Standard name
Human Ortholog
Description Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0.06 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0.07 0.05 0 – 0 0 0.06 0.13 0.13 0.08 0.05 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0.07 0.1 0 0.15 0.13 0.2 0.24 – 0.28 0.31 0 0 0.05 0 0 0 0 0 0 0 0 0
Nucleus 0.97 0.97 0.96 0.97 0.94 0.91 0.81 0.79 0.82 – 0.84 0.79 0.91 0.82 0.78 0.9 0.93 0.91 0.94 0.95 0.93 0.91 0.78 0.59
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.14 0.12 0.13 0.23 – 0.2 0.23 0 0 0 0 0 0 0 0 0 0 0 0.09
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 2
Bud 0 0 0 0 0 1 2 3 3 – 3 4 0 0 2 0 0 0 2 0 1 2 3 3
Bud Neck 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 2 0 6 8 17 9 – 20 18 0 3 8 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 1 3 3 13 3 27 26 7 – 4 10 21 56 59 23 12 17 0 0 0 2 2 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 2 4 6 0 0 1 0 0 1
Endosome 1 0 0 0 1 0 0 1 1 – 0 0 1 3 3 0 2 1 1 1 2 1 1 5
Golgi 0 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 1
Mitochondria 2 7 16 25 16 50 54 114 104 – 89 129 12 1 24 3 1 7 2 0 0 0 2 13
Nucleus 211 116 209 235 336 301 329 455 347 – 271 323 310 354 367 263 247 248 203 115 210 210 274 232
Nuclear Periphery 1 0 0 2 4 3 11 7 7 – 9 8 3 2 9 3 0 1 0 0 0 0 0 3
Nucleolus 1 2 1 5 8 46 49 75 96 – 65 93 4 12 21 5 5 8 1 0 0 1 8 34
Peroxisomes 0 0 0 0 1 0 0 0 0 – 1 0 0 3 9 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 1 0 0 1 0 0 – 1 0 2 11 10 0 1 1 0 1 0 0 2 3
Vac/Vac Membrane 1 0 2 0 2 0 1 2 1 – 2 1 3 8 6 10 4 4 2 1 8 8 49 86
Unique Cell Count 218 120 218 243 357 331 407 576 425 323 410 340 432 468 293 266 274 217 122 227 233 350 394
Labelled Cell Count 221 126 231 274 381 410 482 701 575 465 586 356 453 518 309 276 293 217 122 227 233 350 394


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.1 6.9 6.2 6.0 6.6 6.2 6.1 5.7 5.5 – 5.3 5.0 7.2 7.8 6.7 9.1 11.0 10.6 7.2 6.8 7.3
Std Deviation (1e-4) 2.0 1.6 1.4 1.4 1.7 1.6 1.7 1.5 1.5 – 1.5 1.5 2.7 2.6 2.3 3.0 4.0 3.5 1.5 1.6 1.7
Intensity Change (Log2) – – – -0.05 0.1 0.01 -0.02 -0.11 -0.18 – -0.22 -0.31 0.23 0.33 0.11 0.55 0.82 0.77 0.22 0.13 0.23


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 3.7 3.1 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 1.6 0 2.9 2.1 0 – 0 0 2.7 4.9 4.8 3.3 2.0 2.7
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 1.1 -1.5 2.7 2.2 4.2 5.3 – 5.8 6.8 -2.0 -5.4 -1.2 -3.7 -4.1 -2.5
Nucleus 0.5 -0.9 -2.2 -5.2 -5.7 -5.0 – -4.3 -5.7 -2.1 -4.9 -5.8 -2.6 -1.4 -2.3
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 5.5 5.1 5.4 7.4 – 6.9 7.4 0 0 2.8 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 1.8 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.6353 7.0554 7.2848 5.4484 5.0948 6.0311 5.363 7.4733 7.198 5.6129 5.6536 5.7744 6.5164 7.8137 7.5061 7.9659 7.2373 6.8529
Actin 0.0103 0 0.0011 0.0162 0.0235 0 0.0151 0 0.0168 0.0148 0.0052 0.0016 0 0 0 0 0 0.0001
Bud 0.0003 0 0.0001 0.0004 0.0003 0 0.0003 0 0.0002 0.0003 0.0011 0.0001 0 0 0 0 0 0
Bud Neck 0.0008 0 0.004 0.0036 0.0011 0.0003 0.001 0 0.0002 0.001 0.0005 0.0003 0 0 0 0 0.0001 0.0018
Bud Periphery 0.0005 0 0.0001 0.0007 0.0005 0 0.0005 0 0.0004 0.0003 0.0028 0.0004 0 0 0 0 0.0001 0.0001
Bud Site 0.0048 0 0.004 0.0028 0.0015 0 0.0014 0 0.0005 0.0034 0.0031 0.0002 0 0 0 0 0.0001 0.0001
Cell Periphery 0.0002 0 0.0002 0.0005 0.0003 0 0.0002 0 0.0001 0.0001 0.0003 0.0001 0 0 0 0 0 0
Cytoplasm 0.0067 0 0.0002 0.0027 0.0014 0 0.0101 0 0.0011 0.0051 0.0019 0.0001 0.0001 0 0.0002 0.0001 0.0001 0
Cytoplasmic Foci 0.0025 0 0.0006 0.0031 0.0042 0 0.0078 0 0.0013 0.0462 0.0266 0.0014 0 0 0 0 0 0
Eisosomes 0.0002 0 0 0.0006 0.0004 0 0.0001 0 0.0001 0.0002 0.0001 0.0001 0 0 0 0 0 0
Endoplasmic Reticulum 0.0011 0 0.0001 0.0022 0.0021 0 0.0041 0 0.0048 0.0013 0.0015 0.0005 0 0 0 0 0 0
Endosome 0.0032 0 0.0017 0.0056 0.0093 0 0.0126 0 0.0042 0.0262 0.0258 0.0016 0 0 0 0 0 0
Golgi 0.0006 0 0.0007 0.0021 0.0035 0 0.0017 0 0.0025 0.0089 0.0093 0.0005 0 0 0 0 0 0
Lipid Particles 0.0011 0 0.0017 0.0135 0.0082 0 0.0054 0 0.0105 0.0192 0.0681 0.0043 0 0 0 0 0 0
Mitochondria 0.0012 0.0001 0.0004 0.0062 0.0033 0.0001 0.0018 0.0001 0.0042 0.0149 0.0253 0.0032 0.0001 0.0001 0.0001 0.0001 0.0008 0.0001
None 0.0071 0 0.0001 0.0035 0.0032 0 0.0045 0 0.0003 0.0031 0.0016 0.0002 0 0 0.0001 0 0 0
Nuclear Periphery 0.0053 0.0012 0.0006 0.0113 0.007 0.0001 0.0256 0.0025 0.0039 0.006 0.0295 0.01 0.0006 0.0007 0.0014 0.001 0.0022 0.0005
Nucleolus 0.0176 0.0133 0.0099 0.0178 0.0622 0.0376 0.0139 0.006 0.006 0.0105 0.0486 0.0204 0.0288 0.0136 0.0083 0.0023 0.059 0.0421
Nucleus 0.9294 0.9843 0.9728 0.8776 0.8517 0.9617 0.8695 0.9912 0.9387 0.811 0.66 0.9529 0.9663 0.9804 0.9783 0.9965 0.9101 0.9546
Peroxisomes 0.001 0 0.0006 0.0203 0.0021 0 0.0018 0 0.0019 0.0103 0.0162 0.0002 0 0 0 0 0 0
Punctate Nuclear 0.0043 0.001 0.0007 0.0063 0.0123 0.0001 0.0186 0 0.0006 0.0127 0.0578 0.0007 0.0038 0.005 0.0115 0 0.0271 0.0005
Vacuole 0.0013 0 0.0002 0.0021 0.0011 0.0001 0.0025 0 0.001 0.0035 0.0087 0.0005 0 0 0 0 0.0001 0.0001
Vacuole Periphery 0.0005 0 0.0001 0.0008 0.0009 0 0.0015 0 0.0007 0.0009 0.0061 0.0008 0 0 0 0 0.0002 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 96.4288 35.0939 17.9507 32.8896 69.6775 75.8052 25.579 21.5075 26.7014 75.8256
Translational Efficiency 1.1256 0.9141 0.8006 0.837 0.9589 1.4161 1.0971 0.6644 0.8201 0.8908

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
928 583 1850 1136 899 1944 198 108 1827 2527 2048 1244

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 713.89 902.28 1066.36 1127.68 763.99 907.25 1238.84 1264.13 738.54 906.10 1083.04 1139.53
Standard Deviation 97.87 181.60 157.15 188.88 134.17 136.76 164.33 211.39 119.79 148.33 165.89 194.76
Intensity Change Log 2 — 0.337873 0.578921 0.659584 — 0.247946 0.697364 0.726519 — 0.292086 0.641363 0.694574

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000100 0.000492 0.000470 0.001237 0.000327 0.000308 0.000934 0.000880 0.000212 0.000350 0.000515 0.001206
Bud Neck 0.000860 0.003012 0.013248 0.022077 0.002472 0.005481 0.007807 0.012629 0.001653 0.004911 0.012722 0.021256
Bud Site 0.000197 0.000448 0.000940 0.008718 0.001642 0.000711 0.000689 0.002522 0.000908 0.000650 0.000916 0.008180
Cell Periphery 0.000126 0.000167 0.000095 0.000229 0.000229 0.000150 0.000032 0.000044 0.000176 0.000154 0.000089 0.000213
Cytoplasm 0.004954 0.000794 0.000360 0.002385 0.004573 0.001093 0.000122 0.000221 0.004766 0.001024 0.000337 0.002197
Cytoplasmic Foci 0.000549 0.000138 0.000015 0.004622 0.000517 0.000580 0.000016 0.002008 0.000533 0.000478 0.000015 0.004395
Eisosomes 0.000011 0.000027 0.000041 0.000035 0.000021 0.000029 0.000056 0.000041 0.000016 0.000029 0.000042 0.000036
Endoplasmic Reticulum 0.002790 0.007010 0.003397 0.003526 0.006156 0.006384 0.004186 0.003646 0.004446 0.006529 0.003474 0.003536
Endosome 0.000222 0.000223 0.000142 0.005504 0.000325 0.000677 0.000063 0.006052 0.000273 0.000572 0.000135 0.005552
Golgi 0.000074 0.000190 0.000027 0.003786 0.000069 0.000787 0.000040 0.002086 0.000071 0.000649 0.000028 0.003638
Lipid Particles 0.000253 0.000931 0.000038 0.000979 0.000114 0.000154 0.000051 0.000363 0.000185 0.000333 0.000039 0.000926
Mitochondria 0.000611 0.000940 0.001009 0.008525 0.000723 0.002020 0.001188 0.001949 0.000666 0.001771 0.001026 0.007954
Mitotic Spindle 0.000621 0.001013 0.000298 0.016592 0.000315 0.003758 0.000036 0.001085 0.000470 0.003125 0.000272 0.015246
None 0.006301 0.004005 0.000813 0.003463 0.008215 0.001894 0.000426 0.000698 0.007243 0.002381 0.000776 0.003223
Nuclear Periphery 0.000202 0.000169 0.000281 0.002689 0.000257 0.000447 0.000136 0.000764 0.000229 0.000383 0.000267 0.002522
Nuclear Periphery Foci 0.000061 0.000578 0.000140 0.002242 0.000353 0.000212 0.000015 0.003888 0.000205 0.000296 0.000128 0.002385
Nucleolus 0.004180 0.006753 0.004377 0.007887 0.009908 0.005649 0.004762 0.016358 0.006999 0.005903 0.004415 0.008622
Nucleus 0.977165* 0.971972* 0.973267* 0.896318* 0.962738* 0.967509* 0.977801* 0.934391* 0.970066* 0.968539* 0.973705* 0.899624*
Peroxisomes 0.000297 0.000376 0.000161 0.001420 0.000305 0.000316 0.000484 0.000433 0.000301 0.000330 0.000192 0.001335
Vacuole 0.000364 0.000622 0.000706 0.005773 0.000511 0.001143 0.001075 0.007066 0.000436 0.001023 0.000742 0.005885
Vacuole Periphery 0.000063 0.000139 0.000174 0.001993 0.000230 0.000698 0.000079 0.002876 0.000145 0.000569 0.000165 0.002069

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.15 -14.12 -10.98 -6.84 -7.24 0.14 -10.51 -5.43 -5.36 -1.26 -3.68 -11.58 -10.67 -8.77 -7.29
Bud Neck -5.75 -19.08 -16.47 -14.62 -6.98 -4.51 -5.11 -4.44 -3.23 -2.11 -6.65 -18.27 -16.41 -13.42 -7.26
Bud Site -3.50 -6.43 -4.65 -4.48 -4.08 1.21 1.14 -0.77 -1.73 -1.69 0.59 -0.30 -4.14 -4.42 -4.18
Cell Periphery -1.11 1.48 -1.10 -0.02 -1.90 1.75 4.69 4.14 4.44 -1.45 0.83 3.48 0.47 -0.12 -1.96
Cytoplasm 4.17 4.71 1.22 -3.29 -3.95 2.57 3.51 3.35 1.79 -3.16 4.27 5.51 1.54 -2.68 -3.98
Cytoplasmic Foci 2.17 2.98 -2.62 -3.25 -3.43 0.36 1.52 -0.30 -0.51 -1.07 0.63 2.48 -2.42 -2.80 -3.53
Eisosomes -6.98 -17.05 -14.21 -3.94 1.79 -3.66 -10.63 -5.03 -3.23 2.47 -7.75 -16.45 -12.70 -4.48 2.41
Endoplasmic Reticulum -5.60 -2.33 -2.87 4.38 -1.28 -0.49 3.56 0.99 1.16 -0.19 -5.93 3.46 1.79 7.66 -1.17
Endosome 0.03 0.77 -4.38 -4.41 -4.53 -1.25 2.42 -1.15 -1.03 -1.25 -1.41 1.76 -4.45 -3.88 -4.67
Golgi -1.07 0.83 -3.81 -3.56 -3.90 -1.75 1.23 -1.09 -0.41 -1.12 -1.84 1.53 -3.94 -2.46 -4.04
Lipid Particles -0.79 1.45 -1.33 0.35 -2.50 -0.66 2.28 -1.09 -0.83 -1.57 -0.69 1.92 -1.77 -0.89 -2.58
Mitochondria -0.67 -1.03 -4.23 -4.03 -4.03 -2.12 -3.33 -4.30 -0.31 -3.00 -2.18 -1.51 -4.42 -3.28 -4.10
Mitotic Spindle -0.44 0.25 -5.29 -5.04 -5.44 -3.04 1.06 -1.30 2.23 -2.01 -2.90 0.13 -5.44 -4.06 -5.47
None 1.85 6.56 3.09 0.58 -5.35 4.32 5.48 5.09 2.08 -2.79 5.44 7.86 4.48 -1.38 -5.45
Nuclear Periphery 0.91 -1.25 -2.28 -2.32 -2.15 -2.40 2.93 -2.60 -1.63 -3.10 -2.60 -0.81 -2.31 -2.10 -2.23
Nuclear Periphery Foci -1.40 -0.76 -3.21 -1.63 -2.98 0.74 2.19 -0.90 -0.96 -1.06 -0.82 0.70 -3.00 -2.75 -3.16
Nucleolus -2.18 -0.82 -4.91 -3.01 -4.79 3.85 4.51 -0.72 -1.44 -1.57 1.39 2.87 -3.36 -4.24 -5.04
Nucleus 1.34 2.11 11.28 10.07 10.88 -1.20 -3.94 1.44 1.79 2.44 0.52 -0.92 10.42 10.14 11.15
Peroxisomes -0.35 0.69 -1.58 -1.50 -2.03 -0.04 -1.81 -0.97 -0.84 0.44 -0.24 1.11 -1.66 -1.61 -2.01
Vacuole -1.76 -1.66 -5.63 -5.25 -5.10 -2.63 -4.73 -2.26 -1.99 -1.96 -3.19 -1.74 -5.95 -5.11 -5.42
Vacuole Periphery -2.04 -1.16 -4.03 -3.75 -3.51 -1.36 1.34 -1.19 -0.85 -1.29 -1.64 -0.18 -3.87 -1.92 -3.74
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Msh2

Msh2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Msh2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available