Standard name
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0 0.12 0.08 0 0 0 0 0 0 0
Bud 0 0 0.08 0 0 0 – 0 0 0 0.06 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0.06 0.13 0.05 0.05 – 0 0 0 0 0 0.1 0.12 0.15 0.17 0.05 0.23 0 0 0 0 0 0
Cytoplasm 0.43 0.27 0.42 0.27 0.48 0.51 – 0.44 0.37 0.44 0.42 0.42 0.28 0.35 0.36 0.43 0.48 0.39 0.19 0.08 0.11 0.14 0.11 0.17
Endoplasmic Reticulum 0.39 0.77 0.29 0.44 0.36 0.16 – 0.06 0.14 0.12 0.1 0.07 0.71 0.59 0.58 0 0.05 0 0.67 0.81 0.67 0.66 0.68 0.6
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 0.29 0.5 0.19 0.45 – 0.46 0.56 0.52 0.53 0.58 0 0 0 0 0.11 0 0 0 0.1 0.08 0.05 0.05
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.15 0 0.06 0 0.06 0.07 – 0.15 0.07 0.08 0.07 0.07 0 0 0.05 0.33 0.33 0.46 0 0 0 0 0 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 4 2 9 3 8 3 – 3 1 2 2 1 8 13 0 12 9 4 14 8 8 5 15 10
Bud 7 2 19 4 3 10 – 23 9 15 24 23 0 2 0 3 6 2 3 1 3 2 8 4
Bud Neck 0 0 2 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 6 2 4 2 5 3
Bud Site 0 0 0 0 0 1 – 1 0 2 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 13 16 13 25 12 24 – 30 19 19 16 14 37 31 53 16 6 26 5 5 5 2 4 11
Cytoplasm 177 70 98 52 123 226 – 324 164 242 162 264 102 93 132 41 56 45 97 23 35 28 45 63
Endoplasmic Reticulum 160 199 68 83 93 70 – 47 61 66 37 42 255 158 213 0 6 5 350 237 207 138 275 224
Endosome 6 0 0 0 2 6 – 5 1 3 0 3 1 4 1 3 4 3 2 0 1 1 5 5
Golgi 0 0 0 0 0 0 – 0 0 2 0 0 0 0 1 2 0 1 2 0 0 0 2 3
Mitochondria 24 3 68 95 50 202 – 338 245 289 204 365 4 2 2 4 13 5 15 6 30 15 19 16
Nucleus 8 2 0 1 0 1 – 15 2 2 4 6 0 1 1 3 2 3 0 0 0 1 0 1
Nuclear Periphery 3 3 0 3 1 1 – 13 4 4 7 8 1 3 2 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 1 0 0 1 2 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 0 0 0 0 – 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 62 8 14 5 16 32 – 112 33 45 25 43 5 5 18 32 38 52 20 4 9 6 16 24
Unique Cell Count 407 260 234 190 258 445 735 440 553 384 627 360 268 365 96 116 114 522 294 312 208 405 373
Labelled Cell Count 464 305 291 271 308 576 913 539 691 482 772 413 314 423 116 140 146 522 294 312 208 405 373


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.7 8.4 4.8 5.6 6.0 4.8 – 4.8 4.1 4.5 4.6 4.4 7.4 7.4 7.2 10.3 8.7 10.1 6.8 7.3 7.4
Std Deviation (1e-4) 1.1 1.2 0.9 1.3 1.6 1.1 – 1.2 1.0 0.9 1.1 0.9 1.2 1.1 1.0 1.8 1.9 2.0 1.1 1.2 1.3
Intensity Change (Log2) – – – 0.22 0.33 -0.0 – -0.0 -0.22 -0.08 -0.07 -0.12 0.63 0.63 0.59 1.11 0.86 1.07 0.51 0.6 0.63


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 -0.5 0 – 0 0 0 0 0 -1.2 0.5 0 2.9 1.6 0
Bud -2.7 -3.7 0 – 0 0 0 0 0 -5.5 -4.1 -5.5 -1.7 -1.0 -2.3
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2.7 -0.5 0 – 0 0 0 0 0 2.0 2.4 3.4 3.2 -0.1 4.8
Cytoplasm -3.1 1.3 2.2 – 0.6 -1.2 0.5 0.1 0.1 -3.4 -1.7 -1.4 0.1 1.1 -0.4
Endoplasmic Reticulum 3.1 1.6 0 – 0 0 0 0 0 10.0 6.7 7.0 -5.9 -5.2 -5.3
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.4 -2.5 0 – 0 0 0 0 0 -10.2 -9.1 -10.6 -5.0 -3.7 -5.3
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.7 0.1 0.6 – 3.7 0.7 1.0 0.3 0.5 -3.1 -2.4 -0.6 6.5 6.6 8.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.888 4.0042 2.9824 2.3285 2.4406 3.1235 3.0268 3.8956 3.5124 3.2445 2.6836 3.3868 4.2937 5.6413 5.0127 4.6768 4.6863 5.1953
Actin 0.0272 0.0016 0.0144 0.0346 0.0964 0.0091 0.0656 0.0014 0.031 0.0029 0.0209 0.0015 0.045 0.0011 0.0059 0.0041 0.0026 0.0064
Bud 0.0004 0.0001 0.0023 0.0032 0.0011 0.0002 0.0012 0.0015 0.0042 0.0004 0.0013 0.0003 0.0006 0.0046 0.0052 0.0001 0.0019 0.0001
Bud Neck 0.0004 0.0003 0.0022 0.0011 0.0009 0.0097 0.0085 0.0004 0.0081 0.0019 0.0021 0.0029 0.0017 0.0003 0.0006 0.0006 0.0008 0.002
Bud Periphery 0.0007 0.0002 0.0094 0.005 0.0017 0.0007 0.0024 0.0008 0.0042 0.0008 0.0029 0.0003 0.0007 0.001 0.0026 0.0003 0.0037 0.0001
Bud Site 0.0011 0.0015 0.006 0.0112 0.0016 0.0001 0.018 0.0144 0.0074 0.0012 0.0027 0.0002 0.0032 0.0068 0.0077 0.0006 0.0031 0.0002
Cell Periphery 0.0017 0.0032 0.0017 0.0005 0.0023 0.0013 0.0057 0.0034 0.0023 0.0007 0.0014 0.0009 0.0022 0.0034 0.0035 0.0011 0.0014 0.0007
Cytoplasm 0.2062 0.3039 0.2266 0.1129 0.1994 0.2997 0.2054 0.2028 0.2238 0.2549 0.216 0.1972 0.1925 0.3178 0.2173 0.117 0.3954 0.2474
Cytoplasmic Foci 0.0196 0.004 0.0166 0.0116 0.0282 0.0034 0.0311 0.0086 0.0116 0.0065 0.0224 0.01 0.017 0.0061 0.0099 0.0065 0.0087 0.0046
Eisosomes 0.0002 0.0001 0.0001 0.0003 0.0005 0.0001 0.001 0.0001 0.0004 0 0.0004 0 0.0005 0 0.0001 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.549 0.6287 0.6141 0.6252 0.5091 0.6103 0.4478 0.6633 0.6034 0.6385 0.4152 0.7324 0.5814 0.5812 0.6734 0.7529 0.4247 0.6853
Endosome 0.0326 0.0077 0.0268 0.0603 0.0456 0.011 0.0635 0.0252 0.0271 0.0238 0.0957 0.0088 0.0187 0.0101 0.0138 0.0154 0.0255 0.0114
Golgi 0.0103 0.001 0.0141 0.0358 0.0255 0.0026 0.0229 0.0031 0.0093 0.0078 0.0299 0.0014 0.0122 0.001 0.0051 0.0089 0.0142 0.0016
Lipid Particles 0.0215 0.0062 0.0093 0.0169 0.0122 0.0025 0.0233 0.018 0.0109 0.0084 0.0324 0.0084 0.018 0.0167 0.0057 0.0336 0.0028 0.0024
Mitochondria 0.0038 0.0002 0.0099 0.0295 0.0091 0.0011 0.0109 0.0009 0.0139 0.0034 0.0332 0.0006 0.0131 0.0004 0.0107 0.0227 0.0395 0.0007
None 0.072 0.0175 0.0107 0.0081 0.0052 0.0197 0.0247 0.0292 0.0132 0.0022 0.0509 0.0162 0.0404 0.0288 0.0168 0.0054 0.0537 0.015
Nuclear Periphery 0.0125 0.0144 0.0161 0.0175 0.0113 0.0193 0.0136 0.0128 0.0126 0.0274 0.0218 0.0101 0.0153 0.0087 0.009 0.016 0.0096 0.0105
Nucleolus 0.0013 0.0001 0.0003 0.0018 0.0001 0.0001 0.0012 0.0003 0.0007 0.0004 0.0005 0.0002 0.0057 0.0009 0.0004 0.0001 0.0002 0.0001
Nucleus 0.0035 0.0044 0.0066 0.0045 0.0014 0.0037 0.0063 0.0033 0.0036 0.0085 0.0089 0.0031 0.0088 0.0036 0.0017 0.0018 0.0037 0.0063
Peroxisomes 0.0213 0 0.0054 0.0082 0.042 0.0001 0.0164 0.0002 0.0024 0.0013 0.0264 0.0003 0.0105 0.0001 0.0018 0.0048 0.0007 0.0002
Punctate Nuclear 0.0059 0.0006 0.0013 0.0034 0.002 0.0011 0.0188 0.0025 0.0023 0.0016 0.0045 0.002 0.0083 0.0009 0.0005 0.0023 0.0008 0.0008
Vacuole 0.0065 0.0039 0.0046 0.0059 0.0027 0.0032 0.0095 0.007 0.0066 0.0062 0.007 0.0028 0.0036 0.0063 0.0069 0.0047 0.0056 0.0038
Vacuole Periphery 0.0023 0.0004 0.0014 0.0023 0.0018 0.0009 0.0019 0.0008 0.001 0.0013 0.0033 0.0003 0.0008 0.0003 0.0011 0.0011 0.0015 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.6229 8.3238 7.7208 10.5614 18.109 18.6126 14.2024 15.6211 8.8954 16.8314
Translational Efficiency 0.4076 0.8157 0.7586 0.4078 0.3579 0.8081 0.715 0.4408 0.8213 0.6004

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1930 1423 991 1341 1323 87 2211 1366 3253 1510 3202 2707

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 819.37 957.83 1217.49 1068.94 804.93 1009.38 1083.11 998.12 813.50 960.80 1124.70 1033.20
Standard Deviation 99.07 148.73 163.45 133.93 111.25 149.41 127.38 148.79 104.44 149.25 152.74 145.98
Intensity Change Log 2 — 0.225255 0.571323 0.383594 — 0.326534 0.428245 0.310350 — 0.276333 0.502192 0.347762

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000563 0.002343 0.001807 0.023125 0.000846 0.001718 0.003679 0.013272 0.000678 0.002307 0.003100 0.018153
Bud Neck 0.003908 0.003076 0.004402 0.017776 0.004235 0.002507 0.009684 0.022739 0.004041 0.003043 0.008049 0.020280
Bud Site 0.006212 0.008599 0.015755 0.071911 0.007315 0.011822 0.018488 0.047389 0.006660 0.008784 0.017642 0.059537
Cell Periphery 0.001333 0.003012 0.003156 0.009514 0.001406 0.012372 0.004165 0.009011 0.001363 0.003552 0.003853 0.009260
Cytoplasm 0.272594* 0.115200* 0.143754* 0.209610* 0.233267* 0.125523* 0.222327* 0.268903* 0.256600* 0.115795* 0.198009* 0.239530*
Cytoplasmic Foci 0.061569 0.023988 0.023934 0.052730 0.078561 0.037124 0.010763 0.070304 0.068480 0.024745 0.014839 0.061598
Eisosomes 0.000835 0.001266 0.000190 0.004628 0.001134 0.003258 0.001256 0.005893 0.000957 0.001381 0.000926 0.005266
Endoplasmic Reticulum 0.480031* 0.762916* 0.623369* 0.264121* 0.474487* 0.680601* 0.525689* 0.220281* 0.477776* 0.758173* 0.555921* 0.241999*
Endosome 0.006788 0.006121 0.014445 0.022122 0.008743 0.007537 0.006972 0.018567 0.007583 0.006203 0.009285 0.020328
Golgi 0.020172 0.012101 0.001870 0.008881 0.015586 0.029429 0.002298 0.009500 0.018307 0.013100 0.002166 0.009194
Lipid Particles 0.056977 0.019870 0.023090 0.057312 0.065600 0.030131 0.019990 0.051435 0.060484 0.020461 0.020949 0.054346
Mitochondria 0.008744 0.006360 0.000518 0.004510 0.011444 0.014092 0.001526 0.004179 0.009842 0.006805 0.001214 0.004343
Mitotic Spindle 0.000294 0.000753 0.001016 0.010993 0.000156 0.001375 0.001490 0.004640 0.000238 0.000789 0.001344 0.007787
None 0.008131 0.004881 0.001765 0.000385 0.003501 0.000153 0.001463 0.001183 0.006248 0.004609 0.001556 0.000787
Nuclear Periphery 0.002530 0.000952 0.010127 0.001688 0.003970 0.001408 0.004400 0.002136 0.003116 0.000978 0.006173 0.001914
Nuclear Periphery Foci 0.005701 0.004967 0.061244 0.024305 0.008079 0.007793 0.021610 0.015999 0.006668 0.005130 0.033876 0.020114
Nucleolus 0.000398 0.000397 0.000193 0.000232 0.000455 0.000031 0.000139 0.000582 0.000421 0.000376 0.000156 0.000408
Nucleus 0.044612 0.009524 0.025097 0.038596 0.053611 0.004406 0.087258 0.048076 0.048272 0.009229 0.068020 0.043380
Peroxisomes 0.003252 0.003265 0.000607 0.004204 0.004799 0.014067 0.000728 0.005751 0.003881 0.003888 0.000691 0.004985
Vacuole 0.013527 0.008893 0.043183 0.169376 0.020791 0.013914 0.055586 0.178189 0.016481 0.009183 0.051748 0.173823
Vacuole Periphery 0.001828 0.001514 0.000476 0.003981 0.002016 0.000739 0.000488 0.001972 0.001904 0.001469 0.000484 0.002967

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.57 -4.14 -11.01 -9.80 -10.22 -1.55 -6.55 -10.59 -8.87 -7.29 -3.46 -7.82 -14.84 -12.40 -12.01
Bud Neck 0.99 -0.89 -10.59 -10.76 -9.93 1.47 -5.96 -10.33 -10.20 -6.57 1.36 -6.23 -14.62 -14.21 -9.81
Bud Site -1.73 -3.96 -15.71 -14.92 -11.65 -0.59 -5.72 -11.40 -4.23 -7.44 -1.59 -7.64 -19.44 -17.81 -13.65
Cell Periphery -3.37 -3.42 -7.99 -5.49 -5.25 -2.23 -7.69 -8.38 0.81 -4.81 -4.00 -8.66 -11.59 -6.11 -6.98
Cytoplasm 22.93 14.63 8.03 -12.87 -7.07 5.00 1.22 -3.74 -6.53 -5.41 23.89 10.21 3.10 -19.93 -6.61
Cytoplasmic Foci 12.75 11.78 2.45 -10.19 -9.37 3.89 19.78 1.41 -3.33 -20.20 16.50 25.28 2.02 -14.72 -23.37
Eisosomes -1.51 9.24 -7.65 -5.69 -9.20 -1.43 -0.72 -7.10 -1.39 -7.02 -1.49 0.29 -10.34 -7.52 -10.45
Endoplasmic Reticulum -24.87* -9.65 20.36 44.70* 26.16 -4.95 -2.92 20.87 11.55 27.63* -27.72 -7.31 29.61 54.56* 36.84*
Endosome 1.13 -8.25 -10.06 -10.34 -3.92 0.54 2.30 -8.05 -4.44 -9.26 2.60 -3.57 -13.12 -13.73 -10.40
Golgi 6.02 17.64 9.47 3.56 -7.36 -2.10 14.22 5.49 3.15 -7.48 4.51 22.27 10.86 4.45 -10.34
Lipid Particles 14.96 11.87 0.29 -11.51 -9.49 5.70 14.40 4.03 -3.31 -10.85 18.56 19.79 2.93 -14.21 -14.88
Mitochondria 2.37 11.10 4.29 2.20 -4.46 -0.25 6.20 4.28 0.98 -2.96 2.58 10.94 6.12 2.76 -4.88
Mitotic Spindle -1.50 -2.97 -6.26 -5.88 -5.71 -1.05 -3.42 -4.48 -2.47 -3.03 -1.92 -3.92 -7.67 -6.84 -6.17
None 2.26 5.22 7.59 4.42 2.03 4.12 2.49 2.75 -3.22 0.88 1.39 6.45 7.77 3.97 2.72
Nuclear Periphery 5.96 -7.60 2.65 -2.72 8.39 4.47 -0.79 3.40 -1.32 4.01 8.55 -6.63 3.97 -3.56 8.96
Nuclear Periphery Foci 1.14 -15.88 -10.78 -11.07 9.52 0.15 -11.87 -6.61 -4.12 3.52 2.59 -20.19 -12.87 -13.71 8.18
Nucleolus -0.02 3.35 3.26 0.95 -0.58 5.74 4.24 -0.74 -3.35 -2.69 0.25 6.31 0.10 -0.18 -2.90
Nucleus 17.61 6.93 1.65 -14.77 -5.22 17.25 -9.01 1.46 -18.15 11.12 22.59 -8.04 1.81 -21.01 9.61
Peroxisomes -0.04 10.39 -1.90 -1.45 -9.42 -1.48 10.04 -1.25 1.35 -10.03 -0.01 14.66 -2.56 -1.55 -13.67
Vacuole 3.72 -11.12 -29.61 -30.22 -22.52 1.12 -15.59 -27.35 -21.37 -19.84 6.24 -20.41 -40.43 -41.52 -29.19
Vacuole Periphery 0.90 4.53 -2.15 -2.65 -4.11 4.29 6.29 0.37 -2.09 -2.73 1.68 6.67 -1.61 -2.55 -4.89
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
Localization
Cell Percentages ER (94%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Irc23

Irc23


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Irc23-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available