Standard name
Human Ortholog
Description Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.05 0 0 0 0 0 – 0.06 0 0 0 0 0.05 0.1 0.08 0 0 0 0 0 0
Cytoplasm 0.99 0.95 1.0 0.99 0.96 0.93 0.9 0.86 0.78 – 0.76 0.76 0.99 0.98 0.99 0.96 0.99 0.93 0.95 0.81 0.94 0.85 0.89 0.89
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.1 0.06 0.21 – 0.25 0.17 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.07 0 – 0 0.06 0 0 0 0 0 0.06 0 0.12 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 6 6 6 8 – 5 11 0 0 1 0 0 1 0 1 1 2 2 1
Bud 1 0 3 0 2 0 10 7 10 – 20 11 1 0 2 0 0 0 0 2 2 1 2 4
Bud Neck 0 0 2 0 0 2 0 1 0 – 0 0 0 0 0 0 0 0 0 1 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 1 – 2 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 10 15 10 15 16 13 7 – 22 14 1 16 13 6 19 14 0 1 0 0 0 1
Cytoplasm 190 262 527 286 367 366 521 491 267 – 298 319 202 473 507 115 187 162 174 248 501 96 284 284
Endoplasmic Reticulum 0 5 0 0 2 7 2 4 10 – 5 7 1 6 3 3 3 3 0 1 3 4 6 5
Endosome 0 1 1 1 1 0 6 7 3 – 9 11 0 1 1 1 0 3 1 1 2 1 2 0
Golgi 1 0 0 1 0 0 0 0 0 – 0 0 0 1 0 0 0 2 1 0 2 0 2 0
Mitochondria 2 0 0 3 10 19 56 37 72 – 97 73 1 0 0 3 1 1 0 4 6 0 4 4
Nucleus 0 9 0 2 2 1 5 9 1 – 3 2 1 4 1 3 1 2 0 2 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 1 0 – 1 0 0 0 0 0 0 0 0 0 0 1 0 0
Nucleolus 0 1 0 0 0 0 0 2 0 – 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 3 1 3 8 1 – 3 5 0 0 0 0 0 0 0 2 1 0 0 0
Vac/Vac Membrane 0 2 4 1 7 2 13 41 13 – 2 25 0 0 2 3 4 10 1 35 4 3 6 7
Unique Cell Count 192 275 529 290 384 393 578 574 343 390 422 204 482 514 120 189 174 184 306 533 114 318 321
Labelled Cell Count 194 282 547 310 405 419 638 627 393 469 478 207 501 530 134 215 198 184 306 533 114 318 321


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.4 8.3 7.0 6.7 7.5 6.0 6.4 6.7 5.6 – 5.3 6.0 7.6 7.9 7.8 11.7 12.8 11.0 7.1 6.9 7.8
Std Deviation (1e-4) 1.3 1.6 1.2 1.2 1.5 1.0 1.3 1.2 1.0 – 1.0 1.3 1.5 1.4 1.3 2.6 2.4 2.0 1.6 1.5 1.8
Intensity Change (Log2) – – – -0.05 0.1 -0.22 -0.13 -0.06 -0.32 – -0.4 -0.22 0.12 0.17 0.17 0.74 0.88 0.66 0.03 -0.01 0.16

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 1.8 0 2.8 – 4.4 2.6 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 2.6 0.7 1.8 1.0 0.4 0.2 – 3.1 1.4 0 1.4 0.7 0 4.9 3.9
Cytoplasm -1.6 -4.2 -5.6 -7.0 -8.8 -11.0 – -11.5 -11.7 -1.0 -2.3 -1.7 -3.6 -1.1 -5.3
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 3.3 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.1 7.3 5.9 11.0 – 12.1 10.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.0 5.4 3.2 – 0 4.6 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.0801 7.0169 5.9538 5.4362 5.4706 5.9781 5.2644 6.114 5.5977 4.9969 4.5369 5.6622 3.2896 4.1329 3.506 3.9077 3.6847 3.5148
Actin 0.0179 0.0003 0.0016 0.011 0.0436 0.0026 0.018 0.0018 0.0136 0.0096 0.0025 0.0145 0.0322 0.0006 0.0274 0.004 0.0184 0.0072
Bud 0.0007 0.0002 0.0002 0.0003 0.0009 0.0003 0.0015 0.0015 0.0015 0.0032 0.0012 0.001 0.001 0.0002 0.0002 0.0002 0.0001 0.0001
Bud Neck 0.0096 0.0002 0.005 0.0005 0.0023 0.0027 0.0096 0.0006 0.0018 0.0049 0.0014 0.008 0.0061 0.0002 0.0012 0.0004 0.0007 0.001
Bud Periphery 0.0009 0.0001 0.0002 0.0002 0.0009 0.0003 0.0017 0.0008 0.0014 0.0033 0.0016 0.0012 0.0012 0.0002 0.0002 0.0002 0.0002 0.0001
Bud Site 0.0054 0.0032 0.0006 0.0006 0.0159 0.0017 0.008 0.0087 0.0108 0.0062 0.0034 0.0008 0.0024 0.0013 0.0008 0.0003 0.0001 0.0001
Cell Periphery 0.001 0.0007 0.0003 0.0002 0.0003 0.0005 0.0006 0.0002 0.0004 0.0006 0.0002 0.0002 0.0004 0.0003 0.0001 0.0001 0.0001 0.0001
Cytoplasm 0.8064 0.9217 0.9337 0.8299 0.8159 0.9156 0.8351 0.9488 0.8877 0.8197 0.8311 0.9004 0.6799 0.9259 0.8807 0.7335 0.8655 0.9082
Cytoplasmic Foci 0.0303 0.0116 0.0081 0.0278 0.048 0.0196 0.0263 0.0137 0.0222 0.0243 0.0369 0.0249 0.0257 0.0086 0.0091 0.0036 0.002 0.0147
Eisosomes 0.0003 0 0 0.0001 0.0002 0 0.0001 0 0.0001 0.0002 0 0 0.0004 0 0.0002 0.0001 0.0002 0
Endoplasmic Reticulum 0.0071 0.004 0.0034 0.0027 0.0024 0.0037 0.0093 0.0022 0.0041 0.0039 0.0045 0.004 0.012 0.0037 0.0052 0.0144 0.003 0.0047
Endosome 0.0165 0.0083 0.0096 0.0348 0.011 0.0043 0.035 0.0052 0.0131 0.038 0.0377 0.0113 0.0414 0.0063 0.0096 0.0063 0.0067 0.0202
Golgi 0.0059 0.0007 0.002 0.0048 0.0157 0.0007 0.0075 0.0007 0.0045 0.0094 0.0062 0.0032 0.0101 0.0006 0.0027 0.0004 0.0029 0.0015
Lipid Particles 0.0145 0.0003 0.0052 0.0411 0.0034 0.0002 0.0018 0.0001 0.0012 0.0109 0.0029 0.0004 0.0041 0.0002 0.0027 0.0004 0.0017 0.0005
Mitochondria 0.0063 0.0001 0.0005 0.0032 0.002 0.0002 0.0033 0.0004 0.0079 0.0323 0.0036 0.0016 0.0039 0.0002 0.0007 0.0027 0.0012 0.0007
None 0.0559 0.0469 0.025 0.0059 0.0161 0.0443 0.0222 0.0093 0.018 0.0137 0.0465 0.0189 0.1413 0.0482 0.0398 0.1229 0.0626 0.0279
Nuclear Periphery 0.0016 0.0003 0.0005 0.0007 0.0003 0.0002 0.0029 0.0009 0.0009 0.0028 0.0031 0.0008 0.0088 0.0009 0.0028 0.0502 0.0266 0.0083
Nucleolus 0.0014 0 0 0.0002 0.0001 0 0.0003 0.0001 0.0002 0.0004 0.0005 0.0001 0.0012 0 0.0003 0.001 0.0003 0.0001
Nucleus 0.0014 0.0005 0.0007 0.0006 0.0005 0.0006 0.0034 0.002 0.0023 0.0018 0.0046 0.0017 0.0059 0.0009 0.0028 0.0526 0.0031 0.0015
Peroxisomes 0.0094 0.0001 0.0015 0.0328 0.0168 0.0014 0.0062 0.0003 0.004 0.0098 0.0039 0.0044 0.0101 0 0.0034 0.0001 0.0003 0.0003
Punctate Nuclear 0.0037 0.0001 0.0003 0.0014 0.0028 0.0002 0.0019 0.0005 0.0014 0.0013 0.0016 0.001 0.0075 0.0002 0.0084 0.0032 0.0027 0.001
Vacuole 0.0032 0.0005 0.0012 0.0008 0.0007 0.0009 0.0044 0.0021 0.0025 0.0032 0.0055 0.0012 0.0033 0.0015 0.0013 0.0016 0.0006 0.0011
Vacuole Periphery 0.0007 0.0001 0.0002 0.0003 0.0002 0.0001 0.0009 0.0002 0.0004 0.0008 0.0011 0.0002 0.0011 0.0002 0.0003 0.0017 0.001 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.4614 6.2777 10.4812 21.3128 5.6906 5.7026 13.2897 7.6309 18.6585 12.9505
Translational Efficiency 0.6849 0.9667 0.8434 0.6181 1.07 1.6998 0.6237 1.164 0.8649 0.8441

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1950 1589 1448 1364 671 1328 124 2796 2621 2917 1572 4160

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 763.21 827.90 1153.32 976.93 796.62 779.62 1129.90 1030.11 771.76 805.92 1151.47 1012.67
Standard Deviation 99.90 119.56 189.61 147.74 113.86 114.48 155.75 139.52 104.68 119.72 187.27 144.44
Intensity Change Log 2 — 0.117376 0.595641 0.356175 — -0.031121 0.504231 0.370835 — 0.043448 0.549681 0.363681

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000134 0.000221 0.000175 0.001074 0.000329 0.000356 0.000534 0.000637 0.000184 0.000283 0.000203 0.000780
Bud Neck 0.007455 0.010721 0.001609 0.006686 0.006659 0.016189 0.001749 0.008792 0.007251 0.013210 0.001620 0.008102
Bud Site 0.008650 0.013397 0.006182 0.042944 0.011667 0.019821 0.005462 0.030109 0.009422 0.016322 0.006126 0.034318
Cell Periphery 0.000115 0.000066 0.000090 0.000101 0.000175 0.000075 0.000103 0.000044 0.000130 0.000070 0.000091 0.000063
Cytoplasm 0.701859 0.653861 0.707004 0.659444 0.630795 0.571968 0.425670 0.786442 0.683666 0.616579 0.684812 0.744802
Cytoplasmic Foci 0.136828 0.146556 0.015998 0.032892 0.216599 0.157850 0.046085 0.008703 0.157250 0.151698 0.018371 0.016634
Eisosomes 0.000074 0.000043 0.000014 0.000020 0.000088 0.000064 0.000048 0.000009 0.000078 0.000052 0.000017 0.000012
Endoplasmic Reticulum 0.000575 0.000556 0.000966 0.000724 0.001396 0.000506 0.001684 0.000156 0.000786 0.000534 0.001023 0.000343
Endosome 0.007506 0.011086 0.002711 0.005807 0.015778 0.016005 0.026533 0.002709 0.009624 0.013325 0.004590 0.003725
Golgi 0.002553 0.002363 0.000169 0.003073 0.003597 0.003934 0.003139 0.001268 0.002820 0.003078 0.000403 0.001860
Lipid Particles 0.001532 0.001707 0.000805 0.000998 0.003244 0.001581 0.002308 0.000206 0.001971 0.001650 0.000924 0.000466
Mitochondria 0.001269 0.002794 0.000132 0.002740 0.001124 0.006155 0.001442 0.003107 0.001232 0.004324 0.000235 0.002987
Mitotic Spindle 0.000782 0.006223 0.004590 0.053993 0.000569 0.010384 0.014871 0.050408 0.000728 0.008117 0.005401 0.051584
None 0.004550 0.002920 0.007223 0.003835 0.002233 0.001514 0.004019 0.003749 0.003957 0.002280 0.006970 0.003777
Nuclear Periphery 0.000071 0.000175 0.000395 0.000250 0.000105 0.000234 0.000972 0.000308 0.000080 0.000202 0.000440 0.000289
Nuclear Periphery Foci 0.000563 0.000673 0.002743 0.001417 0.001601 0.000380 0.005656 0.000247 0.000829 0.000539 0.002973 0.000631
Nucleolus 0.000460 0.000599 0.000246 0.000219 0.000332 0.000859 0.000152 0.000202 0.000427 0.000717 0.000239 0.000207
Nucleus 0.044032 0.064779 0.159034 0.041906 0.036673 0.065814 0.042077 0.052012 0.042148 0.065250 0.149808 0.048699
Peroxisomes 0.001292 0.003917 0.000190 0.003965 0.001657 0.008321 0.001404 0.002578 0.001386 0.005922 0.000286 0.003033
Vacuole 0.078916 0.076388 0.089526 0.135869 0.064137 0.115369 0.415531 0.046127 0.075132 0.094134 0.115242 0.075552
Vacuole Periphery 0.000781 0.000956 0.000196 0.002041 0.001243 0.002622 0.000562 0.002185 0.000900 0.001714 0.000224 0.002138

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.37 -5.21 -5.43 -4.42 -4.42 -0.17 0.38 0.10 0.37 -0.33 -3.42 -1.59 -4.36 -2.73 -3.82
Bud Neck -3.05 9.00 5.27 7.41 -3.53 -5.61 3.47 1.79 9.47 -3.19 -6.64 9.46 4.79 11.42 -5.19
Bud Site -3.14 2.91 -5.63 -3.01 -6.67 -3.44 2.88 -0.57 3.24 -4.05 -5.52 3.89 -5.26 0.40 -7.63
Cell Periphery 7.41 2.88 4.40 -2.79 1.32 9.25 5.59 13.21 7.65 6.16 10.70 5.26 14.17 5.17 6.94
Cytoplasm 6.14 6.92 14.27 7.89 7.27 5.64 11.28 -7.30 -15.89 -15.33 10.69 7.76 3.49 -7.84 -5.24
Cytoplasmic Foci -1.37 34.16 29.24 25.37 -7.31 7.29 24.79 29.62 30.54 4.02 1.75 42.69 43.58 40.91 0.13
Eisosomes 7.21 15.12 12.39 7.85 -8.03 4.02 6.71 14.53 17.00 10.03 6.96 18.53 19.21 19.63 0.62
Endoplasmic Reticulum 0.01 -2.72 0.63 0.76 4.10 2.40 -0.34 3.36 6.22 6.52 1.82 -1.35 4.08 5.01 8.60
Endosome -3.71 11.72 8.91 9.38 -0.85 0.31 2.82 9.52 12.47 2.17 -3.83 12.27 15.04 16.20 3.12
Golgi 0.75 8.90 3.51 3.07 -1.68 -0.00 4.52 5.62 4.81 0.32 -0.17 10.59 7.94 6.53 -2.37
Lipid Particles -0.85 5.05 3.18 2.62 -1.74 4.91 3.65 8.61 9.68 7.29 1.79 7.50 11.16 7.27 4.05
Mitochondria -1.73 2.93 0.66 2.04 -1.23 -3.59 2.47 -0.08 3.64 -3.52 -3.78 3.65 0.49 4.16 -4.11
Mitotic Spindle -3.50 -5.82 -6.98 -4.62 -4.22 -5.24 -3.03 -10.19 -4.15 -3.97 -6.08 -6.41 -12.20 -6.62 -6.74
None 2.75 -1.96 3.60 0.55 6.31 1.14 -0.11 -3.39 -8.29 -2.60 3.76 -2.88 1.06 -4.39 4.80
Nuclear Periphery -7.55 -21.70 -20.08 -12.19 4.97 -6.39 -10.40 -10.25 -6.10 6.54 -10.44 -23.44 -15.65 -9.89 5.25
Nuclear Periphery Foci -1.46 -10.13 -6.97 -4.98 6.11 7.17 -5.40 7.79 2.06 7.72 4.11 -10.08 2.86 -1.62 11.01
Nucleolus -1.39 4.19 4.74 5.12 1.10 -1.27 1.51 1.24 3.57 -2.30 -2.13 3.51 3.62 5.43 0.16
Nucleus -8.71 -25.94 -9.07 -0.13 20.16 -8.33 -4.10 -18.32 -5.95 -1.65 -11.58 -26.37 -21.27 -6.09 17.78
Peroxisomes -6.30 11.70 -0.41 4.40 -3.43 -7.23 5.30 2.26 7.87 -1.22 -9.58 13.50 1.41 9.22 -3.29
Vacuole -0.98 -9.32 -25.45 -24.36 -15.46 -11.67 -17.42 -15.95 -2.03 14.24 -8.75 -14.09 -27.27 -18.35 -3.37
Vacuole Periphery -1.48 9.45 1.00 1.68 -2.10 -1.45 4.99 2.02 2.25 -1.88 -1.97 10.13 1.57 2.56 -2.68
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Rod1

Rod1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rod1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available