Standard name
Human Ortholog
Description Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0.05
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.06 0 0.08 0.11 0.17 0.14 0.12 0.24 0.13 0.21 0.21 0.13 0.14 0.13 0.21 0.19 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0.06 0.12 0.06 0.05 0 0.12 0 0.09 0.05 0.05 0 0.07 0.16 0.14 0.07 0 0 0 0.06 0.09 0.08 0.09 0.09 0.07
Endosome 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 0.05 0.06 0.09 0.17
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0.16 0.15 0.16 0.33 0.39 0.46 0 0 0 0 0.1 0.09
Mitochondria 0 0 0.12 0.12 0.1 0.24 0.32 0.2 0.34 0.39 0.47 0.48 0 0 0 0.07 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0
Nuclear Periphery 0.19 0.25 0.31 0.46 0.32 0.32 0.37 0.33 0.29 0.38 0.23 0.31 0.17 0.13 0.05 0 0 0 0.78 0.51 0.79 0.66 0.57 0.47
Nucleolus 0.1 0.12 0.06 0.14 0.08 0.09 0.1 0.1 0.09 0.05 0.08 0.09 0.05 0.07 0.05 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.76 0.75 0.62 0.52 0.62 0.28 0.41 0.36 0.22 0.26 0.12 0.15 0.65 0.58 0.68 0.52 0.59 0.64 0.05 0.19 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 1 0 1 1 1 1 1 0 0 3 9 9 15 2 3 1 0 0 5 7 32
Bud 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 0 2 2 0 4 8 26
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 5 1 0 5 10 19 20 25 35 24 15 32 34 56 71 54 46 17 2 1 0 2 3 3
Endoplasmic Reticulum 9 2 1 3 3 14 4 18 8 10 1 10 41 56 39 9 8 2 10 5 5 17 45 42
Endosome 0 0 0 2 0 7 3 11 3 1 1 1 1 10 24 4 0 0 4 1 3 11 43 100
Golgi 2 0 0 1 1 4 1 3 1 0 1 2 42 62 86 87 96 68 1 0 0 7 49 55
Mitochondria 5 0 2 8 9 27 46 42 50 72 34 73 0 0 1 17 9 5 0 0 1 1 4 10
Nucleus 1 0 0 1 1 5 1 4 8 8 3 4 2 1 2 1 1 0 3 3 0 0 2 3
Nuclear Periphery 28 4 5 30 29 36 53 67 42 70 17 47 43 53 27 7 3 3 147 33 53 126 273 281
Nucleolus 15 2 1 9 7 10 15 21 13 10 6 13 12 28 25 7 5 3 2 1 0 1 4 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 2 4
SpindlePole 0 0 0 0 0 0 0 2 0 0 0 0 0 0 2 0 1 0 0 1 0 1 5 5
Vac/Vac Membrane 113 12 10 34 57 31 59 75 33 48 9 23 165 241 357 137 146 95 9 12 0 7 25 26
Unique Cell Count 149 16 16 65 92 112 145 206 147 186 73 151 255 414 526 261 247 149 189 66 68 193 482 605
Labelled Cell Count 178 22 19 94 117 154 203 269 195 246 88 207 343 517 644 339 317 196 189 66 68 193 482 605


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 17.7 18.4 13.0 12.6 12.0 10.4 9.6 9.8 9.2 9.2 8.0 8.3 21.3 20.6 20.4 22.1 25.3 30.5 20.0 19.8 20.7
Std Deviation (1e-4) 3.9 4.7 2.9 3.4 2.9 2.7 2.5 2.4 2.3 2.1 2.1 2.1 5.0 4.5 4.7 6.5 7.5 7.5 4.5 4.1 4.3
Intensity Change (Log2) – – – -0.05 -0.11 -0.32 -0.43 -0.4 -0.49 -0.51 -0.7 -0.65 0.71 0.66 0.65 0.76 0.96 1.23 0.62 0.61 0.67


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 2.8 3.1 3.5
Mitochondria 0 0 0 0 0 1.8 2.1 2.5 2.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 1.1 0 0.1 0.4 0.1 0 0.5 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.7 0 -2.8 -1.7 -2.1 0 0 0 0 0.2 -0.3 0.5 -0.8 -0.3 0.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.5665 16.8899 16.7192 15.7612 17.1848 16.0576 12.9463 13.1523 12.7349 11.8698 10.6437 11.9062 14.8184 17.3042 15.2752 15.1367 14.3482 14.9917
Actin 0.0139 0.0034 0.0093 0.0022 0.0002 0.0004 0.0122 0.0347 0.0046 0.0175 0.0049 0.0035 0.0358 0.0011 0.0088 0.0265 0.0006 0.0103
Bud 0.0001 0.0003 0.0002 0 0 0 0.0002 0.0002 0.0002 0.0003 0.0069 0.0002 0.0001 0 0.0001 0.0004 0 0.0001
Bud Neck 0.0004 0.0003 0.0005 0.0006 0 0.0002 0.0003 0.0004 0.0003 0.0005 0.0011 0.0002 0.0003 0.0001 0.0002 0.0011 0 0.0002
Bud Periphery 0.0003 0.0008 0.0002 0.0001 0 0.0001 0.0004 0.0005 0.0006 0.0008 0.0074 0.0003 0.0002 0.0001 0.0003 0.0015 0 0.0002
Bud Site 0.0002 0.0007 0.0021 0 0 0 0.0035 0.0018 0.0006 0.0004 0.042 0.0005 0.0006 0.0001 0.0003 0.0006 0 0.0001
Cell Periphery 0.0001 0.0013 0.0001 0.0001 0 0 0.0002 0.0003 0.0002 0.0002 0.0008 0.0001 0.0001 0.0001 0.0001 0.0005 0 0
Cytoplasm 0.0055 0.0384 0.009 0.0044 0.0074 0.0031 0.0112 0.0132 0.0028 0.0013 0.0262 0.0022 0.0057 0.0053 0.0009 0.0071 0.0002 0.0004
Cytoplasmic Foci 0.0057 0.0004 0.0012 0.0002 0.0001 0.0001 0.0227 0.0028 0.0095 0.0013 0.0114 0.0032 0.0187 0.0004 0.0076 0.0168 0.0001 0.0023
Eisosomes 0.0002 0.0006 0.0001 0 0 0 0.0002 0.0005 0.0002 0.0001 0.0002 0.0001 0.0002 0 0.0001 0.0002 0 0.0001
Endoplasmic Reticulum 0.0148 0.0228 0.0202 0.0246 0.0033 0.0033 0.0096 0.0314 0.0194 0.0284 0.0043 0.0083 0.015 0.0395 0.0262 0.0766 0.0113 0.0054
Endosome 0.0198 0.0027 0.0042 0.0035 0.0014 0.0013 0.0273 0.008 0.0308 0.0113 0.0349 0.0184 0.0219 0.0083 0.0064 0.0058 0.0043 0.0041
Golgi 0.0024 0.0004 0.0008 0.0007 0.0005 0.0001 0.0063 0.0049 0.0097 0.0043 0.0051 0.0071 0.0033 0.001 0.0018 0.0026 0.0005 0.0028
Lipid Particles 0.0034 0.0007 0.0012 0.0014 0.0022 0.0004 0.0155 0.011 0.017 0.0054 0.0014 0.0181 0.0195 0.0058 0.0044 0.0027 0.0009 0.0063
Mitochondria 0.0025 0.0025 0.0007 0.0007 0.0002 0.0003 0.0037 0.0026 0.003 0.0055 0.044 0.0181 0.0019 0.0011 0.0011 0.0031 0.0006 0.0018
None 0.0029 0.0002 0.0003 0.0001 0.0001 0.0001 0.0175 0.0059 0.0232 0.0005 0.0005 0.0005 0.0046 0.0002 0.0008 0.0013 0.0001 0.0003
Nuclear Periphery 0.8524 0.8084 0.8742 0.8442 0.8934 0.9407 0.8132 0.8128 0.812 0.8513 0.7703 0.8917 0.8155 0.8609 0.8851 0.7436 0.9537 0.9317
Nucleolus 0.0007 0.0043 0.0006 0.0003 0.0002 0.0003 0.0003 0.0003 0.001 0.001 0.0009 0.0002 0.0008 0.0005 0.0002 0.0003 0.0001 0.0002
Nucleus 0.0343 0.0889 0.0531 0.0952 0.0727 0.0362 0.0114 0.0101 0.0136 0.0201 0.0036 0.0055 0.0089 0.0391 0.0151 0.0539 0.0074 0.0128
Peroxisomes 0.0003 0 0.0002 0 0 0 0.0066 0.0004 0.0047 0.0002 0.001 0.0005 0.0026 0 0.0017 0.0114 0 0.0032
Punctate Nuclear 0.0137 0.0024 0.0021 0.002 0.0014 0.0014 0.0022 0.0021 0.0056 0.007 0.0008 0.0008 0.01 0.003 0.0059 0.005 0.0009 0.0016
Vacuole 0.003 0.0045 0.0018 0.002 0.0007 0.0013 0.0022 0.0039 0.0037 0.0043 0.0092 0.0015 0.0044 0.006 0.0029 0.0031 0.0009 0.0011
Vacuole Periphery 0.0235 0.0161 0.018 0.0177 0.0159 0.0107 0.0333 0.0522 0.0373 0.0384 0.0231 0.0189 0.0299 0.0272 0.0299 0.036 0.0184 0.0149

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 111.5588 106.1937 78.2952 104.9463 109.5914 84.479 96.0157 87.3346 80.8701 103.2363
Translational Efficiency 1.87 2.0253 2.3243 1.5438 1.6927 2.4511 1.7615 1.7943 2.0011 1.7059

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1844 1094 108 1559 1211 1203 174 146 3055 2297 282 1705

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1399.16 1546.76 2068.64 2345.65 1544.84 1599.95 2493.52 2520.98 1456.91 1574.62 2330.80 2360.66
Standard Deviation 350.54 378.82 390.86 425.34 280.30 305.16 352.71 502.35 332.25 343.26 421.81 435.24
Intensity Change Log 2 — 0.144688 0.564122 0.745427 — 0.050569 0.690726 0.706527 — 0.096067 0.631939 0.725145

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001007 0.000305 0.000191 0.000096 0.000185 0.000170 0.000063 0.000159 0.000681 0.000234 0.000112 0.000101
Bud Neck 0.001899 0.001848 0.010721 0.003778 0.001947 0.001440 0.003736 0.011215 0.001918 0.001634 0.006411 0.004415
Bud Site 0.000529 0.000504 0.000520 0.001272 0.000438 0.000678 0.000105 0.003629 0.000493 0.000595 0.000264 0.001474
Cell Periphery 0.000254 0.000176 0.000136 0.000231 0.000129 0.000064 0.000067 0.000367 0.000204 0.000117 0.000094 0.000242
Cytoplasm 0.011335 0.018475 0.000623 0.010818 0.010052 0.008305 0.000301 0.003076 0.010826 0.013148 0.000424 0.010155
Cytoplasmic Foci 0.001789 0.001495 0.001084 0.002655 0.001870 0.001782 0.000350 0.003000 0.001821 0.001645 0.000631 0.002684
Eisosomes 0.000006 0.000002 0.000004 0.000002 0.000002 0.000002 0.000001 0.000003 0.000004 0.000002 0.000002 0.000002
Endoplasmic Reticulum 0.011262 0.006002 0.002202 0.007201 0.007047 0.004414 0.001952 0.003670 0.009591 0.005170 0.002048 0.006898
Endosome 0.006403 0.005283 0.002559 0.009432 0.006167 0.003536 0.001471 0.011655 0.006310 0.004368 0.001888 0.009622
Golgi 0.002854 0.003196 0.000929 0.011586 0.002291 0.001684 0.000800 0.011548 0.002631 0.002404 0.000849 0.011583
Lipid Particles 0.012971 0.002789 0.002319 0.013462 0.005751 0.001431 0.001503 0.013998 0.010109 0.002078 0.001815 0.013508
Mitochondria 0.013555 0.002624 0.000803 0.000690 0.001157 0.002115 0.000396 0.000161 0.008640 0.002357 0.000552 0.000644
Mitotic Spindle 0.005764 0.016458 0.029741 0.090825 0.010508 0.019631 0.013604 0.078170 0.007645 0.018120 0.019784 0.089741
None 0.009633 0.002582 0.000130 0.000402 0.001246 0.000929 0.000046 0.000126 0.006308 0.001716 0.000079 0.000379
Nuclear Periphery 0.301002* 0.358732* 0.576089* 0.215335* 0.299643* 0.480186* 0.616017* 0.242236* 0.300463* 0.422341* 0.600725* 0.217639*
Nuclear Periphery Foci 0.488888* 0.531352* 0.352425* 0.558518* 0.621856* 0.445413* 0.346084* 0.544854* 0.541597* 0.486344* 0.348513* 0.557348*
Nucleolus 0.003836 0.002071 0.003618 0.000122 0.002284 0.001563 0.000247 0.000070 0.003221 0.001805 0.001538 0.000117
Nucleus 0.096541 0.012582 0.005941 0.001539 0.006916 0.009511 0.000908 0.000611 0.061014 0.010973 0.002836 0.001460
Peroxisomes 0.000091 0.000031 0.000110 0.000053 0.000037 0.000201 0.000007 0.000022 0.000070 0.000120 0.000047 0.000050
Vacuole 0.012182 0.017959 0.005889 0.054641 0.008998 0.007812 0.008049 0.058087 0.010920 0.012645 0.007222 0.054936
Vacuole Periphery 0.018199 0.015534 0.003967 0.017345 0.011475 0.009136 0.004290 0.013342 0.015534 0.012183 0.004166 0.017002

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 5.22 4.82 7.80 2.20 1.72 0.26 2.48 -0.28 -0.36 -1.33 5.73 6.50 7.44 2.16 0.58
Bud Neck -0.22 -3.19 -6.31 -5.91 2.55 1.56 -3.09 -3.72 -3.83 -3.18 1.12 -3.75 -7.18 -7.40 1.54
Bud Site 0.29 -0.87 -4.39 -4.45 -2.33 -1.12 4.08 -2.66 -2.49 -2.83 -0.79 0.95 -5.33 -4.53 -5.43
Cell Periphery 1.89 0.87 -0.43 -2.16 -1.07 3.88 2.90 -3.04 -3.57 -3.52 3.97 2.99 -3.13 -5.95 -4.95
Cytoplasm -2.46 7.46 -2.16 0.68 -7.98 0.54 5.11 2.52 2.12 -2.02 -1.38 9.10 -2.10 -0.75 -8.33
Cytoplasmic Foci 0.73 1.48 -2.02 -2.26 -2.75 0.07 6.77 -1.98 -1.85 -3.21 0.42 5.78 -2.44 -2.34 -4.70
Eisosomes 6.50 0.11 7.15 0.08 1.94 0.27 3.03 -1.48 -1.52 -2.00 6.05 1.94 5.02 -0.80 0.66
Endoplasmic Reticulum 5.68 11.61 3.05 -1.35 -5.17 2.69 5.59 3.04 1.05 -2.01 6.68 12.50 2.26 -2.05 -5.50
Endosome 1.71 6.09 -3.82 -4.92 -7.97 3.31 6.48 -2.55 -3.75 -4.71 4.02 10.11 -4.46 -7.11 -10.66
Golgi -0.36 5.24 -8.12 -6.05 -10.12 1.04 6.38 -2.85 -3.00 -3.31 0.41 7.96 -8.93 -8.25 -10.88
Lipid Particles 8.63 8.22 -0.87 -8.82 -8.49 5.11 4.81 -3.64 -5.43 -5.38 10.25 10.05 -3.15 -10.32 -10.28
Mitochondria 7.23 9.36 9.49 2.74 0.31 -2.10 2.35 5.32 4.58 1.29 6.84 9.64 9.50 3.91 -0.68
Mitotic Spindle -4.20 -2.39 -16.63 -13.63 -5.27 -3.00 -0.65 -4.15 -3.57 -3.78 -5.37 -2.48 -16.86 -14.28 -10.13
None 5.60 8.19 7.83 4.54 -3.57 1.08 5.70 5.23 3.77 -1.39 6.08 8.81 8.16 4.85 -4.60
Nuclear Periphery -5.93 -10.77 12.50 16.41 14.74 -18.42* -18.26 3.55 12.53 15.75 -17.49 -20.87 14.17 29.08* 26.99
Nuclear Periphery Foci -3.91 6.82 -5.28 -1.01 -9.37 18.23* 17.41 4.06 -3.66 -6.98 7.58 15.43 0.23 -6.43 -14.55
Nucleolus 3.09 -0.50 9.53 4.86 1.67 1.03 3.81 4.19 3.71 2.12 3.25 0.79 9.76 5.83 1.71
Nucleus 13.08 11.43 15.25 4.45 1.44 -1.30 4.14 4.92 4.80 0.42 12.34 13.53 15.06 5.24 0.61
Peroxisomes 4.54 -0.95 1.35 -0.74 1.29 -1.41 3.43 0.80 1.50 -1.72 -0.82 -0.22 0.76 1.06 0.60
Vacuole -2.96 3.58 -15.06 -11.54 -16.16 0.74 0.31 -5.60 -5.68 -5.57 -1.63 2.06 -16.60 -15.26 -16.25
Vacuole Periphery 1.41 11.28 0.83 -0.68 -9.39 1.36 5.86 -0.44 -1.05 -2.42 2.61 12.86 -0.75 -2.87 -10.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress
Localization
Cell Percentages nuclear periphery (72%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Dbp5

Dbp5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dbp5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available