Standard name
Human Ortholog
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.05 0.05 0 0.05 0.09 0.09 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.97 0.95 0.89 0.78 0.71 0.66 0.63 0.61 0.59 0.52 0.95 0.96 0.96 0.86 0.94 0.93 0.94 0.95 0.88 0.92 0.88 0.84
Endoplasmic Reticulum 0 0 0 0 0.06 0.05 0.09 0.15 0.12 0.07 0.08 0.11 0 0 0 0 0 0 0 0 0 0 0.05 0.07
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.24 0.24 0.2 0.35 0.39 0.4 0.44 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.09 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 4 4 7 12 11 5 13 20 0 0 1 4 0 1 0 0 1 0 1 1
Bud 0 1 2 0 1 1 0 1 3 3 1 2 0 0 0 1 0 0 0 1 0 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 6 6 7 9 15 17 14 13 23 26 38 10 9 15 6 2 0 0 0 2 0 0 0
Cytoplasm 189 360 310 194 210 248 246 225 166 155 176 167 337 507 492 220 173 185 179 355 287 227 305 250
Endoplasmic Reticulum 0 11 2 6 13 16 30 51 32 19 24 34 14 16 16 7 5 4 4 3 14 7 15 21
Endosome 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 1 0 0 0 3 1 1 1
Golgi 1 0 0 0 1 1 3 1 2 1 3 2 0 1 3 3 1 1 0 0 1 0 5 2
Mitochondria 2 0 5 3 9 75 82 67 93 99 120 143 0 5 2 11 0 1 0 1 1 3 2 2
Nucleus 0 0 1 0 2 1 4 2 0 2 0 1 2 0 1 1 3 3 1 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 1 6 1 4 6 9 1 6 3 5 1 1 0 34 17 12 1 4 6 4 3 7
Unique Cell Count 190 367 318 204 235 319 346 341 264 256 299 322 355 526 510 257 185 198 190 373 328 248 345 298
Labelled Cell Count 192 378 327 217 250 365 395 382 321 315 366 414 364 539 530 292 202 207 190 373 328 248 345 298


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.4 18.9 13.2 13.0 12.2 10.6 9.5 9.9 10.5 9.9 9.7 9.9 16.9 15.9 15.4 17.3 20.2 20.3 13.4 13.5 14.6
Std Deviation (1e-4) 2.8 3.1 2.3 2.1 2.1 1.7 1.9 1.9 1.9 2.1 1.9 2.1 2.4 2.6 2.7 4.7 4.8 5.7 2.8 2.8 2.8
Intensity Change (Log2) – – – -0.02 -0.12 -0.31 -0.48 -0.42 -0.34 -0.41 -0.44 -0.42 0.36 0.26 0.22 0.39 0.61 0.62 0.02 0.02 0.15


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 3.4 0 0 3.8 4.5 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.1 1.4 2.0 2.1 1.7 2.1 3.9 3.8 5.0 0.8 -0.2 0.9 0.4 0 0
Cytoplasm -1.5 -4.0 -7.6 -9.2 -10.3 -10.8 -11.2 -11.7 -13.2 -1.7 -0.9 -0.8 -5.3 -2.2 -2.3
Endoplasmic Reticulum 0 3.5 3.3 4.8 6.8 5.9 4.3 4.6 5.5 2.8 2.4 2.4 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 1.7 8.4 8.4 7.4 10.8 11.5 11.9 12.9 0 0 0 2.0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 6.4 5.2 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.8789 16.2286 13.5481 13.4053 12.4029 13.8043 11.6397 14.8277 13.3596 13.5498 12.7828 14.0104 14.1391 17.528 15.5361 14.6863 14.63 15.6955
Actin 0.0103 0.0083 0.016 0.0009 0.0014 0.017 0.0041 0.0105 0.0195 0.002 0.0021 0.0026 0.0122 0.0009 0.0009 0.0061 0.0122 0.0007
Bud 0.001 0.0004 0.0014 0.0011 0.0012 0.0005 0.0015 0.0004 0.0009 0.0003 0.0023 0.0003 0.0004 0.0002 0.0005 0.0006 0.0004 0.0002
Bud Neck 0.001 0.0005 0.004 0.0011 0.0013 0.0019 0.0013 0.0004 0.0008 0.0004 0.001 0.0013 0.0006 0.0003 0.0007 0.0021 0.0007 0.001
Bud Periphery 0.0008 0.0004 0.0019 0.0005 0.0013 0.0005 0.0015 0.0001 0.0008 0.0003 0.0039 0.0002 0.0004 0 0.0002 0.0003 0.0003 0.0001
Bud Site 0.0033 0.0033 0.0102 0.0006 0.0045 0.0003 0.0014 0.0022 0.0022 0.0006 0.0029 0.0001 0.0012 0.0009 0.0013 0.0215 0.0007 0.0001
Cell Periphery 0.001 0.0007 0.0014 0.0002 0.0006 0.0004 0.0008 0.0002 0.0003 0.0002 0.0004 0.0001 0.0007 0.0002 0.0004 0.0002 0.0001 0.0002
Cytoplasm 0.7663 0.9392 0.7856 0.8948 0.7552 0.8368 0.7941 0.9405 0.843 0.7846 0.7883 0.8921 0.8135 0.9628 0.9 0.881 0.798 0.909
Cytoplasmic Foci 0.0132 0.0038 0.0118 0.0126 0.0227 0.0133 0.0187 0.0081 0.0205 0.015 0.0156 0.015 0.0177 0.0146 0.0112 0.01 0.0233 0.0107
Eisosomes 0.0002 0.0001 0.0002 0 0.0001 0.0002 0 0.0001 0.0001 0 0.0001 0 0.0002 0 0 0.0001 0.0003 0
Endoplasmic Reticulum 0.0614 0.0216 0.0345 0.0032 0.0486 0.0447 0.0465 0.0075 0.0161 0.0494 0.013 0.029 0.0628 0.0075 0.0213 0.0109 0.0205 0.0324
Endosome 0.0527 0.007 0.0484 0.033 0.0533 0.043 0.0555 0.0108 0.0475 0.083 0.0901 0.0315 0.0406 0.0063 0.0313 0.0363 0.0869 0.0291
Golgi 0.0113 0.002 0.0142 0.0111 0.0057 0.0109 0.0163 0.0017 0.0132 0.0076 0.0085 0.0091 0.0115 0.0014 0.0052 0.0014 0.0079 0.0029
Lipid Particles 0.0082 0.0008 0.0043 0 0.0045 0.0031 0.0044 0.0002 0.005 0.0017 0.0021 0.0031 0.0038 0.0003 0.0009 0.0007 0.0053 0.0002
Mitochondria 0.0235 0.0023 0.0229 0.0132 0.0077 0.0118 0.0196 0.0005 0.0076 0.0294 0.0325 0.0038 0.0032 0.0002 0.0018 0.0005 0.0152 0.0038
None 0.0022 0.0004 0.0022 0.0006 0.0015 0.0005 0.0015 0.0007 0.0007 0.0005 0.0013 0.0006 0.0048 0.0003 0.0008 0.0006 0.006 0.0009
Nuclear Periphery 0.0108 0.0012 0.0108 0.0021 0.0104 0.0017 0.0074 0.0006 0.0018 0.002 0.0049 0.0043 0.009 0.001 0.0023 0.0022 0.0057 0.0017
Nucleolus 0.0007 0.0001 0.0003 0 0.0021 0 0.0001 0.0088 0.0002 0.0001 0.0004 0 0.0002 0 0 0.0002 0.0003 0.0001
Nucleus 0.0037 0.0012 0.003 0.0026 0.022 0.0014 0.006 0.0028 0.0011 0.0011 0.0042 0.0022 0.0029 0.0008 0.0018 0.002 0.0028 0.0017
Peroxisomes 0.004 0.0007 0.0021 0.0001 0.0051 0.0007 0.0007 0.0001 0.0058 0.0006 0.0008 0.0007 0.0022 0.0002 0.0002 0.0009 0.0022 0.0001
Punctate Nuclear 0.0034 0.0001 0.0016 0.0001 0.0019 0.0003 0.0004 0.0002 0.0007 0.0001 0.0005 0.0002 0.0027 0.0001 0.0002 0.0009 0.0015 0.0008
Vacuole 0.0171 0.0055 0.0177 0.0186 0.0388 0.0079 0.0149 0.003 0.009 0.017 0.018 0.0027 0.0078 0.0017 0.0155 0.0189 0.0063 0.0029
Vacuole Periphery 0.0039 0.0007 0.0051 0.0035 0.0101 0.0031 0.0029 0.0005 0.0033 0.004 0.0071 0.0011 0.0015 0.0003 0.0033 0.0029 0.0033 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 85.105 96.5868 93.2712 80.1161 84.9156 68.0463 70.7358 74.0394 68.1052 80.3019
Translational Efficiency 1.5423 1.3081 1.2441 1.1858 1.2097 1.5894 1.3756 1.1083 1.1183 1.1258

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2273 1428 1376 1436 1885 1734 1113 142 4158 3162 2489 1578

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1287.38 1276.80 1612.41 1719.15 1223.36 1356.30 1763.87 1920.42 1258.36 1320.40 1680.14 1737.26
Standard Deviation 188.30 236.73 307.34 280.22 181.49 221.21 256.47 308.33 187.97 231.75 295.47 288.67
Intensity Change Log 2 — -0.011905 0.324781 0.417257 — 0.148827 0.527895 0.650573 — 0.068650 0.427322 0.535655

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000144 0.000434 0.000424 0.000546 0.000130 0.000366 0.000291 0.002075 0.000138 0.000397 0.000365 0.000683
Bud Neck 0.000231 0.000647 0.001542 0.001371 0.000247 0.000388 0.001447 0.005046 0.000238 0.000505 0.001499 0.001702
Bud Site 0.019700 0.036992 0.020807 0.028987 0.019554 0.025853 0.015521 0.048518 0.019634 0.030883 0.018443 0.030745
Cell Periphery 0.000743 0.000639 0.001376 0.003231 0.000496 0.000285 0.000786 0.012081 0.000631 0.000445 0.001112 0.004028
Cytoplasm 0.754355* 0.774412* 0.799222* 0.851635* 0.795390* 0.789788* 0.802795* 0.710586* 0.772958* 0.782844* 0.800820* 0.838942*
Cytoplasmic Foci 0.127030 0.088940 0.035809 0.018027 0.097589 0.103589 0.026907 0.028206 0.113683 0.096974 0.031828 0.018943
Eisosomes 0.000004 0.000005 0.000003 0.000004 0.000004 0.000005 0.000002 0.000012 0.000004 0.000005 0.000003 0.000005
Endoplasmic Reticulum 0.005090 0.004050 0.002156 0.000516 0.004280 0.002368 0.002002 0.001032 0.004723 0.003128 0.002087 0.000563
Endosome 0.005214 0.006547 0.007637 0.002638 0.004085 0.006040 0.006502 0.008319 0.004702 0.006269 0.007130 0.003149
Golgi 0.023512 0.023795 0.033895 0.012386 0.019033 0.026760 0.011639 0.016464 0.021481 0.025421 0.023943 0.012753
Lipid Particles 0.000808 0.001526 0.004845 0.009225 0.000760 0.000860 0.005148 0.030469 0.000786 0.001161 0.004980 0.011137
Mitochondria 0.001574 0.001492 0.000084 0.000806 0.001311 0.001455 0.000076 0.000042 0.001455 0.001471 0.000081 0.000737
Mitotic Spindle 0.000795 0.002275 0.004373 0.001614 0.001407 0.003906 0.005759 0.001476 0.001072 0.003169 0.004993 0.001601
None 0.000368 0.000218 0.000540 0.000159 0.000568 0.000172 0.000161 0.000218 0.000459 0.000193 0.000370 0.000164
Nuclear Periphery 0.000015 0.000049 0.000097 0.000026 0.000025 0.000015 0.000111 0.000066 0.000020 0.000030 0.000103 0.000030
Nuclear Periphery Foci 0.000312 0.001412 0.006014 0.001913 0.000691 0.000345 0.004109 0.004987 0.000484 0.000827 0.005162 0.002190
Nucleolus 0.000108 0.000439 0.000051 0.000091 0.000038 0.000049 0.000075 0.000096 0.000076 0.000225 0.000062 0.000092
Nucleus 0.001046 0.003235 0.004246 0.002736 0.001243 0.001116 0.003693 0.003775 0.001135 0.002073 0.003999 0.002829
Peroxisomes 0.000224 0.000491 0.000146 0.000610 0.000202 0.000418 0.000211 0.001075 0.000214 0.000451 0.000175 0.000652
Vacuole 0.021044 0.025821 0.055738 0.057733 0.019159 0.017362 0.101185 0.118014 0.020190 0.021182 0.076060 0.063158
Vacuole Periphery 0.037682 0.026581 0.020995 0.005745 0.033791 0.018860 0.011580 0.007442 0.035918 0.022347 0.016785 0.005898

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.38 -6.92 -6.64 -1.75 -1.79 -2.44 -4.94 -2.69 -2.41 -2.49 -4.46 -8.49 -6.18 -3.11 -3.59
Bud Neck -2.87 -10.44 -12.45 -4.91 1.04 -3.22 -11.12 -7.06 -6.86 -5.05 -3.83 -15.03 -13.80 -10.02 -1.18
Bud Site -8.11 -0.95 -4.65 2.89 -3.56 -3.98 2.28 -5.05 -3.91 -5.58 -8.65 0.57 -6.07 -0.07 -6.10
Cell Periphery 0.35 -1.91 -4.52 -5.64 -3.83 3.96 -2.42 -4.86 -4.95 -4.74 1.12 -2.50 -6.76 -7.58 -6.04
Cytoplasm -2.33 -4.74 -12.08 -8.59 -5.80 0.70 0.12 3.94 3.68 3.83 -1.67 -3.56 -9.20 -7.33 -5.25
Cytoplasmic Foci 8.16 24.09 29.63 20.51 8.60 -1.31 20.33 12.33 13.12 -0.13 5.04 31.31 35.32 29.36 7.85
Eisosomes -1.53 3.58 0.16 1.63 -3.40 -1.63 3.19 -3.08 -2.81 -3.45 -2.09 4.77 -2.26 -0.22 -5.33
Endoplasmic Reticulum 1.09 3.88 6.40 5.56 5.70 2.38 2.70 4.99 2.23 1.23 2.55 4.67 8.70 6.11 4.28
Endosome -2.71 -4.53 6.77 7.40 8.64 -4.46 -4.02 -1.81 -0.93 -0.68 -4.76 -6.07 4.21 7.06 8.00
Golgi -0.19 -4.88 7.94 7.05 9.56 -4.71 6.54 1.27 3.80 -1.69 -3.59 -1.55 7.25 8.86 6.90
Lipid Particles -3.70 -9.29 -10.34 -9.35 -4.92 -0.60 -7.83 -6.57 -6.55 -5.54 -2.95 -12.07 -12.08 -11.60 -6.72
Mitochondria 0.14 7.25 1.55 0.96 -1.43 -0.41 6.97 7.17 4.58 1.51 -0.05 9.95 1.65 1.44 -1.43
Mitotic Spindle -1.87 -8.28 -1.73 0.18 2.84 -2.37 -3.30 -0.02 2.20 3.15 -3.18 -6.10 -1.32 1.29 3.44
None 2.26 -0.96 3.09 2.18 2.33 1.38 1.41 1.20 -0.72 -0.91 1.96 0.59 2.14 1.15 2.22
Nuclear Periphery -2.28 -12.59 -2.99 1.24 9.13 1.89 -4.22 -3.70 -4.90 2.05 -1.50 -8.55 -2.88 -0.39 6.86
Nuclear Periphery Foci -4.12 -13.31 -9.61 -1.88 8.80 1.57 -5.87 -5.76 -6.47 -0.96 -2.15 -13.23 -9.05 -6.93 7.71
Nucleolus -1.33 0.78 0.19 1.44 -7.01 -0.60 -7.69 -4.91 -2.19 -1.34 -1.30 0.30 -0.46 1.21 -5.52
Nucleus -2.93 -10.34 -9.45 0.16 3.48 0.91 -12.19 -4.68 -4.83 0.46 -2.75 -15.12 -10.04 -2.80 4.04
Peroxisomes -3.10 2.70 -2.96 -0.89 -3.50 -4.13 -1.13 -4.18 -3.10 -4.03 -4.87 1.46 -3.64 -1.68 -3.86
Vacuole -2.36 -11.01 -12.89 -10.72 -0.80 1.19 -17.51 -7.26 -7.39 -1.13 -0.77 -20.24 -15.23 -14.78 3.21
Vacuole Periphery 4.27 7.12 17.86 10.56 8.82 7.24 12.21 10.07 4.88 1.76 8.27 12.51 23.47 13.89 9.68
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Prs5

Prs5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Prs5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available