Standard name | |
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Human Ortholog | |
Description | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 1 | 4 | 4 | 7 | 12 | 11 | 5 | 13 | 20 | 0 | 0 | 1 | 4 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Bud | 0 | 1 | 2 | 0 | 1 | 1 | 0 | 1 | 3 | 3 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 6 | 6 | 7 | 9 | 15 | 17 | 14 | 13 | 23 | 26 | 38 | 10 | 9 | 15 | 6 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
Cytoplasm | 189 | 360 | 310 | 194 | 210 | 248 | 246 | 225 | 166 | 155 | 176 | 167 | 337 | 507 | 492 | 220 | 173 | 185 | 179 | 355 | 287 | 227 | 305 | 250 |
Endoplasmic Reticulum | 0 | 11 | 2 | 6 | 13 | 16 | 30 | 51 | 32 | 19 | 24 | 34 | 14 | 16 | 16 | 7 | 5 | 4 | 4 | 3 | 14 | 7 | 15 | 21 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 1 |
Golgi | 1 | 0 | 0 | 0 | 1 | 1 | 3 | 1 | 2 | 1 | 3 | 2 | 0 | 1 | 3 | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 5 | 2 |
Mitochondria | 2 | 0 | 5 | 3 | 9 | 75 | 82 | 67 | 93 | 99 | 120 | 143 | 0 | 5 | 2 | 11 | 0 | 1 | 0 | 1 | 1 | 3 | 2 | 2 |
Nucleus | 0 | 0 | 1 | 0 | 2 | 1 | 4 | 2 | 0 | 2 | 0 | 1 | 2 | 0 | 1 | 1 | 3 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 1 | 6 | 1 | 4 | 6 | 9 | 1 | 6 | 3 | 5 | 1 | 1 | 0 | 34 | 17 | 12 | 1 | 4 | 6 | 4 | 3 | 7 |
Unique Cell Count | 190 | 367 | 318 | 204 | 235 | 319 | 346 | 341 | 264 | 256 | 299 | 322 | 355 | 526 | 510 | 257 | 185 | 198 | 190 | 373 | 328 | 248 | 345 | 298 |
Labelled Cell Count | 192 | 378 | 327 | 217 | 250 | 365 | 395 | 382 | 321 | 315 | 366 | 414 | 364 | 539 | 530 | 292 | 202 | 207 | 190 | 373 | 328 | 248 | 345 | 298 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 15.4 | 18.9 | 13.2 | 13.0 | 12.2 | 10.6 | 9.5 | 9.9 | 10.5 | 9.9 | 9.7 | 9.9 | 16.9 | 15.9 | 15.4 | 17.3 | 20.2 | 20.3 | 13.4 | 13.5 | 14.6 |
Std Deviation (1e-4) | 2.8 | 3.1 | 2.3 | 2.1 | 2.1 | 1.7 | 1.9 | 1.9 | 1.9 | 2.1 | 1.9 | 2.1 | 2.4 | 2.6 | 2.7 | 4.7 | 4.8 | 5.7 | 2.8 | 2.8 | 2.8 |
Intensity Change (Log2) | – | – | – | -0.02 | -0.12 | -0.31 | -0.48 | -0.42 | -0.34 | -0.41 | -0.44 | -0.42 | 0.36 | 0.26 | 0.22 | 0.39 | 0.61 | 0.62 | 0.02 | 0.02 | 0.15 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 3.4 | 0 | 0 | 3.8 | 4.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 1.1 | 1.4 | 2.0 | 2.1 | 1.7 | 2.1 | 3.9 | 3.8 | 5.0 | 0.8 | -0.2 | 0.9 | 0.4 | 0 | 0 |
Cytoplasm | -1.5 | -4.0 | -7.6 | -9.2 | -10.3 | -10.8 | -11.2 | -11.7 | -13.2 | -1.7 | -0.9 | -0.8 | -5.3 | -2.2 | -2.3 |
Endoplasmic Reticulum | 0 | 3.5 | 3.3 | 4.8 | 6.8 | 5.9 | 4.3 | 4.6 | 5.5 | 2.8 | 2.4 | 2.4 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 1.7 | 8.4 | 8.4 | 7.4 | 10.8 | 11.5 | 11.9 | 12.9 | 0 | 0 | 0 | 2.0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.4 | 5.2 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 11.8789 | 16.2286 | 13.5481 | 13.4053 | 12.4029 | 13.8043 | 11.6397 | 14.8277 | 13.3596 | 13.5498 | 12.7828 | 14.0104 | 14.1391 | 17.528 | 15.5361 | 14.6863 | 14.63 | 15.6955 |
Actin | 0.0103 | 0.0083 | 0.016 | 0.0009 | 0.0014 | 0.017 | 0.0041 | 0.0105 | 0.0195 | 0.002 | 0.0021 | 0.0026 | 0.0122 | 0.0009 | 0.0009 | 0.0061 | 0.0122 | 0.0007 |
Bud | 0.001 | 0.0004 | 0.0014 | 0.0011 | 0.0012 | 0.0005 | 0.0015 | 0.0004 | 0.0009 | 0.0003 | 0.0023 | 0.0003 | 0.0004 | 0.0002 | 0.0005 | 0.0006 | 0.0004 | 0.0002 |
Bud Neck | 0.001 | 0.0005 | 0.004 | 0.0011 | 0.0013 | 0.0019 | 0.0013 | 0.0004 | 0.0008 | 0.0004 | 0.001 | 0.0013 | 0.0006 | 0.0003 | 0.0007 | 0.0021 | 0.0007 | 0.001 |
Bud Periphery | 0.0008 | 0.0004 | 0.0019 | 0.0005 | 0.0013 | 0.0005 | 0.0015 | 0.0001 | 0.0008 | 0.0003 | 0.0039 | 0.0002 | 0.0004 | 0 | 0.0002 | 0.0003 | 0.0003 | 0.0001 |
Bud Site | 0.0033 | 0.0033 | 0.0102 | 0.0006 | 0.0045 | 0.0003 | 0.0014 | 0.0022 | 0.0022 | 0.0006 | 0.0029 | 0.0001 | 0.0012 | 0.0009 | 0.0013 | 0.0215 | 0.0007 | 0.0001 |
Cell Periphery | 0.001 | 0.0007 | 0.0014 | 0.0002 | 0.0006 | 0.0004 | 0.0008 | 0.0002 | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0007 | 0.0002 | 0.0004 | 0.0002 | 0.0001 | 0.0002 |
Cytoplasm | 0.7663 | 0.9392 | 0.7856 | 0.8948 | 0.7552 | 0.8368 | 0.7941 | 0.9405 | 0.843 | 0.7846 | 0.7883 | 0.8921 | 0.8135 | 0.9628 | 0.9 | 0.881 | 0.798 | 0.909 |
Cytoplasmic Foci | 0.0132 | 0.0038 | 0.0118 | 0.0126 | 0.0227 | 0.0133 | 0.0187 | 0.0081 | 0.0205 | 0.015 | 0.0156 | 0.015 | 0.0177 | 0.0146 | 0.0112 | 0.01 | 0.0233 | 0.0107 |
Eisosomes | 0.0002 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0614 | 0.0216 | 0.0345 | 0.0032 | 0.0486 | 0.0447 | 0.0465 | 0.0075 | 0.0161 | 0.0494 | 0.013 | 0.029 | 0.0628 | 0.0075 | 0.0213 | 0.0109 | 0.0205 | 0.0324 |
Endosome | 0.0527 | 0.007 | 0.0484 | 0.033 | 0.0533 | 0.043 | 0.0555 | 0.0108 | 0.0475 | 0.083 | 0.0901 | 0.0315 | 0.0406 | 0.0063 | 0.0313 | 0.0363 | 0.0869 | 0.0291 |
Golgi | 0.0113 | 0.002 | 0.0142 | 0.0111 | 0.0057 | 0.0109 | 0.0163 | 0.0017 | 0.0132 | 0.0076 | 0.0085 | 0.0091 | 0.0115 | 0.0014 | 0.0052 | 0.0014 | 0.0079 | 0.0029 |
Lipid Particles | 0.0082 | 0.0008 | 0.0043 | 0 | 0.0045 | 0.0031 | 0.0044 | 0.0002 | 0.005 | 0.0017 | 0.0021 | 0.0031 | 0.0038 | 0.0003 | 0.0009 | 0.0007 | 0.0053 | 0.0002 |
Mitochondria | 0.0235 | 0.0023 | 0.0229 | 0.0132 | 0.0077 | 0.0118 | 0.0196 | 0.0005 | 0.0076 | 0.0294 | 0.0325 | 0.0038 | 0.0032 | 0.0002 | 0.0018 | 0.0005 | 0.0152 | 0.0038 |
None | 0.0022 | 0.0004 | 0.0022 | 0.0006 | 0.0015 | 0.0005 | 0.0015 | 0.0007 | 0.0007 | 0.0005 | 0.0013 | 0.0006 | 0.0048 | 0.0003 | 0.0008 | 0.0006 | 0.006 | 0.0009 |
Nuclear Periphery | 0.0108 | 0.0012 | 0.0108 | 0.0021 | 0.0104 | 0.0017 | 0.0074 | 0.0006 | 0.0018 | 0.002 | 0.0049 | 0.0043 | 0.009 | 0.001 | 0.0023 | 0.0022 | 0.0057 | 0.0017 |
Nucleolus | 0.0007 | 0.0001 | 0.0003 | 0 | 0.0021 | 0 | 0.0001 | 0.0088 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0002 | 0 | 0 | 0.0002 | 0.0003 | 0.0001 |
Nucleus | 0.0037 | 0.0012 | 0.003 | 0.0026 | 0.022 | 0.0014 | 0.006 | 0.0028 | 0.0011 | 0.0011 | 0.0042 | 0.0022 | 0.0029 | 0.0008 | 0.0018 | 0.002 | 0.0028 | 0.0017 |
Peroxisomes | 0.004 | 0.0007 | 0.0021 | 0.0001 | 0.0051 | 0.0007 | 0.0007 | 0.0001 | 0.0058 | 0.0006 | 0.0008 | 0.0007 | 0.0022 | 0.0002 | 0.0002 | 0.0009 | 0.0022 | 0.0001 |
Punctate Nuclear | 0.0034 | 0.0001 | 0.0016 | 0.0001 | 0.0019 | 0.0003 | 0.0004 | 0.0002 | 0.0007 | 0.0001 | 0.0005 | 0.0002 | 0.0027 | 0.0001 | 0.0002 | 0.0009 | 0.0015 | 0.0008 |
Vacuole | 0.0171 | 0.0055 | 0.0177 | 0.0186 | 0.0388 | 0.0079 | 0.0149 | 0.003 | 0.009 | 0.017 | 0.018 | 0.0027 | 0.0078 | 0.0017 | 0.0155 | 0.0189 | 0.0063 | 0.0029 |
Vacuole Periphery | 0.0039 | 0.0007 | 0.0051 | 0.0035 | 0.0101 | 0.0031 | 0.0029 | 0.0005 | 0.0033 | 0.004 | 0.0071 | 0.0011 | 0.0015 | 0.0003 | 0.0033 | 0.0029 | 0.0033 | 0.0012 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 85.105 | 96.5868 | 93.2712 | 80.1161 | 84.9156 | 68.0463 | 70.7358 | 74.0394 | 68.1052 | 80.3019 |
Translational Efficiency | 1.5423 | 1.3081 | 1.2441 | 1.1858 | 1.2097 | 1.5894 | 1.3756 | 1.1083 | 1.1183 | 1.1258 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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