Standard name
Human Ortholog
Description Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.13 0 0 0 0.06 0.11 0.15 0.16 0.26 0.23 0.27 0.34 0 0 0 0.11 0.07 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.07 0 0 0.08 0.06 0.06 0.05 0.05 0.09 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.1 0.11 0.08 0 0.05 0.11 0.07 0.05 0.05 0.05 0 0 0.05 0 0.06 0.21 0.21 0.21 0 0.07 0.05 0.07 0.07 0.06
Nuclear Periphery 0.21 0 0.13 0.28 0.16 0.12 0.17 0.1 0.12 0.07 0.09 0.06 0.07 0.13 0.09 0.08 0.08 0.06 0 0 0.06 0 0 0
Nucleolus 0.08 0 0.08 0.09 0.05 0 0 0 0 0 0 0 0.1 0.08 0 0 0.08 0 0 0 0 0 0.05 0.05
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.62 0.88 0.8 0.84 0.81 0.7 0.7 0.72 0.66 0.66 0.64 0.59 0.84 0.88 0.93 0.75 0.76 0.77 0.83 0.87 0.84 0.79 0.81 0.79
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 3 2 0 1 0 2 0 0 0 0 0 0 0 1 0 0 0 0
Bud 0 0 0 0 0 1 2 5 1 4 4 3 0 0 0 0 0 0 0 2 1 1 3 7
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 0 1 1 4 13 7 8 11 6 5 0 1 1 0 1 0 0 0 0 0 0 0
Cytoplasm 5 11 9 4 26 50 100 100 107 124 85 147 7 9 6 13 5 8 1 1 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 3 3 5 11 9 11 4 9 0 1 2 4 4 0 0 0 0 0 0 0
Endosome 0 0 1 4 2 2 9 2 3 5 1 2 1 2 1 0 0 0 1 4 3 4 6 6
Golgi 2 8 2 10 4 0 0 1 0 1 1 0 9 3 6 0 0 0 0 0 0 1 0 3
Mitochondria 0 6 19 7 19 35 42 38 20 28 28 41 5 3 0 0 1 0 0 1 2 2 1 5
Nucleus 4 49 21 5 22 48 46 33 19 29 11 17 14 14 22 25 15 14 2 34 13 14 20 20
Nuclear Periphery 8 8 34 65 70 52 114 65 48 38 27 24 19 41 36 10 6 4 2 5 16 8 5 7
Nucleolus 3 16 21 22 22 9 14 15 3 8 3 3 28 27 11 1 6 0 1 7 6 8 14 16
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 0 0 0 1 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 24 389 212 196 347 307 462 453 274 361 199 255 234 279 356 91 55 51 55 420 244 163 237 263
Unique Cell Count 39 442 265 232 427 440 662 627 414 543 310 435 277 318 384 121 72 66 67 485 292 207 292 334
Labelled Cell Count 49 488 319 314 516 512 811 732 492 622 369 508 318 381 441 144 93 77 67 485 292 207 292 334


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 22.9 31.9 20.6 21.4 15.8 12.3 11.5 10.4 10.5 9.6 9.7 9.5 29.9 28.2 23.1 35.1 36.4 36.6 31.5 33.6 32.6
Std Deviation (1e-4) 8.3 10.7 7.7 6.2 5.2 5.0 4.8 4.1 4.0 3.9 3.9 3.7 10.6 8.6 7.3 17.5 17.1 18.1 11.6 11.9 12.6
Intensity Change (Log2) – – – 0.06 -0.38 -0.74 -0.84 -0.98 -0.96 -1.11 -1.08 -1.11 0.54 0.45 0.17 0.77 0.82 0.83 0.61 0.71 0.66

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.2 1.6 3.7 5.0 5.2 7.6 7.0 7.8 9.4 -0.6 -0.4 -1.5 2.9 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 2.6 0 0 0 0 0 0 0 0 2.1 0 0 0 0 0
Mitochondria -2.1 -1.5 0.4 -0.5 -0.6 -1.3 -1.1 0.8 1.0 -3.0 -3.9 -5.3 -3.0 0 0
Nucleus -2.9 -1.5 1.3 -0.5 -1.5 -1.8 -1.4 -2.3 -2.3 -1.4 -1.8 -1.1 3.6 3.1 3.1
Nuclear Periphery 4.2 1.3 -0.4 1.6 -1.1 -0.5 -2.7 -1.6 -3.4 -2.3 0 -1.4 -1.3 -1.0 -1.5
Nucleolus 0.6 -1.5 -3.7 -4.2 -3.8 -5.0 -4.6 -4.2 -5.1 0.9 0.2 -2.9 -2.8 0.1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 1.3 0.4 -3.0 -3.2 -2.4 -3.9 -4.0 -4.2 -5.8 1.4 2.6 4.8 -1.1 -0.7 -0.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 21.4792 28.5049 25.9696 23.3663 18.8786 25.3692 22.5592 31.3427 27.828 22.7434 21.0128 26.6092 23.6645 32.117 26.6341 26.4825 23.8745 27.9348
Actin 0.0002 0 0.0012 0 0.0018 0.0001 0.0006 0.0003 0.003 0.0337 0.0331 0.0106 0.0032 0 0 0 0 0
Bud 0.0001 0 0.0001 0 0.0002 0 0.0004 0 0.0003 0.0019 0.0024 0.0002 0.0001 0 0.0003 0 0 0
Bud Neck 0 0 0 0 0.0001 0 0.0002 0 0.0001 0.0004 0.001 0.0001 0.0002 0 0.0001 0 0 0
Bud Periphery 0.0003 0.0001 0.0002 0.0001 0.0005 0.0001 0.0013 0.0001 0.0011 0.0034 0.0036 0.0008 0.0002 0.0001 0.0007 0.0001 0.0001 0.0001
Bud Site 0.0003 0 0.0001 0 0.0002 0 0.0009 0.0001 0.0002 0.0014 0.024 0.0002 0.0001 0 0.0001 0 0 0
Cell Periphery 0.003 0.0025 0.0033 0.0023 0.0029 0.0014 0.0044 0.0051 0.003 0.0028 0.0016 0.0055 0.0039 0.0021 0.0027 0.0028 0.0009 0.0007
Cytoplasm 0.0003 0.0029 0.0002 0.0001 0.0017 0.0004 0.0045 0.0001 0.0007 0.0009 0.0071 0.0001 0.0004 0.0001 0.0001 0 0.0001 0.0001
Cytoplasmic Foci 0.0045 0 0.0005 0 0.0048 0 0.0033 0.0033 0.0005 0.016 0.0076 0.0005 0.0003 0 0 0 0 0
Eisosomes 0.0001 0 0 0 0 0 0 0 0.0002 0.0003 0.0005 0.0001 0 0 0 0 0 0
Endoplasmic Reticulum 0.0001 0 0.0002 0 0.0004 0.0002 0.0008 0 0.002 0.0014 0.0071 0.0006 0.0002 0 0 0 0 0
Endosome 0.0019 0.0006 0.0019 0.0008 0.0066 0.0014 0.0066 0.0017 0.0038 0.011 0.0216 0.0031 0.0018 0.0007 0.0013 0.0008 0.0008 0.0007
Golgi 0.0002 0 0.0004 0 0.0013 0 0.0006 0.002 0.003 0.0085 0.0055 0.0025 0.0002 0 0 0 0 0
Lipid Particles 0.0029 0.0001 0.0009 0.0007 0.0075 0.0002 0.005 0.002 0.0023 0.0179 0.0073 0.0051 0.001 0.0002 0.0007 0.0005 0.0003 0.0004
Mitochondria 0.0104 0.0001 0.0043 0.0066 0.004 0.0004 0.0188 0.002 0.005 0.0197 0.0087 0.0029 0.0065 0.0012 0.0017 0.0003 0.0002 0.0002
None 0.0008 0 0.0001 0 0.0006 0.0001 0.0019 0 0.0007 0.0018 0.0067 0.0002 0.0008 0 0 0 0 0
Nuclear Periphery 0.002 0.0053 0.0016 0.0006 0.0033 0.0065 0.003 0.0005 0.0037 0.0024 0.0077 0.0074 0.0009 0.001 0.0014 0.0003 0.0005 0.0023
Nucleolus 0.0119 0.0012 0.0101 0.0095 0.0037 0.0046 0.0191 0.0063 0.0016 0.0086 0.0014 0.0093 0.0084 0.0026 0.0025 0.0012 0.0006 0.0013
Nucleus 0.0052 0.0032 0.0101 0.0037 0.0048 0.0091 0.0107 0.0024 0.0013 0.0032 0.0036 0.0021 0.0031 0.0036 0.0032 0.0006 0.0005 0.0102
Peroxisomes 0.0004 0 0.0003 0 0.0035 0 0.0007 0.0033 0.0002 0.0034 0.003 0.0004 0.0001 0 0.0001 0 0 0
Punctate Nuclear 0.0005 0 0.0003 0 0.0046 0.0004 0.0011 0.0001 0.0001 0.0017 0.007 0.0003 0.0004 0 0 0 0 0
Vacuole 0.3119 0.3759 0.3496 0.3808 0.3715 0.2932 0.2811 0.2933 0.2927 0.3282 0.2917 0.2733 0.3121 0.3184 0.3255 0.3465 0.2819 0.264
Vacuole Periphery 0.6428 0.6082 0.6145 0.5946 0.576 0.6816 0.6348 0.6773 0.6745 0.5315 0.5479 0.6749 0.6561 0.6697 0.6595 0.6468 0.714 0.72

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 66.6566 61.715 58.4284 67.4242 61.7308 66.6197 62.9379 46.4726 50.0328 72.0783
Translational Efficiency 1.6309 1.5295 1.5298 1.2283 1.2794 1.4464 1.2777 1.2276 1.2014 1.0499

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2768 2765 2151 1143 1369 2437 2679 1607 4137 5202 4830 2750

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1884.82 2547.52 2250.13 1975.15 1895.18 2213.73 2725.00 2601.05 1888.25 2391.15 2513.52 2340.90
Standard Deviation 425.26 751.33 593.08 524.87 613.05 585.74 584.35 664.93 495.37 698.94 633.84 684.12
Intensity Change Log 2 — 0.434667 0.255582 0.067535 — 0.224144 0.523921 0.456759 — 0.332954 0.396348 0.275764

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000010 0.000045 0.000050 0.000315 0.000090 0.000048 0.000063 0.000236 0.000036 0.000046 0.000057 0.000269
Bud Neck 0.000099 0.000183 0.000334 0.004132 0.000705 0.000514 0.000602 0.001216 0.000300 0.000338 0.000482 0.002428
Bud Site 0.000123 0.000374 0.000341 0.006538 0.003456 0.000894 0.000502 0.001803 0.001226 0.000618 0.000431 0.003771
Cell Periphery 0.002312 0.004154 0.000610 0.001810 0.003596 0.001671 0.002256 0.002396 0.002737 0.002991 0.001523 0.002152
Cytoplasm 0.000007 0.000140 0.000028 0.001397 0.003318 0.000198 0.000036 0.000185 0.001102 0.000167 0.000032 0.000689
Cytoplasmic Foci 0.000078 0.000331 0.000593 0.002389 0.000929 0.000614 0.000862 0.001810 0.000360 0.000463 0.000742 0.002051
Eisosomes 0.000097 0.000114 0.000227 0.000076 0.000056 0.000096 0.000886 0.000164 0.000083 0.000106 0.000592 0.000128
Endoplasmic Reticulum 0.000354 0.000278 0.000075 0.000525 0.000645 0.000276 0.000211 0.000289 0.000450 0.000277 0.000151 0.000387
Endosome 0.000082 0.000158 0.000063 0.003521 0.001424 0.000380 0.000228 0.001596 0.000526 0.000262 0.000154 0.002396
Golgi 0.000064 0.000392 0.000129 0.004416 0.000908 0.000407 0.000175 0.002525 0.000344 0.000399 0.000154 0.003311
Lipid Particles 0.001435 0.002073 0.001749 0.002148 0.000543 0.001480 0.004403 0.004681 0.001140 0.001795 0.003221 0.003628
Mitochondria 0.000510 0.001456 0.005745 0.006281 0.000836 0.003066 0.007292 0.014362 0.000618 0.002210 0.006603 0.011003
Mitotic Spindle 0.000001 0.000012 0.000008 0.002681 0.000008 0.000014 0.000072 0.000476 0.000004 0.000013 0.000044 0.001392
None 0.000089 0.000408 0.000506 0.000755 0.001734 0.000596 0.000748 0.000905 0.000633 0.000496 0.000640 0.000842
Nuclear Periphery 0.000378 0.000572 0.001013 0.002230 0.000152 0.000711 0.000932 0.001620 0.000303 0.000637 0.000968 0.001874
Nuclear Periphery Foci 0.000138 0.000225 0.000506 0.002070 0.000194 0.000473 0.000577 0.001013 0.000157 0.000341 0.000546 0.001452
Nucleolus 0.001417 0.002567 0.009099 0.013660 0.004645 0.004881 0.009050 0.004755 0.002486 0.003651 0.009072 0.008456
Nucleus 0.000555 0.000975 0.001428 0.004791 0.003973 0.001491 0.001818 0.001234 0.001686 0.001217 0.001644 0.002712
Peroxisomes 0.000035 0.000076 0.000150 0.000579 0.000193 0.000142 0.000231 0.000288 0.000087 0.000107 0.000195 0.000409
Vacuole 0.395020 0.262445 0.281915 0.357534 0.366706 0.255897 0.468618 0.380366 0.385650 0.259378 0.385471 0.370876
Vacuole Periphery 0.597195 0.723024 0.695430 0.582152 0.605887 0.726150 0.500438 0.578081 0.600071 0.724488 0.587276 0.579773

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.14 -7.19 -3.42 -3.03 -2.98 2.62 1.60 -2.59 -3.44 -3.15 -1.37 -3.04 -4.73 -4.54 -4.32
Bud Neck -1.76 -4.94 -7.98 -7.79 -7.51 1.10 0.63 -2.20 -3.37 -3.06 -0.58 -2.67 -8.72 -8.58 -8.04
Bud Site -1.82 -1.01 -6.24 -5.99 -5.92 2.81 3.46 1.75 -1.87 -3.38 1.81 2.52 -4.79 -6.29 -6.78
Cell Periphery -4.48 7.07 1.37 5.35 -4.32 3.27 2.28 1.85 -1.86 -0.37 -0.80 4.58 1.75 2.72 -2.51
Cytoplasm -2.06 -1.50 -4.61 -4.19 -4.55 3.41 3.61 3.44 0.09 -3.71 3.03 3.54 0.65 -3.98 -5.02
Cytoplasmic Foci -7.22 -5.61 -6.45 -5.75 -4.94 0.76 0.19 -1.65 -3.46 -2.79 -0.68 -2.48 -6.03 -6.40 -5.27
Eisosomes -0.99 -5.75 1.26 3.18 7.90 -2.47 -12.32 -5.20 -3.84 10.65 -1.79 -13.00 -3.09 -1.95 11.94
Endoplasmic Reticulum 2.62 16.54 -2.74 -3.78 -7.33 3.60 4.37 3.48 -0.33 -2.42 4.41 8.49 1.33 -3.09 -7.48
Endosome -1.84 0.62 -7.13 -6.98 -7.18 2.64 3.06 -0.40 -4.22 -4.84 1.94 2.80 -6.52 -8.18 -8.63
Golgi -2.64 -1.58 -6.66 -6.07 -6.57 3.08 5.21 -3.28 -4.40 -4.95 -0.62 3.46 -7.59 -7.38 -8.14
Lipid Particles -7.29 -3.34 -1.93 -0.21 -1.07 -11.60 -22.29 -8.16 -6.26 -0.53 -10.40 -19.13 -7.42 -5.43 -1.17
Mitochondria -3.28 -6.00 -6.08 -4.99 -0.55 -4.62 -7.29 -8.28 -6.68 -3.83 -5.80 -9.55 -10.05 -8.31 -3.71
Mitotic Spindle -2.31 -2.19 -2.47 -2.46 -2.46 -1.84 -1.40 -1.78 -1.76 -1.52 -3.31 -1.57 -2.90 -2.88 -2.82
None -7.79 -9.12 -7.69 -3.69 -2.63 2.40 2.15 1.78 -1.95 -1.47 0.84 -0.04 -1.29 -3.83 -2.78
Nuclear Periphery -0.76 -3.70 -3.41 -2.81 -2.18 -4.77 -10.31 -7.50 -4.00 -3.29 -2.26 -7.23 -6.14 -4.28 -3.42
Nuclear Periphery Foci -1.88 -6.77 -3.95 -3.77 -3.19 -3.38 -7.85 -8.19 -4.53 -4.41 -4.12 -11.58 -6.12 -5.17 -4.27
Nucleolus -5.50 -10.25 -8.42 -7.56 -2.83 -0.26 -4.63 -0.17 0.13 5.98 -3.14 -12.66 -8.41 -6.76 0.69
Nucleus -2.88 -5.65 -6.43 -5.75 -5.14 3.36 2.96 3.61 0.91 2.40 1.75 0.17 -2.93 -4.88 -3.69
Peroxisomes -6.12 -6.89 -3.74 -3.46 -2.95 1.08 -0.88 -1.21 -2.00 -0.86 -1.15 -6.26 -4.32 -4.09 -2.93
Vacuole 19.82 15.62 4.25 -12.18 -9.18 12.21 -11.17 -1.42 -15.67 11.02 23.45 0.03 2.27 -20.07 2.33
Vacuole Periphery -18.24 -13.14 2.03 16.09 12.41 -12.46 10.95 2.72 17.57 -9.18 -22.21 2.14 3.33 24.10 1.46
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication
Localization
Cell Percentages vacuolar membrane (74%)
Cell Cycle Regulation No
Subcompartmental Group vac memb-2

Ypq1

Ypq1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ypq1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available