Standard name
Human Ortholog
Description Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.1 0.12 0 0.1 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.12 0 0 0 0.06 0.12 0.07 0.29 0.27 0.37 0.2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.77 0.71 0.89 0.93 0.93 0.89 0.85 0.86 0.83 0.79 0.75 0.79 0.7 0.66 0.7 0.78 0.75 0.74 0.57 0.62 0.68 0.46 0.29 0.28
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Nucleolus 0.3 0.32 0.09 0 0 0.07 0.07 0.05 0.07 0.09 0.08 0.09 0.28 0.27 0.22 0.11 0.1 0.09 0.36 0.28 0.22 0.26 0.35 0.29
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.06 0.12 0 0.05 0.05 0.22 0.27 0.24
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 1 0 6 4 3 4 5 6 8 0 0 0 0 0 0 3 2 1 2 6 4
Bud Neck 0 0 1 0 1 1 0 0 1 0 0 2 0 0 0 0 0 0 0 0 0 0 1 4
Bud Site 0 0 0 0 0 6 5 6 14 10 9 12 1 2 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 5 6 14 8 7 18 16 7 15 12 10 21 34 52 10 17 7 0 5 0 0 1 0
Endoplasmic Reticulum 0 1 0 1 0 0 0 1 0 0 0 0 1 0 1 3 5 3 0 0 1 0 1 0
Endosome 1 1 1 2 0 0 0 0 1 0 0 2 2 2 3 5 1 1 2 1 4 1 3 10
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 1 0 2
Mitochondria 2 42 0 4 4 38 70 43 151 149 213 95 7 2 3 1 3 1 1 1 2 2 6 7
Nucleus 172 252 359 348 308 551 490 509 436 442 427 377 251 230 304 204 122 125 142 237 320 75 95 88
Nuclear Periphery 0 1 1 4 2 16 3 5 11 14 3 9 8 5 7 7 1 3 0 0 3 0 3 15
Nucleolus 67 112 38 7 9 44 40 28 39 51 44 45 102 92 93 29 17 15 89 107 103 42 115 94
Peroxisomes 0 0 0 0 0 0 0 2 0 0 0 0 1 5 2 0 0 0 0 0 0 0 0 1
SpindlePole 0 1 0 2 0 8 1 7 4 7 1 10 3 10 0 0 0 1 0 2 3 1 3 9
Vac/Vac Membrane 6 11 12 5 10 14 11 17 4 5 15 10 4 9 13 22 10 21 8 20 21 35 89 78
Unique Cell Count 223 353 405 375 330 618 579 592 527 561 571 479 360 347 432 261 162 168 249 383 469 164 331 321
Labelled Cell Count 252 427 418 388 342 691 642 638 672 700 730 580 401 391 478 281 177 177 249 383 469 164 331 321


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.5 7.6 8.6 7.8 7.5 6.0 6.0 6.2 5.2 5.1 4.8 5.4 9.1 8.7 8.4 11.1 11.6 10.8 8.6 8.4 8.6
Std Deviation (1e-4) 1.7 1.5 1.3 1.6 1.3 1.1 1.1 1.2 1.1 1.1 1.2 1.0 2.8 2.7 2.4 2.2 2.7 2.7 1.6 1.8 1.7
Intensity Change (Log2) – – – -0.15 -0.2 -0.52 -0.53 -0.47 -0.74 -0.77 -0.84 -0.67 0.08 0.02 -0.03 0.36 0.43 0.33 -0.01 -0.04 -0.0


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 3.3 0 0 3.2 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.0 0.9 -0.5 1.6 1.3 -0.2 1.3 0.7 0.7 3.3 5.1 6.0 1.9 4.9 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.1 7.3 5.5 11.8 11.3 0 9.5 0 0 0 0 0 0
Nucleus 2.0 2.2 0.3 -1.8 -1.2 -2.5 -4.0 -5.4 -3.9 -6.5 -7.4 -6.5 -3.7 -4.0 -4.3
Nuclear Periphery 0 0 2.9 0 0 2.5 2.8 0 0 0 0 0 0 0 0
Nucleolus -4.5 -3.7 -1.3 -1.4 -2.9 -1.1 -0.2 0 0 6.8 6.2 4.8 0.7 0.4 -0.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.6 0.1 -0.7 -1.1 -0.1 -2.6 -2.4 -0.3 -0.8 -1.8 -0.3 0 3.1 1.8 4.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.0645 4.8449 4.5165 3.1471 3.2569 3.9287 6.5218 6.5777 6.3982 5.5991 5.9302 5.9092 5.0179 5.1157 4.6819 4.6329 4.8632 4.8489
Actin 0.0104 0 0.0001 0 0.0032 0 0.0012 0 0.0041 0.0162 0.0144 0 0.005 0 0.0065 0.0119 0.0502 0.0046
Bud 0.0004 0 0.0001 0 0.0001 0.0001 0.0002 0 0.0002 0.0003 0.0001 0 0.0003 0 0.0002 0.0002 0.0005 0.0001
Bud Neck 0.0006 0.0003 0.0002 0.0002 0.0005 0.0011 0.0008 0.0002 0.0004 0.0009 0.0014 0.0006 0.0015 0.0001 0.0005 0.0003 0.0016 0.0008
Bud Periphery 0.0012 0.0001 0.0002 0.0001 0.0008 0.0003 0.0009 0 0.0003 0.0005 0.0003 0.0001 0.001 0.0001 0.0005 0.0002 0.0012 0.0001
Bud Site 0.0011 0.0001 0.0002 0.0001 0.0003 0.0002 0.0006 0.0001 0.0006 0.0015 0.0002 0.0001 0.001 0.0001 0.001 0.0007 0.0012 0.0001
Cell Periphery 0.0003 0.0001 0.0002 0 0.0008 0.0002 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0.0004 0.0001 0.0004 0 0.0002 0
Cytoplasm 0.0018 0.0003 0.0003 0 0.0015 0 0.0001 0 0.0006 0.0003 0.0001 0 0.0009 0 0.0003 0.0012 0.001 0.0001
Cytoplasmic Foci 0.0115 0 0.0077 0 0.0012 0.0001 0.0011 0 0.0029 0.003 0.0034 0.0001 0.0033 0 0.0016 0.0091 0.0045 0.0001
Eisosomes 0.0001 0 0 0 0.0004 0 0.0001 0 0.0001 0.0001 0.0001 0 0.0002 0 0.0002 0.0001 0.0004 0
Endoplasmic Reticulum 0.0022 0 0.0001 0 0.0008 0 0.0007 0 0.0012 0.0006 0.0003 0 0.0012 0 0.001 0.0005 0.0022 0.0003
Endosome 0.0072 0.0001 0.0013 0 0.0033 0.0001 0.0053 0 0.005 0.0114 0.0035 0.0005 0.0031 0 0.0025 0.0057 0.0218 0.0009
Golgi 0.0014 0 0.0002 0 0.0005 0.0001 0.002 0 0.0017 0.0109 0.0029 0.0001 0.0011 0 0.0006 0.002 0.0093 0.0004
Lipid Particles 0.0072 0 0.002 0 0.002 0.0015 0.0083 0 0.0064 0.006 0.0197 0.0003 0.0118 0 0.0047 0.003 0.0127 0.0002
Mitochondria 0.0025 0.0001 0.0009 0.0002 0.0108 0.0008 0.0154 0.0001 0.0067 0.0028 0.0014 0.0004 0.0053 0.0001 0.0042 0.0005 0.0109 0.0002
None 0.0015 0 0.0001 0 0.0148 0 0.0002 0 0.0003 0.0002 0.0005 0 0.0006 0 0.0005 0.0031 0.0017 0.0001
Nuclear Periphery 0.0081 0.0058 0.0055 0.0081 0.0204 0.0044 0.0073 0.0029 0.009 0.0016 0.0066 0.0002 0.0058 0.0004 0.0062 0.0023 0.0366 0.0018
Nucleolus 0.4032 0.3397 0.4857 0.379 0.3842 0.4481 0.3735 0.4367 0.467 0.356 0.301 0.4661 0.3975 0.4125 0.4363 0.4327 0.4242 0.4796
Nucleus 0.5174 0.6462 0.4915 0.6095 0.5114 0.5389 0.5684 0.5557 0.4847 0.5819 0.6131 0.5284 0.5458 0.5839 0.5267 0.5078 0.3971 0.5082
Peroxisomes 0.0103 0 0.0002 0 0.0007 0.0001 0.0019 0 0.0035 0.0016 0.003 0 0.0032 0 0.0007 0.0067 0.0056 0
Punctate Nuclear 0.0075 0.0018 0.0013 0.0015 0.0167 0.002 0.003 0.0036 0.0033 0.0029 0.0257 0.0013 0.0066 0.0013 0.0037 0.0118 0.0125 0.0021
Vacuole 0.0029 0.0046 0.0009 0.0003 0.0087 0.001 0.0053 0.0004 0.0013 0.0005 0.0008 0.0012 0.003 0.0006 0.0013 0.0002 0.0019 0.0002
Vacuole Periphery 0.0013 0.0008 0.0011 0.0008 0.0169 0.001 0.0033 0.0002 0.0009 0.0004 0.0012 0.0004 0.0013 0.0006 0.0005 0.0001 0.0029 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 38.8346 39.8672 34.5691 39.5039 29.8856 29.5481 36.4598 30.5689 31.7538 35.0856
Translational Efficiency 0.7605 0.95 1.0063 0.7731 0.8622 0.8588 0.8141 0.8048 0.8333 0.7957

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1302 1289 1128 1077 1857 2249 1350 1152 3159 3538 2478 2229

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 759.92 1008.89 1134.75 1096.03 891.73 995.16 1153.65 1193.38 837.40 1000.16 1145.05 1146.34
Standard Deviation 268.84 198.18 182.72 176.93 154.23 167.38 190.39 189.67 219.05 179.33 187.17 189.96
Intensity Change Log 2 — 0.408849 0.578455 0.528368 — 0.158322 0.371527 0.420375 — 0.279011 0.470431 0.471068

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000276 0.000486 0.000960 0.001132 0.000279 0.000382 0.000602 0.000832 0.000278 0.000420 0.000765 0.000977
Bud Neck 0.002816 0.006864 0.021925 0.041204 0.003768 0.009457 0.014422 0.037587 0.003375 0.008512 0.017837 0.039335
Bud Site 0.000359 0.001022 0.001835 0.008915 0.000293 0.000938 0.000928 0.003261 0.000320 0.000968 0.001341 0.005993
Cell Periphery 0.000111 0.000054 0.000073 0.000202 0.000040 0.000084 0.000027 0.000114 0.000069 0.000073 0.000048 0.000157
Cytoplasm 0.002657 0.000509 0.000884 0.004604 0.000604 0.000650 0.000192 0.001822 0.001450 0.000599 0.000507 0.003166
Cytoplasmic Foci 0.000688 0.000698 0.000080 0.003025 0.000120 0.000313 0.000132 0.000680 0.000354 0.000453 0.000108 0.001813
Eisosomes 0.000030 0.000047 0.000058 0.000043 0.000036 0.000047 0.000048 0.000047 0.000034 0.000047 0.000053 0.000045
Endoplasmic Reticulum 0.002977 0.001870 0.002344 0.002249 0.002248 0.002454 0.001072 0.001749 0.002549 0.002241 0.001651 0.001991
Endosome 0.000353 0.001003 0.000224 0.005732 0.000174 0.001019 0.000436 0.001262 0.000248 0.001013 0.000339 0.003421
Golgi 0.000151 0.000384 0.000226 0.008358 0.000087 0.000282 0.000173 0.001051 0.000114 0.000320 0.000197 0.004582
Lipid Particles 0.000120 0.000444 0.000098 0.000264 0.000142 0.000248 0.000072 0.000144 0.000133 0.000320 0.000084 0.000202
Mitochondria 0.000653 0.001154 0.001491 0.005072 0.000560 0.002250 0.001343 0.003676 0.000599 0.001851 0.001410 0.004351
Mitotic Spindle 0.000060 0.000896 0.002307 0.033401 0.000405 0.003318 0.002025 0.012699 0.000263 0.002436 0.002153 0.022702
None 0.006151 0.001589 0.001579 0.003803 0.001917 0.002056 0.000772 0.001571 0.003662 0.001885 0.001139 0.002650
Nuclear Periphery 0.000249 0.000245 0.000297 0.003356 0.000131 0.001306 0.000251 0.001810 0.000179 0.000919 0.000272 0.002557
Nuclear Periphery Foci 0.000445 0.001226 0.000232 0.003552 0.000243 0.000862 0.000169 0.001147 0.000327 0.000994 0.000197 0.002309
Nucleolus 0.181778 0.299332* 0.307698* 0.266024* 0.220738* 0.232495* 0.388588* 0.325809* 0.204680 0.256846* 0.351767* 0.296922*
Nucleus 0.798165* 0.679089* 0.653630* 0.591238* 0.767084* 0.738844* 0.585674* 0.596035* 0.779894* 0.717074* 0.616608* 0.593717*
Peroxisomes 0.000412 0.001392 0.002428 0.001383 0.000450 0.000593 0.002206 0.001180 0.000435 0.000884 0.002307 0.001278
Vacuole 0.000977 0.001183 0.001280 0.009958 0.000308 0.001267 0.000442 0.004828 0.000583 0.001237 0.000823 0.007307
Vacuole Periphery 0.000570 0.000514 0.000352 0.006484 0.000372 0.001133 0.000427 0.002698 0.000454 0.000908 0.000393 0.004527

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.77 -16.63 -11.20 -8.29 -0.79 -3.99 -13.41 -14.22 -11.54 -6.25 -6.77 -20.90 -17.01 -13.50 -4.13
Bud Neck -6.04 -19.32 -21.50 -19.09 -10.77 -9.00 -16.41 -20.77 -17.51 -13.62 -10.92 -25.13 -29.85 -25.68 -17.31
Bud Site -2.16 -14.58 -6.11 -5.37 -4.64 -4.54 -5.43 -7.37 -6.14 -5.70 -4.28 -13.04 -8.41 -7.35 -6.49
Cell Periphery 2.46 1.58 -0.99 -2.35 -1.85 -2.40 1.28 -3.55 -1.22 -4.27 -0.31 1.77 -2.74 -2.44 -3.68
Cytoplasm 2.50 1.75 -1.85 -4.33 -3.67 -0.01 1.77 -2.99 -3.15 -3.97 2.29 2.13 -3.34 -5.36 -5.21
Cytoplasmic Foci -0.19 1.54 -1.78 -1.46 -3.60 -0.91 0.14 -1.31 -0.63 -1.44 -0.49 1.46 -2.41 -1.89 -3.80
Eisosomes -6.03 -12.79 -5.66 1.57 7.32 -4.41 -6.46 -3.13 0.52 1.11 -7.20 -13.50 -5.61 1.39 5.30
Endoplasmic Reticulum 4.71 0.58 0.56 -3.67 0.03 -0.96 6.56 0.62 1.60 -6.51 1.83 4.27 0.51 -1.28 -3.55
Endosome -1.82 0.50 -4.19 -2.98 -4.30 -3.26 -0.80 -2.42 -0.06 -1.45 -3.62 -0.66 -4.86 -2.66 -4.37
Golgi -1.74 -2.12 -3.02 -2.85 -2.93 -1.53 -4.11 -2.93 -2.03 -2.57 -2.18 -4.02 -3.52 -3.22 -3.37
Lipid Particles -1.55 -0.51 -2.11 0.89 -2.21 -0.50 0.63 0.02 0.83 -1.64 -1.39 0.46 -0.76 1.08 -2.73
Mitochondria -1.48 -7.58 -7.21 -5.52 -5.33 -3.63 -5.46 -10.61 -3.56 -8.21 -3.92 -8.82 -11.84 -5.90 -8.94
Mitotic Spindle -1.83 -5.53 -7.98 -7.70 -6.98 -3.48 -2.17 -5.67 -4.42 -4.82 -3.93 -4.78 -9.75 -8.63 -8.47
None 3.27 3.59 1.59 -3.02 -4.35 -0.25 2.73 0.10 0.44 -4.73 2.76 4.32 1.22 -2.45 -5.94
Nuclear Periphery -0.08 -2.53 -7.02 -7.04 -6.68 -2.79 -3.35 -7.71 -1.39 -6.99 -2.76 -4.41 -10.16 -4.39 -9.46
Nuclear Periphery Foci -1.28 0.39 -2.53 -1.29 -2.71 -2.44 1.04 -3.18 -0.64 -3.51 -2.41 0.71 -3.55 -1.61 -3.80
Nucleolus -13.06 -11.07 -4.53 6.84 5.84 -1.65 -16.51 -6.65 -5.51 7.78 -9.31 -19.28 -7.53 -0.13 9.87
Nucleus 13.05 13.96 15.75 4.55 2.59 3.92 18.62 15.08 12.21 -2.16 11.09 22.87 21.52 12.67 0.08
Peroxisomes -6.09 -12.73 -9.31 0.72 7.31 -2.78 -13.31 -10.13 -8.35 7.02 -6.70 -18.31 -13.57 -4.32 10.08
Vacuole -0.40 -1.68 -6.27 -6.25 -5.76 -3.88 -2.30 -5.02 -3.94 -4.80 -2.25 -2.28 -8.07 -7.39 -7.46
Vacuole Periphery 0.21 0.81 -4.49 -4.71 -4.92 -3.72 -0.67 -4.50 -2.52 -4.39 -2.81 0.40 -6.22 -5.09 -6.48
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based
Localization
Cell Percentages nucleus (74%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rrp6

Rrp6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rrp6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available