Standard name
Human Ortholog
Description Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0.05 0.06 0.07 0.07 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0.07 0.07 0.06 0.07 0.09 0.09 0.14 0.09 0.14 0 0.05 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.93 0.94 0.85 0.84 0.75 0.73 0.69 0.66 0.61 0.61 0.98 0.97 0.98 0.94 0.93 0.93 0.93 0.93 0.94 0.94 0.9 0.89
Endoplasmic Reticulum 0 0 0.06 0.05 0 0.05 0.11 0.11 0.15 0.17 0.11 0.19 0 0 0 0 0 0 0 0 0 0 0.06 0.06
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0.08 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.08 0 0 0.08 0.07 0.13 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.11 0 0.05 0.08 0.07 0 0.08 0.05 0 0 0 0 0.07 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 4 13 19 29 23 26 26 37 0 1 0 1 1 1 1 1 0 0 0 0
Bud 0 0 0 0 0 0 3 2 1 0 3 0 0 0 1 0 0 0 0 0 0 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 5 7 13 26 19 35 52 32 52 37 50 8 24 13 3 3 7 0 0 2 0 0 1
Cytoplasm 307 249 140 180 297 285 378 423 253 255 241 224 358 464 536 174 225 248 289 242 146 392 388 423
Endoplasmic Reticulum 7 3 9 9 10 17 55 61 55 66 45 70 9 17 6 7 5 9 9 6 3 16 28 27
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 3
Golgi 0 1 1 2 13 1 38 21 12 17 18 10 0 1 0 4 2 5 0 1 0 1 1 2
Mitochondria 0 1 0 1 3 27 10 13 29 26 51 33 0 0 1 2 5 1 0 0 0 1 1 1
Nucleus 0 0 1 0 0 1 1 5 0 1 1 1 0 0 0 1 0 0 0 0 0 0 1 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 1 1
Nucleolus 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 0 38 14 23 47 25 13 33 17 0 1 0 7 17 12 3 2 1 1 4 2
Unique Cell Count 316 255 150 192 349 341 503 580 366 385 395 366 364 479 546 185 243 266 310 260 156 419 433 474
Labelled Cell Count 319 259 158 207 391 377 564 654 430 456 455 443 375 509 557 199 258 284 310 260 156 419 433 474


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 18.7 21.2 18.5 17.3 19.7 14.7 18.6 17.4 17.1 18.0 16.9 17.3 18.2 21.0 21.8 24.4 23.1 24.7 17.4 18.1 19.2
Std Deviation (1e-4) 2.9 3.9 3.0 2.8 5.9 3.8 3.5 3.5 3.7 4.0 4.1 4.1 3.3 4.1 4.1 6.8 6.6 6.0 2.9 3.4 3.7
Intensity Change (Log2) – – – -0.09 0.09 -0.34 0.0 -0.09 -0.11 -0.04 -0.13 -0.1 -0.02 0.18 0.23 0.4 0.32 0.41 -0.09 -0.03 0.05

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 2.8 3.1 3.3 3.2 4.0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.8 1.1 0.4 1.0 1.7 1.6 2.9 1.8 3.0 0 0.2 0 0 0 -1.1
Cytoplasm 0.2 -2.6 -2.9 -4.8 -5.3 -5.9 -6.4 -7.3 -7.3 3.0 1.9 3.1 0.3 -0.3 0
Endoplasmic Reticulum -0.5 -1.7 -0.5 1.8 1.7 2.8 3.3 1.9 3.8 -2.0 -1.3 0 -0.9 -2.0 -1.3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 3.1 0 0 2.2 2.2 0 0 0 0 0 0 0
Mitochondria 0 0 3.5 0 0 3.5 3.3 4.6 3.8 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 4.2 0 2.7 3.6 3.3 0 3.7 0 0 0 0 0 3.3 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.786 14.6225 14.0868 13.1055 11.7413 13.8 14.6223 20.7999 18.4995 18.4953 15.612 18.7037 17.7158 22.784 21.0821 19.6204 20.8354 21.0542
Actin 0.0175 0.0009 0.0015 0.0015 0.0104 0.0014 0.0187 0.0004 0.0018 0.0006 0.0064 0.0018 0.0007 0.0003 0.0006 0.0003 0.0002 0.004
Bud 0.0007 0.0003 0.001 0.0005 0.001 0.0003 0.0008 0.0001 0.0003 0.0003 0.0002 0.0001 0.0002 0.0001 0.0002 0.0003 0.0001 0.0007
Bud Neck 0.0008 0.0002 0.0004 0.0005 0.0008 0.001 0.0025 0.0002 0.0004 0.0004 0.0005 0.0006 0.0002 0.0002 0.0003 0.0003 0.0004 0.001
Bud Periphery 0.0008 0.0001 0.0012 0.0002 0.001 0.0002 0.0008 0 0.0002 0.0001 0.0002 0.0001 0.0001 0 0.0001 0 0 0.0012
Bud Site 0.0013 0.0005 0.0007 0.0007 0.0008 0.0001 0.0018 0.0002 0.0005 0.0002 0.0005 0.0001 0.0003 0.0003 0.0002 0.0002 0 0.0011
Cell Periphery 0.0004 0.0003 0.0002 0.0002 0.0003 0.0001 0.0004 0.0002 0.0001 0.0001 0.0002 0 0.0003 0.0001 0.0001 0 0 0.0001
Cytoplasm 0.7675 0.9622 0.9371 0.8335 0.7432 0.899 0.7841 0.983 0.9293 0.9135 0.8422 0.9221 0.8941 0.946 0.9542 0.9671 0.9747 0.9129
Cytoplasmic Foci 0.0218 0.0048 0.0085 0.0425 0.0254 0.0132 0.0177 0.0029 0.0091 0.015 0.021 0.0078 0.0105 0.0295 0.0111 0.0048 0.0047 0.0087
Eisosomes 0.0001 0 0 0 0.0001 0 0.0002 0 0 0 0.0001 0 0 0 0 0 0 0.0001
Endoplasmic Reticulum 0.0542 0.0164 0.0118 0.0203 0.0173 0.0309 0.0532 0.0052 0.0147 0.0075 0.0133 0.0349 0.0551 0.0055 0.0163 0.0044 0.0081 0.0371
Endosome 0.0493 0.007 0.02 0.0485 0.0931 0.0318 0.0453 0.0031 0.02 0.0178 0.0497 0.0198 0.0182 0.0056 0.0075 0.0111 0.0063 0.0169
Golgi 0.0131 0.002 0.0018 0.0041 0.0237 0.0041 0.0073 0.0004 0.0032 0.001 0.0084 0.0037 0.002 0.003 0.001 0.0004 0.0003 0.0037
Lipid Particles 0.0088 0.0001 0.0003 0.0125 0.0038 0.002 0.0081 0.0001 0.0027 0.0017 0.0121 0.0007 0.0009 0.0004 0.0001 0.0001 0.0001 0.0002
Mitochondria 0.0125 0.001 0.0056 0.0021 0.059 0.0033 0.0095 0.0001 0.0015 0.0007 0.0147 0.0015 0.0007 0.0002 0.0002 0.0002 0.0001 0.003
None 0.0035 0.0004 0.0006 0.0015 0.0014 0.0005 0.0033 0.0003 0.0009 0.0072 0.0028 0.0006 0.0021 0.0003 0.0003 0.0004 0.0002 0.0011
Nuclear Periphery 0.0166 0.0007 0.0009 0.0044 0.0034 0.0017 0.0142 0.0006 0.0041 0.0038 0.0132 0.0014 0.005 0.0006 0.0015 0.0019 0.0009 0.0026
Nucleolus 0.0005 0 0 0.0002 0.0001 0 0.0006 0 0.0003 0.0001 0.0003 0 0.0001 0.0004 0 0 0 0.0003
Nucleus 0.0055 0.0006 0.0011 0.0014 0.002 0.0008 0.0082 0.0007 0.0032 0.0016 0.0022 0.0009 0.0018 0.0008 0.001 0.0012 0.0017 0.0014
Peroxisomes 0.0033 0 0.0004 0.0019 0.0015 0.0047 0.0037 0 0.0004 0.0004 0.0011 0.0003 0.0002 0.0005 0.0012 0 0 0.0002
Punctate Nuclear 0.0059 0.0001 0.0001 0.0011 0.0007 0.0011 0.0052 0 0.0004 0.0004 0.0025 0.0005 0.0008 0.0027 0.0001 0.0001 0.0001 0.0008
Vacuole 0.0124 0.0018 0.0055 0.0173 0.007 0.0027 0.0116 0.0024 0.0056 0.0241 0.0061 0.0022 0.0057 0.0031 0.0034 0.0062 0.0016 0.0018
Vacuole Periphery 0.0037 0.0003 0.0012 0.0051 0.0042 0.0012 0.0028 0.0002 0.0013 0.0036 0.0021 0.0008 0.001 0.0002 0.0006 0.0012 0.0005 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 43.1692 63.2886 26.345 43.0499 55.9707 32.7904 51.1148 52.6703 51.9627 44.1575
Translational Efficiency 3.5211 2.7198 4.0475 2.5238 2.6407 4.5545 2.2738 2.221 2.1468 2.4772

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
292 855 177 1271 2122 2251 1048 1549 2414 3106 1225 2820

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1357.40 1378.17 1950.68 2021.05 1319.79 1399.84 1905.47 2219.84 1324.34 1393.87 1912.00 2130.24
Standard Deviation 273.85 253.95 263.71 330.29 198.51 216.24 283.80 369.25 209.43 227.45 281.44 365.85
Intensity Change Log 2 — 0.021908 0.523131 0.574259 — 0.084954 0.529839 0.750147 — 0.053332 0.526442 0.663648

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000766 0.000433 0.001817 0.000698 0.000260 0.000366 0.000603 0.000782 0.000322 0.000385 0.000778 0.000744
Bud Neck 0.000624 0.000763 0.008692 0.001947 0.000448 0.000673 0.001618 0.001391 0.000469 0.000698 0.002640 0.001642
Bud Site 0.070761 0.025369 0.048419 0.022092 0.015645 0.017940 0.014741 0.017588 0.022312 0.019985 0.019607 0.019618
Cell Periphery 0.014891 0.000926 0.007335 0.018400 0.000395 0.000262 0.004223 0.011343 0.002148 0.000445 0.004672 0.014524
Cytoplasm 0.551843 0.834407 0.588300 0.774263 0.794347 0.822864 0.873969 0.843260 0.765014 0.826042 0.832693 0.812162
Cytoplasmic Foci 0.184047 0.072985 0.067471 0.011303 0.115064 0.075471 0.012200 0.010091 0.123408 0.074787 0.020186 0.010637
Eisosomes 0.000011 0.000005 0.000013 0.000008 0.000005 0.000005 0.000004 0.000006 0.000006 0.000005 0.000005 0.000007
Endoplasmic Reticulum 0.022573 0.004798 0.002660 0.001640 0.010246 0.003265 0.001536 0.000832 0.011737 0.003687 0.001699 0.001196
Endosome 0.010130 0.006221 0.020653 0.003153 0.005763 0.004899 0.001972 0.001616 0.006292 0.005263 0.004671 0.002309
Golgi 0.056142 0.016641 0.025843 0.013562 0.016897 0.010803 0.011448 0.010853 0.021644 0.012410 0.013528 0.012074
Lipid Particles 0.013647 0.004493 0.028482 0.038281 0.002029 0.001112 0.019093 0.027355 0.003435 0.002042 0.020450 0.032279
Mitochondria 0.000396 0.000225 0.000028 0.000056 0.000352 0.000755 0.000020 0.000099 0.000358 0.000609 0.000021 0.000079
Mitotic Spindle 0.002330 0.001826 0.009844 0.001584 0.000959 0.001933 0.000704 0.000979 0.001125 0.001904 0.002025 0.001252
None 0.000558 0.000635 0.000152 0.000988 0.000312 0.000583 0.000656 0.000518 0.000342 0.000598 0.000583 0.000730
Nuclear Periphery 0.000059 0.000034 0.000225 0.000146 0.000044 0.000028 0.000048 0.000056 0.000045 0.000030 0.000074 0.000097
Nuclear Periphery Foci 0.003184 0.002846 0.013681 0.005131 0.001230 0.000396 0.006418 0.003696 0.001466 0.001070 0.007467 0.004343
Nucleolus 0.001379 0.000065 0.000050 0.000075 0.000041 0.000064 0.000032 0.000072 0.000203 0.000065 0.000035 0.000074
Nucleus 0.006026 0.001983 0.006091 0.003380 0.002032 0.003349 0.005536 0.004252 0.002515 0.002973 0.005616 0.003859
Peroxisomes 0.000681 0.000437 0.000410 0.000290 0.000316 0.000495 0.000091 0.000323 0.000360 0.000479 0.000137 0.000308
Vacuole 0.015506 0.017681 0.162984 0.096737 0.018923 0.044421 0.042796 0.060660 0.018510 0.037060 0.060162 0.076921
Vacuole Periphery 0.044447 0.007229 0.006850 0.006266 0.014692 0.010315 0.002293 0.004227 0.018291 0.009465 0.002951 0.005146

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.98 -4.14 0.26 -3.94 4.44 -1.08 -3.24 -3.99 -2.85 -0.70 -0.82 -4.49 -5.28 -3.97 0.61
Bud Neck -1.24 -9.12 -9.20 -8.34 7.41 -2.21 -7.87 -8.96 -6.37 1.28 -2.76 -11.23 -13.16 -10.26 4.61
Bud Site 7.41 2.65 7.83 0.96 4.82 -1.75 0.06 -1.58 -0.13 -1.26 1.65 0.92 1.27 -0.29 0.06
Cell Periphery 4.96 2.44 -0.82 -11.24 -4.72 3.71 -9.78 -11.23 -11.38 -6.67 4.79 -4.46 -12.87 -15.97 -9.95
Cytoplasm -14.13 -0.82 -10.72 6.63 -8.33 -3.99 -9.50 -5.72 -2.11 3.79 -9.07 -7.23 -5.74 3.37 2.63
Cytoplasmic Foci 9.05 9.10 14.86 14.16 10.08 9.53 29.19 30.29 24.57 1.74 12.42 29.03 33.47 28.28 6.39
Eisosomes 4.90 -1.14 2.37 -4.70 3.66 -0.48 0.96 -2.10 -1.50 -2.69 1.42 -0.14 -2.83 -4.01 -2.43
Endoplasmic Reticulum 5.13 5.95 6.26 3.14 1.98 5.64 6.65 8.14 4.97 1.07 6.88 8.25 9.57 5.40 0.88
Endosome 3.41 -4.92 6.51 3.89 8.69 1.78 10.46 11.11 7.65 1.29 2.33 3.25 10.21 7.24 5.29
Golgi 7.65 5.70 8.40 2.08 4.16 5.98 4.71 5.61 0.08 0.54 8.33 6.63 8.72 0.64 1.30
Lipid Particles 2.48 -3.08 -5.72 -14.70 -2.31 4.25 -11.07 -13.68 -14.23 -3.28 2.73 -11.59 -19.14 -21.01 -5.61
Mitochondria 1.33 4.67 4.33 1.62 -3.28 -2.38 11.67 7.69 3.90 -4.70 -1.98 12.56 9.79 4.23 -5.91
Mitotic Spindle 0.67 -4.58 0.63 0.02 4.88 -1.51 1.26 -0.08 1.45 -1.18 -1.56 -2.98 -0.66 1.00 1.87
None -0.27 1.92 -0.73 -0.65 -1.70 -2.50 -3.54 -2.08 0.41 0.90 -2.88 -2.71 -1.68 -0.50 -0.61
Nuclear Periphery 1.62 -5.65 -1.32 -1.68 1.53 1.37 -0.66 -1.36 -5.22 -1.46 1.52 -3.21 -1.70 -2.28 -0.57
Nuclear Periphery Foci 0.40 -6.41 -2.10 -4.74 5.95 2.74 -10.40 -6.70 -14.08 5.87 1.32 -12.19 -8.43 -14.54 6.91
Nucleolus 1.04 1.05 1.03 -0.50 -4.10 -3.54 1.83 -5.37 -1.46 -8.97 0.92 1.09 0.85 -1.32 -11.46
Nucleus 1.12 -0.21 0.59 -7.44 3.98 -5.86 -10.38 -7.66 -3.97 1.90 -0.96 -6.30 -3.83 -5.76 4.03
Peroxisomes 1.31 1.38 2.07 2.39 1.79 -2.71 4.54 -0.09 2.90 -5.61 -1.94 4.45 0.96 3.91 -6.09
Vacuole -0.93 -9.08 -18.19 -18.29 3.87 -9.59 -8.53 -14.64 -5.07 -4.56 -8.99 -11.72 -23.13 -14.07 -4.04
Vacuole Periphery 7.02 7.22 7.34 0.97 0.34 3.52 12.04 9.76 7.27 -4.15 7.03 13.69 11.50 6.29 -5.07
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Mdy2

Mdy2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mdy2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available