Standard name
Human Ortholog
Description Protein required for normal mitochondrial morphology; has similarity to hemolysins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Cytoplasm 0 0.06 0.05 0.08 0.09 0.12 0.17 0.15 – 0.23 0.27 0.21 0.06 0.06 0 0.42 – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0.06 0.05 – 0.06 0.07 0.06 0 0 0 0 – – 0 0 0 0 0 0
Endosome 0 0 0 0 0.06 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0.05 0.05 0.06 0.06
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Mitochondria 0.05 0.11 0.14 0.24 0.18 0.39 0.37 0.42 – 0.51 0.55 0.54 0 0 0 0.14 – – 0 0 0 0 0 0
Nucleus 0.09 0.07 0 0 0 0 0 0 – 0 0 0 0.08 0.08 0.08 0 – – 0 0 0 0 0 0
Nuclear Periphery 0.07 0 0.13 0.13 0.05 0 0.07 0.05 – 0 0 0 0 0 0 0.07 – – 0.07 0 0.14 0.05 0.08 0.06
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Vac/Vac Membrane 0.86 0.87 0.8 0.74 0.76 0.59 0.53 0.49 – 0.38 0.33 0.36 0.88 0.87 0.92 0.51 – – 0.82 0.85 0.74 0.82 0.79 0.78
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 2 3 – 1 2 3 0 0 0 0 – – 0 0 1 0 0 0
Bud 0 1 0 0 2 2 2 4 – 8 9 2 0 0 0 0 – – 1 5 3 2 3 5
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0 0 1 1 13 7 – 18 11 18 0 0 0 1 – – 0 0 0 0 0 0
Cytoplasm 12 18 21 20 40 58 108 134 – 166 157 146 21 21 12 18 – – 0 3 1 3 1 8
Endoplasmic Reticulum 1 0 5 8 7 16 37 48 – 46 40 39 1 1 0 0 – – 0 0 2 2 2 2
Endosome 12 4 18 7 25 7 13 17 – 4 5 7 6 5 4 1 – – 11 13 21 22 36 37
Golgi 1 0 4 9 9 6 11 10 – 3 1 6 2 2 7 0 – – 1 1 4 1 5 6
Mitochondria 14 31 59 58 77 186 244 367 – 371 325 374 1 1 1 6 – – 4 5 10 8 7 3
Nucleus 24 20 16 2 7 15 12 7 – 4 1 2 30 30 31 1 – – 7 8 5 11 11 19
Nuclear Periphery 20 13 55 31 22 17 48 41 – 22 7 21 13 16 12 3 – – 20 7 58 21 48 39
Nucleolus 3 4 9 2 6 6 4 5 – 0 4 1 3 3 2 0 – – 0 0 0 1 2 4
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
SpindlePole 0 0 1 0 0 0 0 0 – 0 0 1 0 0 0 0 – – 1 0 0 0 0 0
Vac/Vac Membrane 231 254 327 179 323 281 343 427 – 276 194 254 328 322 357 22 – – 234 263 316 355 462 480
Unique Cell Count 269 292 410 242 427 474 651 878 721 586 698 374 369 388 43 285 312 429 434 585 614
Labelled Cell Count 318 345 515 316 520 595 837 1070 919 756 874 405 401 426 52 285 312 429 434 585 614


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.5 8.4 8.1 8.2 8.2 7.2 7.3 7.2 – 6.5 6.7 6.6 10.2 10.2 11.5 7.7 – – 10.1 10.6 11.7
Std Deviation (1e-4) 1.7 2.2 2.0 2.0 1.8 1.7 2.0 1.5 – 1.5 1.6 1.4 2.0 2.0 2.4 2.7 – – 2.0 2.2 2.7
Intensity Change (Log2) – – – 0.02 0.01 -0.18 -0.15 -0.18 – -0.32 -0.28 -0.3 0.32 0.32 0.51 -0.09 – – 0.32 0.39 0.52

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_10510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 – –
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 – –
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 – –
Cell Periphery 0 0 0 2.9 0 – 3.2 0 3.3 0 0 0 0 – –
Cytoplasm 1.6 2.4 3.7 5.6 5.2 – 7.8 8.8 7.1 0.3 0.4 -1.4 0 – –
Endoplasmic Reticulum 0 0.5 2.1 3.6 3.6 – 4.0 4.2 3.6 0 0 0 0 – –
Endosome -1.0 1.0 -2.6 -2.3 -2.5 – -4.5 -3.7 -3.7 -2.3 -2.5 -2.9 0 – –
Golgi 0 1.3 0 1.0 0 – 0 0 0 0 0 1.0 0 – –
Mitochondria 3.1 1.4 8.2 8.1 9.7 – 12.3 13.1 12.9 -7.4 -7.4 -7.6 -0.1 – –
Nucleus -2.3 -2.0 -0.6 -2.0 -3.9 – -4.1 -4.5 -4.6 2.5 2.5 2.5 0 – –
Nuclear Periphery -0.2 -4.1 -5.3 -3.2 -5.6 – -6.7 -7.9 -6.6 -4.9 -4.4 -5.3 -1.2 – –
Nucleolus 0 -0.9 -1.1 -2.3 0 – 0 -2.1 0 -1.6 -1.6 -2.0 0 – –
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 – –
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 – –
Vacuole -1.7 -1.4 -6.6 -8.9 -10.6 – -13.4 -14.5 -14.0 3.0 2.8 4.9 -4.2 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.3345 7.552 6.9948 6.3329 5.7128 7.3762 6.3162 7.8372 7.1121 6.5322 7.0215 7.3694 6.3652 8.5924 7.3521 7.5277 6.7496 7.3477
Actin 0.0124 0 0 0.0019 0.004 0 0.0282 0.0019 0.0071 0 0.0226 0.0012 0.0127 0 0 0 0.0002 0
Bud 0.0006 0.0002 0.0001 0.0003 0.0002 0.0001 0.0004 0.0002 0.0008 0.0002 0.0003 0.0001 0.0002 0.0001 0.0004 0 0.0005 0.0001
Bud Neck 0.0016 0.0002 0.0001 0.0012 0.0001 0.0001 0.003 0.0002 0.0003 0.0002 0.0002 0.0001 0.0003 0.0002 0.0002 0 0.0006 0.0001
Bud Periphery 0.0008 0.0003 0.0003 0.0006 0.0003 0.0007 0.0009 0.0005 0.002 0.0007 0.0005 0.0004 0.0005 0.0002 0.0011 0.0001 0.0012 0.0003
Bud Site 0.0052 0.0004 0.0002 0.0007 0.0001 0.0001 0.0039 0.0005 0.0065 0.0001 0.0003 0.0001 0.0003 0.0001 0.0003 0 0.0007 0
Cell Periphery 0.0006 0.001 0.0005 0.0005 0.0002 0.0003 0.0006 0.0005 0.0011 0.0004 0.0002 0.0005 0.0011 0.0013 0.001 0.0002 0.0006 0.0003
Cytoplasm 0.0106 0.0019 0.0035 0.0043 0.0007 0.0005 0.0042 0.001 0.0047 0.0004 0.0035 0.0002 0.0011 0.0003 0.0006 0.0002 0.0014 0.0001
Cytoplasmic Foci 0.0067 0.0041 0.0007 0.0012 0.0033 0.0001 0.0144 0.0012 0.0127 0.0004 0.003 0.0003 0.0035 0.0007 0.0004 0.0001 0.0013 0.0001
Eisosomes 0.0001 0 0 0 0 0 0.0004 0.0001 0.0012 0 0.0002 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0058 0.0012 0.0009 0.0071 0.0062 0.0004 0.0105 0.0078 0.003 0.0014 0.0046 0.0006 0.0025 0.001 0.0019 0.0004 0.001 0.0006
Endosome 0.0453 0.0191 0.0401 0.0295 0.0221 0.015 0.0655 0.0367 0.0764 0.0483 0.0478 0.0325 0.0646 0.0263 0.0412 0.0335 0.0595 0.0199
Golgi 0.0041 0.0004 0.0011 0.0012 0.0025 0.0002 0.0166 0.0022 0.0074 0.001 0.0035 0.0033 0.0041 0.0005 0.0012 0.0004 0.0032 0.0008
Lipid Particles 0.0047 0.003 0.0005 0.0009 0.0168 0.0004 0.0134 0.0018 0.0068 0.0006 0.0044 0.0019 0.0057 0.003 0.0034 0.0006 0.0017 0.0011
Mitochondria 0.011 0.0015 0.002 0.0033 0.0016 0.0022 0.0244 0.0095 0.0263 0.0012 0.0037 0.0111 0.0213 0.0007 0.0096 0.0016 0.005 0.0019
None 0.0031 0.0001 0 0.0004 0.0002 0 0.0036 0.0003 0.0128 0.0001 0.0081 0 0.0029 0 0.0001 0 0.0001 0
Nuclear Periphery 0.0328 0.0098 0.009 0.033 0.0364 0.0136 0.0489 0.0115 0.021 0.0543 0.0335 0.0159 0.0343 0.0048 0.0248 0.0039 0.0037 0.0131
Nucleolus 0.0013 0.004 0.0005 0.0016 0.0004 0.0005 0.0007 0.0002 0.0007 0.0005 0.0006 0.0003 0.0013 0.001 0.0068 0.0001 0.0006 0.0004
Nucleus 0.0236 0.0036 0.0024 0.0117 0.0013 0.0023 0.0021 0.001 0.0017 0.0021 0.004 0.0007 0.009 0.001 0.0027 0.0003 0.001 0.0007
Peroxisomes 0.0018 0.0005 0 0.0001 0.0258 0 0.0065 0.0002 0.0028 0.0001 0.0017 0.0002 0.0017 0.0001 0.0001 0 0.0002 0
Punctate Nuclear 0.0048 0 0 0.0013 0.0006 0 0.0023 0.0001 0.0031 0 0.006 0 0.0016 0 0 0 0 0
Vacuole 0.328 0.4366 0.4066 0.3941 0.3036 0.3182 0.2987 0.3671 0.3367 0.4147 0.3127 0.3203 0.3579 0.3725 0.382 0.3059 0.406 0.248
Vacuole Periphery 0.495 0.5122 0.5314 0.505 0.5733 0.6452 0.4505 0.5553 0.4648 0.4735 0.5388 0.6104 0.4731 0.5864 0.5221 0.6524 0.5114 0.7123

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.89 28.3682 22.4308 32.1791 18.2115 26.517 45.9634 43.0027 42.989 34.5724
Translational Efficiency 0.7347 0.7595 0.8162 0.6272 0.7638 0.6734 0.5973 0.5647 0.559 0.4854

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
856 675 206 1459 1987 1840 2794 1357 2843 2515 3000 2816

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1104.77 975.26 1256.21 1259.71 944.87 974.52 1164.49 1208.21 993.01 974.72 1170.79 1234.89
Standard Deviation 173.67 159.48 167.86 203.46 148.11 139.75 167.99 184.37 172.60 145.31 169.57 196.19
Intensity Change Log 2 — -0.179887 0.185332 0.189346 — 0.044576 0.301510 0.354683 — -0.072059 0.240054 0.267925

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000185 0.000028 0.000091 0.000198 0.000010 0.000018 0.000009 0.000020 0.000063 0.000021 0.000015 0.000113
Bud Neck 0.002091 0.001374 0.005644 0.001584 0.000332 0.000417 0.000800 0.001280 0.000861 0.000674 0.001133 0.001438
Bud Site 0.007546 0.005060 0.002287 0.004064 0.001886 0.001699 0.002140 0.004119 0.003590 0.002601 0.002150 0.004091
Cell Periphery 0.000374 0.000143 0.000120 0.000288 0.000185 0.000212 0.000339 0.000256 0.000242 0.000194 0.000324 0.000273
Cytoplasm 0.003414 0.009202 0.000754 0.000631 0.002262 0.001350 0.000626 0.000730 0.002609 0.003458 0.000635 0.000679
Cytoplasmic Foci 0.012232 0.010820 0.001188 0.002564 0.002708 0.005245 0.000603 0.002837 0.005576 0.006741 0.000644 0.002695
Eisosomes 0.000011 0.000005 0.000017 0.000008 0.000003 0.000005 0.000007 0.000008 0.000005 0.000005 0.000008 0.000008
Endoplasmic Reticulum 0.001913 0.000786 0.001003 0.000516 0.001218 0.001402 0.000550 0.000511 0.001427 0.001237 0.000581 0.000513
Endosome 0.054924 0.036510 0.012863 0.011283 0.013821 0.027352 0.007867 0.019643 0.026196 0.029810 0.008210 0.015312
Golgi 0.040072 0.006724 0.002250 0.012999 0.002078 0.005303 0.004254 0.019566 0.013518 0.005684 0.004116 0.016164
Lipid Particles 0.000402 0.000372 0.000732 0.000198 0.000265 0.000412 0.000149 0.000177 0.000306 0.000402 0.000189 0.000188
Mitochondria 0.012148 0.003889 0.011593 0.006627 0.002809 0.010994 0.002464 0.003253 0.005621 0.009087 0.003091 0.005001
Mitotic Spindle 0.004875 0.003107 0.004683 0.001465 0.000143 0.000771 0.000464 0.000531 0.001568 0.001398 0.000753 0.001015
None 0.000096 0.000236 0.000211 0.000137 0.000136 0.000161 0.000120 0.000116 0.000124 0.000181 0.000126 0.000127
Nuclear Periphery 0.001837 0.000499 0.008821 0.001395 0.000156 0.000648 0.000600 0.000802 0.000662 0.000608 0.001165 0.001109
Nuclear Periphery Foci 0.002578 0.000545 0.007220 0.000839 0.000083 0.000505 0.000379 0.000822 0.000834 0.000516 0.000848 0.000831
Nucleolus 0.002059 0.000561 0.011761 0.001426 0.000177 0.000901 0.001141 0.001107 0.000744 0.000810 0.001871 0.001272
Nucleus 0.002050 0.001384 0.016398 0.002057 0.000358 0.001788 0.001135 0.001020 0.000867 0.001679 0.002183 0.001557
Peroxisomes 0.000530 0.000773 0.001721 0.000217 0.000118 0.000278 0.000077 0.000474 0.000242 0.000411 0.000190 0.000341
Vacuole 0.482672 0.297771 0.270175 0.436482 0.319298 0.304142 0.421237 0.452925 0.368488 0.302432 0.410864 0.444406
Vacuole Periphery 0.367991 0.620210 0.640466 0.515021 0.651954 0.636396 0.555038 0.489803 0.566456 0.632052 0.560904 0.502869

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.05 1.70 -0.09 -1.20 -0.75 -1.49 0.32 -1.83 -0.54 -2.66 2.68 3.06 -0.66 -1.25 -1.33
Bud Neck 1.18 -2.61 1.08 -0.46 3.04 -0.93 -4.20 -4.72 -4.50 -2.46 1.03 -1.53 -3.06 -3.94 -1.76
Bud Site 1.86 3.72 2.52 1.06 -1.97 0.49 -0.68 -3.45 -4.01 -3.22 2.07 2.96 -0.90 -3.28 -4.19
Cell Periphery 1.98 2.12 0.88 -4.30 -4.16 -0.59 -3.93 -1.74 -0.76 1.60 1.11 -1.35 -0.43 -1.97 1.25
Cytoplasm -2.56 2.37 2.53 4.27 0.22 1.56 3.23 2.83 1.55 -0.52 -1.17 4.08 3.87 4.55 -0.58
Cytoplasmic Foci 0.59 7.06 5.93 4.75 -2.42 -3.52 6.38 -0.20 3.06 -4.53 -1.55 9.35 4.56 5.46 -5.69
Eisosomes 4.38 -1.78 2.36 -2.22 2.99 -2.63 -5.53 -5.16 -2.34 -1.31 0.03 -3.05 -3.07 -3.01 -0.53
Endoplasmic Reticulum 3.17 2.10 3.97 3.60 2.02 -0.87 6.09 5.65 4.50 0.50 1.02 6.35 6.82 5.07 1.26
Endosome 3.69 10.01 13.42 6.40 0.54 -6.42 4.95 -3.20 3.38 -7.84 -1.76 13.29 7.15 7.78 -7.47
Golgi 8.44 9.79 6.59 -3.48 -6.76 -4.49 -4.50 -8.36 -6.58 -7.28 5.87 7.43 -1.50 -7.60 -9.17
Lipid Particles 0.18 -0.94 2.78 1.06 1.58 -1.04 1.02 0.76 2.67 -1.27 -0.84 1.37 1.43 2.77 0.04
Mitochondria 3.79 0.16 2.29 -1.70 1.64 -6.09 0.68 -0.82 5.88 -1.77 -2.95 3.35 0.64 3.41 -2.39
Mitotic Spindle 0.94 -0.08 2.10 1.24 0.98 -3.07 -2.14 -2.79 1.00 -0.24 0.32 1.39 0.99 0.79 -0.52
None -1.89 -3.36 -2.69 1.33 2.08 -0.62 0.48 0.58 1.77 0.33 -1.64 -0.09 -0.12 1.98 -0.10
Nuclear Periphery 2.89 -3.18 0.86 -2.89 3.43 -5.56 -3.88 -5.43 -1.08 -1.23 0.37 -2.20 -2.20 -2.97 0.23
Nuclear Periphery Foci 2.46 -1.12 2.10 -1.54 1.58 -4.06 -3.31 -4.64 -1.52 -2.45 1.14 -0.04 0.00 -2.16 0.05
Nucleolus 2.45 -3.64 0.99 -4.13 3.97 -2.42 -8.59 -5.48 -0.68 -0.02 -0.23 -4.03 -2.47 -1.93 2.38
Nucleus 1.09 -2.31 -0.27 -1.12 2.26 -2.39 -4.87 -2.86 1.19 0.40 -1.69 -2.75 -1.89 -0.05 0.81
Peroxisomes -1.19 -2.12 2.73 2.63 2.66 -1.85 0.98 -1.25 -0.27 -1.43 -2.08 1.00 -0.66 0.83 -1.04
Vacuole 16.03 11.62 4.54 -13.45 -9.51 2.15 -15.33 -16.96 -19.03 -4.31 10.64 -6.90 -12.34 -23.52 -5.66
Vacuole Periphery -18.73 -12.24 -14.05 8.36 5.77 1.95 13.49 18.81 16.47 8.16 -8.85 0.84 9.24 18.46 9.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for normal mitochondrial morphology; has similarity to hemolysins
Localization
Cell Percentages vacuolar membrane (77%)
Cell Cycle Regulation No
Subcompartmental Group vac memb-2

Mam3

Mam3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mam3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available