Standard name
Human Ortholog
Description Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.06 0 0 0 0.05 0.08 0.12 0.1 0.1 0.1 0.05 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.97 0.91 0.9 0.87 0.72 0.62 0.65 0.54 0.61 0.57 1.0 0.99 0.98 0.94 0.96 0.96 0.95 0.95 0.92 0.96 0.92 0.93
Endoplasmic Reticulum 0 0 0 0 0 0.05 0.1 0.13 0.12 0.1 0.07 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.08 0 0.1 0.23 0.23 0.19 0.33 0.33 0.28 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 0 0.1 0.05 0.12 0 0 0 0.06 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 1 4 7 7 10 11 7 12 0 0 1 0 0 0 0 0 1 0 3 0
Bud 0 1 0 1 0 0 2 3 2 4 4 4 0 0 0 0 0 0 0 1 1 1 8 5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 0 15 6 7 9 18 24 35 28 28 33 12 14 16 11 9 5 0 0 0 0 0 0
Cytoplasm 260 149 260 157 164 227 252 190 195 156 167 183 263 437 462 260 272 214 245 147 250 217 403 316
Endoplasmic Reticulum 4 2 8 5 8 13 35 40 37 30 20 30 1 3 7 7 5 5 5 0 9 1 5 6
Endosome 1 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 1 0 0 0 1 0
Golgi 0 0 0 0 0 0 0 3 0 0 4 3 0 0 1 2 0 2 0 0 2 1 1 0
Mitochondria 3 1 4 13 7 25 80 71 58 96 90 88 0 0 0 2 3 1 0 0 2 0 1 0
Nucleus 0 0 0 0 0 0 2 1 3 2 0 0 1 2 0 0 1 1 0 0 0 1 0 1
Nuclear Periphery 0 0 0 0 0 0 0 4 0 0 1 2 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 4 7 3 4 17 9 28 14 37 0 5 4 16 10 4 1 2 1 1 3 1
Unique Cell Count 266 151 268 172 182 261 352 306 299 290 276 320 264 442 472 278 284 223 257 155 274 228 438 339
Labelled Cell Count 274 153 288 186 194 281 400 361 349 355 335 392 277 461 492 298 300 232 257 155 274 228 438 339


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.5 14.9 13.3 12.7 14.3 13.4 13.2 13.7 13.0 12.9 12.3 13.4 14.7 14.4 14.8 23.6 22.2 23.3 14.0 17.0 20.3
Std Deviation (1e-4) 1.9 2.8 3.5 3.6 3.5 2.8 2.9 3.4 3.3 3.4 3.3 3.8 2.9 2.8 3.1 6.9 6.3 6.9 3.0 4.9 6.6
Intensity Change (Log2) – – – -0.07 0.1 0.01 -0.02 0.03 -0.04 -0.05 -0.12 0.01 0.14 0.11 0.15 0.82 0.73 0.81 0.07 0.35 0.61

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 2.6 2.8 0 2.8 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.0 -0.8 -1.2 -0.3 1.1 2.6 1.8 2.0 2.1 -0.6 -1.6 -1.4 -0.9 -1.4 -1.9
Cytoplasm -2.6 -3.1 -4.3 -8.3 -10.1 -9.5 -11.7 -10.4 -11.2 2.3 1.8 0.7 -1.9 -0.8 -0.6
Endoplasmic Reticulum 0 0.8 1.2 3.4 4.4 4.1 3.4 2.2 3.1 0 0 -1.4 -0.3 -0.9 -0.5
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.2 0 4.1 7.7 7.7 6.8 9.7 9.6 8.6 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.9 0 5.2 3.7 5.8 0 0 0 4.0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.3836 10.8612 10.452 10.3225 9.5085 10.5367 8.6515 12.1373 10.3972 9.4961 10.2273 10.2544 6.5903 9.8384 10.199 5.2507 5.4792 9.1229
Actin 0.0044 0.0005 0.0031 0.0003 0.0229 0.002 0.0176 0.0002 0.0104 0.0016 0.0017 0.0018 0.0278 0.0008 0.0006 0.1486 0.035 0.0028
Bud 0.0005 0.0003 0.001 0.0008 0.0005 0.0003 0.0009 0.0018 0.0005 0.0011 0.0004 0.0004 0.0006 0.0029 0.0003 0.0015 0.0118 0.0002
Bud Neck 0.0005 0.0002 0.0005 0.0006 0.0008 0.0009 0.0014 0.0002 0.0005 0.0005 0.0004 0.0009 0.0005 0.0001 0.0003 0.0021 0.0031 0.0004
Bud Periphery 0.0003 0.0001 0.001 0.0003 0.0009 0.0002 0.0008 0.0005 0.0004 0.0014 0.0003 0.0002 0.0006 0.0009 0.0002 0.0015 0.0077 0.0001
Bud Site 0.001 0.0008 0.0032 0.0006 0.002 0.0002 0.0025 0.0008 0.0012 0.0006 0.0004 0.0002 0.0026 0.0009 0.0008 0.005 0.0895 0.0001
Cell Periphery 0.0008 0.0002 0.0004 0.0002 0.001 0.0002 0.0004 0.0001 0.0001 0.0002 0.0001 0.0001 0.0004 0.0002 0.0003 0.0003 0.001 0.0001
Cytoplasm 0.8718 0.9734 0.9377 0.9263 0.868 0.9336 0.7628 0.9688 0.904 0.8755 0.8777 0.9162 0.7671 0.9843 0.9362 0.4629 0.7331 0.8975
Cytoplasmic Foci 0.0189 0.0051 0.01 0.0088 0.0209 0.0107 0.0313 0.005 0.0133 0.0103 0.0244 0.0078 0.0136 0.0016 0.0078 0.0703 0.0349 0.0058
Eisosomes 0 0 0 0 0.0004 0 0.0001 0 0 0 0 0 0.0004 0 0 0.0007 0.0001 0
Endoplasmic Reticulum 0.045 0.0081 0.0086 0.0049 0.0129 0.0148 0.0445 0.0047 0.009 0.0152 0.0051 0.0263 0.0659 0.004 0.0056 0.0153 0.0023 0.0299
Endosome 0.0253 0.0055 0.0176 0.032 0.0323 0.0178 0.0664 0.0047 0.0289 0.0381 0.0379 0.0234 0.0381 0.001 0.0272 0.109 0.0198 0.0272
Golgi 0.0025 0.0006 0.0023 0.0011 0.0158 0.0033 0.0169 0.0005 0.0076 0.005 0.0056 0.0056 0.0134 0.0003 0.0045 0.0916 0.0289 0.0243
Lipid Particles 0.0011 0 0.0003 0.0002 0.0038 0.0037 0.0068 0.0001 0.0021 0.0092 0.0065 0.0023 0.0111 0 0.0006 0.0257 0.0014 0.0008
Mitochondria 0.0012 0.0002 0.0009 0.0003 0.004 0.0018 0.0064 0.0002 0.0018 0.0072 0.0157 0.0034 0.0151 0.0001 0.001 0.0281 0.0124 0.0058
None 0.0059 0.0013 0.0016 0.0008 0.0028 0.0013 0.0031 0.0071 0.0009 0.0012 0.0021 0.0016 0.0075 0.0012 0.0009 0.0011 0.0008 0.0006
Nuclear Periphery 0.0037 0.0005 0.001 0.0012 0.0026 0.0009 0.0116 0.0006 0.0038 0.0041 0.0017 0.0027 0.01 0.0004 0.0016 0.0017 0.0006 0.001
Nucleolus 0.0001 0 0 0 0.0001 0 0.0002 0 0.0001 0.0002 0.0002 0.0001 0.0025 0 0 0.0002 0.0002 0
Nucleus 0.0036 0.0008 0.0012 0.0012 0.0011 0.0007 0.0053 0.0008 0.0024 0.002 0.0017 0.0015 0.0029 0.0005 0.0009 0.0008 0.0012 0.0007
Peroxisomes 0.0007 0 0.0005 0 0.0029 0.0047 0.0052 0.0001 0.0025 0.0018 0.0029 0.0003 0.0031 0 0.0001 0.0273 0.0034 0.0001
Punctate Nuclear 0.0023 0.0001 0.0002 0.0001 0.0004 0.0007 0.0027 0.0001 0.0007 0.0019 0.0011 0.0011 0.0095 0 0.0001 0.0014 0.0004 0.0001
Vacuole 0.0092 0.0023 0.0077 0.0172 0.0029 0.0016 0.0109 0.0034 0.0085 0.0194 0.012 0.0033 0.0055 0.0006 0.0094 0.0032 0.0111 0.0013
Vacuole Periphery 0.0013 0.0003 0.001 0.0031 0.001 0.0006 0.0021 0.0004 0.0013 0.0037 0.0019 0.0009 0.0017 0.0001 0.0015 0.0015 0.0012 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.2191 16.146 14.704 29.2452 17.5633 32.8212 30.0533 30.5511 44.7051 32.4739
Translational Efficiency 2.0263 1.8433 1.7758 1.2342 1.6742 1.8864 1.3319 1.2118 0.9742 1.1756

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
193 324 249 1114 1491 2158 245 106 1684 2482 494 1220

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2481.71 1402.11 1449.61 1635.20 1227.30 1227.03 1566.52 2020.98 1371.07 1249.88 1507.59 1668.72
Standard Deviation 662.55 312.82 216.15 381.71 243.17 200.60 248.86 586.92 512.19 226.36 240.17 418.07
Intensity Change Log 2 — -0.823735 -0.775670 -0.601867 — -0.000317 0.352075 0.719567 — -0.496443 -0.298336 -0.020697

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000295 0.000595 0.001219 0.001366 0.000322 0.000404 0.000416 0.000853 0.000319 0.000429 0.000821 0.001322
Bud Neck 0.001549 0.001139 0.004240 0.001887 0.000755 0.000492 0.002552 0.003729 0.000846 0.000576 0.003403 0.002047
Bud Site 0.033979 0.043465 0.031369 0.026052 0.024112 0.014504 0.020662 0.034267 0.025243 0.018285 0.026059 0.026766
Cell Periphery 0.047828 0.001173 0.000883 0.002142 0.000487 0.000116 0.000196 0.009757 0.005912 0.000254 0.000542 0.002804
Cytoplasm 0.497742 0.828818 0.594739 0.851398 0.860982 0.871236 0.685881 0.768712 0.819352 0.865698 0.639941 0.844214
Cytoplasmic Foci 0.036853 0.077053 0.095957 0.023470 0.075950 0.074871 0.069675 0.029273 0.071469 0.075156 0.082923 0.023974
Eisosomes 0.000004 0.000007 0.000021 0.000009 0.000007 0.000005 0.000010 0.000011 0.000007 0.000006 0.000015 0.000010
Endoplasmic Reticulum 0.002729 0.000945 0.001794 0.000661 0.003575 0.000816 0.000733 0.000156 0.003478 0.000833 0.001267 0.000617
Endosome 0.004384 0.003846 0.014554 0.003587 0.003166 0.003421 0.008934 0.001435 0.003305 0.003477 0.011766 0.003400
Golgi 0.136507 0.009525 0.003416 0.008430 0.007922 0.006816 0.001218 0.003840 0.022659 0.007170 0.002326 0.008031
Lipid Particles 0.021257 0.002477 0.006513 0.009187 0.000869 0.000458 0.003557 0.040476 0.003206 0.000721 0.005047 0.011906
Mitochondria 0.000159 0.001476 0.000072 0.000879 0.000491 0.000496 0.000016 0.000008 0.000453 0.000624 0.000044 0.000803
Mitotic Spindle 0.010296 0.001467 0.001768 0.001697 0.000528 0.003723 0.002498 0.000953 0.001647 0.003429 0.002130 0.001632
None 0.000991 0.000473 0.000237 0.000200 0.000456 0.000500 0.000313 0.000381 0.000518 0.000496 0.000275 0.000215
Nuclear Periphery 0.000379 0.000015 0.000152 0.000135 0.000017 0.000011 0.000073 0.000055 0.000059 0.000011 0.000113 0.000128
Nuclear Periphery Foci 0.011376 0.001020 0.007960 0.002233 0.000430 0.000278 0.003571 0.006189 0.001684 0.000375 0.005784 0.002576
Nucleolus 0.000085 0.000040 0.000055 0.000067 0.000033 0.000040 0.000131 0.000067 0.000039 0.000040 0.000093 0.000067
Nucleus 0.003432 0.002032 0.010460 0.005664 0.002614 0.003343 0.009795 0.004468 0.002708 0.003172 0.010130 0.005560
Peroxisomes 0.000128 0.000778 0.000899 0.000604 0.000280 0.000562 0.000648 0.000709 0.000262 0.000590 0.000774 0.000613
Vacuole 0.084542 0.019862 0.222740 0.057664 0.011552 0.015381 0.188280 0.093438 0.019917 0.015966 0.205650 0.060772
Vacuole Periphery 0.105483 0.003794 0.000951 0.002668 0.005453 0.002525 0.000841 0.001222 0.016917 0.002690 0.000896 0.002542

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.61 -5.16 -3.59 -2.46 -0.72 -0.53 -1.56 -3.95 -2.72 -2.50 -0.81 -4.34 -3.65 -3.02 -1.78
Bud Neck 1.00 -5.33 -1.40 -2.63 4.87 2.43 -6.83 -5.48 -5.93 -1.78 2.47 -10.04 -7.60 -9.66 4.42
Bud Site -1.63 0.79 1.44 3.93 0.86 4.86 0.87 -1.86 -3.85 -2.22 3.70 -0.17 -1.00 -4.50 -0.76
Cell Periphery 6.08 6.15 5.97 -2.56 -4.52 5.52 4.15 -3.43 -3.57 -3.54 5.94 5.72 3.18 -7.66 -6.81
Cytoplasm -11.57 -2.78 -12.93 -1.25 -13.69 -1.61 11.31 4.65 5.07 -2.90 -6.55 14.39 -1.69 4.36 -15.29
Cytoplasmic Foci -5.63 -8.13 2.88 8.99 11.92 0.25 1.23 5.37 5.34 4.08 -1.04 -2.30 15.04 17.85 14.01
Eisosomes -2.91 -8.69 -3.29 -1.15 5.08 1.55 -2.89 -2.70 -3.42 -0.86 1.21 -7.16 -1.84 -2.55 3.84
Endoplasmic Reticulum 2.89 2.08 3.51 1.51 3.02 3.57 3.80 4.49 4.49 1.97 3.85 3.56 4.23 1.53 2.18
Endosome 0.70 -6.26 1.36 0.57 6.93 -0.66 -3.95 4.50 5.17 5.49 -0.48 -7.95 0.17 0.46 7.06
Golgi 10.24 10.84 10.37 0.95 -3.02 1.58 16.05 4.30 2.92 -2.71 8.40 11.61 6.85 -0.06 -3.82
Lipid Particles 6.41 5.04 3.94 -5.77 -2.25 4.12 -3.90 -4.51 -4.56 -4.10 6.48 -3.01 -6.72 -9.00 -4.84
Mitochondria -0.98 2.52 -1.74 0.49 -2.04 -0.02 3.18 3.22 2.13 3.17 -0.57 3.12 -0.74 -0.22 -2.09
Mitotic Spindle 1.79 1.67 1.66 -0.92 0.01 -4.37 -2.36 -0.77 3.11 1.63 -1.65 -0.64 -0.24 1.50 0.40
None 2.41 5.41 6.71 1.44 1.29 -0.50 2.02 0.76 1.16 -0.58 0.34 3.15 4.53 6.08 1.42
Nuclear Periphery 5.69 3.07 1.68 -1.23 0.16 0.78 -7.46 -3.59 -5.55 3.50 4.50 -5.61 -0.87 -1.32 -0.12
Nuclear Periphery Foci 4.09 1.30 3.53 -2.59 5.71 1.03 -8.30 -4.92 -5.08 -1.82 4.00 -7.14 -1.64 -4.95 4.94
Nucleolus 1.76 1.84 1.36 -1.12 -1.19 -2.09 -5.26 -3.68 -2.78 2.95 -0.27 -5.69 -5.93 -5.01 2.21
Nucleus 1.71 -7.12 -4.15 -6.66 4.63 -3.46 -7.54 -2.04 -1.48 3.86 -2.38 -11.08 -6.93 -6.22 5.51
Peroxisomes -3.84 -8.11 -6.30 1.20 2.23 -2.97 -5.84 -3.53 -0.98 -0.52 -3.85 -8.84 -5.11 0.04 1.73
Vacuole 5.31 -7.92 1.86 -7.41 10.97 -3.24 -13.42 -6.23 -5.99 4.49 1.97 -18.95 -12.78 -14.51 13.89
Vacuole Periphery 8.88 9.22 9.06 0.86 -3.14 5.71 10.22 5.85 2.24 -0.75 8.95 10.37 8.88 0.61 -3.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Cmk2

Cmk2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cmk2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available