Standard name
Human Ortholog
Description Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0.06 0.07 0 0 – 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0.08 0.12 0 0 0 0 0 0
Cytoplasm 0.1 0.08 0.06 0.05 0 0.05 – 0 0 0 0 0 0.12 0.09 0.08 0.1 0.14 0.13 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0 0.11 0 0 0.07 0 – 0 0 0 0 0 0.07 0.13 0.09 0.17 0.11 0.11 0.06 0.08 0.12 0.05 0.08 0.08
Golgi 0 0.05 0 0 0 0 – 0 0 0 0 0 0.14 0.13 0.09 0.15 0.09 0.07 0 0 0 0.05 0.06 0.06
Mitochondria 0.88 0.71 0.94 0.95 0.94 0.9 – 0.92 0.96 0.92 0.96 0.95 0.7 0.72 0.68 0.1 0.08 0.1 0.72 0.7 0.67 0.68 0.6 0.56
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.1 – 0.09 0.06 0.06 0.07 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0.05 0.05 – 0.09 0.07 0.07 0.06 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0.05 0.28 0.18 0.27 0 0 0.08 0.07 0.08 0.05
SpindlePole 0 0 0.07 0 0.05 0 – 0 0 0 0 0 0 0 0 0.08 0.15 0.09 0 0 0 0 0 0
Vac/Vac Membrane 0.18 0.23 0 0 0.06 0 – 0 0 0 0 0 0.09 0.07 0.14 0.21 0.2 0.22 0.06 0.05 0 0 0.05 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 1 0 0 2 1 0 0 2 0 3 9 1 2 6 5
Bud 7 4 8 9 5 2 – 3 6 5 8 6 2 2 0 2 9 5 4 2 0 0 0 3
Bud Neck 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 3 2 1 0 1 2
Bud Site 2 1 2 0 2 0 – 4 3 3 4 5 0 0 0 1 2 2 – – – – – –
Cell Periphery 3 11 0 0 1 2 – 0 0 2 1 2 5 3 1 12 11 20 0 1 0 0 0 0
Cytoplasm 27 21 8 6 2 6 – 8 5 7 3 4 24 12 12 18 19 22 5 2 1 4 3 3
Endoplasmic Reticulum 3 4 0 0 0 1 – 0 0 1 2 1 7 2 5 5 4 10 3 2 0 2 1 1
Endosome 5 30 1 0 11 0 – 0 0 1 1 0 14 17 14 30 15 18 18 27 18 8 15 15
Golgi 0 13 0 1 2 0 – 0 0 0 0 0 28 17 13 26 13 11 4 14 2 8 10 10
Mitochondria 237 198 130 120 145 115 – 176 198 185 221 249 138 97 102 17 11 16 208 246 99 116 106 111
Nucleus 5 2 3 0 1 0 – 2 3 1 2 1 0 1 1 6 7 8 0 0 0 1 1 2
Nuclear Periphery 1 4 4 2 4 13 – 17 13 12 16 23 1 2 2 2 1 1 2 1 0 3 0 2
Nucleolus 2 2 1 2 7 6 – 18 14 14 14 27 1 0 0 3 5 5 1 0 0 1 0 3
Peroxisomes 7 9 1 1 5 0 – 1 0 1 2 2 7 7 8 49 24 44 8 14 11 11 14 10
SpindlePole 6 2 10 0 8 1 – 5 1 2 5 4 1 2 2 15 20 15 3 2 2 2 4 6
Vac/Vac Membrane 49 63 5 2 10 3 – 4 5 6 3 4 18 9 21 37 28 37 18 18 2 3 8 15
Unique Cell Count 270 279 138 126 155 128 191 206 201 231 262 197 135 150 177 137 166 290 351 149 170 179 198
Labelled Cell Count 354 364 173 143 203 149 238 248 242 282 328 248 172 181 223 171 214 290 351 149 170 179 198


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 5.8 3.8 4.3 5.7 5.6 – 5.4 5.2 5.3 5.2 5.1 5.7 6.1 6.2 7.6 7.9 7.3 5.8 6.2 6.2
Std Deviation (1e-4) 1.0 1.1 0.8 1.1 1.7 1.9 – 2.3 1.8 1.8 1.7 1.7 1.1 1.3 1.3 1.9 2.6 1.9 1.6 2.2 1.7
Intensity Change (Log2) – – – 0.21 0.61 0.58 – 0.53 0.46 0.5 0.47 0.45 0.61 0.71 0.72 1.02 1.06 0.97 0.63 0.73 0.73

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 -1.1 0 – 0 -1.3 -1.6 -1.1 0 0 0 0 0 0.3 -1.2
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 3.1 3.4 4.2
Cytoplasm -0.4 0 -0.4 – -0.7 -1.6 -1.0 0 0 2.0 1.0 0.7 1.4 2.2 2.2
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 2.7 0 – 0 0 0 0 0 2.8 4.0 3.3 4.8 3.6 3.6
Golgi 0 0 0 – 0 0 0 0 0 4.6 4.3 3.5 4.7 3.7 0
Mitochondria 0 -0.2 -1.3 – -0.7 0.8 -0.8 0.6 0.4 -5.4 -4.9 -5.6 -14.9 -14.3 -14.7
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 2.4 – 2.2 1.4 1.3 1.7 2.2 0 0 0 0 0 0
Nucleolus 0 0 0 – 3.3 2.7 2.7 2.5 3.6 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 6.5 4.8 6.3
SpindlePole 0 -0.7 -2.6 – -2.0 0 0 -2.4 0 0 -2.3 -2.5 0.4 2.0 0.6
Vacuole 0 1.1 0 – 0 0 0 0 0 2.0 1.1 3.1 4.5 4.3 4.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.9287 3.0509 2.9169 2.4119 3.1558 2.9544 1.6829 1.7584 1.5431 1.7037 1.5848 1.698 4.5124 4.8271 4.3566 4.1468 4.3036 4.4292
Actin 0.0027 0.0018 0.0011 0.0002 0.0004 0.0008 0.0313 0.012 0.0175 0.0087 0.0073 0.0085 0.0023 0.0098 0.004 0.0014 0.0018 0.0021
Bud 0.0001 0.0002 0.0003 0 0.0001 0.0001 0.0009 0.0019 0.0015 0.0045 0.0017 0.0007 0.0003 0.0009 0.0005 0.0002 0.0001 0.0004
Bud Neck 0.0001 0.0001 0.0001 0 0 0.0001 0.0006 0.0006 0.0006 0.002 0.0003 0.0007 0.0001 0.0003 0.0001 0.0001 0.0001 0.0001
Bud Periphery 0.0003 0.0005 0.0009 0.0001 0.0002 0.0002 0.0013 0.0018 0.0031 0.0056 0.0047 0.0016 0.0009 0.0024 0.0026 0.0012 0.0003 0.0022
Bud Site 0.0006 0.0012 0.0011 0 0.0001 0.0001 0.0024 0.0171 0.0085 0.0268 0.0007 0.001 0.0007 0.0017 0.0004 0.0003 0.0002 0.0001
Cell Periphery 0.0001 0.0001 0.0003 0 0.0001 0.0001 0.0003 0.001 0.0004 0.0004 0.0003 0.0004 0.0002 0.0002 0.0003 0.0001 0.0001 0.0005
Cytoplasm 0.0009 0.0002 0.0004 0 0.0002 0.0002 0.0042 0.0016 0.0025 0.0014 0.0014 0.0032 0.0045 0.0006 0.0005 0.0002 0.0004 0.0006
Cytoplasmic Foci 0.0078 0.0125 0.0075 0.0021 0.0033 0.0066 0.0219 0.0288 0.0192 0.0242 0.0107 0.0266 0.012 0.0106 0.0073 0.0117 0.0177 0.0091
Eisosomes 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0005 0.0003 0.0016 0.0003 0.0002 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001 0.0002
Endoplasmic Reticulum 0.0004 0.0004 0.0001 0 0.0001 0.0003 0.0029 0.0007 0.0007 0.0004 0.0007 0.0025 0.0008 0.0002 0.0003 0.0001 0.0001 0.0003
Endosome 0.0273 0.0248 0.0179 0.0088 0.022 0.0126 0.054 0.0498 0.031 0.0226 0.0481 0.0183 0.0264 0.0322 0.0194 0.0254 0.0186 0.0193
Golgi 0.0276 0.0661 0.0158 0.0123 0.0263 0.0218 0.0472 0.0702 0.031 0.0427 0.0643 0.0338 0.0353 0.0462 0.0288 0.0279 0.0471 0.0293
Lipid Particles 0.0114 0.0071 0.0046 0.0011 0.0015 0.01 0.0351 0.0155 0.0045 0.0176 0.0305 0.0075 0.0297 0.0063 0.0025 0.0148 0.0034 0.0101
Mitochondria 0.8856 0.8582 0.926 0.9658 0.9325 0.9215 0.7207 0.7544 0.8233 0.7985 0.8085 0.8531 0.845 0.8554 0.9038 0.8601 0.8431 0.9008
None 0.001 0.0001 0.0001 0 0.0001 0.0002 0.0051 0.0003 0.0092 0.0008 0.001 0.0017 0.0018 0.0012 0.0004 0.0002 0.0001 0.0013
Nuclear Periphery 0.001 0.0016 0.0001 0 0 0.0007 0.0169 0.0003 0.0035 0.0003 0.0004 0.0029 0.0008 0.0001 0.0001 0.0001 0 0.0009
Nucleolus 0.0003 0.0001 0.0002 0 0.0001 0.0001 0.0004 0.0006 0.0003 0.0012 0.0001 0.0003 0.0003 0.0003 0.0001 0.0003 0 0.0001
Nucleus 0.0006 0.0001 0.0001 0 0 0.0001 0.006 0.0002 0.0005 0.0007 0.0002 0.0002 0.0004 0.0003 0.0001 0.0001 0 0.0001
Peroxisomes 0.0261 0.0207 0.0167 0.0076 0.0101 0.0216 0.0366 0.0339 0.0332 0.0336 0.0132 0.0317 0.0303 0.024 0.0247 0.0508 0.0658 0.0198
Punctate Nuclear 0.0004 0 0 0 0 0.0001 0.0017 0.0003 0.0033 0.0025 0.0003 0.0013 0.0002 0.0021 0 0.0001 0 0.0001
Vacuole 0.0028 0.0013 0.004 0.0005 0.0012 0.0009 0.0057 0.0048 0.0028 0.0025 0.0022 0.0014 0.0028 0.0028 0.0019 0.0024 0.0003 0.0009
Vacuole Periphery 0.0027 0.0027 0.0026 0.0011 0.0018 0.0019 0.0042 0.0039 0.0019 0.0026 0.0031 0.0024 0.0052 0.0024 0.0019 0.0022 0.0006 0.0019

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.154 4.0343 10.4776 13.2783 5.8512 27.0624 17.8458 21.3363 26.586 20.8738
Translational Efficiency 3.0612 4.9308 2.4482 2.9355 4.9703 1.946 2.2933 2.4158 2.0914 2.3417

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1491 1330 293 1081 1736 2214 1870 838 3227 3544 2163 1919

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 592.02 751.89 1157.70 917.95 713.00 777.18 911.16 926.20 657.10 767.69 944.56 921.55
Standard Deviation 86.69 108.54 173.25 153.04 81.60 104.27 121.08 170.37 103.40 106.60 154.46 160.89
Intensity Change Log 2 — 0.344876 0.967544 0.632770 — 0.124347 0.353802 0.377422 — 0.228583 0.664764 0.498884

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000438 0.002993 0.005612 0.007248 0.000979 0.000490 0.005480 0.031793 0.000729 0.001429 0.005497 0.017967
Bud Neck 0.046495 0.007928 0.007417 0.005884 0.005218 0.007732 0.008123 0.004060 0.024290 0.007806 0.008027 0.005088
Bud Site 0.024848 0.014092 0.017164 0.044405 0.008282 0.008086 0.034313 0.062117 0.015936 0.010340 0.031990 0.052140
Cell Periphery 0.000507 0.000510 0.000365 0.000455 0.000269 0.000281 0.000244 0.002383 0.000379 0.000367 0.000261 0.001297
Cytoplasm 0.093570 0.008501 0.002051 0.007615 0.008268 0.005250 0.010448 0.011910 0.047681 0.006470 0.009311 0.009491
Cytoplasmic Foci 0.197011 0.066271 0.091235 0.047748 0.060872 0.046921 0.061890 0.039926 0.123773 0.054183 0.065865 0.044332
Eisosomes 0.000312 0.000121 0.000097 0.000101 0.000104 0.000066 0.000089 0.000208 0.000200 0.000087 0.000090 0.000148
Endoplasmic Reticulum 0.001855 0.000340 0.004163 0.001267 0.000411 0.000260 0.001210 0.001267 0.001078 0.000290 0.001610 0.001267
Endosome 0.076705 0.090305 0.095013 0.079817 0.073931 0.088062 0.097928 0.052340 0.075213 0.088903 0.097533 0.067818
Golgi 0.060681 0.129479 0.078345 0.099502 0.111930 0.116448 0.080747 0.075190 0.088251 0.121338 0.080422 0.088885
Lipid Particles 0.028416 0.004538 0.006585 0.001968 0.005256 0.003838 0.001778 0.000763 0.015957 0.004101 0.002429 0.001442
Mitochondria 0.327477 0.554902 0.502358 0.537942 0.654117 0.634622 0.484298 0.568024 0.503197 0.604705 0.486745 0.551078
Mitotic Spindle 0.008063 0.012578 0.068931 0.055570 0.007475 0.016618 0.089620 0.028517 0.007746 0.015102 0.086817 0.043756
None 0.010955 0.000614 0.000366 0.000326 0.000369 0.000519 0.000297 0.000287 0.005260 0.000554 0.000307 0.000309
Nuclear Periphery 0.000545 0.000101 0.001862 0.000484 0.000100 0.000200 0.000318 0.000061 0.000306 0.000163 0.000527 0.000299
Nuclear Periphery Foci 0.000615 0.000457 0.002060 0.000551 0.000237 0.000288 0.000480 0.000224 0.000412 0.000352 0.000694 0.000408
Nucleolus 0.005574 0.001118 0.000699 0.000312 0.000466 0.001342 0.000727 0.000322 0.002826 0.001258 0.000723 0.000317
Nucleus 0.026143 0.001379 0.001479 0.000852 0.000912 0.002089 0.002619 0.000649 0.012570 0.001822 0.002465 0.000763
Peroxisomes 0.036921 0.083690 0.044019 0.038064 0.034369 0.034876 0.059589 0.101010 0.035548 0.053195 0.057480 0.065552
Vacuole 0.037118 0.011326 0.036747 0.043151 0.013392 0.018356 0.041681 0.010952 0.024355 0.015718 0.041012 0.029090
Vacuole Periphery 0.015751 0.008757 0.033433 0.026738 0.013042 0.013657 0.018120 0.007997 0.014293 0.011818 0.020195 0.018554

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.37 -4.31 -6.03 -3.16 -1.00 2.26 -6.46 -8.15 -8.30 -6.86 -2.25 -7.84 -9.63 -9.14 -6.61
Bud Neck 12.15 12.60 13.47 1.18 0.96 -2.21 -3.12 1.58 3.37 4.63 10.11 10.19 12.72 2.79 3.43
Bud Site 4.52 2.01 -5.23 -8.37 -6.02 0.16 -12.24 -11.73 -11.74 -5.48 4.49 -8.08 -12.43 -14.66 -6.06
Cell Periphery -0.06 1.94 0.75 0.65 -1.44 -0.21 0.75 -4.20 -4.17 -4.26 0.21 3.43 -4.10 -4.12 -4.66
Cytoplasm 18.88 21.01 19.22 0.23 -6.21 2.76 -2.00 -2.64 -5.03 -0.74 18.12 15.98 16.31 -3.57 -0.16
Cytoplasmic Foci 22.59 11.11 26.16 5.04 5.08 4.72 -0.34 6.09 2.35 6.57 21.11 15.69 23.09 4.27 7.51
Eisosomes 3.09 3.47 3.42 2.57 -0.44 5.82 2.03 -7.32 -10.88 -8.91 3.95 3.79 1.77 -8.78 -8.01
Endoplasmic Reticulum 5.16 -0.84 1.69 -5.59 1.05 2.56 -4.53 -3.41 -4.00 -0.53 5.67 -1.32 -1.29 -6.69 0.68
Endosome -2.77 -2.44 -0.63 2.01 1.98 -3.31 -5.35 4.86 8.04 9.83 -4.27 -6.01 2.21 6.11 7.58
Golgi -12.44 -2.33 -6.50 4.46 -2.33 -0.84 6.34 6.20 7.16 0.95 -8.57 2.12 -0.07 7.29 -1.89
Lipid Particles 10.61 7.12 12.00 2.70 1.96 1.44 4.04 5.18 5.21 2.77 10.10 11.75 12.59 4.72 1.92
Mitochondria -17.39 -7.21 -14.57 1.37 -1.23 1.83 14.91 5.72 4.52 -5.54 -11.65 1.77 -4.29 5.38 -5.48
Mitotic Spindle -3.11 -7.05 -11.14 -9.96 1.32 -5.50 -19.63 -7.57 -4.01 12.61 -6.33 -20.95 -13.28 -10.25 9.35
None 6.49 6.72 6.74 1.68 0.69 -1.57 0.84 0.93 3.23 0.24 6.34 6.73 6.73 3.02 -0.03
Nuclear Periphery 6.02 -2.05 0.57 -3.98 2.14 -1.36 -5.43 1.74 1.96 6.99 2.58 -2.26 0.13 -1.99 2.17
Nuclear Periphery Foci 0.52 -3.35 0.51 -0.28 3.54 -0.43 -2.21 0.07 0.59 2.71 0.43 -2.75 0.03 -0.44 3.05
Nucleolus 5.27 6.89 7.72 1.74 1.44 -2.04 -1.04 0.55 2.17 1.30 3.64 5.70 7.26 2.92 1.93
Nucleus 13.33 12.58 13.82 1.04 0.66 -2.19 -3.44 0.62 2.45 3.63 11.45 10.13 13.22 2.61 3.69
Peroxisomes -8.81 -1.12 -0.36 7.75 0.83 -0.13 -6.29 -8.85 -8.88 -5.26 -6.22 -6.61 -7.46 -2.86 -1.71
Vacuole 11.15 0.05 -2.14 -10.45 -1.57 -2.98 -12.12 1.30 3.92 12.46 6.00 -7.80 -2.73 -7.09 4.40
Vacuole Periphery 5.15 -4.34 -5.04 -8.71 1.57 -0.57 -3.79 4.35 4.88 7.30 2.81 -4.70 -3.20 -5.18 1.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
Localization
Cell Percentages mitochondrion (87%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Sdh5

Sdh5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sdh5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available