Standard name
Human Ortholog
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.08 0.05 0 0 0.05 0.07 0.1 0.08 0.06 0.09 0 0 0 0 0.05 0.06 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.91 0.93 0.91 0.8 0.68 0.7 0.63 0.57 0.54 0.54 0.98 0.98 0.99 0.93 0.96 0.95 0.93 0.93 0.91 0.94 0.92 0.93
Endoplasmic Reticulum 0 0 0.05 0 0 0 0.1 0.13 0.12 0.17 0.09 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.05 0.1 0.06 0.21 0.28 0.17 0.22 0.3 0.34 0.31 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0.05 0.05 0.09 0.07 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 2 0 4 11 6 9 14 11 13 0 0 0 0 1 1 0 0 1 0 3 1
Bud 0 0 0 0 0 0 1 2 7 5 1 5 0 0 0 0 0 1 2 0 1 0 5 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 5 2 19 9 5 8 14 20 29 23 12 26 9 12 10 9 17 20 0 0 3 0 0 0
Cytoplasm 169 143 221 172 197 169 175 198 180 170 114 162 299 262 343 211 313 314 164 128 229 156 287 280
Endoplasmic Reticulum 1 1 13 1 7 7 27 36 34 49 19 36 3 5 2 9 12 9 1 2 5 1 5 2
Endosome 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 1 2 0 0
Golgi 0 0 0 0 1 1 1 4 1 0 0 2 0 0 0 1 2 0 2 0 0 0 0 0
Mitochondria 7 1 12 19 13 44 73 49 64 89 72 93 0 0 0 4 5 3 1 1 2 0 0 0
Nucleus 0 0 0 1 1 0 0 0 1 4 1 1 2 1 2 2 2 2 0 0 1 1 1 1
Nuclear Periphery 0 0 0 1 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 1 0 1 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 5 3 3 0 2 12 15 15 19 21 1 2 3 8 7 6 1 1 1 0 1 3
Unique Cell Count 174 146 244 185 217 210 259 282 287 296 212 298 304 268 347 227 326 331 176 138 251 167 311 300
Labelled Cell Count 182 148 270 208 227 233 304 327 340 369 250 361 314 283 360 244 359 356 176 138 251 167 311 300


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.3 15.7 13.5 12.4 14.0 13.8 13.5 14.3 14.0 13.3 13.0 13.6 14.5 14.5 14.4 20.8 22.1 22.7 13.5 16.4 19.6
Std Deviation (1e-4) 2.5 3.2 3.4 2.9 3.1 3.2 3.5 3.6 3.6 3.7 3.8 4.3 3.2 2.9 3.0 6.6 6.4 6.7 3.3 4.6 6.0
Intensity Change (Log2) – – – -0.12 0.04 0.02 0.0 0.08 0.05 -0.03 -0.06 0.01 0.1 0.1 0.09 0.62 0.71 0.75 -0.01 0.28 0.54

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 3.3 0 0 3.4 3.6 3.3 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.2 -2.6 -1.8 -1.1 -0.3 0.9 0 -0.9 0.4 -2.6 -1.6 -2.7 -1.8 -1.2 -0.8
Cytoplasm 0.9 0.1 -3.1 -6.3 -5.8 -7.4 -8.6 -8.9 -9.2 4.1 3.5 4.7 0.9 2.6 2.0
Endoplasmic Reticulum -2.8 -1.1 -1.0 2.1 2.9 2.6 4.1 1.5 2.7 -3.0 -2.1 -3.6 -0.7 -1.0 -1.6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.1 0.5 5.2 7.0 4.5 5.7 7.5 8.0 7.7 -3.9 -3.7 0 -1.9 -2.4 -3.0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 1.4 1.9 1.8 3.3 2.7 0 0 0 1.0 0.1 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.6529 11.2739 10.6754 8.9884 9.396 9.885 8.1045 10.6985 10.0061 8.8633 8.996 9.6 7.7736 11.9207 10.8444 7.8578 11.2836 9.9689
Actin 0.004 0.001 0.0076 0.0096 0.0008 0.0006 0.0087 0.0002 0.0046 0.0006 0.0007 0.0043 0.0269 0.0003 0.0037 0.0023 0.0013 0.0016
Bud 0.0009 0.0005 0.0013 0.001 0.0003 0.0004 0.0005 0.0003 0.0005 0.0004 0.0002 0.0003 0.0012 0.0002 0.0004 0.0005 0.0004 0.0011
Bud Neck 0.0032 0.0003 0.0005 0.0008 0.0005 0.0012 0.0011 0.0003 0.0003 0.0009 0.0004 0.0009 0.0019 0.0001 0.0019 0.0013 0.0004 0.0036
Bud Periphery 0.001 0.0001 0.001 0.0007 0.0001 0.0003 0.0005 0.0002 0.0003 0.0004 0.0001 0.0002 0.001 0.0001 0.0003 0.0003 0.0001 0.0004
Bud Site 0.0024 0.0018 0.0011 0.0047 0.0002 0.0002 0.0044 0.001 0.0005 0.0004 0.0001 0.0002 0.0031 0.0002 0.0025 0.0003 0.0005 0.0002
Cell Periphery 0.0009 0.0004 0.0004 0.0003 0.0001 0.0003 0.0007 0.0001 0.0002 0.0001 0 0.0001 0.0004 0.0001 0.0004 0.0006 0.0001 0.0001
Cytoplasm 0.848 0.968 0.9268 0.8141 0.9516 0.9278 0.8181 0.9746 0.924 0.8539 0.8324 0.9307 0.8075 0.9596 0.9231 0.8529 0.9588 0.9273
Cytoplasmic Foci 0.0154 0.0058 0.0084 0.0261 0.0119 0.0085 0.029 0.0038 0.0092 0.0194 0.0148 0.0065 0.0124 0.0079 0.006 0.0094 0.0109 0.0093
Eisosomes 0.0001 0 0.0002 0 0 0 0.0001 0 0.0001 0 0 0 0.0002 0 0.0003 0.0001 0 0
Endoplasmic Reticulum 0.0523 0.0045 0.0156 0.0353 0.0078 0.0284 0.0237 0.0032 0.0135 0.012 0.0062 0.0104 0.066 0.0086 0.0267 0.0207 0.0055 0.0172
Endosome 0.0251 0.0086 0.0149 0.0405 0.0171 0.0198 0.0467 0.0061 0.0153 0.0647 0.0653 0.0174 0.0324 0.0168 0.0174 0.0418 0.01 0.0241
Golgi 0.0039 0.0011 0.0019 0.0106 0.0017 0.0025 0.0079 0.0004 0.0046 0.0127 0.0129 0.0065 0.0067 0.0008 0.0008 0.0018 0.0011 0.0035
Lipid Particles 0.0014 0.0001 0.0005 0.0044 0.0001 0.0002 0.0131 0.0001 0.0022 0.001 0.0374 0.0037 0.0093 0.0001 0.0008 0.0009 0.0003 0.0001
Mitochondria 0.0029 0.0003 0.0009 0.0056 0.0003 0.0034 0.0028 0.0002 0.0088 0.0056 0.0105 0.0033 0.0025 0.0003 0.0016 0.0024 0.0016 0.0056
None 0.0102 0.0014 0.0062 0.0008 0.0019 0.001 0.0034 0.0009 0.0016 0.0009 0.0011 0.0006 0.0049 0.0007 0.0027 0.0027 0.0026 0.0007
Nuclear Periphery 0.0059 0.0004 0.0012 0.0021 0.0007 0.001 0.0047 0.0007 0.0012 0.0036 0.0018 0.004 0.0061 0.0008 0.0021 0.0237 0.0006 0.0009
Nucleolus 0.0002 0 0 0.0002 0 0 0.0009 0.0001 0 0 0.0001 0.0001 0.0003 0 0.0002 0.0016 0 0
Nucleus 0.0054 0.0009 0.0009 0.0013 0.0008 0.0008 0.0044 0.0017 0.0011 0.0017 0.0015 0.0019 0.0019 0.0007 0.0011 0.0143 0.0008 0.0009
Peroxisomes 0.0007 0 0.0026 0.0224 0.0001 0.0001 0.008 0 0.001 0.001 0.0026 0.0008 0.0049 0 0.0002 0.0002 0.0001 0.0002
Punctate Nuclear 0.0022 0.0001 0.0001 0.0026 0.0001 0.0004 0.0077 0.0001 0.0012 0.0002 0.0003 0.0033 0.0032 0.0001 0.0003 0.0042 0.0005 0.0001
Vacuole 0.0122 0.0042 0.007 0.0143 0.0033 0.0025 0.0119 0.0058 0.0087 0.0168 0.0092 0.0037 0.0059 0.0023 0.0065 0.0151 0.0033 0.0024
Vacuole Periphery 0.0015 0.0004 0.0009 0.0026 0.0006 0.0007 0.0015 0.0005 0.0009 0.0036 0.0024 0.0009 0.0012 0.0004 0.0011 0.0031 0.001 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.3364 41.8329 46.2904 38.8337 13.8378 12.308 66.2285 73.1224 57.1232 23.3079
Translational Efficiency 0.8972 0.7459 0.6472 0.6871 0.5961 0.3373 0.67 0.6073 0.57 0.4508

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
195 161 1762 929 1205 2257 763 294 1400 2418 2525 1223

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2775.68 1329.59 1361.06 1679.22 1252.06 1204.95 1541.92 1882.16 1464.28 1213.25 1415.71 1728.01
Standard Deviation 1217.06 304.88 201.39 497.61 253.93 190.92 267.49 510.05 734.93 202.92 238.37 508.08
Intensity Change Log 2 — -1.061860 -1.028111 -0.725050 — -0.055330 0.300424 0.588086 — -0.668247 -0.472436 -0.177534

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001381 0.000363 0.000199 0.001332 0.000270 0.000410 0.000406 0.002563 0.000425 0.000407 0.000261 0.001628
Bud Neck 0.001660 0.000745 0.000580 0.002437 0.000469 0.000584 0.001188 0.004564 0.000635 0.000594 0.000764 0.002948
Bud Site 0.033604 0.037285 0.008233 0.030326 0.022480 0.015850 0.012165 0.046621 0.024029 0.017277 0.009421 0.034244
Cell Periphery 0.119125 0.000586 0.000168 0.004242 0.000553 0.000176 0.000181 0.008635 0.017068 0.000203 0.000172 0.005298
Cytoplasm 0.223313 0.824552 0.921983 0.840824 0.844329 0.824933 0.865347 0.768242 0.757830 0.824907 0.904869 0.823376
Cytoplasmic Foci 0.034356 0.088678 0.022142 0.023485 0.082284 0.091542 0.036119 0.032212 0.075608 0.091351 0.026365 0.025583
Eisosomes 0.000026 0.000004 0.000003 0.000008 0.000005 0.000006 0.000004 0.000016 0.000008 0.000006 0.000003 0.000010
Endoplasmic Reticulum 0.010924 0.002743 0.000525 0.000908 0.004922 0.002556 0.000704 0.000280 0.005758 0.002569 0.000579 0.000757
Endosome 0.006186 0.005772 0.001225 0.002302 0.003816 0.006373 0.003394 0.003418 0.004146 0.006333 0.001881 0.002570
Golgi 0.199284 0.009030 0.000991 0.004754 0.009513 0.009384 0.002341 0.006378 0.035946 0.009360 0.001399 0.005144
Lipid Particles 0.059381 0.001288 0.001268 0.013402 0.001181 0.000602 0.001866 0.027212 0.009287 0.000648 0.001449 0.016722
Mitochondria 0.003047 0.000023 0.000032 0.000189 0.000360 0.001196 0.000026 0.000344 0.000734 0.001118 0.000030 0.000226
Mitotic Spindle 0.008131 0.000646 0.000641 0.001695 0.001007 0.002139 0.001919 0.003743 0.002000 0.002040 0.001027 0.002187
None 0.004844 0.000484 0.001114 0.000361 0.000391 0.000309 0.000480 0.000449 0.001011 0.000321 0.000922 0.000382
Nuclear Periphery 0.003065 0.000017 0.000027 0.000073 0.000056 0.000031 0.000069 0.000057 0.000475 0.000030 0.000040 0.000069
Nuclear Periphery Foci 0.023439 0.001289 0.001691 0.002387 0.000961 0.000207 0.002786 0.003953 0.004092 0.000279 0.002022 0.002764
Nucleolus 0.006561 0.000019 0.000049 0.000086 0.000030 0.000070 0.000065 0.000070 0.000940 0.000067 0.000054 0.000082
Nucleus 0.019795 0.001796 0.014646 0.005499 0.002641 0.003089 0.011146 0.003876 0.005031 0.003003 0.013588 0.005109
Peroxisomes 0.000992 0.000438 0.000131 0.000616 0.000232 0.000642 0.000267 0.001235 0.000338 0.000629 0.000172 0.000765
Vacuole 0.084021 0.019698 0.023958 0.062689 0.014167 0.035536 0.058744 0.084549 0.023897 0.034481 0.034470 0.067944
Vacuole Periphery 0.156865 0.004545 0.000395 0.002383 0.010335 0.004364 0.000784 0.001583 0.030745 0.004376 0.000513 0.002191

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.13 3.54 0.02 -2.34 -2.64 -1.08 -1.38 -3.38 -3.12 -3.17 0.17 2.36 -3.34 -3.27 -3.75
Bud Neck 3.88 4.51 -3.55 -8.94 -10.23 -2.45 -9.14 -7.59 -7.41 -5.73 0.83 -4.31 -12.49 -12.83 -10.93
Bud Site -0.37 4.32 0.54 1.13 -9.59 4.00 5.55 -4.50 -5.83 -6.39 4.01 8.79 -4.20 -7.79 -11.39
Cell Periphery 10.82 10.87 10.48 -4.27 -5.02 5.13 7.04 -6.29 -6.60 -6.60 8.99 9.01 6.02 -7.32 -7.39
Cytoplasm -23.98 -34.32 -28.72 -0.17 10.82 2.65 0.61 5.87 4.80 5.42 -7.18 -15.15 -4.70 2.13 11.10
Cytoplasmic Foci -6.05 2.49 2.19 7.88 -0.47 -2.08 10.58 8.08 10.42 0.40 -3.85 14.47 13.66 20.12 0.34
Eisosomes 5.03 5.27 3.96 -4.87 -6.95 -2.57 -0.14 -4.01 -3.32 -3.94 1.47 5.65 -2.38 -3.76 -7.33
Endoplasmic Reticulum 2.84 4.80 4.62 1.00 -1.12 2.40 5.07 5.63 4.16 1.36 3.42 6.70 6.34 3.34 -0.72
Endosome 0.30 7.28 5.39 3.08 -3.64 -4.95 0.93 0.43 2.70 0.00 -4.52 7.28 3.73 7.27 -1.90
Golgi 13.58 14.24 13.96 2.87 -4.80 0.14 9.48 2.50 2.16 -3.09 9.56 13.05 11.34 4.29 -5.54
Lipid Particles 7.48 7.48 5.71 -8.82 -9.25 4.11 -3.68 -6.90 -7.05 -6.64 7.14 6.30 -4.51 -11.94 -11.22
Mitochondria 3.52 3.51 3.31 -1.27 -1.18 -2.72 3.67 0.25 2.48 -1.33 -1.22 4.85 2.98 3.12 -1.69
Mitotic Spindle 2.26 2.19 1.70 -1.88 -1.60 -2.72 -2.18 -1.59 -0.91 -0.89 -0.11 1.38 -0.73 -0.70 -1.72
None 2.06 1.80 2.12 0.40 2.94 1.33 -0.92 -0.44 -0.76 -0.16 2.30 0.42 1.86 -0.73 2.62
Nuclear Periphery 3.08 3.06 3.02 -1.83 -1.19 0.79 -1.20 -0.42 -2.20 1.50 3.11 2.95 2.78 -1.57 -0.78
Nuclear Periphery Foci 4.58 4.45 4.31 -3.05 -2.72 3.93 -5.81 -6.51 -8.64 -1.95 5.29 2.40 1.39 -13.76 -2.98
Nucleolus 1.99 1.98 1.97 -3.60 -1.84 -1.43 -7.20 -4.43 -0.17 0.06 1.89 1.91 1.86 -0.52 -1.68
Nucleus 3.44 0.58 2.53 -8.60 11.98 -2.10 -13.24 -4.14 -3.43 8.76 2.66 -11.61 -1.28 -7.33 14.27
Peroxisomes 1.64 2.56 1.11 -2.25 -9.25 -5.37 -1.98 -3.03 -1.66 -2.84 -3.42 3.05 -4.26 -1.11 -6.66
Vacuole 8.32 7.98 1.73 -8.91 -9.46 -9.30 -13.14 -8.91 -6.66 -2.05 -4.45 -8.45 -12.97 -10.40 -7.80
Vacuole Periphery 11.08 11.45 11.30 1.48 -2.96 5.03 8.42 7.31 5.56 -2.05 10.34 11.98 11.16 4.08 -3.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Hst3

Hst3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hst3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available