Standard name
Human Ortholog
Description Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.12 0.05 0 0 0 0 0 0 0 0 0 0 0 0.08 0.06 0.07 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.99 0.97 0.94 0.82 0.78 0.83 0.69 0.69 0.64 0.59 1.0 0.99 0.99 0.96 0.95 0.96 0.97 0.97 0.92 0.96 0.94 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0.08 0.26 0.34 0.19 0.41 0.44 0.53 0.51 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.06 0 0.06 0.08 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 1
Bud 1 0 0 0 3 2 6 6 6 8 7 7 1 0 0 0 2 0 0 0 1 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 9 34 7 4 7 12 12 6 9 7 8 13 14 13 23 20 20 0 0 0 0 0 0
Cytoplasm 180 464 289 128 174 196 256 334 177 255 162 171 502 428 483 281 309 268 178 460 263 384 392 426
Endoplasmic Reticulum 0 2 2 0 0 2 0 1 0 1 1 3 1 4 4 16 10 11 0 2 4 2 3 2
Endosome 0 0 1 0 0 3 1 2 0 0 1 0 0 1 0 0 1 0 0 3 3 3 3 8
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 1 1 1
Mitochondria 2 0 3 6 14 61 111 76 106 163 134 149 1 0 0 3 3 3 0 0 1 1 3 2
Nucleus 1 2 1 0 0 2 1 3 2 2 1 1 2 4 3 5 3 1 0 0 0 0 2 1
Nuclear Periphery 1 0 0 0 0 1 1 1 1 2 6 5 0 0 0 0 0 1 0 0 0 0 1 4
Nucleolus 0 0 0 0 0 1 0 1 1 5 0 0 0 0 0 0 1 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0
SpindlePole 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0
Vac/Vac Membrane 1 3 3 3 7 15 14 24 20 21 16 6 0 0 0 4 10 1 1 0 0 0 2 2
Unique Cell Count 184 469 293 132 186 239 328 401 257 372 255 292 504 433 488 293 324 280 184 473 288 399 418 464
Labelled Cell Count 189 481 334 144 202 291 402 460 319 467 336 350 520 452 503 332 359 307 184 473 288 399 418 464


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.2 10.0 10.4 8.4 7.7 6.6 5.9 6.2 5.5 5.7 5.1 4.7 10.1 9.8 9.0 18.0 16.5 18.4 11.2 10.9 10.8
Std Deviation (1e-4) 0.9 1.4 3.9 2.4 2.6 2.3 2.0 1.9 1.1 2.6 1.8 0.9 1.1 1.0 1.0 4.1 3.8 4.3 1.3 1.5 1.6
Intensity Change (Log2) – – – -0.29 -0.43 -0.64 -0.8 -0.74 -0.92 -0.87 -1.01 -1.13 -0.04 -0.08 -0.2 0.8 0.67 0.83 0.12 0.07 0.06

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.0 -3.7 -3.7 -3.8 -4.5 -4.2 -4.8 -3.9 0 -5.2 -4.5 -5.1 -1.5 -2.4 -1.8
Cytoplasm -1.2 -3.0 -6.7 -7.8 -6.6 -9.7 -10.0 -10.7 -11.8 1.5 0.3 0.4 -2.0 -2.3 -2.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 3.4 2.2 2.6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.7 8.6 10.5 7.3 11.8 12.7 13.9 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 3.3 2.5 3.3 4.0 3.2 3.4 0 0 0 0 0 1.8 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.1169 6.0918 6.0091 5.5181 5.515 5.7739 3.4913 5.1839 4.1695 4.04 3.7433 4.8094 4.4552 5.603 4.8926 5.4105 5.0634 5.0044
Actin 0.0188 0.0007 0.0052 0.0086 0.0052 0.0003 0.0684 0.0014 0.0295 0.0685 0.0368 0.002 0.0184 0.0009 0.0015 0.0001 0.0001 0.0049
Bud 0.0007 0.0001 0.0003 0.0003 0.0003 0.0001 0.005 0.0005 0.0013 0.0009 0.0008 0.0003 0.0005 0.011 0.0038 0.0001 0.0001 0.0024
Bud Neck 0.0019 0.0001 0.001 0.0004 0.001 0.0005 0.0153 0.0003 0.0023 0.001 0.0018 0.0019 0.0015 0.0002 0.0004 0.0004 0.0002 0.0009
Bud Periphery 0.0004 0 0.0003 0.0001 0.0003 0 0.0068 0.0002 0.0011 0.001 0.0007 0.0003 0.0006 0.0031 0.0013 0 0 0.001
Bud Site 0.0099 0.0005 0.0007 0.0019 0.0002 0 0.0083 0.0062 0.0054 0.014 0.005 0.0002 0.0031 0.0049 0.0027 0 0 0.0003
Cell Periphery 0.0003 0.0002 0.0002 0.0001 0.0001 0 0.0008 0.0002 0.0002 0.0003 0.0002 0 0.0003 0.0002 0.0001 0 0 0.0001
Cytoplasm 0.8818 0.9502 0.9535 0.9333 0.8937 0.9541 0.7217 0.968 0.8458 0.8457 0.7248 0.9526 0.8562 0.9471 0.9475 0.982 0.978 0.9498
Cytoplasmic Foci 0.0117 0.0031 0.0056 0.0208 0.0161 0.0038 0.0245 0.0045 0.0193 0.009 0.047 0.0064 0.0244 0.0052 0.0084 0.0036 0.0052 0.0087
Eisosomes 0.0002 0 0.0001 0.0001 0.0001 0 0.0004 0 0.0001 0.0002 0.0002 0 0.0002 0 0 0 0 0.0001
Endoplasmic Reticulum 0.0072 0.0023 0.0021 0.0022 0.0025 0.0028 0.014 0.0031 0.0041 0.0012 0.0082 0.0014 0.0067 0.0037 0.0017 0.002 0.0029 0.0028
Endosome 0.007 0.0019 0.0039 0.0075 0.0105 0.0026 0.029 0.0029 0.0274 0.0101 0.0667 0.0095 0.0272 0.0045 0.0053 0.003 0.006 0.0086
Golgi 0.0015 0.0002 0.0009 0.0021 0.0028 0.0002 0.009 0.0004 0.0104 0.0046 0.0421 0.0045 0.005 0.0003 0.0013 0.0001 0.0002 0.0023
Lipid Particles 0.0012 0.0001 0.0005 0.0018 0.0003 0.0001 0.0123 0.0002 0.0067 0.0039 0.0363 0.0086 0.0093 0.0001 0.0035 0 0 0.0012
Mitochondria 0.0006 0.0001 0.0007 0.0008 0.001 0.0001 0.0071 0.0001 0.0048 0.0181 0.0067 0.0052 0.0027 0.0005 0.0012 0.0001 0.0002 0.0006
None 0.0318 0.0381 0.0192 0.0052 0.0628 0.0256 0.0187 0.0096 0.0199 0.0034 0.0016 0.003 0.0204 0.0113 0.0152 0.0055 0.0035 0.0074
Nuclear Periphery 0.0095 0.0005 0.0009 0.0016 0.0005 0.0069 0.02 0.0004 0.0024 0.0007 0.0016 0.0005 0.0051 0.002 0.0006 0.0003 0.0008 0.002
Nucleolus 0.0001 0 0.0001 0.0002 0 0 0.0027 0 0.0003 0.0007 0.0006 0 0.0002 0.0002 0.0001 0 0 0.0002
Nucleus 0.0049 0.0007 0.0013 0.0014 0.0009 0.0016 0.011 0.0008 0.0023 0.0014 0.001 0.0012 0.0035 0.0023 0.0017 0.0011 0.0014 0.0025
Peroxisomes 0.007 0 0.0003 0.0032 0.0006 0.0001 0.0099 0.0001 0.007 0.0111 0.0111 0.0011 0.0079 0.0001 0.0014 0 0 0.0005
Punctate Nuclear 0.0016 0.0002 0.002 0.0077 0.0003 0.0002 0.0063 0.0002 0.0032 0.0003 0.002 0.0005 0.0039 0.0006 0.0011 0.0001 0.0002 0.003
Vacuole 0.0016 0.0008 0.0011 0.0008 0.0005 0.0005 0.0061 0.0006 0.0057 0.0033 0.0038 0.0005 0.002 0.0014 0.001 0.0013 0.001 0.0007
Vacuole Periphery 0.0004 0.0001 0.0002 0.0002 0.0002 0.0003 0.0026 0.0001 0.001 0.0007 0.0012 0.0002 0.0007 0.0004 0.0002 0.0003 0.0002 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.2377 37.8793 41.5999 27.1431 31.8646 13.552 30.8313 22.7477 16.192 32.7104
Translational Efficiency 1.5285 1.4302 0.9296 0.8161 0.9019 1.7569 1.2339 0.9187 1.1143 0.9651

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1668 664 989 1925 1885 2067 1095 1345 3553 2731 2084 3270

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 841.27 1043.99 1191.71 1436.85 858.06 992.28 1265.69 1465.33 850.18 1004.85 1230.58 1448.56
Standard Deviation 108.58 141.43 159.26 198.85 113.21 134.54 174.25 203.09 111.38 138.04 171.33 201.10
Intensity Change Log 2 — 0.311467 0.502392 0.772269 — 0.209669 0.560774 0.772075 — 0.260963 0.532167 0.772171

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000173 0.000333 0.000175 0.002207 0.000185 0.000241 0.000359 0.000415 0.000179 0.000263 0.000272 0.001470
Bud Neck 0.002157 0.001527 0.000644 0.001593 0.002474 0.001766 0.001028 0.001397 0.002326 0.001708 0.000846 0.001513
Bud Site 0.009479 0.019181 0.005264 0.014575 0.010283 0.012043 0.006659 0.012639 0.009905 0.013779 0.005997 0.013779
Cell Periphery 0.000069 0.000093 0.000041 0.000068 0.000147 0.000056 0.000097 0.000105 0.000111 0.000065 0.000070 0.000083
Cytoplasm 0.712116 0.771394 0.821213 0.826612 0.677360 0.794651 0.796029 0.850830 0.693677 0.788996 0.807981 0.836573
Cytoplasmic Foci 0.162285 0.129180 0.010533 0.014940 0.201373 0.101138 0.019646 0.022972 0.183023 0.107956 0.015321 0.018243
Eisosomes 0.000024 0.000013 0.000004 0.000005 0.000049 0.000014 0.000011 0.000004 0.000037 0.000014 0.000008 0.000005
Endoplasmic Reticulum 0.001560 0.001177 0.000220 0.000198 0.004688 0.000491 0.000605 0.000086 0.003219 0.000658 0.000422 0.000152
Endosome 0.010121 0.009307 0.000477 0.002551 0.009574 0.006211 0.003122 0.002521 0.009831 0.006964 0.001867 0.002539
Golgi 0.004593 0.002705 0.000092 0.002275 0.008757 0.003406 0.001588 0.002786 0.006802 0.003236 0.000878 0.002485
Lipid Particles 0.001546 0.001010 0.000284 0.000787 0.002861 0.000629 0.000766 0.000809 0.002243 0.000721 0.000537 0.000796
Mitochondria 0.002616 0.000228 0.000108 0.000878 0.001826 0.000503 0.000489 0.000454 0.002197 0.000436 0.000308 0.000704
Mitotic Spindle 0.000914 0.001255 0.001226 0.037138 0.002216 0.007338 0.008666 0.018801 0.001605 0.005859 0.005136 0.029596
None 0.001918 0.000982 0.005174 0.001860 0.003585 0.002472 0.004523 0.004201 0.002802 0.002110 0.004832 0.002823
Nuclear Periphery 0.000069 0.000067 0.000151 0.000150 0.000094 0.000046 0.000255 0.000104 0.000082 0.000051 0.000206 0.000131
Nuclear Periphery Foci 0.000709 0.002138 0.001745 0.001547 0.000831 0.000840 0.006423 0.002517 0.000774 0.001156 0.004203 0.001946
Nucleolus 0.000260 0.000148 0.000066 0.000145 0.000252 0.000167 0.000096 0.000100 0.000256 0.000162 0.000082 0.000126
Nucleus 0.020633 0.013671 0.126993 0.047602 0.024193 0.017989 0.077535 0.042473 0.022522 0.016939 0.101007 0.045493
Peroxisomes 0.000885 0.001286 0.000081 0.000782 0.000951 0.001553 0.000504 0.000657 0.000920 0.001488 0.000303 0.000731
Vacuole 0.065504 0.042790 0.025457 0.041549 0.044890 0.047208 0.070870 0.035752 0.054567 0.046134 0.049318 0.039165
Vacuole Periphery 0.002370 0.001516 0.000051 0.002538 0.003410 0.001237 0.000728 0.000377 0.002922 0.001305 0.000407 0.001649

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.47 -1.05 -2.62 -1.99 -2.37 -1.21 -4.88 -3.26 -1.75 1.71 -2.44 -4.06 -2.96 -2.40 -2.01
Bud Neck 2.46 7.40 4.29 0.40 -4.07 3.05 5.66 3.90 0.59 -1.28 3.53 9.10 6.00 1.20 -3.45
Bud Site -4.65 2.42 0.93 5.02 -1.75 -1.53 3.33 0.21 1.51 -2.53 -4.01 3.80 1.04 4.49 -2.69
Cell Periphery -2.96 3.99 -0.81 2.37 -4.51 15.63 5.19 5.69 -9.90 0.36 11.32 6.39 5.35 -5.93 -1.17
Cytoplasm -5.38 -8.02 -6.86 0.46 1.72 -16.11 -4.35 -12.02 2.92 -6.39 -16.23 -8.48 -13.54 3.59 -3.89
Cytoplasmic Foci 4.67 34.80 34.56 19.11 -1.68 19.85 42.04 39.50 23.16 -4.06 19.02 54.24 53.06 32.47 -3.13
Eisosomes 4.40 8.22 8.59 7.19 1.10 12.12 12.24 15.57 8.23 11.91 12.13 14.66 17.60 10.70 10.45
Endoplasmic Reticulum 0.90 4.41 4.92 2.80 3.45 6.16 6.03 6.85 2.97 11.14 6.41 7.17 8.09 3.85 9.98
Endosome 0.75 15.65 14.45 7.38 -2.70 5.14 13.72 16.88 9.10 3.03 4.99 20.81 22.21 12.02 1.75
Golgi 3.45 14.26 10.46 4.02 -2.68 6.83 10.88 11.58 4.10 -0.16 6.70 15.19 15.31 5.48 -0.99
Lipid Particles 1.58 5.08 0.18 -1.70 -8.97 10.39 8.33 4.66 -8.31 -5.02 9.04 9.62 3.78 -7.67 -9.09
Mitochondria 2.63 2.76 2.57 -0.32 -1.38 4.39 4.87 5.64 3.25 0.55 3.87 4.41 4.34 2.20 -0.36
Mitotic Spindle -0.69 -1.52 -6.75 -6.68 -6.05 -3.07 -3.02 -4.73 -2.22 -1.82 -3.47 -3.35 -8.11 -4.63 -5.13
None 2.41 -6.39 -0.26 -5.59 9.24 1.43 -0.23 0.97 -0.84 2.21 1.37 -3.35 1.04 -0.76 7.98
Nuclear Periphery -0.09 -10.58 -12.26 -8.83 0.04 3.26 -14.53 -6.47 -12.97 10.17 2.85 -17.80 -12.96 -18.17 7.57
Nuclear Periphery Foci -6.17 -6.57 -10.25 0.52 0.94 -0.18 -12.31 -13.57 -13.45 5.78 -4.36 -13.74 -16.57 -11.45 6.26
Nucleolus 2.44 4.97 2.90 -0.16 -8.16 2.20 5.43 4.31 1.17 -1.21 2.94 7.30 4.96 0.77 -5.86
Nucleus 3.98 -27.45 -19.43 -21.97 17.22 5.39 -22.30 -13.21 -16.41 11.67 5.74 -34.74 -23.61 -27.84 19.99
Peroxisomes -1.80 12.26 6.41 4.33 -3.33 -1.99 4.43 3.77 3.87 -0.83 -2.50 8.65 6.79 5.10 -2.01
Vacuole 5.09 2.98 -13.08 -16.13 -13.86 -1.73 -15.99 -15.74 -14.56 3.67 3.19 -11.38 -20.91 -22.70 -4.88
Vacuole Periphery 1.95 10.57 4.61 1.62 -2.03 4.43 8.35 10.80 2.74 0.89 4.48 12.31 9.56 2.32 -1.18
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Trm11

Trm11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Trm11-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available