Standard name
Human Ortholog
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.12 0.16 0.06 0.1 0 0 0 0 – 0 0 0 0.06 0 0 – – 0.21 0.17 0.22 0.24 0.24 0.2 0.16
Bud 0 0.05 0 0 0.06 0.05 0.07 0 – 0.05 0.09 0.06 0 0 0 – – 0.06 0 0.05 0 0.05 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0.13 0.11 0.06 0.08 0.08 0.09
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 – – – – – –
Cell Periphery 0.09 0.05 0.1 0.09 0 0 0 0 – 0 0 0 0.06 0.1 0.05 – – 0.09 0.11 0.14 0.21 0.15 0.14 0.15
Cytoplasm 0.79 0.74 0.77 0.76 0.82 0.81 0.73 0.76 – 0.68 0.57 0.52 0.9 0.93 0.94 – – 0.6 0.38 0.31 0.22 0.28 0.38 0.35
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Mitochondria 0 0.08 0.06 0.1 0.06 0.21 0.35 0.3 – 0.47 0.59 0.61 0 0 0 – – 0.07 0.1 0.08 0.12 0.14 0.1 0.1
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Peroxisomes 0 0 0.05 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0.13 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 28 35 9 18 5 5 2 2 – 0 0 2 38 25 19 – – 45 46 56 39 48 77 48
Bud 10 10 6 8 14 14 17 9 – 19 19 18 3 9 5 – – 13 9 13 4 9 12 11
Bud Neck 6 1 1 2 6 2 1 4 – 5 0 3 23 22 18 – – 2 34 27 9 15 30 28
Bud Site 3 7 4 5 3 7 3 1 – 4 0 2 6 0 2 – – 5 – – – – – –
Cell Periphery 21 11 15 17 9 9 6 7 – 1 3 6 39 57 39 – – 20 29 36 34 30 55 44
Cytoplasm 188 162 117 143 189 209 170 234 – 236 116 168 544 553 679 – – 128 101 78 35 55 145 104
Endoplasmic Reticulum 5 6 1 1 1 0 0 0 – 0 0 6 5 3 5 – – 15 4 3 4 2 3 5
Endosome 0 0 0 0 0 2 0 1 – 0 0 2 0 0 1 – – 1 4 3 2 1 2 4
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 – – 0 0 0 2 0 0 1
Mitochondria 9 17 9 18 13 54 81 94 – 164 121 197 0 0 0 – – 15 26 20 19 28 38 31
Nucleus 0 0 1 0 0 1 1 0 – 2 1 1 0 0 0 – – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 1 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Peroxisomes 0 1 7 6 7 8 2 4 – 0 0 0 0 0 0 – – 5 2 1 2 1 2 2
SpindlePole 7 1 3 7 9 3 7 11 – 10 9 9 24 9 8 – – 27 1 1 0 1 3 4
Vac/Vac Membrane 1 0 0 0 0 2 1 0 – 0 0 1 0 0 0 – – 3 6 5 3 2 7 6
Unique Cell Count 239 220 151 187 230 258 234 309 348 205 324 604 596 719 215 269 255 164 199 385 302
Labelled Cell Count 278 251 173 225 257 316 291 368 441 269 415 682 678 777 279 269 255 164 199 385 302


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 4.1 4.0 4.0 3.9 3.1 3.2 3.0 – 2.4 2.7 2.6 5.2 5.1 5.5 4.0 4.3 5.0 5.2 5.4 5.6
Std Deviation (1e-4) 0.7 1.0 1.6 1.6 1.6 1.1 1.7 1.3 – 0.9 0.8 0.6 0.8 0.6 0.9 1.0 0.8 0.9 1.1 1.2 1.4
Intensity Change (Log2) – – – -0.01 -0.03 -0.35 -0.32 -0.4 – -0.71 -0.57 -0.64 0.39 0.34 0.46 0.01 0.1 0.34 0.38 0.44 0.49

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9288 1.1737 1.1623 2.0256 1.3021 1.5074 0.8802 1.3994 1.5278 2.4246 2.0179 1.8752 0.8591 0.8944 0.8805 1.3951 0.903 1.0838
Actin 0.0597 0.0235 0.0451 0.0237 0.0442 0.037 0.0475 0.0158 0.055 0.0095 0.0086 0.0658 0.0052 0.0075 0.0267 0.0046 0.0097 0.0322
Bud 0.0056 0.0092 0.0069 0.0191 0.0157 0.0062 0.0027 0.0018 0.005 0.0006 0.0032 0.0017 0.0014 0.0023 0.003 0.0021 0.0013 0.0017
Bud Neck 0.0382 0.0097 0.0645 0.0973 0.0631 0.1635 0.0357 0.0093 0.0545 0.1164 0.1685 0.1829 0.028 0.0098 0.0575 0.1588 0.2288 0.1689
Bud Periphery 0.0272 0.0232 0.0589 0.0521 0.0397 0.0401 0.0171 0.0069 0.0343 0.0073 0.031 0.0192 0.0056 0.0138 0.0147 0.0666 0.011 0.0275
Bud Site 0.0538 0.248 0.1279 0.0592 0.02 0.0176 0.1096 0.324 0.1077 0.0047 0.0425 0.0145 0.0361 0.2701 0.1171 0.0257 0.019 0.0039
Cell Periphery 0.1109 0.0724 0.1075 0.0925 0.106 0.099 0.2311 0.1094 0.1633 0.2088 0.2968 0.199 0.3073 0.0623 0.1378 0.1439 0.0967 0.1683
Cytoplasm 0.1766 0.2036 0.1965 0.2626 0.1807 0.2298 0.3468 0.2316 0.2252 0.3082 0.2507 0.274 0.2196 0.2268 0.2881 0.214 0.1887 0.3589
Cytoplasmic Foci 0.0163 0.0084 0.015 0.0218 0.0379 0.0183 0.023 0.0032 0.0176 0.0094 0.0103 0.0047 0.0043 0.0038 0.0051 0.0049 0.005 0.0161
Eisosomes 0.0099 0.0093 0.0042 0.0021 0.0026 0.0021 0.0083 0.0028 0.0059 0.0037 0.0015 0.0032 0.0088 0.0027 0.005 0.0026 0.0005 0.001
Endoplasmic Reticulum 0.0104 0.0024 0.0023 0.0053 0.0065 0.0026 0.0016 0.0009 0.0028 0.0038 0.0036 0.001 0.0023 0.0025 0.0022 0.0022 0.0008 0.0013
Endosome 0.0209 0.0007 0.0074 0.016 0.0172 0.0029 0.0018 0.0002 0.0039 0.0119 0.0011 0.0003 0.0001 0.0005 0.0003 0.0003 0.0001 0.0003
Golgi 0.0068 0.0012 0.0044 0.0052 0.0069 0.0013 0.0026 0.0004 0.0064 0.0234 0.0003 0.0006 0.0004 0.0004 0.0008 0.0003 0.0003 0.0005
Lipid Particles 0.0135 0.0008 0.008 0.0155 0.0257 0.0019 0.0105 0.0003 0.0049 0.0149 0.0002 0.0005 0.001 0.0007 0.0007 0.0012 0.0004 0.0015
Mitochondria 0.006 0.0014 0.0065 0.0068 0.0028 0.0011 0.0009 0.0002 0.0028 0.029 0.0028 0.0005 0.0003 0.0002 0.0002 0.0002 0 0.0002
None 0.3948 0.3713 0.3235 0.2417 0.3859 0.3548 0.1495 0.2915 0.3017 0.2369 0.131 0.2289 0.3765 0.3931 0.3368 0.3689 0.4361 0.2151
Nuclear Periphery 0.014 0.0005 0.0042 0.0121 0.0039 0.0042 0.0003 0.0001 0.0004 0.0003 0.0222 0.0001 0.0002 0.0003 0.0002 0.0002 0 0.0001
Nucleolus 0.0018 0.001 0.0023 0.003 0.0023 0.0011 0.0008 0.0003 0.0005 0.0005 0.0003 0.0003 0.0003 0.0005 0.0003 0.0003 0.0001 0.0001
Nucleus 0.0102 0.0022 0.0029 0.0185 0.0088 0.0051 0.0005 0.0004 0.0007 0.0006 0.0216 0.0004 0.0004 0.0007 0.0006 0.0004 0.0001 0.0003
Peroxisomes 0.007 0.0053 0.0061 0.0144 0.0189 0.0023 0.0064 0.0002 0.0042 0.0055 0.0002 0.0006 0.0002 0.0001 0.0003 0.0003 0.0003 0.0004
Punctate Nuclear 0.0062 0.0038 0.0014 0.0192 0.0074 0.0042 0.0011 0.0004 0.0006 0.0002 0.0005 0.0001 0.0004 0.0003 0.0008 0.0003 0.0002 0.0001
Vacuole 0.0078 0.002 0.0038 0.0093 0.0033 0.0047 0.0023 0.0007 0.0024 0.0038 0.0022 0.0018 0.0014 0.0014 0.0017 0.0021 0.0006 0.0015
Vacuole Periphery 0.0025 0.0001 0.0007 0.0024 0.0006 0.0003 0.0001 0 0.0002 0.0006 0.001 0.0001 0 0 0 0.0001 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.5462 8.2641 9.1984 7.5935 6.4211 11.2193 12.5337 10.8764 8.6212 10.7425
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
54 984 1071 144 192 1999 1324 1336 246 2983 2395 1480

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 993.16 674.84 856.66 909.62 681.84 704.95 827.09 835.54 750.18 695.02 840.31 842.75
Standard Deviation 166.63 87.32 102.25 122.68 86.43 86.00 102.13 114.20 168.91 87.59 103.24 117.13
Intensity Change Log 2 — -0.557481 -0.213303 -0.126762 — 0.048088 0.278611 0.293276 — -0.279712 0.007517 0.059198

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.018495 0.008667 0.007408 0.007220 0.002803 0.005837 0.025804 0.011510 0.006248 0.006770 0.017578 0.011092
Bud Neck 0.055332 0.049693 0.011241 0.010144 0.077930 0.079804 0.060206 0.029299 0.072970 0.069871 0.038310 0.027435
Bud Site 0.104941 0.026876 0.039689 0.072639 0.021368 0.032422 0.085714 0.076149 0.039713 0.030593 0.065133 0.075807
Cell Periphery 0.075439 0.002069 0.001912 0.015553 0.022414 0.002977 0.022340 0.014523 0.034054 0.002677 0.013205 0.014623
Cytoplasm 0.179747 0.414666 0.444401 0.270105 0.423587 0.397462 0.382761 0.434970 0.370061 0.403137 0.410326 0.418929
Cytoplasmic Foci 0.044757 0.260948 0.041415 0.059171 0.244888 0.248504 0.034870 0.034496 0.200957 0.252609 0.037796 0.036897
Eisosomes 0.008792 0.002962 0.000598 0.008445 0.015698 0.003971 0.008566 0.005335 0.014182 0.003638 0.005003 0.005637
Endoplasmic Reticulum 0.014883 0.000776 0.006848 0.008999 0.004057 0.000847 0.008341 0.002808 0.006433 0.000823 0.007674 0.003410
Endosome 0.048023 0.020721 0.003914 0.009235 0.010210 0.019362 0.001610 0.003123 0.018510 0.019810 0.002641 0.003718
Golgi 0.006389 0.005243 0.000263 0.004724 0.011646 0.007853 0.000497 0.000997 0.010492 0.006992 0.000393 0.001360
Lipid Particles 0.007060 0.010023 0.003180 0.005405 0.024612 0.011715 0.003269 0.002040 0.020759 0.011157 0.003229 0.002367
Mitochondria 0.004744 0.007424 0.000604 0.000271 0.008489 0.011871 0.000356 0.002641 0.007667 0.010404 0.000467 0.002410
Mitotic Spindle 0.000321 0.000727 0.001993 0.002376 0.000054 0.001577 0.000191 0.011925 0.000113 0.001297 0.000997 0.010996
None 0.000068 0.002431 0.002193 0.001077 0.000521 0.001023 0.001030 0.001374 0.000422 0.001488 0.001550 0.001346
Nuclear Periphery 0.003477 0.000259 0.001042 0.000586 0.000223 0.000285 0.000396 0.000623 0.000937 0.000276 0.000685 0.000619
Nuclear Periphery Foci 0.003741 0.000415 0.003117 0.003410 0.000231 0.000194 0.001081 0.001036 0.001002 0.000267 0.001991 0.001267
Nucleolus 0.000254 0.001146 0.000378 0.000151 0.000249 0.000650 0.000113 0.000231 0.000250 0.000813 0.000232 0.000224
Nucleus 0.063412 0.087087 0.345661 0.133460 0.075124 0.090158 0.276359 0.203245 0.072553 0.089145 0.307350 0.196455
Peroxisomes 0.005128 0.026643 0.001756 0.000893 0.022944 0.027211 0.002569 0.002009 0.019033 0.027023 0.002205 0.001900
Vacuole 0.345897 0.069769 0.082177 0.385559 0.030777 0.055151 0.083862 0.160752 0.099949 0.059973 0.083108 0.182625
Vacuole Periphery 0.009099 0.001456 0.000212 0.000578 0.002176 0.001127 0.000063 0.000915 0.003695 0.001236 0.000130 0.000882

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.86 1.05 1.25 2.10 1.23 -2.50 -8.92 -3.74 -1.91 5.86 -0.22 -3.49 -0.81 -1.16 4.20
Bud Neck 0.27 3.35 3.55 10.91 1.53 -0.15 1.93 4.83 14.07 7.71 0.30 3.96 5.43 14.97 4.81
Bud Site 3.09 2.73 1.91 -1.80 -1.12 -1.39 -6.90 -4.72 -5.91 3.00 1.12 -2.41 -2.32 -6.68 -0.06
Cell Periphery 2.91 2.93 2.62 -1.91 -2.05 2.88 0.32 1.70 -4.98 3.91 4.07 2.81 2.97 -5.47 0.80
Cytoplasm -8.58 -8.62 -2.55 6.93 6.98 1.47 2.73 0.94 -0.96 -3.21 -2.04 -1.35 -1.34 1.24 -0.06
Cytoplasmic Foci -18.59 0.30 -0.46 24.46 -1.34 -0.26 13.04 13.24 41.98 1.08 -3.70 11.83 12.09 51.64 1.70
Eisosomes 1.67 2.47 1.03 -0.88 -2.26 3.76 2.48 3.74 -0.03 3.75 4.12 3.74 3.92 -0.66 0.68
Endoplasmic Reticulum 2.33 1.13 1.24 -5.48 0.62 2.22 -2.55 0.71 -9.10 5.94 3.19 -0.99 1.68 -11.21 8.04
Endosome 1.99 3.29 3.07 5.22 -1.00 -5.01 5.70 4.79 14.19 -2.90 -0.56 4.84 4.70 17.07 -0.81
Golgi 0.32 2.11 0.99 1.12 -0.96 2.24 6.95 6.66 11.04 -0.93 2.38 7.19 6.58 10.96 -1.54
Lipid Particles -1.52 1.79 1.15 5.40 -2.03 3.58 5.96 6.39 13.71 2.15 3.33 6.10 6.52 15.97 3.14
Mitochondria -0.68 0.97 1.07 7.10 2.61 -1.74 4.92 3.56 7.92 -2.23 -1.58 4.58 3.39 8.47 -2.04
Mitotic Spindle -1.55 -2.15 -1.74 -1.64 -1.32 -2.78 -3.00 -5.36 -4.43 -5.29 -3.17 -2.58 -5.60 -4.85 -5.03
None -6.32 -12.95 -2.57 0.78 0.31 -2.83 -2.35 -3.44 -1.21 -1.29 -5.95 -7.07 -4.46 0.55 0.46
Nuclear Periphery 0.97 0.65 0.77 -7.00 3.61 -0.57 -4.73 -3.15 -2.45 -1.66 0.90 0.10 0.19 -3.03 0.41
Nuclear Periphery Foci 1.76 0.03 0.18 -5.98 0.54 0.52 -9.22 -8.25 -8.60 0.35 1.73 -2.93 -0.79 -10.05 6.16
Nucleolus -4.78 -1.02 -0.14 5.71 1.28 -6.58 3.25 -0.22 4.57 -1.84 -8.54 -0.09 -0.24 6.79 -0.20
Nucleus -0.53 -9.52 -2.43 -4.33 12.81 -2.01 -21.88 -15.05 -18.65 8.69 -1.72 -24.88 -13.15 -19.60 15.11
Peroxisomes -7.74 1.93 2.59 11.52 2.86 -1.07 5.51 5.69 15.21 1.42 -2.48 5.70 5.83 18.62 1.13
Vacuole 6.49 5.71 -1.36 -14.07 -12.64 -5.29 -11.80 -23.64 -23.23 -15.77 3.13 0.18 -8.93 -25.60 -18.79
Vacuole Periphery 1.17 1.37 1.35 3.83 -0.54 1.04 2.10 1.34 0.95 -1.42 1.51 2.22 1.82 1.39 -1.32
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Wsc3

Wsc3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Wsc3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available