Standard name
Human Ortholog
Description Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.05 0.07 0.09 0.07 0.08 0.06 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.98 0.99 0.98 0.95 0.88 0.81 0.83 0.86 0.85 0.83 0.99 0.99 0.99 0.99 0.99 0.99 0.87 0.96 0.95 0.94 0.95 0.95
Endoplasmic Reticulum 0 0 0 0 0 0 0.08 0.12 0.11 0.09 0 0.06 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 3 8 11 4 7 7 10 0 0 0 0 0 0 2 0 0 0 0 0
Bud 0 0 1 1 0 2 7 3 2 5 5 3 0 0 0 0 0 0 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 3 12 10 16 33 68 82 29 52 25 49 0 7 3 11 9 6 0 0 0 0 0 0
Cytoplasm 45 119 320 435 690 610 908 767 359 596 331 482 80 210 215 440 287 264 56 116 314 49 119 202
Endoplasmic Reticulum 0 1 2 5 11 11 87 115 46 59 17 36 1 1 0 22 15 8 0 0 5 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 3 3 3 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1 2 0 0 0 2 9 6 8 11 12 20 0 0 0 0 0 1 0 0 1 0 0 0
Nucleus 0 0 2 3 3 2 7 10 5 6 2 3 0 1 3 0 0 2 0 2 1 0 1 3
Nuclear Periphery 0 0 0 0 0 0 1 0 0 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 4 2 0 4 12 21 11 10 11 21 1 0 1 1 2 0 0 0 2 1 0 2
Unique Cell Count 46 122 327 441 704 644 1031 945 433 693 391 580 81 212 218 445 289 267 65 122 330 53 125 214
Labelled Cell Count 46 125 341 456 720 670 1111 1018 466 749 410 625 82 219 222 475 313 281 65 122 330 53 125 214


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 23.3 26.6 25.9 24.2 23.7 22.4 22.4 22.3 20.2 19.5 18.4 18.4 30.6 32.4 29.8 49.1 47.2 48.9 20.8 30.3 31.9
Std Deviation (1e-4) 6.3 5.7 4.9 5.2 4.2 4.6 4.8 4.9 4.5 4.3 4.3 4.1 7.8 6.0 5.9 14.4 14.5 17.2 7.2 8.0 9.4
Intensity Change (Log2) – – – -0.1 -0.13 -0.21 -0.21 -0.21 -0.36 -0.41 -0.5 -0.49 0.24 0.32 0.2 0.92 0.87 0.92 -0.32 0.23 0.3

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.2 -1.3 1.0 2.0 3.0 1.8 2.4 1.6 2.8 0 -0.2 -1.6 -1.0 -0.4 -1.0
Cytoplasm 0.8 0.2 -2.3 -5.2 -7.4 -6.6 -5.8 -6.1 -6.7 0.5 1.1 0.7 1.1 1.5 1.0
Endoplasmic Reticulum 0 0 0 5.0 6.2 5.6 5.0 3.1 4.0 0 0 0 3.4 3.5 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 3.2 3.4 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 1.1 1.3 0 1.5 2.1 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.8916 22.0211 18.2987 18.0957 17.7956 20.3868 14.2551 25.4683 22.7005 17.5598 18.7638 21.6883 17.2935 23.533 22.1682 20.4433 21.4993 21.921
Actin 0.0287 0.0002 0.0029 0.0001 0.0222 0.0004 0.0997 0.0073 0.0221 0.036 0.0023 0.0018 0.0006 0.0003 0.0036 0 0 0.0003
Bud 0.0009 0.0001 0.0003 0.0001 0.0006 0.0002 0.001 0 0.0002 0.0022 0.0005 0.0006 0.0001 0.0001 0.0006 0 0 0.0001
Bud Neck 0.0025 0.0001 0.0007 0.0003 0.0012 0.0007 0.0011 0.0001 0.0005 0.001 0.0003 0.0009 0.0002 0.0001 0.0001 0.0002 0.0001 0.0004
Bud Periphery 0.0007 0 0.0003 0 0.001 0.0001 0.001 0 0.0002 0.0022 0.0002 0.0003 0 0 0.0001 0 0 0
Bud Site 0.0033 0.0001 0.0016 0 0.0031 0 0.0032 0.0004 0.0011 0.0104 0.0004 0.0001 0 0 0.0001 0 0 0
Cell Periphery 0.0003 0 0.0001 0 0.0001 0 0.0003 0 0.0001 0.0002 0 0 0 0 0 0 0 0
Cytoplasm 0.7958 0.9955 0.9319 0.99 0.9121 0.9719 0.7425 0.9894 0.9453 0.7917 0.9696 0.9674 0.983 0.9958 0.9903 0.9921 0.9754 0.992
Cytoplasmic Foci 0.0312 0.0007 0.007 0.0004 0.0038 0.0018 0.0194 0.0003 0.0033 0.0102 0.0065 0.0045 0.0006 0.0004 0.0005 0.0002 0.0003 0.0008
Eisosomes 0.0004 0 0 0 0.0002 0 0.0004 0 0.0001 0.0003 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0145 0.0003 0.0018 0.0003 0.0023 0.0015 0.0104 0.0001 0.0003 0.0008 0.0033 0.0054 0.0008 0.0003 0.0002 0.0002 0.0004 0.0004
Endosome 0.0267 0.0002 0.0069 0.0002 0.0128 0.0014 0.0209 0 0.0052 0.0233 0.005 0.0074 0.0003 0.0002 0.0002 0.0001 0.0001 0.0003
Golgi 0.0091 0 0.0025 0 0.0117 0.0001 0.0172 0.0001 0.0037 0.0171 0.0007 0.0012 0 0 0.0001 0 0 0
Lipid Particles 0.009 0 0.0041 0 0.004 0 0.009 0 0.0031 0.0168 0.0002 0.0001 0 0 0 0 0 0
Mitochondria 0.0039 0.0001 0.0133 0 0.0073 0.0014 0.013 0.0007 0.0079 0.0301 0.0018 0.0042 0.0001 0.0001 0.0005 0 0 0
None 0.0057 0.0003 0.0009 0.0003 0.0008 0.0006 0.018 0.0001 0.0004 0.0006 0.003 0.0005 0.0009 0.0002 0.0003 0.0001 0.0002 0.0003
Nuclear Periphery 0.0267 0.0003 0.0038 0.001 0.0078 0.0026 0.0101 0.0002 0.0006 0.0035 0.0011 0.001 0.0027 0.0005 0.0005 0.0011 0.0052 0.0008
Nucleolus 0.0021 0 0.0053 0 0.0002 0.0011 0.0012 0 0 0.0013 0 0 0 0 0 0 0 0
Nucleus 0.0193 0.0019 0.0096 0.0069 0.0043 0.0137 0.0157 0.0009 0.0012 0.0113 0.0034 0.0027 0.01 0.002 0.0026 0.0057 0.0176 0.0042
Peroxisomes 0.0061 0 0.0013 0 0.0011 0 0.005 0.0002 0.0031 0.0118 0.0002 0.0003 0 0 0.0001 0 0 0
Punctate Nuclear 0.0078 0.0001 0.0034 0.0001 0.0008 0.0015 0.0056 0 0.0011 0.0031 0.0004 0.0002 0.0003 0.0001 0.0001 0 0.0002 0.0002
Vacuole 0.0035 0.0002 0.0016 0.0002 0.0012 0.0006 0.0038 0 0.0003 0.0206 0.0006 0.0009 0.0004 0.0001 0.0002 0.0002 0.0003 0.0002
Vacuole Periphery 0.0016 0 0.0007 0.0001 0.0012 0.0002 0.0017 0 0.0002 0.0058 0.0003 0.0007 0.0001 0 0.0001 0.0001 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 168.1511 132.5107 138.8892 143.8276 138.1363 145.3725 130.4225 138.7511 132.6106 134.0223
Translational Efficiency 1.3022 1.5022 1.4836 1.4086 1.5505 1.4918 1.4589 1.3928 1.536 1.5891

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1594 147 1686 664 1218 183 539 1188 2812 330 2225 1852

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1719.56 2164.87 2219.78 3254.28 1774.26 2015.89 2770.05 3254.22 1743.25 2082.25 2353.08 3254.24
Standard Deviation 270.90 308.03 494.37 774.30 287.75 312.97 519.66 770.06 279.64 319.48 553.35 771.58
Intensity Change Log 2 — 0.332241 0.368377 0.920299 — 0.184199 0.642695 0.875094 — 0.258960 0.514185 0.897520

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000106 0.000250 0.000124 0.000426 0.000113 0.000221 0.000176 0.000304 0.000109 0.000234 0.000137 0.000348
Bud Neck 0.000216 0.000765 0.000700 0.001865 0.000186 0.000690 0.001619 0.002300 0.000203 0.000723 0.000922 0.002144
Bud Site 0.002125 0.002892 0.002074 0.009807 0.001232 0.004912 0.003426 0.008512 0.001738 0.004012 0.002401 0.008976
Cell Periphery 0.000127 0.000373 0.000189 0.002552 0.000140 0.000209 0.001035 0.001236 0.000133 0.000282 0.000394 0.001708
Cytoplasm 0.952819 0.877438 0.857190 0.857387 0.938537 0.902105 0.859266 0.854352 0.946633 0.891117 0.857693 0.855440
Cytoplasmic Foci 0.007975 0.018574 0.004997 0.005983 0.005553 0.021281 0.010457 0.007077 0.006926 0.020075 0.006320 0.006685
Eisosomes 0.000001 0.000002 0.000001 0.000004 0.000001 0.000001 0.000002 0.000004 0.000001 0.000001 0.000001 0.000004
Endoplasmic Reticulum 0.000236 0.000183 0.000276 0.000046 0.000515 0.000091 0.000063 0.000302 0.000357 0.000132 0.000224 0.000210
Endosome 0.000249 0.000669 0.000322 0.000670 0.000255 0.000637 0.000381 0.004147 0.000251 0.000651 0.000337 0.002901
Golgi 0.001727 0.001894 0.000593 0.005316 0.001581 0.001929 0.001807 0.004319 0.001664 0.001914 0.000887 0.004676
Lipid Particles 0.000691 0.001465 0.000745 0.004254 0.000379 0.000858 0.003134 0.003266 0.000556 0.001128 0.001324 0.003620
Mitochondria 0.000341 0.000041 0.000080 0.000531 0.000040 0.000040 0.000075 0.001980 0.000211 0.000040 0.000079 0.001460
Mitotic Spindle 0.000580 0.000577 0.001728 0.001357 0.000526 0.005506 0.001059 0.005750 0.000557 0.003310 0.001566 0.004175
None 0.003437 0.007490 0.006523 0.002278 0.006271 0.006547 0.003738 0.002359 0.004664 0.006967 0.005848 0.002330
Nuclear Periphery 0.000118 0.000076 0.000137 0.000100 0.000034 0.000044 0.000147 0.000223 0.000082 0.000058 0.000139 0.000179
Nuclear Periphery Foci 0.002270 0.004534 0.001826 0.002388 0.003509 0.002779 0.003634 0.002520 0.002807 0.003561 0.002264 0.002473
Nucleolus 0.000045 0.000181 0.000093 0.000115 0.000033 0.000067 0.000093 0.000188 0.000040 0.000118 0.000093 0.000162
Nucleus 0.020955 0.064585 0.102827 0.054388 0.037296 0.041735 0.073299 0.051220 0.028033 0.051913 0.095674 0.052356
Peroxisomes 0.000042 0.000036 0.000019 0.000061 0.000010 0.000075 0.000030 0.000090 0.000028 0.000058 0.000022 0.000080
Vacuole 0.005207 0.013679 0.019367 0.045906 0.003384 0.009991 0.035548 0.046201 0.004417 0.011634 0.023287 0.046095
Vacuole Periphery 0.000733 0.004298 0.000190 0.004567 0.000406 0.000283 0.001011 0.003650 0.000592 0.002072 0.000389 0.003979

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.61 -2.71 -4.66 -0.95 -3.90 -2.47 -4.63 -3.22 0.19 0.20 -4.20 -4.83 -5.48 -0.27 -3.35
Bud Neck -3.71 -10.90 -6.72 -3.11 -3.27 -4.61 -9.99 -10.93 -6.40 0.84 -5.82 -14.57 -12.79 -6.76 -4.25
Bud Site -2.29 -1.49 -4.31 -3.13 -3.92 -3.91 -5.50 -7.29 -0.71 -1.50 -4.37 -4.58 -7.75 -2.72 -5.43
Cell Periphery -4.59 -5.63 -8.18 -6.79 -7.71 -2.59 -7.45 -7.49 -6.62 0.10 -5.26 -8.97 -11.03 -9.17 -8.20
Cytoplasm 6.85 30.16 19.24 3.56 0.50 5.91 17.60 22.53 7.22 -0.98 9.26 34.45 30.25 7.68 1.01
Cytoplasmic Foci -3.25 -0.47 -1.78 2.77 -1.47 -4.82 -7.45 -4.85 3.80 4.69 -5.68 -5.26 -4.03 4.72 1.23
Eisosomes -3.06 -6.66 -6.39 -3.24 -4.66 -4.07 -9.27 -7.93 -3.43 -0.61 -4.79 -11.36 -9.90 -4.54 -5.11
Endoplasmic Reticulum 0.28 -0.14 2.38 2.20 3.44 1.43 1.53 1.27 -0.71 -1.19 1.52 1.05 1.84 0.87 1.77
Endosome -2.36 -3.69 -1.10 1.50 0.37 -2.40 -2.77 -3.10 -2.09 -2.63 -3.37 -4.61 -3.23 -1.58 -2.59
Golgi -0.54 6.56 -0.77 -0.63 -1.49 -0.45 0.24 -0.85 -0.50 -0.90 -0.62 5.47 -1.09 -0.79 -2.29
Lipid Particles -2.54 -3.60 -8.37 -5.50 -7.38 -3.76 -7.82 -10.31 -7.46 0.42 -3.83 -8.68 -12.94 -8.73 -7.67
Mitochondria 1.04 0.86 0.14 -1.21 -0.96 0.27 -1.67 -1.87 -1.88 -1.81 1.05 0.76 -1.33 -2.12 -1.96
Mitotic Spindle -0.13 -4.43 -0.78 -0.75 2.67 -1.66 -1.66 -2.31 0.57 -1.39 -1.68 -4.64 -2.50 0.29 0.31
None -1.88 -2.87 3.67 2.72 5.49 0.32 4.12 6.14 2.30 2.99 -1.22 -0.30 7.07 3.51 5.99
Nuclear Periphery 0.14 -1.13 -0.34 -1.85 4.29 -3.27 -10.64 -5.77 -4.79 0.47 0.00 -2.66 -1.99 -4.86 1.31
Nuclear Periphery Foci -3.63 -0.53 -2.22 2.65 -2.39 0.38 -2.87 0.87 0.25 3.85 -2.97 -0.86 -1.24 2.34 -0.56
Nucleolus -1.11 -8.48 -3.06 0.53 1.10 -5.25 -11.69 -7.72 -4.81 -2.30 -1.54 -11.61 -7.79 -0.51 -0.82
Nucleus -5.70 -31.12 -13.27 0.03 11.75 -1.73 -10.94 -10.08 -4.07 4.65 -6.04 -31.11 -17.96 -2.39 14.15
Peroxisomes -0.35 1.08 -1.07 -0.61 -2.61 -3.65 -5.93 -6.73 1.10 -2.49 -3.14 -1.31 -4.54 0.71 -4.16
Vacuole -3.50 -14.31 -15.52 -8.39 -7.48 -4.20 -13.02 -21.05 -10.22 -2.48 -5.39 -19.30 -25.90 -13.40 -10.20
Vacuole Periphery -0.83 2.48 -1.25 0.37 -1.69 0.75 -0.44 -2.54 -2.97 -1.77 -0.76 1.74 -2.34 -0.05 -2.93
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Mvd1

Mvd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mvd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available