Standard name
Human Ortholog
Description Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0.06 0.05 0.05 0.06 0.05 0.08 0.06 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.08 0.29 0.21 0.22 0.17 0.17 0.16 0.15 0.16 0.14 0.13 0.1 0.59 0.62 0.74 – – – 0 0.05 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0.05 0.09 0 0 0 0 0 0 0 0 0 0 0.09 0.14 0.08 – – – 0.15 0.09 0.08 0.07 0.08 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.84 0.53 0.75 0.79 0.8 0.86 0.86 0.85 0.86 0.85 0.91 0.9 0.17 0.09 0 – – – 0.68 0.66 0.7 0.74 0.62 0.68
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0.06 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0.08 0.06 0 0.05 0.06 0.08 0.06 0.11 0.08 0.09 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.15 0 0 0.08 0 0 0 0 0 0 0 0.13 0.15 0.1 – – – 0 0.07 0 0.06 0.09 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 0 0 0 0 0 0 0 0 0 0 0 1 1 – – – 2 7 7 2 10 12
Bud 1 4 13 11 20 36 35 41 32 44 47 44 1 4 1 – – – 0 2 0 1 2 5
Bud Neck 0 1 2 1 1 5 0 0 1 4 2 5 3 1 1 – – – 1 4 2 1 6 7
Bud Site 0 0 1 1 3 15 15 9 18 22 14 16 0 0 0 – – – – – – – – –
Cell Periphery 0 4 2 2 2 2 2 1 4 4 4 0 3 1 8 – – – 0 1 1 0 3 0
Cytoplasm 14 68 67 74 90 96 121 111 91 118 72 69 101 163 199 – – – 2 15 8 3 6 6
Endoplasmic Reticulum 4 10 1 1 0 1 0 1 1 1 1 1 6 3 3 – – – 0 3 5 2 4 7
Endosome 9 20 12 7 13 1 5 2 1 4 0 2 16 37 21 – – – 29 27 28 13 29 24
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 – – – 5 5 2 2 10 8
Mitochondria 149 123 238 261 410 482 653 636 478 697 517 614 29 23 9 – – – 139 210 251 142 238 289
Nucleus 3 1 1 0 5 20 16 30 17 11 7 13 3 1 1 – – – 0 2 0 0 1 1
Nuclear Periphery 1 0 0 2 0 1 0 1 4 4 1 4 1 0 0 – – – 2 0 2 1 1 1
Nucleolus 0 1 1 0 0 2 2 7 4 5 4 2 0 0 1 – – – 0 0 1 0 2 2
Peroxisomes 3 1 17 18 14 2 1 4 2 10 3 7 5 16 11 – – – 7 6 14 6 13 8
SpindlePole 3 6 24 21 20 28 48 59 36 89 47 61 6 8 11 – – – 1 5 10 1 9 5
Vac/Vac Membrane 19 34 14 8 41 9 20 10 11 10 6 3 23 40 26 – – – 7 21 11 11 35 32
Unique Cell Count 177 233 319 330 515 558 756 750 556 817 568 682 171 264 269 205 317 360 193 385 423
Labelled Cell Count 206 275 393 407 619 700 918 912 700 1023 725 841 198 298 293 205 317 360 193 385 423


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 4.5 3.6 3.5 3.5 3.4 2.9 3.3 2.9 2.8 2.7 2.7 5.1 5.0 5.0 – – – 5.5 5.9 5.8
Std Deviation (1e-4) 0.6 0.7 1.0 1.3 1.3 1.4 1.3 1.6 1.3 0.9 1.0 1.0 1.3 1.1 1.0 – – – 1.1 1.6 1.3
Intensity Change (Log2) – – – -0.05 -0.02 -0.08 -0.29 -0.12 -0.29 -0.36 -0.41 -0.38 0.5 0.5 0.49 – – – 0.61 0.71 0.7

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.5945 0.4357 0.3927 0.3125 0.4273 0.5192 2.0531 2.2537 1.9694 1.2927 2.3711 2.0464 -1.2476 -0.938 -0.9016 -0.8886 -1.1562 -0.8998
Actin 0.0109 0.0067 0.0118 0.0047 0.0158 0.011 0.0354 0.0146 0.0142 0.0054 0.0323 0.0125 0.0138 0.0127 0.0088 0.0459 0.0023 0.0045
Bud 0.0014 0.0118 0.0023 0.0113 0.0052 0.0035 0.0017 0.0023 0.0024 0.0037 0.0017 0.001 0.0008 0.0015 0.0009 0.0025 0.0006 0.0007
Bud Neck 0.0027 0.0013 0.0022 0.0029 0.0041 0.0073 0.0015 0.0023 0.0081 0.0423 0.0024 0.0052 0.0024 0.0036 0.0082 0.0026 0.0005 0.0036
Bud Periphery 0.0036 0.0079 0.0055 0.008 0.0083 0.0028 0.0031 0.004 0.0094 0.0152 0.0051 0.0043 0.0025 0.0045 0.003 0.0078 0.0011 0.0031
Bud Site 0.0133 0.0269 0.0121 0.0148 0.0015 0.0021 0.0056 0.041 0.0114 0.0038 0.0019 0.0027 0.0084 0.0287 0.0053 0.0043 0.0009 0.0009
Cell Periphery 0.0017 0.0014 0.0015 0.0028 0.0008 0.0006 0.0013 0.0014 0.0055 0.0017 0.0008 0.0045 0.0022 0.0021 0.0013 0.0018 0.0003 0.0011
Cytoplasm 0.0212 0.0315 0.0166 0.0218 0.0251 0.0275 0.0313 0.0272 0.0335 0.0292 0.0209 0.0251 0.0197 0.0186 0.021 0.0398 0.0073 0.0178
Cytoplasmic Foci 0.1101 0.0882 0.0745 0.0582 0.0726 0.0796 0.0995 0.093 0.0782 0.0528 0.0842 0.0927 0.085 0.1342 0.0776 0.0654 0.0356 0.084
Eisosomes 0.001 0.0007 0.0008 0.0006 0.0014 0.0005 0.0012 0.0013 0.0029 0.0005 0.0008 0.0009 0.002 0.0025 0.0025 0.0017 0.0002 0.0009
Endoplasmic Reticulum 0.0097 0.0054 0.0011 0.0016 0.0035 0.0021 0.0065 0.0014 0.0023 0.0014 0.0021 0.0015 0.0034 0.0009 0.0031 0.0026 0.001 0.0015
Endosome 0.1236 0.1296 0.0831 0.1297 0.0879 0.0901 0.1167 0.1055 0.064 0.045 0.1123 0.0697 0.1122 0.0912 0.079 0.0608 0.1597 0.078
Golgi 0.0523 0.0695 0.0351 0.052 0.0407 0.041 0.0654 0.0903 0.0408 0.0226 0.0621 0.0502 0.0535 0.0681 0.0307 0.042 0.0661 0.053
Lipid Particles 0.0684 0.0193 0.0271 0.0251 0.0204 0.0292 0.0536 0.0373 0.0131 0.0099 0.0173 0.0249 0.1025 0.0277 0.0449 0.0168 0.0086 0.0493
Mitochondria 0.3844 0.4141 0.5516 0.5891 0.4706 0.5122 0.3629 0.4428 0.5164 0.5837 0.4604 0.5203 0.4081 0.4582 0.5521 0.461 0.5512 0.5121
None 0.0803 0.079 0.0956 0.0423 0.1163 0.0805 0.0962 0.0515 0.0844 0.0836 0.0951 0.0665 0.0756 0.0403 0.0627 0.1267 0.0668 0.069
Nuclear Periphery 0.0077 0.0035 0.0011 0.0012 0.0034 0.0029 0.0061 0.0005 0.0008 0.0007 0.007 0.0007 0.0051 0.0002 0.001 0.0062 0.0004 0.0004
Nucleolus 0.004 0.0038 0.0021 0.001 0.0013 0.0016 0.002 0.0008 0.0027 0.0017 0.001 0.0008 0.0014 0.0029 0.007 0.0038 0.0003 0.0009
Nucleus 0.0031 0.0035 0.0017 0.0015 0.0067 0.0035 0.0047 0.0008 0.0021 0.0013 0.0035 0.0008 0.0019 0.0014 0.0016 0.0033 0.0004 0.0008
Peroxisomes 0.0788 0.0748 0.0583 0.0191 0.0978 0.0858 0.0872 0.0723 0.0978 0.0829 0.0737 0.1078 0.0868 0.0933 0.0749 0.0877 0.0829 0.1072
Punctate Nuclear 0.0073 0.0048 0.0064 0.002 0.0054 0.0047 0.0039 0.0018 0.0011 0.0023 0.0074 0.0014 0.0025 0.0013 0.001 0.0074 0.0003 0.0014
Vacuole 0.0102 0.0107 0.0066 0.0062 0.0057 0.0075 0.0097 0.0053 0.0063 0.0075 0.0043 0.0041 0.007 0.0043 0.0091 0.0059 0.0076 0.0064
Vacuole Periphery 0.0042 0.0055 0.003 0.0042 0.0054 0.0039 0.0046 0.0026 0.0027 0.0028 0.0035 0.0024 0.0035 0.0018 0.0044 0.0041 0.0058 0.0035

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.2561 22.9185 24.8557 23.5647 24.291 27.5945 18.7165 21.054 30.929 23.2238
Translational Efficiency 1.1598 0.7593 0.8593 1.2205 0.787 0.7011 0.9954 1.0261 0.8213 0.7779

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
517 1677 1236 1385 1936 1491 1638 2512 2453 3168 2874 3897

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 682.11 726.40 868.72 814.70 662.53 732.57 789.27 852.01 666.66 729.30 823.44 838.75
Standard Deviation 114.15 100.07 107.37 112.05 84.72 91.36 89.23 119.76 92.06 96.12 105.09 118.43
Intensity Change Log 2 — 0.090760 0.348887 0.256264 — 0.144981 0.252533 0.362885 — 0.117730 0.302215 0.309783

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000556 0.001850 0.001562 0.008024 0.000487 0.001432 0.004045 0.001362 0.000501 0.001653 0.002977 0.003730
Bud Neck 0.054751 0.028864 0.019765 0.028868 0.028971 0.025607 0.042842 0.056136 0.034405 0.027331 0.032918 0.046445
Bud Site 0.041500 0.028101 0.025903 0.059814 0.017372 0.013850 0.057694 0.058989 0.022457 0.021394 0.044022 0.059283
Cell Periphery 0.000744 0.000355 0.000147 0.000358 0.000236 0.000291 0.000195 0.000294 0.000343 0.000325 0.000175 0.000317
Cytoplasm 0.084918 0.042463 0.258710 0.276090 0.030451 0.031124 0.227172 0.277649 0.041930 0.037126 0.240735 0.277095
Cytoplasmic Foci 0.231869 0.181108 0.188968 0.119995 0.140485 0.145339 0.190853 0.113844 0.159745 0.164273 0.190042 0.116030
Eisosomes 0.000301 0.000222 0.000087 0.000185 0.000175 0.000170 0.000156 0.000135 0.000202 0.000198 0.000127 0.000153
Endoplasmic Reticulum 0.001211 0.000925 0.008171 0.004699 0.001057 0.000638 0.003874 0.002301 0.001090 0.000790 0.005722 0.003153
Endosome 0.087404 0.080598 0.046864 0.026558 0.093318 0.108436 0.026133 0.036892 0.092072 0.093700 0.035049 0.033219
Golgi 0.063970 0.109068 0.016656 0.009347 0.095198 0.110061 0.015525 0.012386 0.088617 0.109535 0.016011 0.011306
Lipid Particles 0.025402 0.011089 0.011567 0.011683 0.013780 0.020393 0.007707 0.009553 0.016229 0.015468 0.009367 0.010310
Mitochondria 0.258495 0.367472 0.019592 0.027269 0.473892 0.405501 0.049061 0.060978 0.428494 0.385370 0.036388 0.048998
Mitotic Spindle 0.005561 0.013695 0.074288 0.042966 0.008189 0.009829 0.053355 0.050283 0.007635 0.011876 0.062358 0.047682
None 0.005014 0.002406 0.002303 0.003304 0.001550 0.002182 0.002199 0.002435 0.002280 0.002300 0.002244 0.002744
Nuclear Periphery 0.000928 0.000187 0.005153 0.002984 0.000333 0.000334 0.001407 0.001515 0.000459 0.000256 0.003018 0.002037
Nuclear Periphery Foci 0.000326 0.000234 0.004609 0.001540 0.000236 0.000409 0.001126 0.000588 0.000255 0.000316 0.002624 0.000927
Nucleolus 0.001851 0.002025 0.005690 0.004354 0.002119 0.003893 0.003387 0.002917 0.002063 0.002904 0.004377 0.003427
Nucleus 0.023208 0.007236 0.150961 0.169415 0.007097 0.008540 0.132061 0.114550 0.010492 0.007850 0.140189 0.134049
Peroxisomes 0.070657 0.083792 0.021699 0.046235 0.036841 0.055067 0.091880 0.036610 0.043968 0.070273 0.061698 0.040031
Vacuole 0.027932 0.026701 0.127983 0.151910 0.031359 0.038142 0.085426 0.153555 0.030637 0.032086 0.103728 0.152970
Vacuole Periphery 0.013401 0.011607 0.009323 0.004403 0.016854 0.018763 0.003900 0.007027 0.016126 0.014975 0.006232 0.006094

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.06 -5.29 -6.57 -5.10 -5.27 -2.17 -9.06 -6.14 0.30 6.66 -4.71 -10.45 -7.81 -3.85 -0.79
Bud Neck 4.34 6.03 4.70 0.68 -3.15 1.18 -4.89 -8.93 -9.84 -4.10 2.90 0.57 -4.22 -8.38 -5.97
Bud Site 2.28 2.66 -1.69 -6.30 -6.67 2.01 -11.61 -13.64 -15.00 0.02 0.56 -7.91 -12.48 -14.22 -4.25
Cell Periphery 2.70 4.20 3.03 1.09 -5.04 -1.87 2.08 -1.18 0.86 -3.76 0.48 4.96 1.68 1.75 -6.36
Cytoplasm 5.68 -16.69 -18.69 -30.52 -1.79 -0.29 -31.36 -42.86 -41.50 -6.45 1.69 -38.60 -48.46 -51.14 -6.05
Cytoplasmic Foci 5.00 4.77 12.33 12.05 10.77 -1.01 -7.99 6.33 6.77 13.99 -1.07 -5.02 11.61 13.87 17.61
Eisosomes 2.96 8.64 4.89 3.01 -7.60 0.28 1.33 3.32 4.67 3.90 0.28 6.14 4.56 6.00 -2.84
Endoplasmic Reticulum 0.78 -12.91 -8.47 -11.55 6.94 2.38 -8.13 -3.55 -5.45 4.19 1.69 -15.48 -7.95 -10.04 8.19
Endosome 1.02 6.92 10.97 17.63 9.06 -2.97 20.12 17.14 17.94 -4.59 -0.43 19.48 20.99 24.08 2.43
Golgi -6.98 8.94 10.60 26.55 4.93 -2.67 23.48 24.97 22.57 2.33 -5.16 25.07 27.32 34.50 4.76
Lipid Particles 5.08 4.96 5.10 0.46 0.81 -3.16 4.59 3.29 5.96 -1.29 0.49 5.69 5.17 5.09 -0.10
Mitochondria -6.98 17.96 17.64 40.71 -1.07 6.04 51.94 51.21 39.10 -2.37 4.82 54.99 53.52 54.95 -3.46
Mitotic Spindle -4.88 -13.51 -9.42 -6.93 5.55 -1.28 -12.33 -13.91 -13.05 1.02 -3.78 -17.95 -16.48 -14.28 4.50
None 1.50 1.74 1.30 -0.47 -1.16 -1.21 -1.56 -1.70 0.33 -0.09 -0.32 0.14 -0.37 0.04 -0.83
Nuclear Periphery 1.52 -6.21 -3.39 -7.42 3.60 -0.02 -8.55 -5.65 -5.83 -0.50 1.68 -10.36 -7.33 -9.45 3.31
Nuclear Periphery Foci 0.90 -10.95 -7.29 -8.97 7.38 -3.06 -9.25 -4.12 -1.97 4.68 -1.54 -13.41 -8.70 -8.04 8.95
Nucleolus -0.42 -5.57 -3.40 -2.86 2.33 -2.26 -2.72 -1.82 1.19 1.15 -1.72 -5.43 -3.17 -0.90 2.77
Nucleus 4.01 -18.68 -21.30 -28.34 -1.96 -1.18 -25.95 -29.25 -28.56 3.10 2.00 -34.19 -37.90 -39.99 1.62
Peroxisomes -2.02 8.55 5.07 9.47 -5.15 -5.12 -11.23 0.84 5.88 11.89 -8.42 -4.76 3.12 11.78 7.84
Vacuole 0.34 -19.80 -24.66 -26.43 -7.57 -2.42 -18.08 -31.44 -28.18 -14.62 -0.71 -26.90 -39.95 -39.62 -15.07
Vacuole Periphery 0.95 2.50 5.62 9.56 5.34 -1.28 14.10 10.34 10.17 -4.59 1.14 11.62 12.48 12.92 0.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant
Localization
Cell Percentages mitochondrion (76%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Coq2

Coq2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Coq2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available