Standard name | |
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Human Ortholog | |
Description | 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | – | – | 1 | 2 | 3 | 0 | 2 | 3 |
Bud | 0 | 1 | 0 | 1 | 0 | 3 | 2 | 2 | 0 | 7 | 8 | 4 | 2 | 0 | 0 | 0 | – | – | 2 | 4 | 0 | 1 | 1 | 5 |
Bud Neck | 1 | 1 | 14 | 6 | 12 | 13 | 14 | 27 | 4 | 9 | 3 | 5 | 0 | 0 | 0 | 0 | – | – | 1 | 1 | 1 | 1 | 1 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 5 | 0 | 7 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | – | – | 0 | 0 | 2 | 0 | 1 | 2 |
Cytoplasm | 211 | 257 | 229 | 184 | 256 | 336 | 419 | 346 | 187 | 178 | 142 | 132 | 136 | 142 | 184 | 26 | – | – | 174 | 214 | 158 | 87 | 162 | 186 |
Endoplasmic Reticulum | 2 | 2 | 2 | 0 | 1 | 0 | 2 | 0 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 2 | – | – | 2 | 0 | 1 | 1 | 1 | 3 |
Endosome | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | – | – | 4 | 4 | 3 | 0 | 1 | 2 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | – | – | 0 | 0 | 0 | 0 | 1 | 0 |
Mitochondria | 41 | 27 | 0 | 8 | 5 | 53 | 63 | 32 | 113 | 132 | 147 | 55 | 19 | 4 | 8 | 5 | – | – | 28 | 23 | 21 | 20 | 19 | 20 |
Nucleus | 26 | 22 | 12 | 22 | 55 | 22 | 18 | 31 | 23 | 31 | 45 | 26 | 57 | 50 | 53 | 6 | – | – | 36 | 59 | 20 | 4 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | – | – | 1 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 4 | 1 | 11 | 5 | 1 | 2 | 2 | 5 | 0 | 0 | 0 | 0 | – | – | 17 | 20 | 14 | 1 | 1 | 4 |
Vac/Vac Membrane | 28 | 66 | 7 | 3 | 7 | 3 | 5 | 9 | 3 | 4 | 5 | 1 | 30 | 43 | 52 | 19 | – | – | 46 | 61 | 45 | 14 | 14 | 22 |
Unique Cell Count | 280 | 353 | 253 | 218 | 327 | 406 | 491 | 420 | 280 | 293 | 278 | 202 | 232 | 228 | 279 | 55 | 333 | 406 | 294 | 141 | 214 | 260 | ||
Labelled Cell Count | 309 | 379 | 269 | 224 | 349 | 432 | 534 | 455 | 334 | 369 | 357 | 232 | 247 | 242 | 299 | 61 | 333 | 406 | 294 | 141 | 214 | 260 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.5 | 3.6 | 4.6 | 4.0 | 4.5 | 3.6 | 3.7 | 3.9 | 3.0 | 3.0 | 2.9 | 3.4 | 4.1 | 4.4 | 4.3 | 6.2 | – | – | 3.8 | 3.8 | 4.2 |
Std Deviation (1e-4) | 0.5 | 0.7 | 0.6 | 0.7 | 1.1 | 1.0 | 1.0 | 0.9 | 0.4 | 0.7 | 0.8 | 0.8 | 0.8 | 1.3 | 1.0 | 1.5 | – | – | 1.6 | 1.7 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.21 | -0.02 | -0.36 | -0.3 | -0.22 | -0.6 | -0.63 | -0.63 | -0.42 | -0.17 | -0.06 | -0.09 | 0.45 | – | – | -0.26 | -0.27 | -0.13 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -1.3489 | -1.0145 | -0.9287 | -1.411 | -1.3663 | -1.0746 | -1.3506 | -0.9261 | -0.874 | -0.8237 | -1.2071 | -1.16 | -1.1829 | -0.8998 | -1.0019 | -1.0188 | -1.2616 | -1.3694 |
Actin | 0.0155 | 0.0003 | 0.0057 | 0.0031 | 0.0233 | 0.0065 | 0.024 | 0.0002 | 0.0085 | 0.0145 | 0.0031 | 0.0006 | 0.0473 | 0.0002 | 0.01 | 0.0012 | 0.0391 | 0.0073 |
Bud | 0.0029 | 0.0006 | 0.0011 | 0.0007 | 0.0002 | 0.0034 | 0.0016 | 0.0003 | 0.0002 | 0.0004 | 0.0011 | 0.0002 | 0.0006 | 0.0001 | 0.0002 | 0.0001 | 0.0006 | 0.0002 |
Bud Neck | 0.0012 | 0.0004 | 0.0016 | 0.0006 | 0.0021 | 0.002 | 0.0014 | 0.0004 | 0.0006 | 0.0007 | 0.0008 | 0.0018 | 0.0092 | 0.0002 | 0.0009 | 0.001 | 0.0003 | 0.0011 |
Bud Periphery | 0.0067 | 0.0003 | 0.0018 | 0.0021 | 0.0003 | 0.0013 | 0.0037 | 0.0003 | 0.0003 | 0.0004 | 0.0015 | 0.0002 | 0.0008 | 0.0001 | 0.0003 | 0.0001 | 0.0007 | 0.0003 |
Bud Site | 0.0049 | 0.0053 | 0.012 | 0.0003 | 0.0005 | 0.0067 | 0.0042 | 0.0023 | 0.0013 | 0.0011 | 0.0035 | 0.0002 | 0.0036 | 0.0012 | 0.0025 | 0.0003 | 0.0005 | 0.0002 |
Cell Periphery | 0.0003 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 |
Cytoplasm | 0.0856 | 0.1455 | 0.0929 | 0.0659 | 0.169 | 0.1363 | 0.2525 | 0.2102 | 0.1459 | 0.1202 | 0.1709 | 0.2564 | 0.1534 | 0.1656 | 0.1229 | 0.1639 | 0.1247 | 0.1935 |
Cytoplasmic Foci | 0.0221 | 0.0078 | 0.0201 | 0.0143 | 0.0098 | 0.0108 | 0.0212 | 0.0085 | 0.0073 | 0.0178 | 0.0179 | 0.016 | 0.0267 | 0.0027 | 0.0093 | 0.0081 | 0.0042 | 0.0086 |
Eisosomes | 0.0003 | 0.0001 | 0.0003 | 0.0001 | 0.0006 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0002 | 0.0002 | 0.0002 | 0.0004 | 0.0003 |
Endoplasmic Reticulum | 0.0071 | 0.004 | 0.003 | 0.0026 | 0.0044 | 0.0027 | 0.0097 | 0.0055 | 0.0032 | 0.0016 | 0.0039 | 0.0017 | 0.0072 | 0.0028 | 0.0027 | 0.0043 | 0.0017 | 0.002 |
Endosome | 0.0136 | 0.0054 | 0.0104 | 0.0251 | 0.0064 | 0.0069 | 0.0171 | 0.0046 | 0.0086 | 0.0138 | 0.0279 | 0.0037 | 0.0171 | 0.0019 | 0.0049 | 0.0025 | 0.0025 | 0.0028 |
Golgi | 0.0033 | 0.0001 | 0.0053 | 0.0011 | 0.0019 | 0.0031 | 0.0043 | 0.0001 | 0.0011 | 0.0136 | 0.014 | 0.0003 | 0.005 | 0.0001 | 0.0015 | 0.0001 | 0.0041 | 0.0009 |
Lipid Particles | 0.011 | 0.0021 | 0.0087 | 0.0091 | 0.0017 | 0.0016 | 0.0095 | 0.0009 | 0.0051 | 0.0076 | 0.0275 | 0.0005 | 0.01 | 0.0002 | 0.0026 | 0.0003 | 0.0076 | 0.0006 |
Mitochondria | 0.0112 | 0.0005 | 0.0071 | 0.002 | 0.0015 | 0.0066 | 0.0072 | 0.0005 | 0.0015 | 0.006 | 0.0185 | 0.0048 | 0.0024 | 0.0004 | 0.0012 | 0.0007 | 0.0023 | 0.0008 |
None | 0.7187 | 0.6326 | 0.3841 | 0.707 | 0.5593 | 0.7557 | 0.5273 | 0.4871 | 0.242 | 0.2611 | 0.5081 | 0.6377 | 0.6055 | 0.6206 | 0.3807 | 0.4546 | 0.6383 | 0.6627 |
Nuclear Periphery | 0.0229 | 0.0188 | 0.0249 | 0.0243 | 0.0196 | 0.0074 | 0.02 | 0.01 | 0.037 | 0.0145 | 0.0087 | 0.0029 | 0.0144 | 0.0071 | 0.0139 | 0.0113 | 0.005 | 0.0074 |
Nucleolus | 0.0019 | 0.0029 | 0.0085 | 0.0051 | 0.0032 | 0.0013 | 0.0025 | 0.0028 | 0.007 | 0.0054 | 0.0017 | 0.0011 | 0.0017 | 0.0021 | 0.005 | 0.0017 | 0.0014 | 0.0015 |
Nucleus | 0.0413 | 0.1453 | 0.3561 | 0.0895 | 0.1616 | 0.0339 | 0.0628 | 0.2338 | 0.5062 | 0.4683 | 0.1499 | 0.0582 | 0.0535 | 0.1859 | 0.4106 | 0.3211 | 0.15 | 0.1017 |
Peroxisomes | 0.0083 | 0.0002 | 0.0072 | 0.0016 | 0.0005 | 0.0006 | 0.0052 | 0.0002 | 0.0022 | 0.0117 | 0.0046 | 0.0003 | 0.0117 | 0.0001 | 0.0032 | 0.0001 | 0.0048 | 0.0013 |
Punctate Nuclear | 0.0154 | 0.0243 | 0.0441 | 0.0406 | 0.0308 | 0.011 | 0.0112 | 0.0288 | 0.0177 | 0.0394 | 0.03 | 0.0111 | 0.0202 | 0.0065 | 0.0205 | 0.0263 | 0.0111 | 0.0055 |
Vacuole | 0.004 | 0.0028 | 0.0037 | 0.0031 | 0.0022 | 0.0014 | 0.0115 | 0.003 | 0.003 | 0.0015 | 0.0046 | 0.0017 | 0.0075 | 0.0019 | 0.0059 | 0.0018 | 0.0004 | 0.001 |
Vacuole Periphery | 0.0019 | 0.0004 | 0.0011 | 0.0018 | 0.0009 | 0.0004 | 0.0023 | 0.0004 | 0.0011 | 0.0004 | 0.0013 | 0.0004 | 0.0016 | 0.0002 | 0.0007 | 0.0004 | 0.0002 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 24.3283 | 13.0956 | 10.0645 | 15.9108 | 26.116 | 27.7136 | 12.4133 | 11.3305 | 13.4949 | 24.6165 |
Translational Efficiency | 0.4886 | 0.2499 | 0.2762 | 0.4317 | 0.291 | 0.4522 | 0.3203 | 0.3724 | 0.3098 | 0.4069 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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