Standard name
Human Ortholog
Description Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.05 0 0.05 0.09 0.07 0.09 0 0.09 0.1 0 0.07 0.08 0.09 0 0 0 0 0 0.06 0 0.05 0.06 0.09
Bud 0.08 0.07 0.11 0.12 0.15 0.18 0.18 0.17 0.17 0.19 0.17 0.15 0.09 0.08 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0.1 0.06 0.05 0 0.05 0.08 0.07 0 0.07 0.05 0.06 0.06 0 0 0 0 0 0.06 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.05 0 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.09 0.07 0.1 0.25 0.12 0.1 0.14 0.09 0.09 0.06 0.06 0.06 0.09 0.13 0.18 0.16 0.16 0.09 0.12 0.06 0.11 0.14 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.38 0.47 0.16 0.24 0.11 0.21 0.27 0.19 0.34 0.33 0.54 0.42 0.1 0.1 0.11 0.08 0.1 0.09 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0.07 0 0 0.05 0.05 0.05 0 0.05 0.05 0.05 0.05 0 0 0 0.07 0.07 0.08 0 0 0 0 0 0
Peroxisomes 0.67 0.55 0.7 0.73 0.58 0.66 0.57 0.61 0.59 0.59 0.44 0.54 0.63 0.64 0.69 0.57 0.56 0.58 0.71 0.56 0.72 0.5 0.56 0.7
SpindlePole 0.34 0.18 0.51 0.38 0.29 0.3 0.29 0.33 0.28 0.22 0.17 0.2 0.37 0.37 0.38 0.38 0.41 0.4 0.12 0.13 0.13 0.19 0.13 0.05
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 12 12 15 40 35 65 28 45 58 22 37 19 26 12 5 5 5 4 15 7 13 21 39
Bud 22 17 39 36 64 89 124 110 89 110 84 81 22 22 13 10 8 8 2 7 7 7 9 7
Bud Neck 0 1 3 5 0 3 2 1 2 2 2 1 1 1 1 1 3 0 2 4 4 6 5 2
Bud Site 27 14 18 10 19 40 51 22 34 27 28 34 8 4 3 8 7 12 – – – – – –
Cell Periphery 0 1 0 0 0 2 3 4 6 7 3 2 1 0 2 1 0 0 0 0 0 0 0 0
Cytoplasm 2 3 9 3 20 5 15 22 8 15 7 7 6 12 10 12 4 13 0 0 0 2 0 3
Endoplasmic Reticulum 0 0 0 0 4 1 0 0 0 0 0 2 3 0 0 4 1 1 0 0 1 1 1 1
Endosome 11 21 24 30 104 60 72 92 47 53 32 32 15 25 43 46 41 31 25 32 21 27 52 25
Golgi 0 0 0 0 10 3 0 2 2 0 0 1 3 8 4 10 8 1 4 7 5 6 6 10
Mitochondria 101 116 58 71 46 105 187 121 175 188 271 223 24 27 36 20 26 16 2 8 1 6 10 5
Nucleus 2 2 1 1 0 2 2 6 0 1 1 1 2 0 2 1 2 3 1 0 0 1 0 0
Nuclear Periphery 2 1 0 0 0 2 0 1 1 2 3 3 0 0 0 2 1 0 0 0 0 0 0 0
Nucleolus 10 18 4 10 20 27 32 22 23 26 23 29 10 10 10 19 18 15 1 0 0 2 0 0
Peroxisomes 180 135 249 213 244 333 395 397 298 332 224 292 154 175 225 146 142 109 200 156 259 128 209 293
SpindlePole 92 44 181 110 122 151 200 213 142 122 85 106 91 102 122 96 104 75 34 35 47 48 49 21
Vac/Vac Membrane 0 2 0 3 4 2 5 18 6 10 8 9 1 1 3 3 3 5 0 2 0 0 2 3
Unique Cell Count 267 245 358 292 422 507 693 650 509 567 505 537 245 274 324 255 253 188 281 277 358 257 375 421
Labelled Cell Count 450 387 598 507 697 860 1153 1059 878 953 793 860 360 413 486 384 373 294 281 277 358 257 375 421


Peroxisomes

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.5 7.1 6.0 6.7 9.5 8.1 7.3 7.7 7.6 7.9 7.1 7.5 9.1 9.7 10.3 10.5 10.0 9.3 8.6 8.3 8.5
Std Deviation (1e-4) 1.0 1.5 1.4 1.5 2.5 2.2 1.9 2.1 2.2 2.4 2.1 2.4 2.1 2.4 3.1 3.0 3.1 2.4 2.7 2.2 2.4
Intensity Change (Log2) – – – 0.17 0.65 0.43 0.28 0.36 0.33 0.39 0.24 0.31 0.6 0.68 0.77 0.8 0.74 0.63 0.52 0.47 0.49

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.1 3.4 2.3 3.6 0.7 3.2 3.9 0.7 2.3 2.4 3.2 0.2 -1.0 -1.0 -0.4
Bud 0.6 1.8 2.7 3.0 2.6 2.7 3.4 2.4 1.8 -0.8 -1.2 -3.4 -3.1 -3.5 -2.6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site -1.0 -0.3 1.7 1.4 -1.3 1.0 -0.2 0.3 0.8 -1.0 -2.4 -3.1 -1.1 -1.4 0.7
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.4 1.6 -1.8 -0.4 0.8 -1.0 0.1 -1.2 -1.3 -0.1 1.3 0.5 1.5 -0.8 2.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 1.6 6.7 2.5 2.0 3.5 1.3 1.4 -0.2 -0.5 -0.3 1.1 2.9 4.3 3.8 3.6
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.6 -2.2 1.7 3.9 1.0 5.9 5.7 11.2 8.0 -2.3 -2.3 -1.9 -3.1 -2.1 -2.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 2.0 2.9 3.3 3.0 2.2 2.8 2.9 2.9 3.3 2.4 2.1 1.8 4.1 3.9 4.2
Peroxisomes 0.9 -3.4 -1.2 -4.0 -2.7 -3.3 -3.4 -7.3 -4.5 -1.7 -1.5 0 -3.1 -3.4 -2.7
SpindlePole -3.3 -6.2 -6.2 -6.9 -5.5 -6.8 -9.2 -10.6 -9.7 -3.3 -3.3 -3.4 -3.2 -2.3 -2.4
Vacuole 0 0 0 0 3.2 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.8109 7.9354 7.891 7.0558 8.3726 7.9376 3.4306 5.1644 4.307 3.4433 4.0376 4.4724 3.8392 5.4795 4.8737 5.3389 4.0066 4.6555
Actin 0.1042 0.0547 0.0957 0.017 0.0124 0.0034 0.0375 0.046 0.0616 0.0016 0.0296 0.0405 0.0212 0.032 0.0256 0.0019 0.0347 0.0353
Bud 0.0004 0.0024 0.0009 0.0001 0.0001 0.0001 0.0013 0.0029 0.0026 0.0001 0.0005 0.0004 0.0002 0.003 0.0012 0 0.0032 0.0003
Bud Neck 0.0023 0.008 0.0027 0.0006 0.0007 0.0003 0.0016 0.004 0.009 0.0001 0.0112 0.0215 0.0004 0.0035 0.0019 0.0048 0.0004 0.0006
Bud Periphery 0.0005 0.0029 0.0009 0.0001 0.0001 0.0003 0.0015 0.0019 0.0014 0.0001 0.0005 0.0005 0.0002 0.0026 0.0012 0.0001 0.0031 0.0004
Bud Site 0.0035 0.0376 0.0136 0.0005 0.0003 0.0003 0.0128 0.0458 0.0104 0.0003 0.0022 0.001 0.0035 0.0294 0.0045 0.0003 0.0013 0.0008
Cell Periphery 0.0004 0.0005 0.0001 0 0.0001 0 0.0003 0.0002 0.0003 0 0.0001 0.0001 0.0001 0.0002 0.0001 0 0.0002 0.0001
Cytoplasm 0.0077 0.0005 0.0001 0 0.0001 0.0001 0.0068 0.0003 0.0002 0.0002 0.0003 0.0002 0.0009 0.0006 0.0002 0 0.0009 0.0001
Cytoplasmic Foci 0.2274 0.1935 0.1883 0.2586 0.2947 0.2029 0.232 0.278 0.2405 0.2376 0.3253 0.2234 0.1996 0.1947 0.2079 0.1471 0.343 0.2633
Eisosomes 0.0006 0.0001 0.0002 0 0 0 0.0003 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0001
Endoplasmic Reticulum 0.0067 0.0001 0 0 0 0 0.0068 0 0 0.0007 0.0001 0 0.0007 0 0 0 0.0012 0.0003
Endosome 0.0343 0.0123 0.0033 0.0024 0.0097 0.003 0.0565 0.0095 0.0118 0.0247 0.0177 0.0111 0.0188 0.0164 0.0048 0.0057 0.0133 0.0053
Golgi 0.0103 0.0201 0.0103 0.0091 0.0408 0.0077 0.0319 0.0154 0.0235 0.0218 0.0359 0.0182 0.0158 0.0216 0.0191 0.0145 0.0192 0.0133
Lipid Particles 0.0774 0.0584 0.097 0.0484 0.1742 0.1542 0.1245 0.0727 0.0617 0.1857 0.2673 0.134 0.1189 0.0636 0.058 0.2055 0.1922 0.22
Mitochondria 0.0033 0.015 0.0233 0.0091 0.0123 0.0104 0.0183 0.0092 0.0205 0.0044 0.0039 0.0049 0.0179 0.0224 0.0222 0.0122 0.0579 0.0231
None 0.0044 0.0002 0.0003 0.0001 0 0.0001 0.0025 0.0001 0.0001 0.0001 0.0001 0 0.0009 0.0001 0.0001 0 0.0008 0.0002
Nuclear Periphery 0.0205 0.0001 0 0 0 0.0007 0.01 0.0002 0 0.0015 0 0 0.001 0.0001 0 0 0.018 0.0013
Nucleolus 0.0007 0.0159 0.0004 0.0001 0.0005 0.0028 0.0011 0.0096 0.0016 0.0008 0.0005 0.0003 0.0006 0.0019 0.0015 0.0004 0.0021 0.0069
Nucleus 0.0017 0.0014 0.0001 0 0 0.0006 0.0014 0.0009 0.0003 0.0001 0.0001 0 0.0003 0.0002 0.0004 0 0.0043 0.0005
Peroxisomes 0.4423 0.5685 0.5501 0.6502 0.3491 0.6013 0.4426 0.4917 0.5395 0.5043 0.3018 0.5419 0.5777 0.5909 0.6478 0.6059 0.2923 0.4216
Punctate Nuclear 0.048 0.0048 0.0125 0.0035 0.1043 0.0109 0.004 0.0071 0.014 0.0142 0.0022 0.0016 0.02 0.0145 0.0026 0.001 0.0044 0.006
Vacuole 0.0023 0.0025 0.0001 0.0001 0.0004 0.0007 0.0035 0.0036 0.0007 0.0007 0.0005 0.0002 0.0008 0.0016 0.0003 0.0001 0.0034 0.0002
Vacuole Periphery 0.0011 0.0005 0.0001 0.0001 0.0003 0.0004 0.003 0.0008 0.0003 0.0009 0.0002 0.0001 0.0004 0.0008 0.0003 0.0002 0.0042 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 28.7041 34.7928 16.7815 23.253 10.7233 40.8442 53.2082 45.1125 42.1392 36.6253
Translational Efficiency 1.1947 1.1773 1.6531 0.9866 1.6034 1.5373 1.2612 1.5586 1.4156 1.2065

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2210 988 1661 1451 1329 891 1496 299 3539 1879 3157 1750

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 806.54 845.22 1615.28 1555.23 802.94 829.44 1273.32 1494.20 805.19 837.74 1453.24 1544.80
Standard Deviation 105.03 143.23 327.10 456.52 110.81 119.78 243.08 331.29 107.25 132.86 336.82 438.27
Intensity Change Log 2 — 0.067581 1.001966 0.947310 — 0.046845 0.665231 0.896009 — 0.057274 0.843776 0.921945

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.007562 0.013561 0.040676 0.389045 0.019314 0.009769 0.078067 0.471470 0.011975 0.011763 0.058394 0.403128
Bud Neck 0.002804 0.002960 0.006682 0.005807 0.002787 0.003441 0.009174 0.003365 0.002797 0.003188 0.007863 0.005389
Bud Site 0.009090 0.011911 0.020702 0.031512 0.010856 0.013441 0.030594 0.018902 0.009753 0.012637 0.025390 0.029357
Cell Periphery 0.000118 0.000156 0.000099 0.000199 0.000165 0.000142 0.000231 0.000121 0.000136 0.000149 0.000162 0.000186
Cytoplasm 0.002887 0.005529 0.006998 0.005918 0.003816 0.005696 0.006009 0.004193 0.003236 0.005609 0.006529 0.005623
Cytoplasmic Foci 0.157040 0.115022 0.092486 0.056488 0.128135 0.123703 0.093482 0.036685 0.146185 0.119138 0.092958 0.053105
Eisosomes 0.000151 0.000925 0.002528 0.003696 0.000318 0.000185 0.001550 0.002853 0.000214 0.000574 0.002065 0.003552
Endoplasmic Reticulum 0.000072 0.000206 0.000127 0.000426 0.000136 0.000220 0.000384 0.000312 0.000096 0.000213 0.000249 0.000407
Endosome 0.009685 0.017904 0.005816 0.010913 0.010923 0.026239 0.009615 0.010416 0.010150 0.021857 0.007616 0.010828
Golgi 0.027423 0.039091 0.020445 0.021449 0.032552 0.035847 0.024733 0.014072 0.029349 0.037552 0.022477 0.020189
Lipid Particles 0.027592 0.062187 0.024910 0.030856 0.038245 0.057555 0.066566 0.016081 0.031593 0.059990 0.044650 0.028331
Mitochondria 0.003180 0.004312 0.029111 0.012502 0.003644 0.007384 0.008473 0.003813 0.003354 0.005769 0.019331 0.011018
Mitotic Spindle 0.003973 0.009255 0.027124 0.011982 0.006600 0.012361 0.049156 0.011943 0.004959 0.010728 0.037564 0.011975
None 0.000111 0.000261 0.000139 0.000117 0.000123 0.000137 0.000194 0.000058 0.000116 0.000202 0.000165 0.000107
Nuclear Periphery 0.000017 0.000058 0.000199 0.000115 0.000027 0.000092 0.000235 0.000044 0.000021 0.000074 0.000216 0.000103
Nuclear Periphery Foci 0.000464 0.002890 0.000461 0.000117 0.001024 0.001374 0.001354 0.000057 0.000674 0.002171 0.000884 0.000107
Nucleolus 0.000250 0.000920 0.000265 0.000073 0.000096 0.000393 0.000429 0.000013 0.000192 0.000670 0.000343 0.000063
Nucleus 0.000261 0.000362 0.000055 0.000114 0.000084 0.000528 0.000292 0.000019 0.000195 0.000441 0.000167 0.000098
Peroxisomes 0.747085 0.710868 0.719481 0.416067 0.740777 0.699401 0.617971 0.405064 0.744716 0.705430 0.671379 0.414187
Vacuole 0.000179 0.000980 0.001500 0.002152 0.000322 0.001419 0.001397 0.000456 0.000233 0.001188 0.001451 0.001862
Vacuole Periphery 0.000056 0.000642 0.000196 0.000453 0.000055 0.000674 0.000094 0.000062 0.000055 0.000657 0.000148 0.000386

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.18 -12.03 -41.41 -40.46 -36.37 3.95 -12.33 -21.19 -21.70 -18.18 0.16 -17.55 -45.93 -45.94 -39.05
Bud Neck -0.23 -5.49 -4.63 -5.22 1.26 -0.83 -7.65 -0.68 0.05 5.83 -0.73 -9.12 -5.11 -4.58 4.35
Bud Site -1.26 -6.40 -9.50 -7.02 -4.27 -1.00 -7.22 -2.55 -1.60 3.29 -1.72 -9.84 -9.71 -7.40 -1.95
Cell Periphery -1.28 1.07 -4.26 -1.59 -6.16 0.76 -1.88 1.67 1.05 3.89 -0.70 -1.56 -3.14 -2.00 -1.57
Cytoplasm -2.86 -7.79 -5.91 -0.51 1.06 -1.95 -2.60 -0.35 1.46 1.86 -3.57 -6.92 -5.06 -0.02 1.16
Cytoplasmic Foci 5.88 10.35 17.61 9.16 6.97 0.59 5.24 12.69 11.47 9.29 5.15 11.69 20.65 13.61 10.28
Eisosomes -7.84 -6.48 -9.41 -7.11 -2.20 4.67 -13.57 -3.81 -4.01 -1.95 -6.67 -9.35 -10.04 -8.84 -3.83
Endoplasmic Reticulum -3.21 -3.26 -5.87 -2.08 -5.01 -1.57 -7.17 -3.22 -1.25 1.36 -3.63 -8.10 -6.13 -2.67 -2.94
Endosome -3.97 3.97 -1.06 3.19 -4.43 -5.67 0.87 0.21 5.13 -0.37 -7.00 3.07 -0.70 6.15 -3.19
Golgi -5.65 4.50 3.48 7.71 -0.52 -1.40 4.21 6.80 7.69 4.20 -5.41 5.89 6.13 9.88 1.53
Lipid Particles -6.45 0.92 -0.93 5.56 -1.73 -3.40 -5.76 4.76 6.95 9.77 -7.33 -4.64 1.07 7.54 5.02
Mitochondria -1.07 -11.35 -6.65 -5.34 6.51 -2.04 -4.07 -0.14 1.80 3.30 -2.33 -11.91 -6.62 -3.72 5.00
Mitotic Spindle -2.93 -9.76 -4.82 -1.23 5.21 -3.24 -11.82 -1.47 -0.07 6.50 -4.57 -15.40 -4.64 -0.77 9.69
None -1.66 -0.60 -0.08 1.75 1.82 -0.32 -0.93 2.53 2.13 1.90 -1.65 -1.10 0.49 2.05 1.65
Nuclear Periphery -2.43 -10.20 -8.50 -1.38 4.09 -1.57 -13.15 -1.82 1.14 11.25 -2.71 -16.23 -8.62 -0.76 7.66
Nuclear Periphery Foci -2.75 -0.21 3.43 3.10 2.04 -0.54 -0.92 1.74 3.56 3.68 -2.83 -1.22 2.60 4.01 4.11
Nucleolus -1.13 -0.30 1.17 1.45 3.65 -1.41 -1.71 2.70 1.85 2.20 -1.45 -1.27 1.38 1.89 3.05
Nucleus -0.77 1.21 0.44 1.25 -1.26 -1.57 -1.64 2.59 1.81 2.16 -1.50 0.10 0.35 1.83 0.33
Peroxisomes 3.62 3.24 32.27 23.61 27.02 3.59 11.58 16.00 13.40 9.83 5.21 10.79 36.57 28.37 26.61
Vacuole -3.06 -5.78 -4.87 -2.37 -1.48 -2.00 -6.92 -1.15 1.76 5.53 -3.26 -8.69 -4.83 -1.46 -1.23
Vacuole Periphery -1.14 -3.22 -2.82 0.34 -1.79 -1.94 -2.34 -0.23 1.91 1.09 -1.94 -3.60 -2.85 0.81 -2.03
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
Localization
Cell Percentages peroxisome (75%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mdh2

Mdh2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mdh2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available