ORF
Human Ortholog
Description Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.99 0.97 0.97 0.9 0.86 – 0.75 0.78 0.6 0.75 0.99 0.98 0.99 0.95 0.93 0.96 0.97 0.96 0.95 0.9 0.77 0.59
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Mitochondria 0 0 0 0 0 0.08 0.09 – 0.21 0.17 0.32 0.1 0 0 0 0 0 0 0 0 0 0 0 0.05
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0.07 0.08 0.16 0.12 0 0 0 0.06 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 1 – 0 0 1 1 0 0 0 1 1 0 0 0 0 1 2 3
Bud 2 0 1 1 1 0 2 – 3 1 5 4 0 1 2 0 0 0 0 0 2 1 4 13
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2
Bud Site 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 13 4 5 4 8 – 5 7 8 9 1 0 1 5 13 7 0 0 0 0 0 0
Cytoplasm 356 353 401 346 421 361 489 – 334 363 265 351 243 316 363 389 300 243 353 337 390 232 250 184
Endoplasmic Reticulum 2 4 3 2 4 2 8 – 1 10 4 13 1 1 0 13 11 9 1 0 1 5 4 8
Endosome 0 0 2 1 0 0 0 – 0 0 0 1 0 3 0 5 7 1 1 2 2 0 12 41
Golgi 2 0 0 1 0 0 0 – 0 0 0 0 0 1 0 0 0 1 1 0 2 0 13 15
Mitochondria 3 0 0 0 3 32 50 – 92 79 143 46 3 1 1 2 0 1 0 1 4 2 8 14
Nucleus 1 3 3 0 5 8 11 – 10 12 17 23 0 0 2 3 9 1 0 2 0 0 0 0
Nuclear Periphery 0 0 0 0 1 0 0 – 0 0 3 0 0 0 1 0 0 0 0 0 0 1 1 0
Nucleolus 0 0 0 0 0 0 0 – 0 1 0 1 0 0 1 2 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 5
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 1 1 0 0 0 0 5 8
Vac/Vac Membrane 2 0 2 11 3 17 22 – 29 38 70 58 0 5 2 26 16 10 2 3 1 7 10 8
Unique Cell Count 364 357 407 355 436 399 567 445 468 441 468 245 324 368 411 322 253 363 351 411 260 325 312
Labelled Cell Count 369 361 425 366 443 424 591 474 511 517 508 248 328 373 446 358 274 363 351 411 260 325 312


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 8.0 7.2 6.7 7.1 6.0 6.2 – 5.9 5.8 5.5 6.4 6.7 6.9 6.2 8.5 8.6 8.2 6.4 6.3 6.9
Std Deviation (1e-4) 0.8 1.1 1.0 1.1 1.0 0.9 1.0 – 1.1 1.0 0.8 1.1 1.0 1.3 1.2 1.5 1.5 1.5 1.2 1.4 1.5
Intensity Change (Log2) – – – -0.1 -0.02 -0.27 -0.21 – -0.29 -0.32 -0.4 -0.17 -0.09 -0.05 -0.22 0.24 0.26 0.2 -0.16 -0.19 -0.06


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.9 -2.1 -2.2 -1.9 – -2.1 -1.7 -1.3 -1.2 -2.4 -3.2 -3.1 -1.9 0.6 -0.3
Cytoplasm -1.1 -1.8 -5.0 -6.7 – -9.9 -9.3 -13.6 -10.0 0.7 -1.0 0.1 -3.1 -3.7 -2.0
Endoplasmic Reticulum 0 0 0 0 – 0 1.7 0 2.2 0 0 0 2.5 2.6 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.8 6.2 – 9.7 8.7 12.6 6.5 0 0 0 0 0 0
Nucleus 0 0 1.6 1.6 – 1.8 2.1 3.0 3.6 0 0 0 0 2.2 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 2.8 0 3.5 3.4 – 4.7 5.4 8.0 6.9 0 0 0 4.6 3.9 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5461 2.1272 1.7587 1.025 1.6491 1.7825 3.5102 3.7732 3.4509 3.4053 3.2338 3.6978 2.438 3.2402 2.7575 2.8656 2.8173 2.9398
Actin 0.1093 0.0036 0.0364 0.0309 0.0689 0.0099 0.0605 0.0013 0.0157 0.0262 0.0089 0.0008 0.0181 0.0007 0.0014 0.0148 0.0006 0.0004
Bud 0.004 0.0002 0.0007 0.0017 0.0019 0.0008 0.0013 0.0015 0.0025 0.0011 0.0007 0.0003 0.0003 0.0002 0.0001 0.0002 0.0001 0.0001
Bud Neck 0.0202 0.0002 0.0013 0.0004 0.0048 0.0011 0.0016 0.0002 0.0025 0.0059 0.0011 0.0134 0.0007 0.0001 0.0002 0.0004 0.0005 0.0007
Bud Periphery 0.0067 0.0001 0.0004 0.0018 0.0022 0.0039 0.0015 0.0004 0.0014 0.001 0.0004 0.0003 0.0004 0.0001 0 0.0001 0 0
Bud Site 0.0122 0.0008 0.0143 0.002 0.0118 0.0009 0.0079 0.004 0.0175 0.009 0.0016 0.0002 0.0004 0.0007 0.0003 0.0003 0.0001 0
Cell Periphery 0.0015 0.0001 0.0001 0.0001 0.0002 0.0002 0.0004 0.0003 0.0002 0.0002 0.0001 0 0.0001 0.0001 0.0001 0 0 0
Cytoplasm 0.4705 0.8799 0.772 0.6553 0.7248 0.8027 0.5933 0.9309 0.8405 0.6922 0.7661 0.9009 0.7915 0.8728 0.8955 0.8234 0.963 0.8771
Cytoplasmic Foci 0.0363 0.007 0.016 0.0263 0.0158 0.0055 0.0591 0.0058 0.0138 0.0565 0.074 0.0053 0.007 0.0033 0.0089 0.0123 0.0064 0.0107
Eisosomes 0.0016 0 0.0001 0.0001 0.0002 0.0001 0.0003 0.0001 0.0001 0.0002 0 0 0.0002 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0164 0.0053 0.004 0.0094 0.0037 0.0076 0.0087 0.0017 0.0011 0.0079 0.0016 0.0025 0.0059 0.0022 0.0025 0.0054 0.0013 0.002
Endosome 0.0749 0.0058 0.0071 0.0341 0.0054 0.0117 0.0679 0.0008 0.0056 0.0153 0.0303 0.007 0.0114 0.0013 0.0034 0.009 0.0023 0.0034
Golgi 0.0178 0.0015 0.0035 0.0137 0.0028 0.0025 0.0274 0.0002 0.0074 0.0154 0.0321 0.0027 0.0038 0.0001 0.0004 0.0014 0.0001 0.0002
Lipid Particles 0.0253 0.0017 0.0013 0.0022 0.0011 0.001 0.0125 0.0001 0.0057 0.0092 0.0201 0.0007 0.0017 0.0001 0.0002 0.0018 0 0.0001
Mitochondria 0.0092 0.0001 0.0008 0.0132 0.0006 0.0013 0.0111 0.0007 0.0242 0.0095 0.0051 0.024 0.0009 0.0001 0.0003 0.0006 0.0002 0.0002
None 0.0902 0.0861 0.1288 0.1695 0.0533 0.1222 0.07 0.0452 0.0382 0.0916 0.0094 0.0271 0.1176 0.1097 0.0774 0.0962 0.0143 0.0949
Nuclear Periphery 0.0402 0.0017 0.0019 0.0164 0.0018 0.0106 0.0173 0.0008 0.0006 0.0035 0.0013 0.0027 0.0103 0.0012 0.0012 0.0063 0.0019 0.0009
Nucleolus 0.0017 0 0.0004 0.0002 0.0006 0.0002 0.0013 0.0012 0.0006 0.0008 0.0007 0.0001 0.0003 0 0 0.0003 0 0
Nucleus 0.028 0.0036 0.0051 0.008 0.0029 0.0109 0.0211 0.003 0.0044 0.0086 0.0037 0.0072 0.0224 0.0059 0.0036 0.0086 0.0071 0.0077
Peroxisomes 0.0103 0.0001 0.0018 0.006 0.0012 0.0004 0.01 0.0001 0.0143 0.0298 0.0377 0.0008 0.0005 0.0001 0.0029 0.0016 0.0002 0.0002
Punctate Nuclear 0.0129 0.0007 0.0021 0.0029 0.095 0.0044 0.0179 0.0011 0.0026 0.0135 0.0037 0.0005 0.0052 0.0008 0.0009 0.016 0.0014 0.0008
Vacuole 0.007 0.0012 0.0016 0.0037 0.001 0.0015 0.0066 0.0006 0.001 0.0019 0.0009 0.0017 0.0011 0.0006 0.0006 0.0009 0.0004 0.0005
Vacuole Periphery 0.0037 0.0002 0.0003 0.0022 0.0002 0.0007 0.0024 0.0001 0.0003 0.0005 0.0005 0.0016 0.0004 0.0001 0.0001 0.0003 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 41.8426 26.3218 34.2666 44.2517 41.1904 29.4285 32.1002 34.3496 31.9948 38.0922
Translational Efficiency 0.844 1.2478 1.064 0.7606 0.7743 0.9485 1.0359 0.8011 1.02 0.796

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2274 893 1949 1480 1723 2052 2022 109 3997 2945 3971 1589

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 744.69 893.02 1045.27 1125.23 707.53 886.38 1126.41 1171.80 728.67 888.39 1086.59 1128.42
Standard Deviation 85.94 128.28 156.87 159.59 119.14 116.29 151.93 155.10 103.24 120.09 159.61 159.72
Intensity Change Log 2 — 0.262053 0.489164 0.595508 — 0.325134 0.670869 0.727863 — 0.293131 0.580552 0.661510

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000042 0.001453 0.001235 0.003521 0.000099 0.000641 0.000241 0.004549 0.000067 0.000887 0.000729 0.003592
Bud Neck 0.006571 0.006012 0.002187 0.007172 0.003193 0.007834 0.002643 0.018972 0.005115 0.007281 0.002419 0.007981
Bud Site 0.003091 0.011984 0.005731 0.034995 0.002552 0.013418 0.008122 0.074938 0.002858 0.012983 0.006949 0.037735
Cell Periphery 0.000100 0.000094 0.000066 0.000162 0.000089 0.000079 0.000059 0.000291 0.000095 0.000084 0.000062 0.000171
Cytoplasm 0.655814* 0.650615* 0.622248* 0.443118* 0.642914* 0.677057* 0.614171* 0.387524* 0.650253* 0.669039* 0.618135* 0.439304*
Cytoplasmic Foci 0.107616 0.125425 0.006768 0.023408 0.092796 0.107850 0.005523 0.028528 0.101227 0.113179 0.006134 0.023759
Eisosomes 0.000068 0.000047 0.000013 0.000019 0.000056 0.000046 0.000010 0.000130 0.000063 0.000046 0.000012 0.000026
Endoplasmic Reticulum 0.000963 0.000774 0.001227 0.001662 0.000873 0.000625 0.001013 0.002286 0.000924 0.000670 0.001118 0.001705
Endosome 0.004626 0.009920 0.001237 0.017007 0.004660 0.008680 0.001336 0.015135 0.004640 0.009056 0.001287 0.016878
Golgi 0.000704 0.001123 0.000306 0.012857 0.000682 0.002515 0.000561 0.001985 0.000695 0.002093 0.000436 0.012111
Lipid Particles 0.002203 0.003018 0.000643 0.001122 0.003352 0.001389 0.000409 0.002208 0.002699 0.001883 0.000524 0.001196
Mitochondria 0.000721 0.001693 0.000543 0.002806 0.002234 0.002707 0.000875 0.003113 0.001373 0.002400 0.000712 0.002827
Mitotic Spindle 0.000702 0.004959 0.010917 0.248114* 0.001053 0.010499 0.022717 0.077326 0.000853 0.008819 0.016925 0.236398*
None 0.006972 0.002096 0.006663 0.012820 0.015634 0.001389 0.008385 0.006006 0.010706 0.001604 0.007540 0.012352
Nuclear Periphery 0.000248 0.000355 0.000948 0.000924 0.000451 0.000308 0.001016 0.000645 0.000335 0.000322 0.000983 0.000905
Nuclear Periphery Foci 0.000404 0.001373 0.001279 0.003917 0.000983 0.000684 0.000987 0.006662 0.000654 0.000893 0.001130 0.004105
Nucleolus 0.000631 0.000446 0.000147 0.000504 0.002156 0.000528 0.000209 0.000275 0.001289 0.000503 0.000179 0.000488
Nucleus 0.154989* 0.075956 0.289957* 0.090437 0.168413* 0.075602 0.282034* 0.116310 0.160776* 0.075709 0.285922* 0.092212
Peroxisomes 0.000788 0.003447 0.000747 0.006289 0.001106 0.003580 0.001039 0.012831 0.000925 0.003540 0.000896 0.006737
Vacuole 0.052290 0.098538 0.046675 0.079455 0.055713 0.083042 0.048466 0.239541* 0.053766 0.087741 0.047587 0.090437
Vacuole Periphery 0.000458 0.000672 0.000463 0.009693 0.000993 0.001527 0.000186 0.000744 0.000688 0.001268 0.000322 0.009079

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.28 -2.41 -2.34 0.42 -0.06 -2.97 -5.58 -2.37 -1.46 -2.14 -2.36 -2.88 -2.56 -0.18 -1.03
Bud Neck 1.08 6.90 -2.06 -2.74 -9.15 -6.27 -0.05 -2.23 -0.47 -2.24 -3.35 5.60 -4.89 -1.54 -9.24
Bud Site -4.16 -2.89 -10.00 -3.04 -8.24 -8.42 -2.87 -3.80 -2.43 -3.51 -9.22 -3.98 -10.92 -3.85 -9.26
Cell Periphery 0.66 4.39 1.26 0.06 -1.52 0.90 4.71 -3.78 -3.87 -5.25 1.45 6.94 -0.13 -1.34 -3.91
Cytoplasm 2.49 19.21 32.74 21.85 15.29 -4.04 18.76 14.68 16.07 8.59 -1.83 27.41 35.40 34.20 16.33
Cytoplasmic Foci -2.47 36.69 29.60 19.89 -7.48 -3.25 29.98 12.36 14.61 -4.47 -3.08 47.43 34.83 31.37 -9.14
Eisosomes 4.48 13.74 12.74 8.23 -2.80 1.20 4.76 -0.52 -1.37 -3.57 3.64 10.95 8.64 8.31 -5.89
Endoplasmic Reticulum 0.46 -4.46 -0.78 -2.22 6.03 1.82 -4.98 -2.92 -3.54 -1.54 1.61 -5.68 -1.78 -4.10 4.40
Endosome -5.04 8.93 -0.80 3.92 -6.20 -5.46 11.24 -1.38 0.49 -3.26 -7.33 13.79 -1.07 4.41 -7.02
Golgi -0.97 3.78 -1.73 -1.12 -2.59 -4.20 3.01 0.53 4.20 -1.59 -4.26 4.68 -1.75 0.42 -2.59
Lipid Particles -0.69 4.88 1.33 1.07 -8.62 3.96 5.38 1.02 -3.72 -5.87 2.14 7.27 3.03 -0.28 -11.77
Mitochondria -1.13 1.36 -1.74 0.79 -3.22 -0.43 2.11 2.19 2.99 0.58 -1.61 2.29 1.31 2.71 -2.49
Mitotic Spindle -2.76 -7.67 -21.56 -20.71 -19.87 -5.11 -10.33 -5.69 -5.37 -4.63 -5.82 -12.60 -22.30 -21.04 -19.19
None 6.09 1.20 -4.07 -11.00 -6.54 7.78 3.54 3.86 -3.66 1.61 10.11 3.41 -0.41 -12.69 -4.65
Nuclear Periphery -2.54 -17.99 -22.57 -21.10 -7.23 1.40 -22.00 -6.48 -6.57 2.24 -0.02 -28.17 -23.51 -19.65 -5.88
Nuclear Periphery Foci -7.51 -10.77 -9.10 -7.39 -6.93 2.36 -4.18 -3.03 -3.11 -2.79 -2.82 -9.38 -9.26 -8.82 -7.39
Nucleolus 2.63 10.34 -7.49 -8.15 -9.45 3.34 3.62 2.50 -1.15 -1.68 3.59 4.64 -3.16 -7.85 -9.07
Nucleus 17.25 -29.44 -1.32 -14.45 23.96 19.89 -25.10 3.12 -2.89 13.42 27.98 -39.12 0.32 -17.05 29.87
Peroxisomes -4.52 2.30 -3.14 1.13 -3.75 -4.86 2.51 -1.19 -0.60 -1.39 -7.08 3.36 -3.06 1.16 -4.04
Vacuole -11.32 -13.36 -23.10 -10.03 -12.62 -7.86 -12.89 -9.24 -8.24 -7.13 -14.12 -18.79 -24.54 -16.98 -14.22
Vacuole Periphery -1.20 1.45 -1.67 -1.30 -2.02 -0.88 3.08 2.65 2.55 -1.53 -1.46 3.58 -1.11 0.01 -2.23
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
Localization
Cell Percentages cytoplasm (90%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YOL057W

YOL057W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yol057w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available