Standard name
Human Ortholog
Description Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.12 0.16 0.13 0.05 0 0 0 0 – 0 0 0 0.23 0.38 0.3 0.05 0.05 0.07 0.05 0.07 0 0.11 0.13 0.09
Bud 0 0.06 0 0 0 0 0 0 – 0 0 0 0.13 0.09 0 0 0 0 0 0.08 0 0.19 0.12 0.1
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0 0 0 0 0 0 – 0 0 0 0.16 0.19 0.34 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 0.2 0.22 0.43 0.35 0.48 0.43 0.46 – 0.56 0.6 0.65 0.36 0.26 0.29 0.21 0.17 0.22 0 0 0 0 0 0
Endoplasmic Reticulum 0.34 0.34 0.32 0.15 0.13 0.11 0.06 0 – 0 0 0 0.32 0.28 0.22 0 0 0 0.22 0.2 0.21 0.07 0.08 0.1
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0
Golgi 0.07 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
Mitochondria 0 0 0 0 0 0 0 0 – 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0.08 0.12 0.07 0.07 – 0.09 0.07 0.06 0 0 0 0.14 0.11 0.1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.48 0.34 0.38 0.46 0.6 0.48 0.55 0.52 – 0.42 0.42 0.38 0.08 0.05 0 0.63 0.64 0.61 0.58 0.49 0.62 0.4 0.46 0.55
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 32 20 35 17 8 14 8 7 – 8 2 5 40 110 79 14 11 12 17 11 12 19 42 24
Bud 3 7 7 3 3 5 10 14 – 12 5 8 23 27 11 0 2 1 11 12 8 34 39 28
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 6 4 9 12 7 10
Bud Site 1 0 2 0 0 2 0 0 – 1 0 1 0 2 2 0 1 0 – – – – – –
Cell Periphery 8 6 10 0 0 1 0 6 – 1 2 5 28 56 89 4 5 1 1 0 2 1 0 0
Cytoplasm 28 25 59 140 169 323 355 423 – 415 355 458 62 76 77 55 36 40 6 2 3 2 2 1
Endoplasmic Reticulum 92 43 84 47 62 73 53 16 – 32 6 10 55 81 59 4 8 7 73 30 67 12 25 27
Endosome 1 0 3 7 4 2 3 16 – 0 2 6 0 4 1 4 2 1 3 7 8 6 15 9
Golgi 19 2 4 2 4 1 0 0 – 1 0 0 2 6 8 6 6 6 11 3 4 2 15 8
Mitochondria 3 2 10 3 9 25 27 22 – 17 28 33 0 0 2 10 9 5 3 2 3 4 7 5
Nucleus 3 2 1 8 38 78 61 62 – 65 41 45 2 4 2 37 23 19 0 0 0 0 1 1
Nuclear Periphery 0 0 0 0 0 0 0 0 – 1 2 1 0 1 0 0 0 0 0 0 1 1 3 2
Nucleolus 2 1 0 0 0 0 1 8 – 3 2 1 0 0 0 2 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 1 3 1 0 0 – 1 0 0 0 6 4 0 0 0 0 0 0 3 5 2
SpindlePole 1 0 0 1 0 1 0 2 – 0 0 0 1 3 3 2 0 0 0 0 0 2 2 1
Vac/Vac Membrane 130 42 100 150 290 326 448 480 – 313 247 265 14 14 8 164 133 111 190 75 199 70 146 154
Unique Cell Count 270 125 263 324 486 675 822 918 742 588 703 174 292 264 260 207 181 330 154 323 176 320 283
Labelled Cell Count 323 150 315 379 590 852 966 1056 870 692 838 227 390 345 302 237 203 330 154 323 176 320 283


Ambiguous, Bud, Bud Neck, Cytoplasm, Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.3 15.1 10.7 10.5 10.9 9.4 9.0 9.1 – 9.3 8.5 8.6 12.5 11.6 11.7 12.2 11.5 11.9 14.3 14.3 13.9
Std Deviation (1e-4) 3.2 3.1 2.0 2.0 2.7 2.4 2.5 2.2 – 2.4 2.2 2.3 2.1 2.4 2.4 2.7 2.7 2.6 2.3 3.3 2.5
Intensity Change (Log2) – – – -0.02 0.04 -0.18 -0.24 -0.22 – -0.2 -0.34 -0.31 0.23 0.12 0.13 0.2 0.11 0.15 0.42 0.43 0.38


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -3.4 -6.5 -6.9 -8.9 -9.7 – -8.4 -8.6 -8.7 2.6 6.5 4.6 -3.1 -2.9 -2.2
Bud 0 0 0 0 0 – 0 0 0 4.3 3.2 1.0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 4.5 5.6 8.8 -1.6 -0.8 0
Cytoplasm 5.3 3.5 7.1 6.0 6.9 – 9.4 10.2 11.8 3.0 1.0 1.8 -0.4 -1.4 -0.1
Endoplasmic Reticulum -5.0 -6.3 -7.8 -10.8 -15.5 – -12.0 -13.6 -14.2 -0.1 -1.1 -2.5 -9.3 -7.6 -7.2
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 1.2 0 0 0
Mitochondria -2.4 -1.6 -0.1 -0.4 -1.2 – -1.3 0.6 0.6 0 0 -2.3 0 0.3 -0.6
Nucleus 0 4.4 5.5 4.3 4.1 – 4.7 4.1 3.9 0 0 0 6.1 5.2 5.1
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 2.0 5.7 2.8 4.7 4.1 – 1.2 1.1 -0.1 -7.0 -9.7 -10.0 5.7 5.6 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.5979 8.426 8.2535 7.4746 7.2038 8.1775 11.3323 12.1846 11.949 11.3195 11.5687 12.2654 8.7183 9.0675 9.1746 8.968 8.6319 9.2268
Actin 0.0485 0.0127 0.0285 0.0025 0.0123 0.014 0.0244 0.0066 0.0134 0.0099 0.004 0.0088 0.0486 0.0163 0.0295 0.0017 0.0096 0.0086
Bud 0.0249 0.0144 0.1447 0.0379 0.0292 0.0042 0.0163 0.0239 0.0835 0.0198 0.015 0.0061 0.0248 0.0218 0.1445 0.0245 0.0274 0.0076
Bud Neck 0.0302 0.023 0.0111 0.0037 0.0051 0.4193 0.0174 0.0097 0.0063 0.003 0.0027 0.3336 0.0279 0.014 0.0036 0.0048 0.0277 0.3727
Bud Periphery 0.0597 0.0302 0.3292 0.2293 0.1058 0.0231 0.0708 0.0528 0.284 0.1483 0.1103 0.0275 0.0588 0.04 0.33 0.1832 0.1507 0.0246
Bud Site 0.1192 0.2626 0.0391 0.0074 0.013 0.0065 0.0661 0.1808 0.0309 0.0132 0.0038 0.0116 0.126 0.2688 0.0564 0.0401 0.0182 0.0118
Cell Periphery 0.1109 0.0433 0.0181 0.0371 0.0625 0.063 0.1684 0.0366 0.0377 0.0579 0.1034 0.0844 0.1368 0.0387 0.0104 0.0376 0.0348 0.0519
Cytoplasm 0.0933 0.0733 0.033 0.0597 0.0441 0.0252 0.0778 0.0403 0.029 0.0386 0.0197 0.0415 0.119 0.0754 0.0262 0.0195 0.0394 0.0566
Cytoplasmic Foci 0.0414 0.017 0.0064 0.0018 0.0317 0.0134 0.0114 0.0102 0.0062 0.004 0.006 0.0124 0.0271 0.0209 0.0218 0.0081 0.0139 0.0199
Eisosomes 0.001 0.0002 0.0002 0 0.0001 0.0002 0.0007 0.0001 0.0002 0.0005 0.0001 0.0002 0.0005 0.0001 0.0002 0 0.0003 0.0001
Endoplasmic Reticulum 0.0321 0.0262 0.009 0.0101 0.0122 0.0241 0.0561 0.0365 0.0142 0.0411 0.0164 0.0328 0.0284 0.0266 0.0091 0.0104 0.0485 0.0319
Endosome 0.0697 0.091 0.0587 0.0407 0.0857 0.0676 0.0626 0.1216 0.0606 0.0721 0.0575 0.053 0.0649 0.0875 0.0789 0.0878 0.0924 0.0751
Golgi 0.0341 0.0261 0.0125 0.0039 0.0302 0.0261 0.0242 0.0273 0.0146 0.0106 0.0095 0.0181 0.0162 0.0136 0.0291 0.0074 0.025 0.0328
Lipid Particles 0.0577 0.0157 0.002 0.0028 0.0503 0.0111 0.0468 0.0119 0.0028 0.0039 0.0059 0.0151 0.0235 0.0164 0.0089 0.0132 0.0127 0.0197
Mitochondria 0.013 0.0044 0.0071 0.0037 0.0141 0.0147 0.0114 0.0052 0.0179 0.0124 0.0024 0.0049 0.0028 0.0029 0.0152 0.0031 0.038 0.0028
None 0.004 0.0004 0.0004 0.0003 0.0035 0.0007 0.0017 0.0011 0.0003 0.0005 0.0003 0.0002 0.0087 0.0003 0.0016 0.0002 0.005 0.003
Nuclear Periphery 0.0083 0.0046 0.0037 0.0048 0.0031 0.0052 0.0048 0.0052 0.0037 0.0076 0.0055 0.0026 0.004 0.0029 0.0041 0.0047 0.0258 0.0044
Nucleolus 0.002 0.0022 0.0013 0.0017 0.0048 0.002 0.0016 0.0042 0.0013 0.0007 0.0009 0.002 0.0015 0.0017 0.0008 0.0012 0.0027 0.0018
Nucleus 0.0037 0.0043 0.0034 0.0039 0.0057 0.0041 0.0034 0.0106 0.0038 0.0029 0.003 0.0033 0.0029 0.0034 0.0022 0.0026 0.008 0.0037
Peroxisomes 0.0155 0.0006 0.0005 0.0002 0.0039 0.0012 0.0021 0.0005 0.0003 0.0005 0.0002 0.0006 0.0028 0.0006 0.0039 0.0003 0.0014 0.001
Punctate Nuclear 0.0029 0.0004 0.0002 0.0001 0.0007 0.0005 0.0005 0.002 0.0001 0.0001 0.0002 0.0003 0.0045 0.0003 0.0054 0.0001 0.002 0.0015
Vacuole 0.2184 0.3251 0.2483 0.4836 0.4454 0.2607 0.3142 0.3818 0.3429 0.4881 0.5707 0.3254 0.2625 0.3292 0.1818 0.4885 0.3805 0.2586
Vacuole Periphery 0.0096 0.0222 0.0427 0.0649 0.0366 0.013 0.0172 0.0313 0.0463 0.0643 0.0626 0.0156 0.008 0.0183 0.0363 0.0609 0.036 0.0101

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 56.7715 30.3634 24.4622 37.8826 31.4559 54.3153 42.7613 43.2174 38.9377 53.0903
Translational Efficiency 1.0314 1.2147 1.3817 0.6952 1.1887 1.1075 0.9016 0.8251 0.9499 0.8888

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2030 1973 1527 1606 1556 1416 3158 1696 3586 3389 4685 3302

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1056.94 1193.89 1168.73 1346.39 978.38 1176.04 1269.09 1248.38 1022.85 1186.43 1236.38 1296.05
Standard Deviation 158.10 265.40 176.11 221.38 204.52 207.21 171.26 213.75 183.89 242.95 179.14 222.94
Intensity Change Log 2 — 0.175776 0.145048 0.349203 — 0.265470 0.375328 0.351590 — 0.219589 0.260336 0.350351

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003352 0.009773 0.022775 0.010136 0.002367 0.007879 0.052782 0.008113 0.002924 0.008982 0.043002 0.009097
Bud Neck 0.047344 0.046737 0.054751 0.036652 0.026364 0.039766 0.072792 0.032464 0.038241 0.043824 0.066912 0.034501
Bud Site 0.104498* 0.265429* 0.303394* 0.245545* 0.147325* 0.165459* 0.423572* 0.264792* 0.123081* 0.223659* 0.384402* 0.255431*
Cell Periphery 0.186399* 0.118807* 0.044219 0.149659* 0.073541 0.215179* 0.057488 0.067422 0.137429* 0.159073* 0.053163 0.107420*
Cytoplasm 0.044345 0.072222 0.065314 0.074778 0.057113 0.037455 0.078294 0.106896* 0.049885 0.057696 0.074064 0.091275
Cytoplasmic Foci 0.016426 0.060686 0.049452 0.012146 0.056308 0.022807 0.036862 0.038758 0.033731 0.044860 0.040965 0.025815
Eisosomes 0.000469 0.000656 0.000907 0.000639 0.000270 0.000489 0.001925 0.000385 0.000383 0.000587 0.001593 0.000508
Endoplasmic Reticulum 0.077810 0.058726 0.079682 0.023520 0.053948 0.076577 0.022808 0.022623 0.067456 0.066185 0.041345 0.023060
Endosome 0.033438 0.070938 0.134507 0.033628 0.086839 0.045127 0.073528 0.079564 0.056609 0.060153 0.093403 0.057222
Golgi 0.009975 0.037623 0.028163 0.017031 0.030811 0.016434 0.041745 0.022237 0.019016 0.028770 0.037318 0.019705
Lipid Particles 0.006515 0.025619 0.048918 0.016987 0.007441 0.008823 0.030208 0.013353 0.006917 0.018601 0.036306 0.015121
Mitochondria 0.004660 0.006305 0.005592 0.002495 0.005268 0.002893 0.030933 0.006011 0.004924 0.004879 0.022674 0.004301
Mitotic Spindle 0.000125 0.000318 0.002578 0.001336 0.000186 0.000177 0.001061 0.004372 0.000151 0.000259 0.001556 0.002895
None 0.000044 0.000365 0.000108 0.000377 0.000205 0.000043 0.000125 0.000417 0.000114 0.000230 0.000120 0.000397
Nuclear Periphery 0.000092 0.000163 0.000142 0.000255 0.000087 0.000127 0.000054 0.000129 0.000090 0.000148 0.000083 0.000190
Nuclear Periphery Foci 0.000446 0.001340 0.001412 0.001030 0.001954 0.000738 0.000299 0.000874 0.001100 0.001088 0.000661 0.000950
Nucleolus 0.000513 0.000387 0.000185 0.000299 0.000462 0.000299 0.000165 0.000331 0.000491 0.000350 0.000171 0.000315
Nucleus 0.000776 0.000926 0.001356 0.001452 0.000801 0.000609 0.000834 0.002491 0.000787 0.000793 0.001004 0.001986
Peroxisomes 0.004329 0.007335 0.007154 0.003011 0.003020 0.004050 0.012984 0.003551 0.003761 0.005963 0.011084 0.003288
Vacuole 0.419667* 0.180075 0.132880 0.331473* 0.380566* 0.323107* 0.046428 0.288334* 0.402701* 0.239837* 0.074606 0.309315*
Vacuole Periphery 0.038777 0.035570 0.016509 0.037549 0.065124 0.031962 0.015111 0.036884 0.050209 0.034062 0.015567 0.037208

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.22 -10.09 -5.90 -0.18 5.85 -4.81 -23.60 -6.85 -0.13 19.72* -7.89 -25.24 -8.69 -0.04 19.91*
Bud Neck 0.21 -2.00 3.74 3.49 5.42 -4.45 -16.14 -2.47 2.50 14.23 -2.45 -12.17 2.05 4.53 14.82
Bud Site -20.03* -21.09* -16.28 2.05 5.20 -2.01 -33.98* -12.19 -9.76 17.37* -16.48 -44.44 -20.63 -4.25 18.47*
Cell Periphery 9.93 24.14* 4.88 -3.55 -14.42 -17.60* 3.57 1.21 18.00 -1.89 -4.04 21.57 6.17 9.50 -12.18
Cytoplasm -7.41 -5.53 -7.60 -0.83 -2.27 5.13 -5.71 -9.66 -14.17 -6.02 -2.87 -9.37 -12.66 -10.04 -5.42
Cytoplasmic Foci -15.53 -13.18 2.69 17.60 15.52 10.07 6.31 4.90 -5.84 -0.92 -4.99 -3.99 4.09 8.96 8.97
Eisosomes -2.22 -5.32 -1.67 0.28 2.77 -3.09 -11.86 -2.22 1.51 11.02 -3.57 -12.16 -2.18 1.36 10.61
Endoplasmic Reticulum 4.77 -0.34 16.73 10.93 12.21 -4.83 10.46 9.92 13.02 0.10 0.42 10.00 19.32 16.89 9.09
Endosome -13.03 -20.76 -0.07 12.29 20.32 9.99 3.29 1.62 -8.55 -1.47 -1.43 -13.40 -0.17 1.21 12.82
Golgi -12.96 -9.14 -3.86 8.60 4.93 5.58 -4.03 3.43 -2.54 8.26 -5.83 -10.72 -0.34 5.46 10.31
Lipid Particles -10.47 -13.57 -5.27 3.49 8.97 -1.13 -12.77 -3.90 -2.65 7.57 -9.84 -18.69 -6.60 2.17 11.11
Mitochondria -2.65 -1.30 4.85 6.87 4.75 3.90 -19.00 -0.85 -4.12 17.62* 0.10 -18.94 1.41 1.27 19.23*
Mitotic Spindle -9.40 -4.25 -4.22 -3.61 1.73 0.51 -3.88 -5.27 -5.28 -4.05 -7.83 -5.81 -6.40 -6.16 -2.86
None -2.50 -2.25 -1.15 -0.01 -0.92 2.70 1.34 -1.26 -2.38 -1.85 -1.48 -0.24 -1.73 -0.92 -1.71
Nuclear Periphery -1.15 -4.38 -2.35 -1.03 -1.63 -1.46 3.19 -2.18 -0.16 -4.33 -1.54 1.12 -2.87 -0.90 -3.07
Nuclear Periphery Foci -3.57 -8.27 -5.84 1.08 2.36 1.71 2.30 1.41 -1.67 -5.52 0.07 1.39 0.36 0.57 -3.77
Nucleolus 4.38 15.97 8.80 2.87 -5.38 4.59 9.82 2.84 -1.13 -5.65 6.23 19.01 7.06 1.19 -8.02
Nucleus -2.20 -4.52 -5.56 -4.04 -0.79 3.82 -0.77 -3.82 -4.25 -3.75 -0.21 -4.36 -5.19 -5.10 -4.19
Peroxisomes -4.59 -4.28 2.57 6.39 6.08 -1.90 -13.11 -1.41 0.90 12.26 -4.96 -12.96 1.48 5.95 13.68
Vacuole 28.13* 34.53* 8.24 -16.27 -21.65 5.03 40.18* 8.37 3.10 -32.10 23.27 58.77* 12.26 -10.00 -40.85
Vacuole Periphery 1.57 12.50 0.57 -0.72 -9.31 11.33 20.25 9.56 -1.88 -11.35 9.33 23.79 6.92 -1.67 -14.82
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
Localization
Cell Percentages vacuole (28%), ER (7%), mixed (46%)
Cell Cycle Regulation Yes
vacuole - S/G2 (5.5e-05)
ER - T/G1 (2.1e-05)
Subcompartmental Group N/A

Slg1

Slg1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Slg1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available