Standard name
Human Ortholog
Description Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0.12 0.11 0.33 0.25 0.32 0.31 0.35 0.38 0.34 – 0.24 0.27 0.28 0.43 0.53 0.17 0.17 – 0.08 0.05 0.14 0.14 0.24 0.31
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.09 0 – 0 0 0 0 0 0
Endosome 0 0 0 0 0.07 0 0 0 0 – 0 0 0 0 0 0 0.06 – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Mitochondria 0 0.22 0.35 0.59 0.3 0.66 0.53 0.62 0.71 – 0.77 0.81 0.06 0.06 0.22 0 0 – 0 0 0.08 0 0.05 0.05
Nucleus 0.78 0.6 0.31 0.36 0.26 0.16 0.23 0.17 0.17 – 0.16 0.14 0.55 0.36 0.2 0.43 0.56 – 0.58 0.65 0.3 0.39 0.23 0.13
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0.05 0.06 0.06 0 0
Vac/Vac Membrane 0.13 0.27 0.11 0 0.16 0.08 0.11 0.06 0.05 – 0.06 0.05 0.2 0.22 0.18 0.48 0.22 – 0.17 0.14 0.29 0.27 0.36 0.33
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 1 1 1 0 0 1
Bud 0 0 0 0 2 4 1 5 5 – 6 8 0 1 1 0 0 – 2 3 3 8 4 5
Bud Neck 0 0 1 0 2 1 0 0 0 – 1 0 0 1 0 0 0 – 0 0 0 0 3 2
Bud Site 0 0 0 0 3 2 3 3 7 – 5 7 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 1 – 0 1 0 1 0 0 0 – 0 0 0 0 0 0
Cytoplasm 13 25 49 32 75 80 103 109 106 – 82 109 65 110 139 4 3 – 11 13 28 28 53 65
Endoplasmic Reticulum 1 1 0 0 1 0 0 0 0 – 0 0 0 1 1 2 0 – 0 0 1 0 1 2
Endosome 0 2 1 0 17 2 4 1 2 – 0 0 0 6 1 1 1 – 4 4 6 3 1 8
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 1 0 1 1 0
Mitochondria 2 51 53 75 71 172 155 176 218 – 260 329 13 14 57 1 0 – 4 6 17 4 10 9
Nucleus 85 142 47 46 61 42 68 48 54 – 54 56 127 92 52 10 10 – 85 173 61 81 52 27
Nuclear Periphery 0 2 0 0 0 0 1 0 0 – 1 0 1 1 0 0 0 – 1 0 3 0 0 0
Nucleolus 1 2 0 0 8 2 1 1 2 – 2 3 0 0 0 0 0 – 2 4 2 2 1 2
Peroxisomes 0 0 0 0 0 1 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 1 11 1 1 2 9 – 2 7 0 1 0 0 0 – 5 13 13 13 9 9
Vac/Vac Membrane 14 63 16 5 39 21 31 16 14 – 20 21 46 55 47 11 4 – 24 38 58 56 81 71
Unique Cell Count 109 235 150 128 238 262 291 285 309 337 408 232 253 262 23 18 146 266 205 210 225 214
Labelled Cell Count 116 288 167 159 290 328 368 361 418 433 541 252 283 298 29 18 146 266 205 210 225 214


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.3 4.0 3.5 3.4 3.9 3.3 3.6 3.0 2.9 – 2.9 2.6 4.5 4.4 3.8 6.1 9.0 – 4.6 4.7 5.3
Std Deviation (1e-4) 0.8 0.6 0.8 1.0 1.8 1.1 2.0 1.1 1.2 – 1.0 0.8 1.1 1.1 1.0 1.2 3.6 – 1.6 2.1 2.4
Intensity Change (Log2) – – – -0.06 0.15 -0.09 0.04 -0.22 -0.3 – -0.3 -0.45 0.37 0.33 0.12 0.8 1.35 – 0.4 0.41 0.58

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_20510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.9052 1.6955 1.8785 1.9636 1.5672 1.4339 2.4942 2.5995 2.6024 2.1891 3.0577 2.4297 2.8933 3.0126 3.294 3.3673 3.7181 2.8544
Actin 0.0846 0.0008 0.0132 0.0201 0.0169 0.0081 0.0493 0.0002 0.0026 0.0033 0.0069 0.0067 0.0224 0.0001 0.0006 0.0123 0.0361 0.0002
Bud 0.0023 0.0001 0.0003 0.0003 0.0005 0 0.0008 0.0001 0.0004 0.0001 0.0014 0.0002 0.0005 0.0001 0.0002 0.0001 0.0004 0
Bud Neck 0.0167 0.0006 0.0071 0.0024 0.0014 0.0036 0.0019 0.0091 0.0028 0.0024 0.0031 0.0032 0.0049 0.0006 0.0007 0.0009 0.0012 0.013
Bud Periphery 0.0048 0.0001 0.0007 0.0005 0.0006 0.0001 0.0011 0.0001 0.0007 0.0001 0.0022 0.0005 0.0008 0.0001 0.0004 0.0001 0.0004 0.0001
Bud Site 0.0122 0.0008 0.0031 0.002 0.0067 0.0001 0.0037 0.0041 0.0009 0.0003 0.004 0.0006 0.0084 0.0014 0.0005 0.0001 0.0029 0.0001
Cell Periphery 0.0009 0.0001 0.0003 0.0003 0.0002 0 0.0003 0.0001 0.0002 0 0.0003 0.0001 0.0005 0 0 0 0.0001 0
Cytoplasm 0.0236 0.0288 0.0067 0.0088 0.0039 0.0058 0.0366 0.0557 0.0167 0.0043 0.0139 0.0103 0.0467 0.0363 0.0075 0.01 0.0142 0.0158
Cytoplasmic Foci 0.0335 0.0013 0.0032 0.0393 0.028 0.0006 0.028 0.0007 0.0086 0.0059 0.0494 0.0075 0.0046 0.0005 0.0082 0.0066 0.0133 0.0003
Eisosomes 0.0008 0 0.0001 0.0002 0.0002 0 0.0004 0 0 0 0.0004 0.0001 0.0003 0 0 0.0001 0.0003 0
Endoplasmic Reticulum 0.0077 0.0026 0.0006 0.0023 0.0015 0.0004 0.0023 0.0015 0.0008 0.0005 0.004 0.0013 0.0048 0.0016 0.0005 0.0031 0.0006 0.0006
Endosome 0.0301 0.0028 0.0032 0.0316 0.0242 0.0015 0.0223 0.0008 0.0129 0.0083 0.0797 0.0082 0.0116 0.0007 0.0066 0.0084 0.0124 0.0005
Golgi 0.013 0.0007 0.0017 0.0302 0.0094 0.001 0.0107 0 0.0039 0.0014 0.0274 0.0038 0.0049 0 0.0066 0.0014 0.0087 0
Lipid Particles 0.0263 0.0008 0.0012 0.0232 0.0503 0.0024 0.0246 0.0001 0.0027 0.0022 0.0157 0.0096 0.0069 0.0001 0.0033 0.0011 0.0037 0
Mitochondria 0.0086 0.005 0.0013 0.0186 0.006 0.0011 0.0127 0.0003 0.0036 0.0009 0.0354 0.0137 0.004 0.0003 0.0022 0.0004 0.0028 0.0002
None 0.0201 0.0222 0.0155 0.0093 0.0062 0.0104 0.0448 0.0927 0.0256 0.0009 0.0771 0.0276 0.0998 0.0382 0.0589 0.0583 0.1221 0.0225
Nuclear Periphery 0.0628 0.021 0.021 0.0131 0.0147 0.0075 0.0199 0.0099 0.0083 0.0121 0.0141 0.0146 0.0151 0.009 0.0256 0.0187 0.0104 0.0076
Nucleolus 0.0168 0.0166 0.0141 0.0086 0.0152 0.0123 0.0059 0.0106 0.0327 0.0186 0.0046 0.0109 0.0063 0.019 0.0243 0.0278 0.0166 0.0115
Nucleus 0.5382 0.8598 0.8797 0.7244 0.7268 0.9224 0.6465 0.7895 0.8511 0.8841 0.5842 0.8462 0.7305 0.878 0.8261 0.8058 0.7252 0.8904
Peroxisomes 0.0179 0.0008 0.0011 0.0333 0.0137 0.0009 0.0306 0 0.0033 0.0038 0.0285 0.0043 0.0028 0 0.0031 0.0002 0.0052 0
Punctate Nuclear 0.0678 0.0326 0.0226 0.0136 0.0708 0.021 0.0521 0.0237 0.0151 0.05 0.0365 0.029 0.0214 0.0131 0.0235 0.0439 0.0223 0.0368
Vacuole 0.0078 0.0022 0.003 0.0161 0.0013 0.0003 0.0038 0.0007 0.006 0.0003 0.0066 0.0008 0.002 0.0009 0.0007 0.0003 0.0008 0.0003
Vacuole Periphery 0.0035 0.0004 0.0004 0.0021 0.0015 0.0003 0.0018 0.0001 0.0012 0.0003 0.0048 0.0008 0.0008 0.0001 0.0004 0.0004 0.0003 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.1118 7.5135 7.1365 11.6589 13.2948 15.4566 10.4838 7.9988 10.01 14.7461
Translational Efficiency 0.6218 0.4794 0.5042 0.4797 0.3286 0.421 0.3438 0.3372 0.4155 0.3935

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
254 126 155 859 1370 1329 1573 86 1624 1455 1728 945

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 682.67 802.39 1064.49 876.14 663.00 753.72 884.00 899.22 666.08 757.93 900.19 878.24
Standard Deviation 73.57 108.86 150.56 115.02 86.48 110.07 104.00 113.96 84.89 110.82 120.58 115.11
Intensity Change Log 2 — 0.233115 0.640902 0.359973 — 0.185020 0.415037 0.439665 — 0.209619 0.534032 0.399787

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000058 0.002406 0.000730 0.000997 0.000104 0.000333 0.000427 0.000536 0.000097 0.000512 0.000454 0.000955
Bud Neck 0.009462 0.012900 0.001686 0.017068 0.004455 0.012018 0.007645 0.004907 0.005238 0.012095 0.007111 0.015961
Bud Site 0.001422 0.008505 0.001755 0.024670 0.001275 0.007456 0.003219 0.010324 0.001298 0.007547 0.003088 0.023365
Cell Periphery 0.000111 0.000219 0.000194 0.000162 0.000118 0.000205 0.000117 0.000207 0.000117 0.000206 0.000124 0.000166
Cytoplasm 0.206590 0.102243 0.119838 0.080262 0.213165 0.191409 0.039500 0.139667 0.212137 0.183687 0.046707 0.085668
Cytoplasmic Foci 0.080046 0.031986 0.010507 0.018856 0.028879 0.059224 0.000992 0.016504 0.036882 0.056866 0.001845 0.018642
Eisosomes 0.000085 0.000096 0.000090 0.000040 0.000040 0.000073 0.000027 0.000052 0.000047 0.000075 0.000032 0.000041
Endoplasmic Reticulum 0.001235 0.005102 0.011310 0.007569 0.001550 0.003046 0.006417 0.007351 0.001500 0.003224 0.006856 0.007549
Endosome 0.003628 0.003102 0.002674 0.028195 0.002025 0.006129 0.000769 0.034249 0.002275 0.005867 0.000940 0.028746
Golgi 0.000387 0.001158 0.000097 0.016319 0.000160 0.001714 0.000051 0.020377 0.000196 0.001666 0.000055 0.016688
Lipid Particles 0.009500 0.004832 0.002306 0.001180 0.003798 0.008717 0.000612 0.001512 0.004690 0.008381 0.000764 0.001210
Mitochondria 0.003742 0.005338 0.000460 0.016587 0.002408 0.011086 0.001229 0.062865 0.002617 0.010588 0.001160 0.020798
Mitotic Spindle 0.001591 0.013191 0.000151 0.113766 0.001295 0.010631 0.005147 0.036591 0.001342 0.010852 0.004698 0.106743
None 0.007612 0.011816 0.003512 0.006798 0.019156 0.008965 0.007879 0.006898 0.017351 0.009212 0.007487 0.006807
Nuclear Periphery 0.002221 0.002634 0.001471 0.006750 0.002062 0.002685 0.001969 0.003232 0.002087 0.002680 0.001924 0.006430
Nuclear Periphery Foci 0.001296 0.003373 0.002420 0.003598 0.002958 0.002225 0.000542 0.014482 0.002698 0.002325 0.000710 0.004588
Nucleolus 0.007619 0.008169 0.001862 0.002364 0.012271 0.009808 0.002223 0.002010 0.011543 0.009666 0.002191 0.002332
Nucleus 0.624596 0.739177 0.768333 0.573184 0.697634 0.631226 0.909527 0.522521 0.686211 0.640574 0.896862 0.568573
Peroxisomes 0.004711 0.014778 0.000366 0.001869 0.001497 0.008765 0.000204 0.000656 0.002000 0.009286 0.000219 0.001758
Vacuole 0.033732 0.027797 0.070057 0.058419 0.004834 0.022594 0.011210 0.093682 0.009354 0.023044 0.016488 0.061628
Vacuole Periphery 0.000355 0.001177 0.000183 0.021347 0.000316 0.001692 0.000294 0.021376 0.000322 0.001647 0.000284 0.021350

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.13 -7.34 -13.95 0.96 -1.00 -4.34 -12.67 -4.46 -3.61 -2.55 -3.89 -14.57 -14.03 -5.90 -6.64
Bud Neck -1.21 2.36 -2.59 -1.29 -10.94 -5.36 -4.12 -2.59 1.32 0.25 -5.15 -3.16 -7.74 -2.45 -4.62
Bud Site -3.08 -2.38 -5.71 -0.53 -4.97 -4.26 -3.34 -2.76 -0.36 -1.86 -4.80 -3.62 -6.12 -1.95 -4.69
Cell Periphery -2.93 -4.61 -1.68 2.40 3.95 -4.29 0.96 -1.27 2.06 -1.76 -4.82 0.02 -1.49 4.06 -1.30
Cytoplasm 5.18 4.78 9.03 2.19 2.33 1.74 23.30 7.74 6.81 -2.89 2.80 24.16 18.40 15.45 -5.56
Cytoplasmic Foci 4.05 8.13 8.75 4.57 1.51 -7.35 15.04 6.53 11.86 -2.28 -5.05 16.99 14.75 17.89 -3.75
Eisosomes -1.60 -1.54 1.39 2.41 3.06 -6.42 4.03 -4.36 -2.40 -5.30 -5.93 3.90 -5.41 0.74 -9.39
Endoplasmic Reticulum -4.90 -8.93 -18.87 -8.09 -0.74 -5.85 -13.99 -6.72 -5.83 -2.83 -7.28 -15.96 -20.29 -16.83 -7.46
Endosome -0.28 0.42 -2.28 -2.01 -2.64 -5.20 3.37 -1.77 -0.62 -2.20 -5.16 3.78 -3.59 -0.47 -5.03
Golgi -1.42 1.79 -3.23 -2.04 -3.57 -3.90 7.40 -1.15 -0.71 -1.20 -4.01 6.41 -3.59 -1.73 -3.83
Lipid Particles 1.78 4.05 4.61 2.98 3.03 -4.43 8.14 4.14 7.25 -3.65 -3.55 9.22 7.79 8.84 -5.62
Mitochondria -0.35 1.89 -0.94 -0.43 -5.10 -4.88 1.82 -1.29 -0.28 -1.43 -4.82 2.38 -2.73 2.14 -4.19
Mitotic Spindle -1.54 1.08 -8.68 -3.23 -9.45 -4.60 -3.57 -2.24 -1.43 -1.70 -4.77 -3.38 -9.46 -7.18 -8.16
None -0.71 2.30 0.74 1.52 -4.34 4.75 6.09 5.90 2.26 0.73 4.41 6.22 6.27 2.58 -0.27
Nuclear Periphery -0.60 0.99 -9.08 -7.67 -10.68 -2.31 -3.83 -5.07 -3.58 -3.27 -2.38 -3.67 -10.45 -9.12 -9.15
Nuclear Periphery Foci -0.97 -1.35 -1.02 0.63 0.77 2.02 4.26 -0.06 -0.95 -1.72 1.59 4.05 1.91 0.07 -3.88
Nucleolus -0.30 2.77 2.17 2.64 -2.86 4.78 8.65 5.36 2.23 -0.46 4.43 8.93 8.98 6.29 0.12
Nucleus -2.78 -3.14 -2.45 1.31 1.65 4.94 -21.93 0.86 -0.84 6.88 3.61 -22.17 0.35 -2.79 18.34
Peroxisomes -1.90 3.29 3.14 2.79 -1.70 -6.11 8.28 4.05 7.43 -1.57 -6.16 8.27 6.84 8.27 -3.37
Vacuole -0.07 -4.87 -7.07 -5.82 1.17 -11.33 -9.18 -5.74 -4.88 -5.03 -7.08 -7.76 -16.92 -14.10 -12.92
Vacuole Periphery -1.43 1.95 -2.91 -2.21 -3.02 -3.57 0.68 -1.45 -0.96 -1.48 -3.72 0.87 -3.17 -2.04 -3.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
Localization
Cell Percentages nucleus (59%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Smc5

Smc5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Smc5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available