0.59 -1.00 -9.22 3.21 9.70 -1.40 -4.40 -9.88 3.45 8.93 0.92 -3.47 -12.43
Endoplasmic Reticulum -9.19 -5.75 -8.83 3.76 -0.32 -0.09 14.89 1.18 1.19 -11.58 -0.60 13.98 5.06 5.49 -9.57
Endosome 1.02 3.30 2.28 3.19 -3.20 -9.77 -6.43 -8.58 -0.18 -2.75 -10.52 -5.07 -10.49 0.28 -4.72
Golgi -11.41 2.43 -2.81 10.89 -11.72 0.74 32.76 20.96 19.14 -11.99 0.26 32.57 24.87 24.58 -13.38
Lipid Particles -7.39 -1.18 -6.97 2.66 -8.59 0.08 12.56 4.24 3.87 -6.54 0.03 12.68 6.97 6.60 -6.23
Mitochondria -2.08 1.11 -1.32 1.33 -4.62 -0.15 17.12 13.10 11.36 -1.16 0.69 17.17 12.71 10.58 -3.14
Mitotic Spindle -0.33 -0.47 -5.31 -5.98 -5.91 -2.96 -8.59 -5.46 -3.35 2.25 -3.39 -8.65 -9.48 -6.91 -0.54
None -2.48 -2.47 -3.28 1.55 -0.92 1.49 2.99 6.23 3.93 2.00 1.47 3.04 5.62 3.84 1.53
Nuclear Periphery -0.95 -6.70 -3.87 -2.50 5.74 -0.31 -12.98 1.61 1.96 13.55 -0.35 -13.57 -1.18 -0.82 13.44
Nuclear Periphery Foci 0.73 -10.70 -7.46 -10.90 8.81 -3.94 -19.49 -13.14 -11.26 10.72 -4.56 -21.77 -18.34 -16.11 11.31
Nucleolus -2.10 -2.51 -3.68 0.41 -1.48 -0.25 -3.76 1.46 1.95 9.22 -0.35 -3.70 0.74 1.44 7.89
Nucleus 2.41 -3.77 -0.49 -11.23 4.92 6.62 -30.19 -2.99 -7.96 27.40 7.46 -30.42 -6.35 -13.56 26.93
Peroxisomes -1.69 1.97 -1.50 0.42 -4.11 3.03 9.74 2.95 0.34 -6.48 2.79 9.95 2.98 0.46 -7.91
Vacuole 12.42 5.34 7.92 -18.26 3.32 -5.34 -36.29 -23.67 -21.22 7.79 2.19 -29.59 -27.52 -32.30 3.83
Vacuole Periphery -2.71 3.10 0.78 3.80 -5.07 -6.82 10.41 4.34 8.77 -2.09 -7.44 10.99 3.85 9.21 -4.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
Localization
Cell Percentages ER (85%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Zrg17

Zrg17


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Zrg17-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available